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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for GRHL1

Z-value: 0.91

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.13 grainyhead like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg19_v2_chr2_+_10091815_10091864,
hg19_v2_chr2_+_10091783_10091811		0.659.5e-05Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_20806440 7.35 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
GJB6
gap junction protein, beta 6, 30kDa
chr1_-_153113927 5.80 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr7_-_102283238 2.78 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr7_-_102184083 2.72 ENST00000379357.5
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr1_-_24469602 2.41 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr11_+_706595 2.19 ENST00000531348.1
ENST00000530636.1
EPS8L2
EPS8-like 2
chr7_+_76139925 2.02 ENST00000394849.1
UPK3B
uroplakin 3B
chr9_+_5450503 1.99 ENST00000381573.4
ENST00000381577.3
CD274
CD274 molecule
chr20_-_54967187 1.97 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr14_-_80677815 1.90 ENST00000557125.1
ENST00000555750.1
DIO2
deiodinase, iodothyronine, type II
chr7_+_76139833 1.88 ENST00000257632.5
UPK3B
uroplakin 3B
chr3_+_101568349 1.78 ENST00000326151.5
ENST00000326172.5
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr2_-_85641162 1.75 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
CAPG
capping protein (actin filament), gelsolin-like
chr2_+_113816215 1.74 ENST00000346807.3
IL36RN
interleukin 36 receptor antagonist
chr7_-_80551671 1.73 ENST00000419255.2
ENST00000544525.1
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_-_67442196 1.67 ENST00000525827.1
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr17_+_9728828 1.51 ENST00000262441.5
GLP2R
glucagon-like peptide 2 receptor
chr1_-_201368707 1.49 ENST00000391967.2
LAD1
ladinin 1
chr2_+_95940220 1.48 ENST00000542147.1
PROM2
prominin 2
chr1_+_155023757 1.45 ENST00000356955.2
ENST00000449910.2
ENST00000359280.4
ENST00000360674.4
ENST00000368412.3
ENST00000355956.2
ENST00000368410.2
ENST00000271836.6
ENST00000368413.1
ENST00000531455.1
ENST00000447332.3
ADAM15
ADAM metallopeptidase domain 15
chr10_+_105036909 1.44 ENST00000369849.4
INA
internexin neuronal intermediate filament protein, alpha
chr1_-_201368653 1.42 ENST00000367313.3
LAD1
ladinin 1
chr14_-_80677613 1.40 ENST00000556811.1
DIO2
deiodinase, iodothyronine, type II
chr8_-_130799134 1.35 ENST00000276708.4
GSDMC
gasdermin C
chr2_+_95940186 1.33 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
PROM2
prominin 2
chr11_-_67442079 1.31 ENST00000349015.3
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr1_+_35247859 1.30 ENST00000373362.3
GJB3
gap junction protein, beta 3, 31kDa
chr19_+_19496728 1.26 ENST00000537887.1
ENST00000417582.2
GATAD2A
GATA zinc finger domain containing 2A
chr12_+_123874589 1.05 ENST00000437502.1
SETD8
SET domain containing (lysine methyltransferase) 8
chr7_+_76139741 1.03 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
UPK3B
uroplakin 3B
chr1_-_28384598 1.03 ENST00000373864.1
EYA3
eyes absent homolog 3 (Drosophila)
chr6_+_32121218 1.03 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
PPT2
palmitoyl-protein thioesterase 2
chr20_-_61002584 1.00 ENST00000252998.1
RBBP8NL
RBBP8 N-terminal like
chr11_+_119039414 0.96 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
NLRX1
NLR family member X1
chr19_-_15590306 0.95 ENST00000292609.4
PGLYRP2
peptidoglycan recognition protein 2
chr18_-_35145728 0.92 ENST00000361795.5
ENST00000603232.1
CELF4
CUGBP, Elav-like family member 4
chr19_-_17356697 0.92 ENST00000291442.3
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr9_+_77703414 0.85 ENST00000346234.6
OSTF1
osteoclast stimulating factor 1
chr3_-_49142504 0.78 ENST00000306125.6
ENST00000420147.2
QARS
glutaminyl-tRNA synthetase
chr5_-_132299313 0.78 ENST00000265343.5
AFF4
AF4/FMR2 family, member 4
chr20_-_25320367 0.69 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chr19_+_19496624 0.65 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A
GATA zinc finger domain containing 2A
chr3_-_49142178 0.64 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
QARS
glutaminyl-tRNA synthetase
chr18_+_9475001 0.63 ENST00000019317.4
RALBP1
ralA binding protein 1
chr9_-_77703115 0.62 ENST00000361092.4
ENST00000376808.4
NMRK1
nicotinamide riboside kinase 1
chr19_+_10736183 0.60 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2
solute carrier family 44 (choline transporter), member 2
chr11_-_69590101 0.50 ENST00000168712.1
FGF4
fibroblast growth factor 4
chr2_-_209118974 0.50 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr6_-_31107127 0.49 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr7_-_138794081 0.46 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr1_-_51425772 0.45 ENST00000371778.4
FAF1
Fas (TNFRSF6) associated factor 1
chr12_+_18414446 0.40 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr4_+_156588249 0.39 ENST00000393832.3
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr14_-_23540826 0.36 ENST00000357481.2
ACIN1
apoptotic chromatin condensation inducer 1
chr19_+_58038683 0.35 ENST00000240719.3
ENST00000376233.3
ENST00000594943.1
ENST00000602149.1
ZNF549
zinc finger protein 549
chr1_+_44440575 0.31 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr18_-_35145981 0.30 ENST00000420428.2
ENST00000412753.1
CELF4
CUGBP, Elav-like family member 4
chr5_-_132299290 0.29 ENST00000378595.3
AFF4
AF4/FMR2 family, member 4
chr4_-_99850243 0.24 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
EIF4E
eukaryotic translation initiation factor 4E
chr18_-_35145689 0.20 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
CELF4
CUGBP, Elav-like family member 4
chr1_+_206643806 0.18 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr6_-_43027105 0.13 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chrX_+_146993449 0.13 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr18_-_35145593 0.11 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
CELF4
CUGBP, Elav-like family member 4
chr1_-_16539094 0.11 ENST00000270747.3
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr9_+_71736177 0.07 ENST00000606364.1
ENST00000453658.2
TJP2
tight junction protein 2
chr1_-_234667504 0.06 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr1_-_36863481 0.04 ENST00000315732.2
LSM10
LSM10, U7 small nuclear RNA associated
chr5_+_134303591 0.03 ENST00000282611.6
CATSPER3
cation channel, sperm associated 3
chr9_+_130565487 0.00 ENST00000373225.3
ENST00000431857.1
FPGS
folylpolyglutamate synthase

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.7 2.0 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.5 1.4 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.3 1.0 GO:0032827 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.3 1.7 GO:0003350 pulmonary myocardium development(GO:0003350)
0.3 2.0 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.2 1.7 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.2 3.3 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.2 2.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.2 0.7 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.2 0.5 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 1.5 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.4 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 3.0 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 7.4 GO:0051602 response to electrical stimulus(GO:0051602)
0.1 1.0 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 1.7 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.0 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 1.4 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.1 5.8 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 0.4 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 0.6 GO:0015871 choline transport(GO:0015871)
0.0 0.5 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.9 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.1 GO:2000301 negative regulation of long term synaptic depression(GO:1900453) regulation of intracellular transport of viral material(GO:1901252) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 1.5 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 2.4 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 1.9 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.6 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 1.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.4 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0044393 microspike(GO:0044393)
0.5 2.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 8.6 GO:0005922 connexon complex(GO:0005922)
0.1 1.7 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.4 GO:0005883 neurofilament(GO:0005883)
0.1 5.8 GO:0001533 cornified envelope(GO:0001533)
0.1 2.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0019034 viral replication complex(GO:0019034)
0.0 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 3.0 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 2.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 2.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.3 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.5 1.5 GO:0004967 glucagon receptor activity(GO:0004967)
0.5 1.4 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.4 2.4 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 1.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.3 1.5 GO:0042835 BRE binding(GO:0042835)
0.2 1.0 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.2 3.0 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 2.0 GO:0035174 histone serine kinase activity(GO:0035174)
0.2 0.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.2 0.6 GO:0061769 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.1 2.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 1.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.6 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 1.3 GO:0005243 gap junction channel activity(GO:0005243)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 2.8 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.0 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 2.3 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID AURORA A PATHWAY Aurora A signaling
0.0 1.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.1 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 3.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 2.0 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 1.1 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 2.0 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling