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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HDX

Z-value: 0.29

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
ENSG00000165259.9 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg19_v2_chrX_-_83757399_837574870.393.5e-02Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_113594279 0.55 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
interleukin 1, beta
chr2_+_128403720 0.35 ENST00000272644.3
G protein-coupled receptor 17
chr1_+_84630053 0.33 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_128403439 0.33 ENST00000544369.1
G protein-coupled receptor 17
chr7_-_69062391 0.31 ENST00000436600.2
RP5-942I16.1
chr18_+_29027696 0.30 ENST00000257189.4
desmoglein 3
chr2_+_113735575 0.26 ENST00000376489.2
ENST00000259205.4
interleukin 36, gamma
chr5_-_35230434 0.24 ENST00000504500.1
prolactin receptor
chr12_+_101869096 0.21 ENST00000551346.1
Spi-C transcription factor (Spi-1/PU.1 related)
chr5_-_41213607 0.19 ENST00000337836.5
ENST00000433294.1
complement component 6
chr19_-_41934635 0.17 ENST00000321702.2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr1_+_117602925 0.16 ENST00000369466.4
transcription termination factor, RNA polymerase II
chr5_+_60933634 0.15 ENST00000505642.1
chromosome 5 open reading frame 64
chr3_-_165555200 0.12 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
butyrylcholinesterase
chr12_+_10460549 0.12 ENST00000543420.1
ENST00000543777.1
killer cell lectin-like receptor subfamily D, member 1
chr7_-_121944491 0.11 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr10_-_14372870 0.11 ENST00000357447.2
FERM domain containing 4A
chr1_-_169680745 0.10 ENST00000236147.4
selectin L
chr5_-_35230649 0.09 ENST00000382002.5
prolactin receptor
chr7_-_135412925 0.08 ENST00000354042.4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr11_-_66675371 0.08 ENST00000393955.2
pyruvate carboxylase
chr12_+_54422142 0.08 ENST00000243108.4
homeobox C6
chr22_+_40440804 0.08 ENST00000441751.1
ENST00000301923.9
trinucleotide repeat containing 6B
chr7_+_99954224 0.08 ENST00000608825.1
paired immunoglobin-like type 2 receptor beta
chr5_-_35230771 0.08 ENST00000342362.5
prolactin receptor
chr6_+_144471643 0.08 ENST00000367568.4
syntaxin 11
chr12_+_10460417 0.07 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
killer cell lectin-like receptor subfamily D, member 1
chr2_+_169926047 0.06 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
dehydrogenase/reductase (SDR family) member 9
chr1_-_11024258 0.06 ENST00000418570.2
chromosome 1 open reading frame 127
chr5_-_135290705 0.05 ENST00000274507.1
leukocyte cell-derived chemotaxin 2
chr1_-_153363452 0.05 ENST00000368732.1
ENST00000368733.3
S100 calcium binding protein A8
chr5_+_140625147 0.05 ENST00000231173.3
protocadherin beta 15
chr2_+_87754887 0.05 ENST00000409054.1
ENST00000331944.6
ENST00000409139.1
long intergenic non-protein coding RNA 152
chr14_+_79745682 0.04 ENST00000557594.1
neurexin 3
chr2_-_40657397 0.04 ENST00000408028.2
ENST00000332839.4
ENST00000406391.2
ENST00000542024.1
ENST00000542756.1
ENST00000405901.3
solute carrier family 8 (sodium/calcium exchanger), member 1
chr9_+_35538616 0.04 ENST00000455600.1
RUN and SH3 domain containing 2
chr15_-_54025300 0.04 ENST00000559418.1
WD repeat domain 72
chr6_+_42584847 0.03 ENST00000372883.3
ubiquitin protein ligase E3 component n-recognin 2
chr8_+_24151620 0.03 ENST00000437154.2
ADAM metallopeptidase domain 28
chr11_+_9685604 0.02 ENST00000447399.2
ENST00000318950.6
SWAP switching B-cell complex 70kDa subunit
chr12_-_31743901 0.02 ENST00000354285.4
DENN/MADD domain containing 5B
chrX_+_55649833 0.02 ENST00000339140.3
forkhead box R2
chr18_-_53804580 0.02 ENST00000590484.1
ENST00000589293.1
ENST00000587904.1
ENST00000591974.1
RP11-456O19.4
chr16_+_1877204 0.01 ENST00000427358.2
fumarylacetoacetate hydrolase domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.4 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.2 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.7 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.2 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.0 0.1 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.7 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling