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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for FOSL2_SMARCC1
Z-value: 2.39
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Transcription factors associated with FOSL2_SMARCC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000075426.7 | FOS like 2, AP-1 transcription factor subunit | |
| ENSG00000173473.6 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL2 | hg19_v2_chr2_+_28618532_28618610 | 0.86 | 1.7e-09 | Click! |
| SMARCC1 | hg19_v2_chr3_-_47823298_47823423 | -0.42 | 2.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_21452964 Show fit | 34.22 |
ENST00000587184.1
|
laminin, alpha 3 |
|
| chr18_+_21452804 Show fit | 29.68 |
ENST00000269217.6
|
laminin, alpha 3 |
|
| chr1_+_150480551 Show fit | 27.54 |
ENST00000369049.4
ENST00000369047.4 |
extracellular matrix protein 1 |
|
| chr1_+_150480576 Show fit | 27.23 |
ENST00000346569.6
|
extracellular matrix protein 1 |
|
| chr19_-_36019123 Show fit | 25.28 |
ENST00000588674.1
ENST00000452271.2 ENST00000518157.1 |
suprabasin |
|
| chr17_-_39769005 Show fit | 19.21 |
ENST00000301653.4
ENST00000593067.1 |
keratin 16 |
|
| chr1_-_153521597 Show fit | 15.86 |
ENST00000368712.1
|
S100 calcium binding protein A3 |
|
| chr2_+_113875466 Show fit | 14.55 |
ENST00000361779.3
ENST00000259206.5 ENST00000354115.2 |
interleukin 1 receptor antagonist |
|
| chr1_-_153029980 Show fit | 14.17 |
ENST00000392653.2
|
small proline-rich protein 2A |
|
| chr6_+_74405804 Show fit | 12.94 |
ENST00000287097.5
|
CD109 molecule |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL2_SMARCC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 82.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 2.1 | 54.7 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.3 | 24.7 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 3.9 | 23.5 | GO:0007296 | vitellogenesis(GO:0007296) |
| 1.3 | 23.5 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.3 | 23.2 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 3.8 | 22.9 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.2 | 17.8 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 2.2 | 17.7 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 3.5 | 17.5 | GO:0061143 | alveolar primary septum development(GO:0061143) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 65.0 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 3.0 | 54.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 44.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.7 | 44.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 41.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 39.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 31.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.8 | 28.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 23.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 23.7 | GO:0031012 | extracellular matrix(GO:0031012) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 91.2 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.2 | 66.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 6.8 | 54.8 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.7 | 26.6 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.2 | 25.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 21.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.4 | 16.7 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.2 | 15.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 3.1 | 15.6 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.1 | 15.6 | GO:0044325 | ion channel binding(GO:0044325) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 83.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 58.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.8 | 54.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 32.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 26.0 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 25.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 19.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.6 | 18.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.4 | 18.2 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.4 | 13.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 72.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.4 | 27.4 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.3 | 20.2 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.7 | 18.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 17.1 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.9 | 15.6 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.3 | 13.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 12.9 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.4 | 12.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 9.4 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |