ISMARA results: HES1

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HES1

Z-value: 0.64

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Transcription factors associated with HES1

Gene Symbol	Gene ID	Gene Info
HES1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000114315.3	hes family bHLH transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HES1	hg19_v2_chr3_+_193853927_193853944	0.06	7.4e-01	Click!

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_9189229 Show fit	2.49	ENST00000377411.4	GPR157 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 157
chr6_+_86159821 Show fit	2.37	ENST00000369651.3	NT5E Ensembl NCBI GeneCards UniProt NextProt Show fit	5'-nucleotidase, ecto (CD73)
chr18_+_33877654 Show fit	2.10	ENST00000257209.4 ENST00000445677.1 ENST00000590592.1 ENST00000359247.4	FHOD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	formin homology 2 domain containing 3
chr20_-_43280325 Show fit	1.59	ENST00000537820.1	ADA Ensembl NCBI GeneCards UniProt NextProt Show fit	adenosine deaminase
chr6_+_151646800 Show fit	1.38	ENST00000354675.6	AKAP12 Ensembl NCBI GeneCards UniProt NextProt Show fit	A kinase (PRKA) anchor protein 12
chr21_-_44495919 Show fit	1.36	ENST00000398158.1	CBS Ensembl NCBI GeneCards UniProt NextProt Show fit	cystathionine-beta-synthase
chr4_+_17812525 Show fit	1.22	ENST00000251496.2	NCAPG Ensembl NCBI GeneCards UniProt NextProt Show fit	non-SMC condensin I complex, subunit G
chr7_+_130131907 Show fit	1.18	ENST00000223215.4 ENST00000437945.1	MEST Ensembl NCBI GeneCards UniProt NextProt Show fit	mesoderm specific transcript
chr20_+_37554955 Show fit	1.17	ENST00000217429.4	FAM83D Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 83, member D
chr4_-_185655278 Show fit	1.14	ENST00000281453.5	MLF1IP Ensembl NCBI GeneCards UniProt NextProt Show fit	centromere protein U

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	3.8	GO:0046086	adenosine biosynthetic process(GO:0046086)
0.1	2.9	GO:0006270	DNA replication initiation(GO:0006270)
0.2	2.5	GO:0060019	radial glial cell differentiation(GO:0060019)
0.6	2.3	GO:0046102	inosine metabolic process(GO:0046102)
0.0	2.2	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.1	2.1	GO:0051639	actin filament network formation(GO:0051639)
0.7	2.0	GO:0036333	hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.6	1.9	GO:0006535	cysteine biosynthetic process from serine(GO:0006535)
0.6	1.9	GO:0071789	spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1	1.9	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)

Showing 1 to 10 of 236 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.4	GO:0005901	caveola(GO:0005901)
0.0	3.9	GO:0031225	anchored component of membrane(GO:0031225)
0.2	2.8	GO:0045120	pronucleus(GO:0045120)
0.0	2.2	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0	2.1	GO:0005865	striated muscle thin filament(GO:0005865)
0.6	1.9	GO:0070762	nuclear pore transmembrane ring(GO:0070762)
0.1	1.9	GO:0031011	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0	1.9	GO:0060170	ciliary membrane(GO:0060170)
0.2	1.6	GO:0000796	condensin complex(GO:0000796)
0.0	1.6	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)

Showing 1 to 10 of 91 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.5	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.2	2.0	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1	2.0	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.1	2.0	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.1	2.0	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.6	1.9	GO:0070025	cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.6	1.8	GO:0070506	high-density lipoprotein particle receptor activity(GO:0070506)
0.1	1.8	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.2	1.7	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1	1.7	GO:0004000	adenosine deaminase activity(GO:0004000)

Showing 1 to 10 of 161 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	2.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.9	PID AURORA B PATHWAY	Aurora B signaling
0.1	1.8	PID S1P S1P1 PATHWAY	S1P1 pathway
0.1	1.7	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	1.7	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	1.6	PID BCR 5PATHWAY	BCR signaling pathway
0.0	1.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	1.3	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	1.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases

Showing 1 to 10 of 29 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	2.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	1.9	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1	1.9	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	1.9	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	1.8	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	1.5	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	1.5	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	1.4	REACTOME LATE PHASE OF HIV LIFE CYCLE	Genes involved in Late Phase of HIV Life Cycle
0.1	1.3	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters

Showing 1 to 10 of 55 entries

Results for HES1

Z-value: 0.64

Motif logo

Transcription factors associated with HES1

Activity-expression correlation:

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: