Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for GLIS2
Z-value: 0.69
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Transcription factors associated with GLIS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLIS2 | hg19_v2_chr16_+_4364762_4364762, hg19_v2_chr16_+_4382225_4382225 | -0.32 | 8.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLIS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.1 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.4 | 3.9 | GO:0098870 | neuronal action potential propagation(GO:0019227) positive regulation of axon regeneration(GO:0048680) action potential propagation(GO:0098870) |
| 1.1 | 3.2 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.6 | 2.2 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.7 | 2.0 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.6 | 1.9 | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) |
| 0.1 | 1.7 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.1 | 1.7 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.4 | 1.6 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.4 | 1.5 | GO:2000537 | regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 3.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 2.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.2 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 2.0 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 1.6 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 1.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 1.5 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 1.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.5 | GO:0070821 | tertiary granule membrane(GO:0070821) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.9 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.1 | 3.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.3 | 3.4 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.1 | 3.2 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.6 | 1.9 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.5 | 1.8 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 1.7 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 1.6 | GO:0019841 | retinol binding(GO:0019841) |
| 0.5 | 1.5 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 1.4 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 2.2 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 1.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.2 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.1 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.7 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.5 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 1.9 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 1.9 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 1.4 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 1.4 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 1.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 1.3 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 1.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |