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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Z-value: 0.94
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Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000251493.2 | forkhead box D1 | |
| ENSG00000150907.6 | forkhead box O1 | |
| ENSG00000204060.4 | forkhead box O6 | |
| ENSG00000176165.7 | forkhead box G1 | |
| ENSG00000114861.14 | forkhead box P1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXP1 | hg19_v2_chr3_-_71632894_71632909 | -0.17 | 3.6e-01 | Click! |
| FOXO6 | hg19_v2_chr1_+_41827594_41827594 | -0.10 | 6.1e-01 | Click! |
| FOXO1 | hg19_v2_chr13_-_41240717_41240735 | -0.10 | 6.2e-01 | Click! |
| FOXG1 | hg19_v2_chr14_+_29234870_29235050, hg19_v2_chr14_+_29236269_29236287 | 0.08 | 6.7e-01 | Click! |
| FOXD1 | hg19_v2_chr5_-_72744336_72744359 | 0.05 | 8.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_116654376 Show fit | 9.57 |
ENST00000369500.3
|
mab-21-like 3 (C. elegans) |
|
| chr2_-_165424973 Show fit | 5.31 |
ENST00000543549.1
|
growth factor receptor-bound protein 14 |
|
| chr11_+_117049910 Show fit | 3.56 |
ENST00000431081.2
ENST00000524842.1 |
SID1 transmembrane family, member 2 |
|
| chr1_+_152486950 Show fit | 3.52 |
ENST00000368790.3
|
cysteine-rich C-terminal 1 |
|
| chr1_-_201096312 Show fit | 2.94 |
ENST00000449188.2
|
achaete-scute family bHLH transcription factor 5 |
|
| chr6_+_101847105 Show fit | 2.74 |
ENST00000369137.3
ENST00000318991.6 |
glutamate receptor, ionotropic, kainate 2 |
|
| chr10_-_101841588 Show fit | 2.41 |
ENST00000370418.3
|
carboxypeptidase N, polypeptide 1 |
|
| chr18_+_3449330 Show fit | 2.28 |
ENST00000549253.1
|
TGFB-induced factor homeobox 1 |
|
| chr12_+_96588279 Show fit | 2.23 |
ENST00000552142.1
|
ELK3, ETS-domain protein (SRF accessory protein 2) |
|
| chr1_-_27816556 Show fit | 2.06 |
ENST00000536657.1
|
WAS protein family, member 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 6.7 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.3 | 4.8 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.1 | 3.9 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 0.2 | 3.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 3.4 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.0 | 3.4 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.6 | 3.0 | GO:0042539 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.1 | 3.0 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.2 | 2.7 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 2.6 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.4 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 5.8 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.2 | 3.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 3.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 3.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 3.1 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.2 | 3.0 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 3.0 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.1 | 2.9 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 2.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 7.7 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 1.1 | 6.7 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.1 | 4.8 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 3.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.0 | 3.1 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.3 | 3.0 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 3.0 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.3 | 2.7 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.0 | 2.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 4.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 4.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.1 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 3.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 2.9 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 2.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 3.9 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 3.0 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 2.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 2.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 2.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.0 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 1.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |