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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for GATA6

Z-value: 0.54

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.4 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_197494040.571.0e-03Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_102928009 9.26 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr9_+_33795533 1.77 ENST00000379405.3
PRSS3
protease, serine, 3
chr17_+_74381343 1.51 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr20_-_54967187 1.37 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chrX_+_37865804 1.23 ENST00000297875.2
ENST00000357972.5
SYTL5
synaptotagmin-like 5
chr6_+_12290586 1.05 ENST00000379375.5
EDN1
endothelin 1
chr18_+_19749386 1.02 ENST00000269216.3
GATA6
GATA binding protein 6
chr1_-_94050668 0.97 ENST00000539242.1
BCAR3
breast cancer anti-estrogen resistance 3
chr7_+_142457315 0.93 ENST00000486171.1
ENST00000311737.7
PRSS1
protease, serine, 1 (trypsin 1)
chr12_+_4430371 0.83 ENST00000179259.4
C12orf5
chromosome 12 open reading frame 5
chr4_-_103266355 0.80 ENST00000424970.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr7_+_155090271 0.78 ENST00000476756.1
INSIG1
insulin induced gene 1
chr5_+_131409476 0.77 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr1_-_24469602 0.73 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr5_+_159848807 0.69 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chrX_+_107288239 0.65 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chrX_+_107288197 0.65 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr2_-_69098566 0.63 ENST00000295379.1
BMP10
bone morphogenetic protein 10
chr6_-_86099898 0.57 ENST00000455071.1
RP11-30P6.6
RP11-30P6.6
chr9_-_114937465 0.56 ENST00000355396.3
SUSD1
sushi domain containing 1
chr9_-_114937543 0.55 ENST00000374264.2
ENST00000374263.3
SUSD1
sushi domain containing 1
chr9_-_114937676 0.49 ENST00000374270.3
SUSD1
sushi domain containing 1
chr2_-_44065889 0.49 ENST00000543989.1
ENST00000405322.1
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_44065946 0.47 ENST00000260645.1
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr19_+_10397621 0.47 ENST00000380770.3
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr1_+_50574585 0.47 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr2_+_138722028 0.46 ENST00000280096.5
HNMT
histamine N-methyltransferase
chr19_+_10397648 0.46 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr4_-_103266219 0.46 ENST00000394833.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr10_-_129691195 0.45 ENST00000368671.3
CLRN3
clarin 3
chr13_-_46716969 0.44 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_158656488 0.43 ENST00000368147.4
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr3_-_47950745 0.41 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr11_-_66206260 0.39 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
MRPL11
mitochondrial ribosomal protein L11
chr17_+_75283973 0.39 ENST00000431235.2
ENST00000449803.2
SEPT9
septin 9
chr22_-_20231207 0.38 ENST00000425986.1
RTN4R
reticulon 4 receptor
chr11_+_10326612 0.34 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr6_+_130339710 0.34 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr17_+_19314505 0.33 ENST00000461366.1
RNF112
ring finger protein 112
chr1_-_167487758 0.31 ENST00000362089.5
CD247
CD247 molecule
chr1_-_226187013 0.31 ENST00000272091.7
SDE2
SDE2 telomere maintenance homolog (S. pombe)
chr1_-_167487808 0.28 ENST00000392122.3
CD247
CD247 molecule
chr8_-_95449155 0.28 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr2_-_219850277 0.27 ENST00000295727.1
FEV
FEV (ETS oncogene family)
chr21_-_39870339 0.27 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr8_+_21823726 0.26 ENST00000433566.4
XPO7
exportin 7
chr11_+_118958689 0.26 ENST00000535253.1
ENST00000392841.1
HMBS
hydroxymethylbilane synthase
chr18_-_28742813 0.26 ENST00000257197.3
ENST00000257198.5
DSC1
desmocollin 1
chr9_+_118950325 0.25 ENST00000534838.1
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr18_+_43304137 0.23 ENST00000502059.2
ENST00000586951.1
ENST00000589322.2
ENST00000415427.3
ENST00000535474.1
ENST00000402943.2
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr19_-_13213662 0.23 ENST00000264824.4
LYL1
lymphoblastic leukemia derived sequence 1
chr12_-_52995291 0.23 ENST00000293745.2
ENST00000354310.4
KRT72
keratin 72
chr2_+_102927962 0.23 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
IL1RL1
IL18R1
interleukin 1 receptor-like 1
interleukin 18 receptor 1
chr1_+_66999799 0.22 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr7_-_100239132 0.20 ENST00000223051.3
ENST00000431692.1
TFR2
transferrin receptor 2
chr10_+_71075552 0.19 ENST00000298649.3
HK1
hexokinase 1
chr1_-_42630389 0.19 ENST00000357001.2
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr2_+_87565634 0.18 ENST00000421835.2
IGKV3OR2-268
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr3_+_148583043 0.18 ENST00000296046.3
CPA3
carboxypeptidase A3 (mast cell)
chr2_-_90538397 0.16 ENST00000443397.3
RP11-685N3.1
Uncharacterized protein
chr12_-_120765565 0.15 ENST00000423423.3
ENST00000308366.4
PLA2G1B
phospholipase A2, group IB (pancreas)
chr1_-_120354079 0.15 ENST00000354219.1
ENST00000369401.4
ENST00000256585.5
REG4
regenerating islet-derived family, member 4
chr1_+_25599018 0.14 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chr8_+_70404996 0.13 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr10_+_118350468 0.13 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr1_+_206317450 0.13 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
CTSE
cathepsin E
chr19_-_11494975 0.12 ENST00000222139.6
ENST00000592375.2
EPOR
erythropoietin receptor
chr22_-_29784519 0.12 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
AP1B1
adaptor-related protein complex 1, beta 1 subunit
chr1_+_12524965 0.12 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr4_+_15376165 0.12 ENST00000382383.3
ENST00000429690.1
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr12_+_70219052 0.11 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr19_-_51522955 0.09 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr5_-_135290705 0.08 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr10_+_118350522 0.08 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr2_-_152830441 0.08 ENST00000534999.1
ENST00000397327.2
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr6_-_30128657 0.07 ENST00000449742.2
ENST00000376704.3
TRIM10
tripartite motif containing 10
chr5_+_1201703 0.07 ENST00000304460.10
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chr17_+_4835580 0.06 ENST00000329125.5
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr20_-_30795511 0.06 ENST00000246229.4
PLAGL2
pleiomorphic adenoma gene-like 2
chr5_-_33984741 0.06 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
SLC45A2
solute carrier family 45, member 2
chr5_+_135496675 0.06 ENST00000507637.1
SMAD5
SMAD family member 5
chr4_+_100495864 0.06 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr1_+_25598872 0.05 ENST00000328664.4
RHD
Rh blood group, D antigen
chr1_+_25598989 0.05 ENST00000454452.2
RHD
Rh blood group, D antigen
chr5_-_33984786 0.04 ENST00000296589.4
SLC45A2
solute carrier family 45, member 2
chr3_+_137717571 0.04 ENST00000343735.4
CLDN18
claudin 18
chr18_+_43304092 0.04 ENST00000321925.4
ENST00000587601.1
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr17_-_4806369 0.03 ENST00000293780.4
CHRNE
cholinergic receptor, nicotinic, epsilon (muscle)
chr11_-_26743546 0.03 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr12_-_6233828 0.03 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr6_+_31674639 0.03 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr20_+_54967409 0.03 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr8_+_70378852 0.03 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
SULF1
sulfatase 1
chr15_+_49715293 0.03 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr19_+_14138960 0.02 ENST00000431365.2
ENST00000585987.1
RLN3
relaxin 3
chr12_-_56221330 0.01 ENST00000546837.1
RP11-762I7.5
Uncharacterized protein
chr15_+_59279851 0.01 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr12_+_72332618 0.01 ENST00000333850.3
TPH2
tryptophan hydroxylase 2
chr17_-_38938786 0.01 ENST00000301656.3
KRT27
keratin 27
chr14_+_21945335 0.01 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX4
TOX high mobility group box family member 4
chr7_+_128379346 0.01 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
CALU
calumenin
chr2_+_220436917 0.00 ENST00000243786.2
INHA
inhibin, alpha
chr3_+_69812877 0.00 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr17_-_62084241 0.00 ENST00000449662.2
ICAM2
intercellular adhesion molecule 2

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.5 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.5 1.5 GO:0046521 sphingoid catabolic process(GO:0046521)
0.5 1.4 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.3 1.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.3 1.0 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.3 0.8 GO:0045796 negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
0.3 0.8 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 0.8 GO:0045918 positive regulation of interleukin-23 production(GO:0032747) negative regulation of cytolysis(GO:0045918)
0.1 1.3 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.6 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 2.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.5 GO:0001692 histamine metabolic process(GO:0001692)
0.1 0.4 GO:0051012 microtubule sliding(GO:0051012)
0.1 1.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.3 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.3 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.1 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.1 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.2 GO:0070627 ferrous iron import(GO:0070627) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 1.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.2 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.2 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 1.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.3 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.6 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.7 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.0 0.2 GO:0002003 angiotensin maturation(GO:0002003)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 1.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 0.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.4 GO:0032437 cuticular plate(GO:0032437)
0.1 0.8 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 0.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 10.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0031105 septin complex(GO:0031105)
0.0 0.0 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0002113 interleukin-33 binding(GO:0002113)
0.3 1.5 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 1.0 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 1.4 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.4 GO:0038131 neuregulin receptor activity(GO:0038131)
0.1 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.3 GO:0015265 urea channel activity(GO:0015265)
0.1 0.2 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.6 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.2 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 1.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.5 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0017091 AU-rich element binding(GO:0017091)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.4 PID AURORA A PATHWAY Aurora A signaling
0.0 1.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.0 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 3.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.0 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)