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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for FOXL1
Z-value: 1.10
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Transcription factors associated with FOXL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXL1 | hg19_v2_chr16_+_86612112_86612123 | -0.22 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 19.2 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.1 | 11.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 8.8 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 6.9 | GO:0016266 | O-glycan processing(GO:0016266) |
| 1.4 | 5.5 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 1.7 | 5.2 | GO:0030505 | inorganic diphosphate transport(GO:0030505) |
| 0.2 | 4.7 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.2 | 4.4 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.2 | 4.4 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 4.4 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 6.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 6.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.6 | 5.5 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.3 | 5.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 5.1 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.1 | 5.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 4.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 3.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 2.9 | GO:0016459 | myosin complex(GO:0016459) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 18.0 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.3 | 6.8 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 1.0 | 4.8 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.2 | 4.0 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 3.6 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.1 | 3.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 3.2 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.5 | 3.0 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.3 | 3.0 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.0 | 2.9 | GO:0003774 | motor activity(GO:0003774) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 3.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.4 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 19.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 7.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 7.0 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.4 | 6.0 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 5.2 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.2 | 4.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 4.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 3.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 2.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |