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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for GLI3
Z-value: 1.39
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Transcription factors associated with GLI3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI3 | hg19_v2_chr7_-_42276612_42276782 | 0.52 | 3.4e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51456344 Show fit | 7.48 |
ENST00000336334.3
ENST00000593428.1 |
kallikrein-related peptidase 5 |
|
| chr19_-_51456321 Show fit | 7.41 |
ENST00000391809.2
|
kallikrein-related peptidase 5 |
|
| chr20_+_62327996 Show fit | 7.01 |
ENST00000369996.1
|
tumor necrosis factor receptor superfamily, member 6b, decoy |
|
| chr1_-_153433120 Show fit | 6.82 |
ENST00000368723.3
|
S100 calcium binding protein A7 |
|
| chr19_-_51456198 Show fit | 6.42 |
ENST00000594846.1
|
kallikrein-related peptidase 5 |
|
| chr10_+_88718397 Show fit | 6.01 |
ENST00000372017.3
|
synuclein, gamma (breast cancer-specific protein 1) |
|
| chr10_+_88718314 Show fit | 5.98 |
ENST00000348795.4
|
synuclein, gamma (breast cancer-specific protein 1) |
|
| chr18_+_21529811 Show fit | 5.88 |
ENST00000588004.1
|
laminin, alpha 3 |
|
| chr22_+_31489344 Show fit | 5.45 |
ENST00000404574.1
|
smoothelin |
|
| chr22_+_31488433 Show fit | 5.27 |
ENST00000455608.1
|
smoothelin |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 21.3 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.4 | 12.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 12.8 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.1 | 11.8 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 2.4 | 9.7 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.9 | 8.5 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.6 | 8.5 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.1 | 8.0 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.6 | 6.8 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.1 | 5.8 | GO:0060113 | inner ear receptor cell differentiation(GO:0060113) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 21.3 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 11.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.3 | 9.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 9.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.4 | 9.2 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 8.5 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 8.1 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.3 | 7.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 7.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 6.2 | GO:0031528 | microvillus membrane(GO:0031528) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 10.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 10.5 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 9.5 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.9 | 9.2 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.9 | 8.5 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.0 | 7.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 7.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.4 | 7.2 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.3 | 6.8 | GO:0050786 | RAGE receptor binding(GO:0050786) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 14.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 14.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 11.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 9.4 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 6.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 6.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 5.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 4.6 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 4.4 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.6 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 9.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 6.0 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 5.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.3 | 4.8 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 4.8 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.2 | 4.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 4.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 4.3 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 4.3 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |