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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for FOXC1

Z-value: 0.62

Motif logo

Transcription factors associated with FOXC1

Gene Symbol Gene ID Gene Info
ENSG00000054598.5 forkhead box C1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXC1hg19_v2_chr6_+_1610681_16106810.393.4e-02Click!

Activity profile of FOXC1 motif

Sorted Z-values of FOXC1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_72375167 3.48 ENST00000001146.2
cytochrome P450, family 26, subfamily B, polypeptide 1
chr8_-_23261589 2.14 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
lysyl oxidase-like 2
chr2_-_161056762 1.46 ENST00000428609.2
ENST00000409967.2
integrin, beta 6
chr2_-_161056802 1.28 ENST00000283249.2
ENST00000409872.1
integrin, beta 6
chr13_-_61989655 1.25 ENST00000409204.4
protocadherin 20
chr8_+_54764346 1.10 ENST00000297313.3
ENST00000344277.6
regulator of G-protein signaling 20
chr21_+_39628852 0.92 ENST00000398938.2
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_-_16524357 0.88 ENST00000432519.1
raftlin, lipid raft linker 1
chr14_+_37126765 0.84 ENST00000402703.2
paired box 9
chr4_-_103266626 0.82 ENST00000356736.4
solute carrier family 39 (zinc transporter), member 8
chr1_+_12524965 0.75 ENST00000471923.1
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr10_+_105314881 0.71 ENST00000437579.1
neuralized E3 ubiquitin protein ligase 1
chr17_-_37764128 0.69 ENST00000302584.4
neuronal differentiation 2
chr22_+_46449674 0.69 ENST00000381051.2
hsa-mir-4763
chr14_-_57272366 0.67 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
orthodenticle homeobox 2
chr9_-_89562104 0.63 ENST00000298743.7
growth arrest-specific 1
chr14_+_76776957 0.63 ENST00000512784.1
estrogen-related receptor beta
chr1_-_94079648 0.62 ENST00000370247.3
breast cancer anti-estrogen resistance 3
chr6_+_34204642 0.61 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr17_-_57229155 0.59 ENST00000584089.1
spindle and kinetochore associated complex subunit 2
chr10_+_71561704 0.58 ENST00000520267.1
collagen, type XIII, alpha 1
chr10_+_54074033 0.58 ENST00000373970.3
dickkopf WNT signaling pathway inhibitor 1
chr7_-_99698338 0.56 ENST00000354230.3
ENST00000425308.1
minichromosome maintenance complex component 7
chr8_+_11666649 0.54 ENST00000528643.1
ENST00000525777.1
farnesyl-diphosphate farnesyltransferase 1
chr1_-_109935819 0.54 ENST00000538502.1
sortilin 1
chr19_-_51141196 0.50 ENST00000338916.4
synaptotagmin III
chr2_+_113885138 0.50 ENST00000409930.3
interleukin 1 receptor antagonist
chr18_+_60382672 0.46 ENST00000400316.4
ENST00000262719.5
PH domain and leucine rich repeat protein phosphatase 1
chr8_+_70404996 0.45 ENST00000402687.4
ENST00000419716.3
sulfatase 1
chr15_+_76016293 0.44 ENST00000332145.2
outer dense fiber of sperm tails 3-like 1
chr4_-_99578789 0.43 ENST00000511651.1
ENST00000505184.1
tetraspanin 5
chr8_-_134309335 0.43 ENST00000522890.1
ENST00000323851.7
ENST00000518176.1
ENST00000354944.5
ENST00000537882.1
ENST00000522476.1
ENST00000518066.1
ENST00000521544.1
ENST00000518480.1
ENST00000523892.1
N-myc downstream regulated 1
chr12_-_99038732 0.42 ENST00000393042.3
ENST00000420861.1
ENST00000299157.4
ENST00000342502.2
IKBKB interacting protein
chr8_-_134309823 0.41 ENST00000414097.2
N-myc downstream regulated 1
chr20_-_22566089 0.41 ENST00000377115.4
forkhead box A2
chr7_+_129906660 0.41 ENST00000222481.4
carboxypeptidase A2 (pancreatic)
chr4_-_99578776 0.39 ENST00000515287.1
tetraspanin 5
chr1_-_94312706 0.37 ENST00000370244.1
breast cancer anti-estrogen resistance 3
chr21_+_39628655 0.37 ENST00000398925.1
ENST00000398928.1
ENST00000328656.4
ENST00000443341.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr2_-_190044480 0.36 ENST00000374866.3
collagen, type V, alpha 2
chr5_-_127674883 0.36 ENST00000507835.1
fibrillin 2
chr10_+_71561649 0.36 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
collagen, type XIII, alpha 1
chr3_-_71632894 0.35 ENST00000493089.1
forkhead box P1
chr5_-_115872142 0.34 ENST00000510263.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr12_+_43086018 0.34 ENST00000550177.1
RP11-25I15.3
chr11_-_121986923 0.34 ENST00000560104.1
BH3-like motif containing, cell death inducer
chr13_+_98086445 0.33 ENST00000245304.4
RAP2A, member of RAS oncogene family
chr4_-_89744457 0.33 ENST00000395002.2
family with sequence similarity 13, member A
chr19_+_36024310 0.33 ENST00000222286.4
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr10_+_105315102 0.32 ENST00000369777.2
neuralized E3 ubiquitin protein ligase 1
chr1_+_150122034 0.32 ENST00000025469.6
ENST00000369124.4
pleckstrin homology domain containing, family O member 1
chr18_+_19749386 0.31 ENST00000269216.3
GATA binding protein 6
chr1_-_28384598 0.30 ENST00000373864.1
eyes absent homolog 3 (Drosophila)
chr4_-_164534657 0.30 ENST00000339875.5
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr16_+_8715574 0.30 ENST00000561758.1
methyltransferase like 22
chr5_+_161494521 0.30 ENST00000356592.3
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr8_-_108510224 0.30 ENST00000517746.1
ENST00000297450.3
angiopoietin 1
chr16_+_8715536 0.30 ENST00000563958.1
ENST00000381920.3
ENST00000564554.1
methyltransferase like 22
chr8_+_31497271 0.29 ENST00000520407.1
neuregulin 1
chr18_+_29171689 0.28 ENST00000237014.3
transthyretin
chr16_+_30064411 0.28 ENST00000338110.5
aldolase A, fructose-bisphosphate
chr10_+_114710425 0.28 ENST00000352065.5
ENST00000369395.1
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr21_+_38071430 0.28 ENST00000290399.6
single-minded family bHLH transcription factor 2
chr16_+_30064444 0.27 ENST00000395248.1
ENST00000566897.1
ENST00000568435.1
aldolase A, fructose-bisphosphate
chr6_+_47666275 0.27 ENST00000327753.3
ENST00000283303.2
G protein-coupled receptor 115
chr8_-_72274467 0.27 ENST00000340726.3
eyes absent homolog 1 (Drosophila)
chr5_+_161494770 0.27 ENST00000414552.2
ENST00000361925.4
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr11_+_112832090 0.26 ENST00000533760.1
neural cell adhesion molecule 1
chrX_+_85969626 0.26 ENST00000484479.1
dachshund homolog 2 (Drosophila)
chr6_+_32121908 0.26 ENST00000375143.2
ENST00000424499.1
palmitoyl-protein thioesterase 2
chr3_-_178865747 0.26 ENST00000435560.1
RP11-360P21.2
chr8_-_72274095 0.26 ENST00000303824.7
eyes absent homolog 1 (Drosophila)
chr20_-_62587735 0.25 ENST00000354216.6
ENST00000369892.3
ENST00000358711.3
uridine-cytidine kinase 1-like 1
chr12_-_53994805 0.25 ENST00000328463.7
activating transcription factor 7
chr2_+_105050794 0.25 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
long intergenic non-protein coding RNA 1102
chr2_+_33359687 0.25 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
latent transforming growth factor beta binding protein 1
chr12_+_93096759 0.25 ENST00000544406.2
chromosome 12 open reading frame 74
chr2_-_208030647 0.25 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr7_+_139529040 0.25 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
thromboxane A synthase 1 (platelet)
chr15_+_63188009 0.25 ENST00000557900.1
RP11-1069G10.2
chrX_+_99839799 0.25 ENST00000373031.4
tenomodulin
chr12_+_99038998 0.24 ENST00000359972.2
ENST00000357310.1
ENST00000339433.3
ENST00000333991.1
apoptotic peptidase activating factor 1
chr2_+_33359646 0.24 ENST00000390003.4
ENST00000418533.2
latent transforming growth factor beta binding protein 1
chr12_+_93096619 0.24 ENST00000397833.3
chromosome 12 open reading frame 74
chr1_-_43855444 0.24 ENST00000372455.4
mediator complex subunit 8
chr6_+_32121789 0.24 ENST00000437001.2
ENST00000375137.2
palmitoyl-protein thioesterase 2
chr1_+_223101757 0.24 ENST00000284476.6
dispatched homolog 1 (Drosophila)
chr4_-_74486347 0.23 ENST00000342081.3
Ras association (RalGDS/AF-6) domain family member 6
chr14_-_24020858 0.23 ENST00000419474.3
zinc finger homeobox 2
chr14_+_100070869 0.23 ENST00000502101.2
RP11-543C4.1
chr10_-_4285923 0.23 ENST00000418372.1
ENST00000608792.1
long intergenic non-protein coding RNA 702
chr8_+_97597148 0.23 ENST00000521590.1
syndecan 2
chr12_+_99038919 0.23 ENST00000551964.1
apoptotic peptidase activating factor 1
chr15_+_67418047 0.23 ENST00000540846.2
SMAD family member 3
chr8_-_93107696 0.23 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_171758344 0.22 ENST00000336824.4
ENST00000423424.1
fibronectin type III domain containing 3B
chr15_-_72563585 0.22 ENST00000287196.9
ENST00000260376.7
poly (ADP-ribose) polymerase family, member 6
chr7_+_136553370 0.22 ENST00000445907.2
cholinergic receptor, muscarinic 2
chr2_+_210517895 0.22 ENST00000447185.1
microtubule-associated protein 2
chr2_+_28974668 0.21 ENST00000296122.6
ENST00000395366.2
protein phosphatase 1, catalytic subunit, beta isozyme
chr4_-_74486109 0.21 ENST00000395777.2
Ras association (RalGDS/AF-6) domain family member 6
chr13_-_36050819 0.21 ENST00000379919.4
mab-21-like 1 (C. elegans)
chr4_+_15376165 0.21 ENST00000382383.3
ENST00000429690.1
C1q and tumor necrosis factor related protein 7
chr7_+_139528952 0.21 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
thromboxane A synthase 1 (platelet)
chr12_+_59989918 0.21 ENST00000547379.1
ENST00000549465.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr8_-_95449155 0.21 ENST00000481490.2
fibrinogen silencer binding protein
chr20_-_35890211 0.20 ENST00000373614.2
growth hormone releasing hormone
chr4_+_71587669 0.20 ENST00000381006.3
ENST00000226328.4
RUN and FYVE domain containing 3
chr10_+_50507181 0.20 ENST00000323868.4
chromosome 10 open reading frame 71
chr8_-_19540086 0.20 ENST00000332246.6
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr6_-_42418999 0.20 ENST00000340840.2
ENST00000354325.2
transcriptional regulating factor 1
chr2_+_28974603 0.20 ENST00000441461.1
ENST00000358506.2
protein phosphatase 1, catalytic subunit, beta isozyme
chr16_-_740354 0.20 ENST00000293883.4
WD repeat domain 24
chr16_-_740419 0.19 ENST00000248142.6
WD repeat domain 24
chr9_+_6413317 0.19 ENST00000276893.5
ENST00000381373.3
ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
chr3_-_168865522 0.19 ENST00000464456.1
MDS1 and EVI1 complex locus
chr22_-_38699003 0.19 ENST00000451964.1
casein kinase 1, epsilon
chr10_+_50507232 0.19 ENST00000374144.3
chromosome 10 open reading frame 71
chr13_-_99667960 0.19 ENST00000448493.2
dedicator of cytokinesis 9
chr5_+_159614374 0.18 ENST00000393980.4
fatty acid binding protein 6, ileal
chr1_+_199996702 0.18 ENST00000367362.3
nuclear receptor subfamily 5, group A, member 2
chr10_+_71561630 0.18 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
collagen, type XIII, alpha 1
chr6_-_100442077 0.18 ENST00000281806.2
ENST00000369212.2
melanin-concentrating hormone receptor 2
chr5_-_36241900 0.18 ENST00000381937.4
ENST00000514504.1
NAD kinase 2, mitochondrial
chr10_+_114709999 0.18 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr7_-_72972319 0.18 ENST00000223368.2
B-cell CLL/lymphoma 7B
chr19_+_17516909 0.17 ENST00000601007.1
ENST00000594913.1
ENST00000599975.1
ENST00000600514.1
CTD-2521M24.9
multivesicular body subunit 12A
chr6_+_119215308 0.17 ENST00000229595.5
anti-silencing function 1A histone chaperone
chr10_-_25010795 0.17 ENST00000416305.1
ENST00000376410.2
Rho GTPase activating protein 21
chr12_+_16109519 0.17 ENST00000526530.1
deoxyribose-phosphate aldolase (putative)
chr8_-_80993010 0.17 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
tumor protein D52
chr2_-_32490859 0.17 ENST00000404025.2
NLR family, CARD domain containing 4
chr4_-_186696425 0.16 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
sorbin and SH3 domain containing 2
chr19_+_29493456 0.16 ENST00000591143.1
ENST00000592653.1
CTD-2081K17.2
chr8_-_145754428 0.16 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
chromosome 8 open reading frame 82
chr20_-_62582475 0.16 ENST00000369908.5
uridine-cytidine kinase 1-like 1
chr6_-_32122106 0.15 ENST00000428778.1
proline-rich transmembrane protein 1
chr6_+_84563295 0.15 ENST00000369687.1
ripply transcriptional repressor 2
chr3_+_57875738 0.15 ENST00000417128.1
ENST00000438794.1
sarcolemma associated protein
chr12_-_76462713 0.15 ENST00000552056.1
nucleosome assembly protein 1-like 1
chr17_-_27503770 0.14 ENST00000533112.1
myosin XVIIIA
chr11_-_66112555 0.14 ENST00000425825.2
ENST00000359957.3
breast cancer metastasis suppressor 1
chr3_+_189349162 0.14 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
tumor protein p63
chr2_-_72374948 0.14 ENST00000546307.1
ENST00000474509.1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr3_-_133969673 0.14 ENST00000427044.2
receptor-like tyrosine kinase
chr17_+_41363854 0.14 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
transmembrane protein 106A
chr19_-_40919271 0.14 ENST00000291825.7
ENST00000324001.7
periaxin
chr12_-_31479107 0.14 ENST00000542983.1
family with sequence similarity 60, member A
chr8_-_93107827 0.14 ENST00000520724.1
ENST00000518844.1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_-_113897545 0.14 ENST00000467632.1
dopamine receptor D3
chr8_-_141931287 0.14 ENST00000517887.1
protein tyrosine kinase 2
chr3_+_178866199 0.14 ENST00000263967.3
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr5_+_161495038 0.14 ENST00000393933.4
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr12_-_92539614 0.13 ENST00000256015.3
B-cell translocation gene 1, anti-proliferative
chr7_+_80231466 0.13 ENST00000309881.7
ENST00000534394.1
CD36 molecule (thrombospondin receptor)
chr1_-_159684371 0.13 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
C-reactive protein, pentraxin-related
chr1_+_18958008 0.13 ENST00000420770.2
ENST00000400661.3
paired box 7
chr1_-_153931052 0.13 ENST00000368630.3
ENST00000368633.1
CREB regulated transcription coactivator 2
chr1_+_197886461 0.13 ENST00000367388.3
ENST00000337020.2
ENST00000367387.4
LIM homeobox 9
chr5_-_36242119 0.13 ENST00000511088.1
ENST00000282512.3
ENST00000506945.1
NAD kinase 2, mitochondrial
chr10_-_97200772 0.12 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
sorbin and SH3 domain containing 1
chr4_+_147096837 0.12 ENST00000296581.5
ENST00000502781.1
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr14_+_69726656 0.12 ENST00000337827.4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr21_+_17792672 0.12 ENST00000602620.1
long intergenic non-protein coding RNA 478
chr8_+_31496809 0.12 ENST00000518104.1
ENST00000519301.1
neuregulin 1
chr15_-_30114622 0.12 ENST00000495972.2
ENST00000346128.6
tight junction protein 1
chrX_-_77914825 0.12 ENST00000321110.1
zinc finger, CCHC domain containing 5
chr1_-_149982624 0.12 ENST00000417191.1
ENST00000369135.4
OTU domain containing 7B
chr18_-_52626622 0.11 ENST00000591504.1
coiled-coil domain containing 68
chr6_+_10528560 0.11 ENST00000379597.3
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr10_+_114710211 0.11 ENST00000349937.2
ENST00000369397.4
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr4_+_86396321 0.11 ENST00000503995.1
Rho GTPase activating protein 24
chr1_+_234509186 0.11 ENST00000366615.4
cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
chr4_-_83765613 0.11 ENST00000503937.1
SEC31 homolog A (S. cerevisiae)
chr4_+_71588372 0.11 ENST00000536664.1
RUN and FYVE domain containing 3
chr19_-_36523529 0.11 ENST00000593074.1
CAP-GLY domain containing linker protein 3
chr10_+_71562180 0.11 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
collagen, type XIII, alpha 1
chr6_+_108882069 0.10 ENST00000406360.1
forkhead box O3
chr12_-_123756781 0.10 ENST00000544658.1
cyclin-dependent kinase 2 associated protein 1
chr3_+_46449049 0.10 ENST00000357392.4
ENST00000400880.3
ENST00000433848.1
chemokine (C-C motif) receptor-like 2
chr3_-_48481518 0.10 ENST00000412398.2
ENST00000395696.1
coiled-coil domain containing 51
chr6_-_42016385 0.10 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
cyclin D3
chr19_-_56343353 0.10 ENST00000592953.1
ENST00000589093.1
NLR family, pyrin domain containing 11
chr6_+_134274322 0.10 ENST00000367871.1
ENST00000237264.4
TBP-like 1
chr3_-_49066811 0.10 ENST00000442157.1
ENST00000326739.4
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr12_-_31479045 0.10 ENST00000539409.1
ENST00000395766.1
family with sequence similarity 60, member A
chr12_+_54348618 0.09 ENST00000243103.3
homeobox C12
chr3_+_57875711 0.09 ENST00000442599.2
sarcolemma associated protein
chr15_-_65321943 0.09 ENST00000220058.4
mitochondrial methionyl-tRNA formyltransferase
chr3_-_48481434 0.09 ENST00000395694.2
ENST00000447018.1
ENST00000442740.1
coiled-coil domain containing 51
chr6_-_32083106 0.09 ENST00000442721.1
tenascin XB
chr12_+_59989791 0.09 ENST00000552432.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr1_-_169703203 0.09 ENST00000333360.7
ENST00000367781.4
ENST00000367782.4
ENST00000367780.4
ENST00000367779.4
selectin E
chr3_-_49131788 0.09 ENST00000395443.2
ENST00000411682.1
glutamine-rich 1
chr3_-_141868293 0.09 ENST00000317104.7
ENST00000494358.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr18_+_32073253 0.09 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
dystrobrevin, alpha
chr5_+_135468516 0.08 ENST00000507118.1
ENST00000511116.1
ENST00000545279.1
ENST00000545620.1
SMAD family member 5
chrX_-_117107680 0.08 ENST00000447671.2
ENST00000262820.3
kelch-like family member 13
chr20_-_17511962 0.08 ENST00000377873.3
beaded filament structural protein 1, filensin
chr19_-_4831701 0.08 ENST00000248244.5
toll-like receptor adaptor molecule 1

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:1902811 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.2 2.7 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.2 0.7 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.2 0.6 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.2 0.6 GO:1904956 regulation of endodermal cell fate specification(GO:0042663) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.2 0.4 GO:1903224 regulation of endodermal cell differentiation(GO:1903224) negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.4 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 0.6 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.7 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.1 0.9 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.5 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.1 0.6 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.3 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 0.9 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.8 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 0.8 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.3 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.2 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.5 GO:0072423 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.1 0.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.2 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 0.3 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.1 0.5 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 0.4 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 2.1 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.1 0.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 0.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.4 GO:0044211 CTP salvage(GO:0044211)
0.1 0.5 GO:0002249 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.1 0.5 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.1 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.1 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416)
0.0 0.1 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.7 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.3 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.6 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.3 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.1 GO:0036518 chemorepulsion of dopaminergic neuron axon(GO:0036518)
0.0 0.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.2 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.2 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.4 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 1.2 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.0 0.8 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 0.1 GO:1904760 myofibroblast differentiation(GO:0036446) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) regulation of myofibroblast differentiation(GO:1904760)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.8 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.4 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.2 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0070269 pyroptosis(GO:0070269)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.1 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880) osteoblast fate commitment(GO:0002051)
0.0 0.2 GO:0060539 diaphragm development(GO:0060539)
0.0 0.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.3 GO:0051194 positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)
0.0 0.0 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.1 GO:0045080 positive regulation of chemokine biosynthetic process(GO:0045080)
0.0 0.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.1 GO:0038007 netrin-activated signaling pathway(GO:0038007)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.3 1.2 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.5 GO:0043293 apoptosome(GO:0043293)
0.1 0.3 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.4 GO:0042587 glycogen granule(GO:0042587) PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.6 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 1.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.0 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.4 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.4 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.4 2.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 0.5 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.2 0.5 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 0.5 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.1 0.5 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.5 GO:0050436 microfibril binding(GO:0050436)
0.1 0.3 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 1.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.4 GO:0017018 myosin phosphatase activity(GO:0017018)
0.1 0.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 0.2 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.1 0.2 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.1 0.7 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 0.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.6 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.4 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.7 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.6 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0097001 ceramide binding(GO:0097001)
0.0 0.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 3.0 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.8 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.1 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 4.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.5 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 1.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.0 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.1 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 2.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.1 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators