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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HDX

Z-value: 0.29

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.9 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg19_v2_chrX_-_83757399_837574870.393.5e-02Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_113594279 0.55 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr2_+_128403720 0.35 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr1_+_84630053 0.33 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_128403439 0.33 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr7_-_69062391 0.31 ENST00000436600.2
RP5-942I16.1
RP5-942I16.1
chr18_+_29027696 0.30 ENST00000257189.4
DSG3
desmoglein 3
chr2_+_113735575 0.26 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr5_-_35230434 0.24 ENST00000504500.1
PRLR
prolactin receptor
chr12_+_101869096 0.21 ENST00000551346.1
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr5_-_41213607 0.19 ENST00000337836.5
ENST00000433294.1
C6
complement component 6
chr19_-_41934635 0.17 ENST00000321702.2
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr1_+_117602925 0.16 ENST00000369466.4
TTF2
transcription termination factor, RNA polymerase II
chr5_+_60933634 0.15 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr3_-_165555200 0.12 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr12_+_10460549 0.12 ENST00000543420.1
ENST00000543777.1
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr7_-_121944491 0.11 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr10_-_14372870 0.11 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr1_-_169680745 0.10 ENST00000236147.4
SELL
selectin L
chr5_-_35230649 0.09 ENST00000382002.5
PRLR
prolactin receptor
chr7_-_135412925 0.08 ENST00000354042.4
SLC13A4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr11_-_66675371 0.08 ENST00000393955.2
PC
pyruvate carboxylase
chr12_+_54422142 0.08 ENST00000243108.4
HOXC6
homeobox C6
chr22_+_40440804 0.08 ENST00000441751.1
ENST00000301923.9
TNRC6B
trinucleotide repeat containing 6B
chr7_+_99954224 0.08 ENST00000608825.1
PILRB
paired immunoglobin-like type 2 receptor beta
chr5_-_35230771 0.08 ENST00000342362.5
PRLR
prolactin receptor
chr6_+_144471643 0.08 ENST00000367568.4
STX11
syntaxin 11
chr12_+_10460417 0.07 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr2_+_169926047 0.06 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_11024258 0.06 ENST00000418570.2
C1orf127
chromosome 1 open reading frame 127
chr5_-_135290705 0.05 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr1_-_153363452 0.05 ENST00000368732.1
ENST00000368733.3
S100A8
S100 calcium binding protein A8
chr5_+_140625147 0.05 ENST00000231173.3
PCDHB15
protocadherin beta 15
chr2_+_87754887 0.05 ENST00000409054.1
ENST00000331944.6
ENST00000409139.1
LINC00152
long intergenic non-protein coding RNA 152
chr14_+_79745682 0.04 ENST00000557594.1
NRXN3
neurexin 3
chr2_-_40657397 0.04 ENST00000408028.2
ENST00000332839.4
ENST00000406391.2
ENST00000542024.1
ENST00000542756.1
ENST00000405901.3
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr9_+_35538616 0.04 ENST00000455600.1
RUSC2
RUN and SH3 domain containing 2
chr15_-_54025300 0.04 ENST00000559418.1
WDR72
WD repeat domain 72
chr6_+_42584847 0.03 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr8_+_24151620 0.03 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr11_+_9685604 0.02 ENST00000447399.2
ENST00000318950.6
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr12_-_31743901 0.02 ENST00000354285.4
DENND5B
DENN/MADD domain containing 5B
chrX_+_55649833 0.02 ENST00000339140.3
FOXR2
forkhead box R2
chr18_-_53804580 0.02 ENST00000590484.1
ENST00000589293.1
ENST00000587904.1
ENST00000591974.1
RP11-456O19.4
RP11-456O19.4
chr16_+_1877204 0.01 ENST00000427358.2
FAHD1
fumarylacetoacetate hydrolase domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.4 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.2 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.7 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.2 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.0 0.1 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.7 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling