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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for GRHL1
Z-value: 0.91
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Transcription factors associated with GRHL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GRHL1 | hg19_v2_chr2_+_10091815_10091864, hg19_v2_chr2_+_10091783_10091811 | 0.65 | 9.5e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GRHL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | GO:0051602 | response to electrical stimulus(GO:0051602) |
| 0.1 | 5.8 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.2 | 3.3 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.1 | 3.0 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.7 | 2.8 | GO:2001287 | negative regulation of caveolin-mediated endocytosis(GO:2001287) |
| 0.0 | 2.4 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.2 | 2.2 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.7 | 2.0 | GO:1900195 | spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195) |
| 0.3 | 2.0 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.0 | 1.9 | GO:0006305 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 5.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 3.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.9 | GO:0005604 | basement membrane(GO:0005604) |
| 0.6 | 2.8 | GO:0044393 | microspike(GO:0044393) |
| 0.1 | 2.7 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 2.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.5 | 2.0 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 1.9 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 1.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.3 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.2 | 3.0 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.0 | 2.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 2.7 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.4 | 2.4 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.0 | 2.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 2.2 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 2.0 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.3 | 1.7 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.1 | 1.7 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.9 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.1 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.6 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 3.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 2.0 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.0 | 2.0 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.0 | 1.5 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 1.1 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.6 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.5 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |