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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for FOXA1
Z-value: 1.17
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Transcription factors associated with FOXA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXA1 | hg19_v2_chr14_-_38064198_38064239 | 0.38 | 3.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_31823792 Show fit | 11.18 |
ENST00000375413.4
ENST00000354297.4 ENST00000375422.2 |
BPI fold containing family A, member 1 |
|
| chr4_+_165675197 Show fit | 10.13 |
ENST00000515485.1
|
RP11-294O2.2 |
|
| chr12_-_71551868 Show fit | 8.44 |
ENST00000247829.3
|
tetraspanin 8 |
|
| chr12_-_71551652 Show fit | 7.85 |
ENST00000546561.1
|
tetraspanin 8 |
|
| chr4_+_165675269 Show fit | 7.52 |
ENST00000507311.1
|
RP11-294O2.2 |
|
| chr10_+_51549498 Show fit | 5.10 |
ENST00000358559.2
ENST00000298239.6 |
microseminoprotein, beta- |
|
| chr13_+_50589390 Show fit | 4.96 |
ENST00000360473.4
ENST00000312942.1 |
potassium channel regulator |
|
| chr5_+_156712372 Show fit | 4.42 |
ENST00000541131.1
|
cytoplasmic FMR1 interacting protein 2 |
|
| chr2_+_71163051 Show fit | 4.19 |
ENST00000412314.1
|
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 |
|
| chr2_+_71162995 Show fit | 4.18 |
ENST00000234396.4
|
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.4 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 2.8 | 11.2 | GO:0044407 | biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229) |
| 0.2 | 7.6 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.3 | 6.5 | GO:0003334 | keratinocyte development(GO:0003334) |
| 2.1 | 6.4 | GO:1903565 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 1.9 | 5.7 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.2 | 5.1 | GO:0072189 | ureter development(GO:0072189) |
| 0.3 | 5.0 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 1.2 | 4.9 | GO:0036118 | hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme morphogenesis(GO:0072134) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) allantois development(GO:1905069) |
| 0.4 | 4.4 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 16.1 | GO:0009986 | cell surface(GO:0009986) |
| 0.6 | 8.4 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 5.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 3.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 3.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.9 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 2.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 2.4 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 1.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 8.1 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.0 | 7.7 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.5 | 5.7 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.4 | 4.9 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 3.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.4 | 3.4 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.8 | 3.0 | GO:0016160 | amylase activity(GO:0016160) |
| 0.1 | 2.9 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.6 | 2.4 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 5.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 5.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 5.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 4.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 4.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 4.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.4 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.4 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 6.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 3.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 3.4 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 3.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 3.0 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.2 | 2.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 2.2 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.9 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |