ISMARA results: FOSL1

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for FOSL1

Z-value: 2.20

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Transcription factors associated with FOSL1

Gene Symbol	Gene ID	Gene Info
FOSL1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000175592.4	FOS like 1, AP-1 transcription factor subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOSL1	hg19_v2_chr11_-_65667884_65667895	0.86	1.2e-09	Click!

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_36019123 Show fit	22.14	ENST00000588674.1 ENST00000452271.2 ENST00000518157.1	SBSN Ensembl NCBI GeneCards UniProt NextProt Show fit	suprabasin
chr1_+_150480551 Show fit	18.24	ENST00000369049.4 ENST00000369047.4	ECM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	extracellular matrix protein 1
chr1_+_150480576 Show fit	18.04	ENST00000346569.6	ECM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	extracellular matrix protein 1
chr18_+_21452964 Show fit	16.70	ENST00000587184.1	LAMA3 Ensembl NCBI GeneCards UniProt NextProt Show fit	laminin, alpha 3
chr18_+_21452804 Show fit	14.36	ENST00000269217.6	LAMA3 Ensembl NCBI GeneCards UniProt NextProt Show fit	laminin, alpha 3
chr1_-_153029980 Show fit	13.95	ENST00000392653.2	SPRR2A Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2A
chr1_+_183155373 Show fit	13.82	ENST00000493293.1 ENST00000264144.4	LAMC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	laminin, gamma 2
chr12_+_13349650 Show fit	13.66	ENST00000256951.5 ENST00000431267.2 ENST00000542474.1 ENST00000544053.1	EMP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	epithelial membrane protein 1
chr6_+_47666275 Show fit	13.62	ENST00000327753.3 ENST00000283303.2	GPR115 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 115
chr1_-_153013588 Show fit	13.62	ENST00000360379.3	SPRR2D Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2D

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	54.6	GO:0018149	peptide cross-linking(GO:0018149)
1.9	54.5	GO:0031581	hemidesmosome assembly(GO:0031581)
1.4	36.3	GO:0030502	negative regulation of bone mineralization(GO:0030502)
8.4	25.3	GO:0046586	regulation of calcium-dependent cell-cell adhesion(GO:0046586)
4.8	19.2	GO:0006218	uridine catabolic process(GO:0006218)
3.1	18.4	GO:0007296	vitellogenesis(GO:0007296)
1.9	15.0	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.5	14.8	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.3	14.4	GO:0043486	histone exchange(GO:0043486)
0.8	14.0	GO:0051546	keratinocyte migration(GO:0051546)

Showing 1 to 10 of 190 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	96.0	GO:0001533	cornified envelope(GO:0001533)
2.0	36.3	GO:0031089	platelet dense granule lumen(GO:0031089)
4.0	32.3	GO:0005610	laminin-5 complex(GO:0005610)
0.2	30.6	GO:0005882	intermediate filament(GO:0005882)
6.5	19.5	GO:0005607	laminin-2 complex(GO:0005607)
0.1	16.4	GO:0042734	presynaptic membrane(GO:0042734)
0.4	14.7	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	14.5	GO:0030027	lamellipodium(GO:0030027)
0.7	14.4	GO:0000812	Swr1 complex(GO:0000812)
2.2	13.3	GO:0070435	Shc-EGFR complex(GO:0070435)

Showing 1 to 10 of 93 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	71.0	GO:0005198	structural molecule activity(GO:0005198)
4.3	34.2	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.4	26.5	GO:0017080	sodium channel regulator activity(GO:0017080)
1.7	24.8	GO:0030280	structural constituent of epidermis(GO:0030280)
0.1	23.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
3.8	19.2	GO:0004850	uridine phosphorylase activity(GO:0004850)
0.2	17.6	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.2	15.0	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.5	14.8	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.4	14.1	GO:0050431	transforming growth factor beta binding(GO:0050431)

Showing 1 to 10 of 131 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	57.9	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.6	39.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	36.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	25.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.3	17.7	PID RAS PATHWAY	Regulation of Ras family activation
0.0	17.5	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	12.8	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	12.8	PID IL1 PATHWAY	IL1-mediated signaling events
0.4	11.9	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3	10.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 10 of 42 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	50.0	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
1.1	19.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.6	14.8	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.5	13.3	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.3	12.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.2	11.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.6	10.6	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	10.6	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.3	9.9	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	9.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis

Showing 1 to 10 of 61 entries

Results for FOSL1

Z-value: 2.20

Motif logo

Transcription factors associated with FOSL1

Activity-expression correlation:

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: