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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for FOXK1_FOXP2_FOXB1_FOXP3
Z-value: 0.98
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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000164916.9 | forkhead box K1 | |
| ENSG00000128573.18 | forkhead box P2 | |
| ENSG00000171956.5 | forkhead box B1 | |
| ENSG00000049768.10 | forkhead box P3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXB1 | hg19_v2_chr15_+_60296421_60296464 | -0.35 | 5.4e-02 | Click! |
| FOXK1 | hg19_v2_chr7_+_4721885_4721945 | -0.32 | 8.5e-02 | Click! |
| FOXP2 | hg19_v2_chr7_+_114055052_114055378 | 0.29 | 1.2e-01 | Click! |
| FOXP3 | hg19_v2_chrX_-_49121165_49121288 | -0.24 | 2.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_7921090 Show fit | 9.99 |
ENST00000378789.3
|
hydroxyacid oxidase (glycolate oxidase) 1 |
|
| chr12_-_71551652 Show fit | 6.03 |
ENST00000546561.1
|
tetraspanin 8 |
|
| chr2_-_158345462 Show fit | 4.73 |
ENST00000439355.1
ENST00000540637.1 |
cytohesin 1 interacting protein |
|
| chr12_-_71551868 Show fit | 4.03 |
ENST00000247829.3
|
tetraspanin 8 |
|
| chr6_-_87804815 Show fit | 3.92 |
ENST00000369582.2
|
glycoprotein hormones, alpha polypeptide |
|
| chr9_+_27109392 Show fit | 3.81 |
ENST00000406359.4
|
TEK tyrosine kinase, endothelial |
|
| chr4_+_165675197 Show fit | 3.61 |
ENST00000515485.1
|
RP11-294O2.2 |
|
| chr1_-_161337662 Show fit | 3.11 |
ENST00000367974.1
|
chromosome 1 open reading frame 192 |
|
| chr4_+_165675269 Show fit | 3.01 |
ENST00000507311.1
|
RP11-294O2.2 |
|
| chr13_+_50589390 Show fit | 2.90 |
ENST00000360473.4
ENST00000312942.1 |
potassium channel regulator |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 9.4 | GO:0009441 | glycolate metabolic process(GO:0009441) |
| 0.1 | 6.4 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.7 | 5.1 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 4.6 | GO:0090383 | phagosome acidification(GO:0090383) |
| 1.0 | 3.1 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.2 | 3.0 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.1 | 3.0 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 2.9 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 2.4 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 2.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 6.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 5.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 4.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 4.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.3 | 4.4 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 3.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 2.1 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 2.1 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 2.1 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 10.0 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
| 0.1 | 6.2 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 4.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 3.9 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.2 | 3.4 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.2 | 3.0 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.6 | 2.6 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.1 | 2.6 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 2.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 2.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.8 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 1.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.5 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.3 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 5.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 4.9 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 4.2 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.2 | 3.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 3.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 3.1 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 2.1 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 2.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |