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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for FOXA3_FOXC2

Z-value: 0.51

Motif logo

Transcription factors associated with FOXA3_FOXC2

Gene Symbol Gene ID Gene Info
ENSG00000170608.2 forkhead box A3
ENSG00000176692.4 forkhead box C2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXC2hg19_v2_chr16_+_86600857_866009210.183.5e-01Click!
FOXA3hg19_v2_chr19_+_46367518_46367567-0.058.0e-01Click!

Activity profile of FOXA3_FOXC2 motif

Sorted Z-values of FOXA3_FOXC2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_31823792 6.50 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
BPI fold containing family A, member 1
chr11_+_27076764 2.88 ENST00000525090.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr5_+_156712372 2.58 ENST00000541131.1
cytoplasmic FMR1 interacting protein 2
chr20_+_31870927 2.11 ENST00000253354.1
BPI fold containing family B, member 1
chr11_-_108464465 1.93 ENST00000525344.1
exophilin 5
chr11_-_108464321 1.65 ENST00000265843.4
exophilin 5
chr7_+_142829162 1.52 ENST00000291009.3
prolactin-induced protein
chr13_+_50589390 1.17 ENST00000360473.4
ENST00000312942.1
potassium channel regulator
chr1_-_207095324 1.10 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
Fas apoptotic inhibitory molecule 3
chr20_+_9049682 1.05 ENST00000334005.3
ENST00000378473.3
phospholipase C, beta 4
chr1_-_146696901 1.05 ENST00000369272.3
ENST00000441068.2
flavin containing monooxygenase 5
chr17_+_79953310 1.02 ENST00000582355.2
alveolar soft part sarcoma chromosome region, candidate 1
chr13_-_86373536 0.98 ENST00000400286.2
SLIT and NTRK-like family, member 6
chr17_+_72426891 0.97 ENST00000392627.1
G protein-coupled receptor, family C, group 5, member C
chr1_+_104293028 0.84 ENST00000370079.3
amylase, alpha 1C (salivary)
chr13_-_36429763 0.81 ENST00000379893.1
doublecortin-like kinase 1
chr4_+_165675197 0.81 ENST00000515485.1
RP11-294O2.2
chr9_-_75567962 0.78 ENST00000297785.3
ENST00000376939.1
aldehyde dehydrogenase 1 family, member A1
chr10_-_21435488 0.74 ENST00000534331.1
ENST00000529198.1
ENST00000377118.4
chromosome 10 open reading frame 113
chr13_-_39564993 0.74 ENST00000423210.1
stomatin (EPB72)-like 3
chrX_+_9431324 0.63 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr1_+_104159999 0.62 ENST00000414303.2
ENST00000423678.1
amylase, alpha 2A (pancreatic)
chr12_-_71551652 0.59 ENST00000546561.1
tetraspanin 8
chr3_+_69985734 0.58 ENST00000314557.6
ENST00000394351.3
microphthalmia-associated transcription factor
chr2_-_175711133 0.56 ENST00000409597.1
ENST00000413882.1
chimerin 1
chr1_-_207095212 0.56 ENST00000420007.2
Fas apoptotic inhibitory molecule 3
chr20_-_55841398 0.55 ENST00000395864.3
bone morphogenetic protein 7
chr4_+_165675269 0.54 ENST00000507311.1
RP11-294O2.2
chr10_+_95848824 0.54 ENST00000371385.3
ENST00000371375.1
phospholipase C, epsilon 1
chr3_-_45957088 0.52 ENST00000539217.1
leucine zipper transcription factor-like 1
chr1_+_61547405 0.52 ENST00000371189.4
nuclear factor I/A
chr20_+_52105495 0.51 ENST00000439873.2
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr12_+_59989918 0.48 ENST00000547379.1
ENST00000549465.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr3_-_107941209 0.46 ENST00000492106.1
intraflagellar transport 57 homolog (Chlamydomonas)
chr18_+_3449330 0.46 ENST00000549253.1
TGFB-induced factor homeobox 1
chr15_+_71185148 0.44 ENST00000443425.2
ENST00000560755.1
leucine rich repeat containing 49
chr12_-_76879852 0.43 ENST00000548341.1
oxysterol binding protein-like 8
chr14_+_56585048 0.41 ENST00000267460.4
pellino E3 ubiquitin protein ligase family member 2
chr3_-_45957534 0.41 ENST00000536047.1
leucine zipper transcription factor-like 1
chr1_-_201096312 0.41 ENST00000449188.2
achaete-scute family bHLH transcription factor 5
chr11_-_116708302 0.40 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
apolipoprotein A-I
chr1_+_87797351 0.39 ENST00000370542.1
LIM domain only 4
chr11_+_6897856 0.38 ENST00000379829.2
olfactory receptor, family 10, subfamily A, member 4
chr4_-_138453559 0.38 ENST00000511115.1
protocadherin 18
chr14_-_31926623 0.37 ENST00000356180.4
D-tyrosyl-tRNA deacylase 2 (putative)
chr7_+_116654935 0.36 ENST00000432298.1
ENST00000422922.1
suppression of tumorigenicity 7
chr17_+_7487146 0.36 ENST00000396501.4
ENST00000584378.1
ENST00000423172.2
ENST00000579445.1
ENST00000585217.1
ENST00000581380.1
mannose-P-dolichol utilization defect 1
chr20_-_55841662 0.35 ENST00000395863.3
ENST00000450594.2
bone morphogenetic protein 7
chr14_-_25479811 0.35 ENST00000550887.1
syntaxin binding protein 6 (amisyn)
chr17_+_72427477 0.34 ENST00000342648.5
ENST00000481232.1
G protein-coupled receptor, family C, group 5, member C
chr1_+_244214577 0.33 ENST00000358704.4
zinc finger and BTB domain containing 18
chr9_-_14722715 0.33 ENST00000380911.3
cerberus 1, DAN family BMP antagonist
chr6_-_41715128 0.32 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
progastricsin (pepsinogen C)
chr3_-_107941230 0.32 ENST00000264538.3
intraflagellar transport 57 homolog (Chlamydomonas)
chr1_+_61548225 0.32 ENST00000371187.3
nuclear factor I/A
chr1_-_223308098 0.32 ENST00000342210.6
toll-like receptor 5
chr19_+_42806250 0.30 ENST00000598490.1
ENST00000341747.3
proline rich 19
chr3_+_69985792 0.28 ENST00000531774.1
microphthalmia-associated transcription factor
chr3_+_50712672 0.28 ENST00000266037.9
dedicator of cytokinesis 3
chr11_-_110561721 0.28 ENST00000357139.3
Rho GTPase activating protein 20
chr9_-_28670283 0.28 ENST00000379992.2
leucine rich repeat and Ig domain containing 2
chr5_-_41213607 0.27 ENST00000337836.5
ENST00000433294.1
complement component 6
chrX_+_10124977 0.27 ENST00000380833.4
chloride channel, voltage-sensitive 4
chr3_-_105588231 0.27 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr1_+_12806141 0.27 ENST00000288048.5
chromosome 1 open reading frame 158
chr14_+_74034310 0.26 ENST00000538782.1
acyl-CoA thioesterase 2
chr14_-_101036119 0.26 ENST00000355173.2
brain-enriched guanylate kinase-associated
chr1_+_35225339 0.26 ENST00000339480.1
gap junction protein, beta 4, 30.3kDa
chr19_-_18902106 0.25 ENST00000542601.2
ENST00000425807.1
ENST00000222271.2
cartilage oligomeric matrix protein
chr1_+_18957500 0.25 ENST00000375375.3
paired box 7
chr5_+_40841276 0.25 ENST00000254691.5
caspase recruitment domain family, member 6
chr16_-_4664860 0.25 ENST00000587615.1
ENST00000587649.1
ENST00000590965.1
ENST00000591401.1
ENST00000283474.7
UBA-like domain containing 1
chr12_-_39734783 0.25 ENST00000552961.1
kinesin family member 21A
chr16_-_4665023 0.24 ENST00000591897.1
UBA-like domain containing 1
chr12_-_92539614 0.24 ENST00000256015.3
B-cell translocation gene 1, anti-proliferative
chr9_-_3469181 0.24 ENST00000366116.2
Uncharacterized protein
chr22_+_46449674 0.23 ENST00000381051.2
hsa-mir-4763
chr18_-_53070913 0.23 ENST00000568186.1
ENST00000564228.1
transcription factor 4
chr10_+_124320156 0.22 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
deleted in malignant brain tumors 1
chr2_-_188312971 0.22 ENST00000410068.1
ENST00000447403.1
ENST00000410102.1
calcitonin receptor-like
chr9_+_70856397 0.22 ENST00000360171.6
COBW domain containing 3
chr2_+_179318295 0.22 ENST00000442710.1
deafness, autosomal recessive 59
chr2_+_175260451 0.22 ENST00000458563.1
ENST00000409673.3
ENST00000272732.6
ENST00000435964.1
secernin 3
chr1_+_114471809 0.21 ENST00000426820.2
homeodomain interacting protein kinase 1
chr10_+_124320195 0.21 ENST00000359586.6
deleted in malignant brain tumors 1
chr4_+_187148556 0.21 ENST00000264690.6
ENST00000446598.2
ENST00000414291.1
ENST00000513864.1
kallikrein B, plasma (Fletcher factor) 1
chr14_-_70263979 0.21 ENST00000216540.4
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr8_+_19171128 0.20 ENST00000265807.3
SH2 domain containing 4A
chr4_-_70080449 0.20 ENST00000446444.1
UDP glucuronosyltransferase 2 family, polypeptide B11
chr9_-_70490107 0.20 ENST00000377395.4
ENST00000429800.2
ENST00000430059.2
ENST00000377384.1
ENST00000382405.3
COBW domain containing 5
chr7_+_134832808 0.20 ENST00000275767.3
transmembrane protein 140
chr11_-_107582775 0.20 ENST00000305991.2
sarcolipin
chr3_-_193096600 0.19 ENST00000446087.1
ENST00000342358.4
ATPase type 13A5
chr4_-_11431389 0.19 ENST00000002596.5
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr17_+_4613776 0.19 ENST00000269260.2
arrestin, beta 2
chr15_+_60296421 0.19 ENST00000396057.4
forkhead box B1
chr10_-_49482907 0.19 ENST00000374201.3
ENST00000407470.4
FERM and PDZ domain containing 2
chr14_+_105267250 0.19 ENST00000342537.7
zinc finger and BTB domain containing 42
chr15_+_96869165 0.19 ENST00000421109.2
nuclear receptor subfamily 2, group F, member 2
chr2_+_135596180 0.19 ENST00000283054.4
ENST00000392928.1
aminocarboxymuconate semialdehyde decarboxylase
chr13_+_52598827 0.19 ENST00000521776.2
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr1_+_29563011 0.19 ENST00000345512.3
ENST00000373779.3
ENST00000356870.3
ENST00000323874.8
ENST00000428026.2
ENST00000460170.2
protein tyrosine phosphatase, receptor type, U
chr16_-_15474904 0.18 ENST00000534094.1
nuclear pore complex interacting protein family, member A5
chr1_+_101361782 0.18 ENST00000357650.4
solute carrier family 30 (zinc transporter), member 7
chr17_+_4613918 0.18 ENST00000574954.1
ENST00000346341.2
ENST00000572457.1
ENST00000381488.6
ENST00000412477.3
ENST00000571428.1
ENST00000575877.1
arrestin, beta 2
chr12_+_59989791 0.18 ENST00000552432.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr16_+_69958887 0.18 ENST00000568684.1
WW domain containing E3 ubiquitin protein ligase 2
chr4_+_86396265 0.18 ENST00000395184.1
Rho GTPase activating protein 24
chr3_+_119316689 0.18 ENST00000273371.4
phospholipase A1 member A
chr12_-_92536433 0.17 ENST00000551563.2
ENST00000546975.1
ENST00000549802.1
chromosome 12 open reading frame 79
chr2_+_135596106 0.17 ENST00000356140.5
aminocarboxymuconate semialdehyde decarboxylase
chr3_+_119316721 0.17 ENST00000488919.1
ENST00000495992.1
phospholipase A1 member A
chr17_-_26733179 0.17 ENST00000440501.1
ENST00000321666.5
solute carrier family 46 (folate transporter), member 1
chr16_-_3350614 0.17 ENST00000268674.2
tigger transposable element derived 7
chr14_-_31926701 0.16 ENST00000310850.4
D-tyrosyl-tRNA deacylase 2 (putative)
chrX_+_24167746 0.16 ENST00000428571.1
ENST00000539115.1
zinc finger protein, X-linked
chr4_+_86396321 0.16 ENST00000503995.1
Rho GTPase activating protein 24
chr17_+_8924837 0.16 ENST00000173229.2
netrin 1
chr15_+_28624878 0.16 ENST00000450328.2
golgin A8 family, member F
chr5_+_140787600 0.15 ENST00000520790.1
protocadherin gamma subfamily B, 6
chr1_-_246729544 0.15 ENST00000544618.1
ENST00000366514.4
transcription factor B2, mitochondrial
chr19_+_47421933 0.15 ENST00000404338.3
Rho GTPase activating protein 35
chr4_-_140223670 0.15 ENST00000394228.1
ENST00000539387.1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr4_-_140223614 0.15 ENST00000394223.1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr3_-_187455680 0.15 ENST00000438077.1
B-cell CLL/lymphoma 6
chr21_-_43786634 0.15 ENST00000291527.2
trefoil factor 1
chr14_-_24664540 0.15 ENST00000530563.1
ENST00000528895.1
ENST00000528669.1
ENST00000532632.1
transmembrane 9 superfamily member 1
chr10_+_123923105 0.15 ENST00000368999.1
transforming, acidic coiled-coil containing protein 2
chr16_+_14802801 0.15 ENST00000526520.1
ENST00000531598.2
nuclear pore complex interacting protein family, member A3
chr8_+_95908041 0.14 ENST00000396113.1
ENST00000519136.1
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr22_-_30867973 0.14 ENST00000402286.1
ENST00000401751.1
ENST00000539629.1
ENST00000403066.1
ENST00000215812.4
SEC14-like 3 (S. cerevisiae)
chrX_+_65382381 0.14 ENST00000519389.1
hephaestin
chr1_+_246729724 0.14 ENST00000366513.4
ENST00000366512.3
consortin, connexin sorting protein
chr3_-_114343039 0.14 ENST00000481632.1
zinc finger and BTB domain containing 20
chr3_+_148545586 0.14 ENST00000282957.4
ENST00000468341.1
carboxypeptidase B1 (tissue)
chrX_+_135730373 0.14 ENST00000370628.2
CD40 ligand
chr1_+_74701062 0.14 ENST00000326637.3
TNNI3 interacting kinase
chr13_+_73629107 0.13 ENST00000539231.1
Kruppel-like factor 5 (intestinal)
chrX_+_24167828 0.13 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
zinc finger protein, X-linked
chr6_+_21666633 0.13 ENST00000606851.1
cancer susceptibility candidate 15 (non-protein coding)
chr4_+_146403912 0.13 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD family member 1
chr1_+_239882842 0.13 ENST00000448020.1
cholinergic receptor, muscarinic 3
chr14_+_56127989 0.13 ENST00000555573.1
kinectin 1 (kinesin receptor)
chr6_+_52051171 0.13 ENST00000340057.1
interleukin 17A
chr1_-_150602035 0.13 ENST00000503241.1
ENST00000369016.4
ENST00000339643.5
ENST00000271690.8
ENST00000356527.5
ENST00000362052.7
ENST00000503345.1
ENST00000369014.5
ENST00000369009.3
endosulfine alpha
chr19_-_46088068 0.13 ENST00000263275.4
ENST00000323060.3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr8_+_95907993 0.13 ENST00000523378.1
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr2_-_32490859 0.13 ENST00000404025.2
NLR family, CARD domain containing 4
chr15_-_40600026 0.13 ENST00000456256.2
ENST00000557821.1
phospholipase C, beta 2
chr2_-_227050079 0.13 ENST00000423838.1
AC068138.1
chrX_+_135730297 0.13 ENST00000370629.2
CD40 ligand
chr5_+_161494770 0.13 ENST00000414552.2
ENST00000361925.4
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr1_-_43855479 0.12 ENST00000290663.6
ENST00000372457.4
mediator complex subunit 8
chr20_+_43935474 0.12 ENST00000372743.1
ENST00000372741.3
ENST00000343694.3
recombination signal binding protein for immunoglobulin kappa J region-like
chr11_-_102401469 0.12 ENST00000260227.4
matrix metallopeptidase 7 (matrilysin, uterine)
chr3_+_132316081 0.12 ENST00000249887.2
atypical chemokine receptor 4
chr5_+_161494521 0.12 ENST00000356592.3
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr3_+_171561127 0.12 ENST00000334567.5
ENST00000450693.1
transmembrane protein 212
chr6_-_159466042 0.12 ENST00000338313.5
T-cell activation RhoGTPase activating protein
chr13_-_99910673 0.12 ENST00000397473.2
ENST00000397470.2
G protein-coupled receptor 18
chr13_+_95364963 0.12 ENST00000438290.2
SOX21 antisense RNA 1 (head to head)
chr6_+_161123270 0.12 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
plasminogen
chr19_-_47157914 0.12 ENST00000300875.4
dishevelled-binding antagonist of beta-catenin 3
chr12_-_122018346 0.12 ENST00000377069.4
lysine (K)-specific demethylase 2B
chr8_-_133772794 0.12 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
transmembrane protein 71
chr17_-_39183452 0.12 ENST00000361883.5
keratin associated protein 1-5
chr22_+_35462129 0.12 ENST00000404699.2
ENST00000308700.6
intestine-specific homeobox
chr3_+_114012819 0.12 ENST00000383671.3
T cell immunoreceptor with Ig and ITIM domains
chr3_+_108855558 0.11 ENST00000467240.1
ENST00000477643.1
ENST00000479039.1
ENST00000593799.1
RP11-59E19.1
chr1_+_43855560 0.11 ENST00000562955.1
seizure threshold 2 homolog (mouse)
chr6_+_44310421 0.11 ENST00000288390.2
spermatogenesis associated, serine-rich 1
chr17_-_6947225 0.11 ENST00000574600.1
ENST00000308009.1
ENST00000447225.1
solute carrier family 16, member 11
chr12_-_15038779 0.11 ENST00000228938.5
ENST00000539261.1
matrix Gla protein
chr14_-_21562648 0.11 ENST00000555270.1
zinc finger protein 219
chr6_-_159466136 0.11 ENST00000367066.3
ENST00000326965.6
T-cell activation RhoGTPase activating protein
chr1_+_159141397 0.11 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
cell adhesion molecule 3
chr1_-_150669500 0.11 ENST00000271732.3
golgi phosphoprotein 3-like
chr14_-_74551096 0.10 ENST00000350259.4
aldehyde dehydrogenase 6 family, member A1
chr14_-_36988882 0.10 ENST00000498187.2
NK2 homeobox 1
chr16_+_20775358 0.10 ENST00000440284.2
acyl-CoA synthetase medium-chain family member 3
chr1_+_154540246 0.10 ENST00000368476.3
cholinergic receptor, nicotinic, beta 2 (neuronal)
chrX_-_133792480 0.10 ENST00000359237.4
placenta-specific 1
chr10_-_31288398 0.10 ENST00000538351.2
zinc finger protein 438
chrX_-_80457385 0.10 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
high mobility group nucleosome binding domain 5
chr12_+_58087901 0.10 ENST00000315970.7
ENST00000547079.1
ENST00000439210.2
ENST00000389146.6
ENST00000413095.2
ENST00000551035.1
ENST00000257966.8
ENST00000435406.2
ENST00000550372.1
ENST00000389142.5
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr12_-_48099754 0.10 ENST00000380650.4
RNA polymerase II associated protein 3
chr1_+_114471972 0.10 ENST00000369559.4
ENST00000369554.2
homeodomain interacting protein kinase 1
chr6_+_44310376 0.10 ENST00000515220.1
ENST00000323108.8
spermatogenesis associated, serine-rich 1
chr4_-_88450244 0.09 ENST00000503414.1
SPARC-like 1 (hevin)
chr12_+_48516357 0.09 ENST00000549022.1
ENST00000547587.1
ENST00000312352.7
phosphofructokinase, muscle
chr1_-_150669604 0.09 ENST00000427665.1
ENST00000540514.1
golgi phosphoprotein 3-like
chr8_+_52730143 0.09 ENST00000415643.1
Uncharacterized protein
chr3_+_137728842 0.09 ENST00000183605.5
claudin 18
chr17_-_79212825 0.09 ENST00000374769.2
ENTH domain containing 2
chr17_-_26697304 0.09 ENST00000536498.1
vitronectin
chr12_-_48099773 0.09 ENST00000432584.3
ENST00000005386.3
RNA polymerase II associated protein 3
chr2_-_225434538 0.09 ENST00000409096.1
cullin 3
chr1_+_150488205 0.08 ENST00000416894.1
long intergenic non-protein coding RNA 568
chr4_+_187187098 0.08 ENST00000403665.2
ENST00000264692.4
coagulation factor XI
chr12_-_18243119 0.08 ENST00000538724.1
ENST00000229002.2
RERG/RAS-like

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA3_FOXC2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.5 GO:0044010 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.3 0.9 GO:1903565 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.3 2.1 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.3 2.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 2.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 0.9 GO:1900106 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme morphogenesis(GO:0072134) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) allantois development(GO:1905069)
0.2 0.8 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.2 1.0 GO:0060005 vestibular reflex(GO:0060005)
0.2 0.3 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.2 3.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.3 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 0.4 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.1 0.6 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.7 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 0.5 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.4 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1 0.2 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 1.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 0.3 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.1 0.1 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.1 0.2 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 0.2 GO:0007412 axon target recognition(GO:0007412)
0.1 0.3 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 0.3 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 0.4 GO:0034627 quinolinate biosynthetic process(GO:0019805) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 1.5 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.1 0.2 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.0 0.7 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.2 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.2 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.4 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.0 0.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.2 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 0.2 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.8 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592)
0.0 0.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.9 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.1 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 1.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.1 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747) negative regulation of intestinal absorption(GO:1904479)
0.0 0.2 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.5 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.3 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.9 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.2 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.0 GO:0060405 regulation of penile erection(GO:0060405)
0.0 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500) negative regulation of muscle hyperplasia(GO:0014740)
0.0 0.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.1 GO:0070269 pyroptosis(GO:0070269)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 1.3 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.1 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.0 0.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.3 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 0.0 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.0 0.1 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.1 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.3 GO:0003417 growth plate cartilage development(GO:0003417)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 0.2 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.1 0.8 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.2 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.2 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 0.5 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.2 0.7 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 0.8 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.2 0.6 GO:0016160 amylase activity(GO:0016160)
0.1 1.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.4 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.1 0.4 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 1.5 GO:0019864 IgG binding(GO:0019864)
0.1 0.3 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.2 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.3 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.0 1.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.1 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.3 GO:0016015 morphogen activity(GO:0016015)
0.0 0.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.6 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.0 0.3 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 3.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.0 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.0 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 2.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.2 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.5 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.3 PID IL6 7 PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 0.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling