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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for GCM1
Z-value: 0.65
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Transcription factors associated with GCM1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GCM1 | hg19_v2_chr6_-_53013620_53013644 | -0.21 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_57547454 Show fit | 1.34 |
ENST00000556376.2
|
HOP homeobox |
|
| chr4_-_57547870 Show fit | 1.33 |
ENST00000381260.3
ENST00000420433.1 ENST00000554144.1 ENST00000557328.1 |
HOP homeobox |
|
| chr2_+_90108504 Show fit | 1.25 |
ENST00000390271.2
|
immunoglobulin kappa variable 6D-41 (non-functional) |
|
| chr11_+_13690249 Show fit | 1.05 |
ENST00000532701.1
|
fatty acyl CoA reductase 1 |
|
| chr2_+_90060377 Show fit | 1.04 |
ENST00000436451.2
|
immunoglobulin kappa variable 6D-21 (non-functional) |
|
| chr2_-_89459813 Show fit | 0.98 |
ENST00000390256.2
|
immunoglobulin kappa variable 6-21 (non-functional) |
|
| chr20_-_1306351 Show fit | 0.98 |
ENST00000381812.1
|
syndecan binding protein (syntenin) 2 |
|
| chr20_+_361261 Show fit | 0.97 |
ENST00000217233.3
|
tribbles pseudokinase 3 |
|
| chr20_-_1306391 Show fit | 0.95 |
ENST00000339987.3
|
syndecan binding protein (syntenin) 2 |
|
| chr12_-_122238464 Show fit | 0.88 |
ENST00000546227.1
|
ras homolog family member F (in filopodia) |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCM1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 3.0 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.1 | 1.6 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 0.1 | 1.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 1.5 | GO:0008611 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.0 | 1.3 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.1 | 1.0 | GO:2000252 | negative regulation of feeding behavior(GO:2000252) |
| 0.0 | 1.0 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.3 | 0.8 | GO:0048627 | myoblast development(GO:0048627) |
| 0.0 | 0.8 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 1.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 1.5 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 1.4 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 1.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 0.6 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.0 | 0.4 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.3 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 0.3 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 0.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.5 | 1.6 | GO:0038131 | neuregulin receptor activity(GO:0038131) |
| 0.3 | 1.5 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.0 | 1.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 1.1 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.1 | 1.0 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.1 | 0.6 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.1 | 0.6 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 0.6 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.1 | 0.4 | GO:0016296 | oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.9 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.4 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 1.0 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 0.8 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 0.7 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.3 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.0 | 0.2 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.2 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.2 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |