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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for GFI1
Z-value: 1.08
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Transcription factors associated with GFI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1 | hg19_v2_chr1_-_92952433_92952489, hg19_v2_chr1_-_92951607_92951661, hg19_v2_chr1_-_92949505_92949543 | 0.31 | 1.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_94727048 Show fit | 7.33 |
ENST00000283357.5
|
family with sequence similarity 81, member B |
|
| chr1_-_60539422 Show fit | 6.81 |
ENST00000371201.3
|
chromosome 1 open reading frame 87 |
|
| chr1_-_60539405 Show fit | 6.59 |
ENST00000450089.2
|
chromosome 1 open reading frame 87 |
|
| chr17_+_45908974 Show fit | 5.98 |
ENST00000269025.4
|
leucine rich repeat containing 46 |
|
| chr19_-_9092018 Show fit | 5.94 |
ENST00000397910.4
|
mucin 16, cell surface associated |
|
| chr1_-_109655355 Show fit | 5.91 |
ENST00000369945.3
|
chromosome 1 open reading frame 194 |
|
| chr1_-_109655377 Show fit | 5.84 |
ENST00000369948.3
|
chromosome 1 open reading frame 194 |
|
| chr9_-_117150243 Show fit | 3.85 |
ENST00000374088.3
|
AT-hook transcription factor |
|
| chr6_-_32920794 Show fit | 3.69 |
ENST00000395305.3
ENST00000395303.3 ENST00000374843.4 ENST00000429234.1 |
major histocompatibility complex, class II, DM alpha Uncharacterized protein |
|
| chr11_+_71900703 Show fit | 3.30 |
ENST00000393681.2
|
folate receptor 1 (adult) |
Network of associatons between targets according to the STRING database.
First level regulatory network of GFI1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.6 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.1 | 6.5 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 2.1 | 6.2 | GO:0003147 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) |
| 0.1 | 6.0 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.3 | 5.8 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.0 | 5.6 | GO:0006835 | dicarboxylic acid transport(GO:0006835) |
| 1.8 | 5.3 | GO:1903568 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 1.3 | 5.3 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.1 | 4.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 4.0 | GO:0010107 | potassium ion import(GO:0010107) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.2 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 1.2 | 5.8 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.0 | 5.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 5.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 5.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 4.1 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.7 | 3.6 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.3 | 3.4 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.2 | 3.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 3.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 10.6 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 2.4 | 7.3 | GO:0015361 | low-affinity sodium:dicarboxylate symporter activity(GO:0015361) |
| 1.5 | 6.2 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.0 | 6.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.9 | 5.8 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 0.2 | 5.2 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.3 | 4.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 4.2 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.2 | 3.5 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.4 | 3.3 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 3.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 3.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 3.2 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 2.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.5 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 1.4 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.3 | 5.0 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 4.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 3.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.2 | 3.4 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.1 | 2.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 2.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.5 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 1.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |