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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HES1

Z-value: 0.64

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Transcription factors associated with HES1

Gene Symbol Gene ID Gene Info
HES1
ENSG00000114315.3 hes family bHLH transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HES1hg19_v2_chr3_+_193853927_1938539440.067.4e-01Click!

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_9189229 2.49 ENST00000377411.4
GPR157
G protein-coupled receptor 157
chr6_+_86159821 2.37 ENST00000369651.3
NT5E
5'-nucleotidase, ecto (CD73)
chr18_+_33877654 2.10 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr20_-_43280325 1.59 ENST00000537820.1
ADA
adenosine deaminase
chr6_+_151646800 1.38 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr21_-_44495919 1.36 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr4_+_17812525 1.22 ENST00000251496.2
NCAPG
non-SMC condensin I complex, subunit G
chr7_+_130131907 1.18 ENST00000223215.4
ENST00000437945.1
MEST
mesoderm specific transcript
chr20_+_37554955 1.17 ENST00000217429.4
FAM83D
family with sequence similarity 83, member D
chr4_-_185655278 1.14 ENST00000281453.5
MLF1IP
centromere protein U
chr9_+_91926103 1.13 ENST00000314355.6
CKS2
CDC28 protein kinase regulatory subunit 2
chr18_-_33077556 1.11 ENST00000589273.1
ENST00000586489.1
INO80C
INO80 complex subunit C
chr11_-_71318487 1.09 ENST00000343767.3
AP000867.1
AP000867.1
chr6_+_86159765 1.08 ENST00000369646.3
ENST00000257770.3
NT5E
5'-nucleotidase, ecto (CD73)
chr2_+_201390843 1.06 ENST00000357799.4
ENST00000409203.3
SGOL2
shugoshin-like 2 (S. pombe)
chr7_-_148581251 1.05 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr1_-_53793725 1.02 ENST00000371454.2
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr8_-_95908902 0.96 ENST00000520509.1
CCNE2
cyclin E2
chr7_-_148581360 0.96 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chrX_-_106960285 0.95 ENST00000503515.1
ENST00000372397.2
TSC22D3
TSC22 domain family, member 3
chr12_-_125348448 0.91 ENST00000339570.5
SCARB1
scavenger receptor class B, member 1
chr19_-_19051927 0.90 ENST00000600077.1
HOMER3
homer homolog 3 (Drosophila)
chr12_-_125348329 0.90 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
SCARB1
scavenger receptor class B, member 1
chr19_-_19051993 0.85 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
HOMER3
homer homolog 3 (Drosophila)
chr7_+_24613034 0.84 ENST00000409761.1
ENST00000396475.2
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr11_+_65029421 0.83 ENST00000541089.1
POLA2
polymerase (DNA directed), alpha 2, accessory subunit
chr6_+_31126291 0.82 ENST00000376257.3
ENST00000376255.4
TCF19
transcription factor 19
chr11_+_43964055 0.79 ENST00000528572.1
C11orf96
chromosome 11 open reading frame 96
chr21_-_40685536 0.79 ENST00000341322.4
BRWD1
bromodomain and WD repeat domain containing 1
chr1_-_54303949 0.77 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin
chr7_-_558876 0.75 ENST00000354513.5
ENST00000402802.3
PDGFA
platelet-derived growth factor alpha polypeptide
chrX_-_109561294 0.73 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_+_91966656 0.73 ENST00000428239.1
ENST00000426137.1
CDC7
cell division cycle 7
chr7_-_99698338 0.72 ENST00000354230.3
ENST00000425308.1
MCM7
minichromosome maintenance complex component 7
chr16_-_72127456 0.70 ENST00000562153.1
TXNL4B
thioredoxin-like 4B
chr1_+_41445413 0.69 ENST00000541520.1
CTPS1
CTP synthase 1
chr7_+_130126165 0.69 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST
mesoderm specific transcript
chr1_-_113498943 0.69 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr14_+_20937538 0.68 ENST00000361505.5
ENST00000553591.1
PNP
purine nucleoside phosphorylase
chr1_-_54303934 0.67 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr1_-_118472171 0.67 ENST00000369442.3
GDAP2
ganglioside induced differentiation associated protein 2
chr17_+_74381343 0.66 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr2_-_136633940 0.66 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr6_-_31869769 0.65 ENST00000375527.2
ZBTB12
zinc finger and BTB domain containing 12
chr1_-_113498616 0.64 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr2_-_25142708 0.62 ENST00000260600.5
ENST00000435135.1
ADCY3
adenylate cyclase 3
chr12_-_124018252 0.62 ENST00000376874.4
RILPL1
Rab interacting lysosomal protein-like 1
chr1_+_28844778 0.62 ENST00000411533.1
RCC1
regulator of chromosome condensation 1
chr12_+_1099675 0.62 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr2_+_192543153 0.61 ENST00000425611.2
NABP1
nucleic acid binding protein 1
chr19_-_55919087 0.60 ENST00000587845.1
ENST00000589978.1
ENST00000264552.9
UBE2S
ubiquitin-conjugating enzyme E2S
chr2_-_224702740 0.59 ENST00000444408.1
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr9_-_136242909 0.59 ENST00000371991.3
ENST00000545297.1
SURF4
surfeit 4
chr9_+_116037922 0.58 ENST00000374198.4
PRPF4
pre-mRNA processing factor 4
chr8_+_92082424 0.57 ENST00000285420.4
ENST00000404789.3
OTUD6B
OTU domain containing 6B
chr10_-_90751038 0.57 ENST00000458159.1
ENST00000415557.1
ENST00000458208.1
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_165797024 0.57 ENST00000372212.4
UCK2
uridine-cytidine kinase 2
chr6_-_150346607 0.57 ENST00000367341.1
ENST00000286380.2
RAET1L
retinoic acid early transcript 1L
chrX_-_131623874 0.57 ENST00000436215.1
MBNL3
muscleblind-like splicing regulator 3
chr1_+_23037323 0.57 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
EPHB2
EPH receptor B2
chr2_-_224702201 0.57 ENST00000446015.2
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr7_+_155089486 0.56 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr21_-_44495964 0.56 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chrX_-_51239425 0.56 ENST00000375992.3
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr8_+_124194752 0.56 ENST00000318462.6
FAM83A
family with sequence similarity 83, member A
chr19_-_1652575 0.55 ENST00000587235.1
ENST00000262965.5
TCF3
transcription factor 3
chr18_-_33077942 0.54 ENST00000334598.7
INO80C
INO80 complex subunit C
chr2_+_208576259 0.54 ENST00000392209.3
CCNYL1
cyclin Y-like 1
chr16_-_46865286 0.53 ENST00000285697.4
C16orf87
chromosome 16 open reading frame 87
chr19_+_30302805 0.53 ENST00000262643.3
ENST00000575243.1
ENST00000357943.5
CCNE1
cyclin E1
chr2_+_204193129 0.52 ENST00000417864.1
ABI2
abl-interactor 2
chr2_-_224702257 0.52 ENST00000409375.1
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr2_+_192542850 0.51 ENST00000410026.2
NABP1
nucleic acid binding protein 1
chr12_-_122238464 0.50 ENST00000546227.1
RHOF
ras homolog family member F (in filopodia)
chr1_+_153950202 0.50 ENST00000608236.1
RP11-422P24.11
RP11-422P24.11
chrX_+_152907913 0.50 ENST00000370167.4
DUSP9
dual specificity phosphatase 9
chr1_-_231175964 0.49 ENST00000366654.4
FAM89A
family with sequence similarity 89, member A
chr2_-_224702270 0.49 ENST00000396654.2
ENST00000396653.2
ENST00000423110.1
ENST00000443700.1
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr19_+_34287174 0.49 ENST00000587559.1
ENST00000588637.1
KCTD15
potassium channel tetramerization domain containing 15
chr15_-_63674034 0.49 ENST00000344366.3
ENST00000422263.2
CA12
carbonic anhydrase XII
chr6_+_43543864 0.48 ENST00000372236.4
ENST00000535400.1
POLH
polymerase (DNA directed), eta
chr9_-_94186131 0.48 ENST00000297689.3
NFIL3
nuclear factor, interleukin 3 regulated
chr12_+_122064673 0.47 ENST00000537188.1
ORAI1
ORAI calcium release-activated calcium modulator 1
chrX_+_21958814 0.47 ENST00000379404.1
ENST00000415881.2
SMS
spermine synthase
chr8_+_66556936 0.47 ENST00000262146.4
MTFR1
mitochondrial fission regulator 1
chr1_+_44445549 0.46 ENST00000356836.6
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr1_-_53793584 0.45 ENST00000354412.3
ENST00000347547.2
ENST00000306052.6
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr2_+_64681641 0.45 ENST00000409537.2
LGALSL
lectin, galactoside-binding-like
chr1_+_152881014 0.44 ENST00000368764.3
ENST00000392667.2
IVL
involucrin
chr17_-_1394940 0.44 ENST00000570984.2
ENST00000361007.2
MYO1C
myosin IC
chr1_-_54304212 0.44 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chr21_-_44846999 0.44 ENST00000270162.6
SIK1
salt-inducible kinase 1
chr3_-_179754806 0.44 ENST00000485199.1
PEX5L
peroxisomal biogenesis factor 5-like
chr5_-_159797627 0.43 ENST00000393975.3
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr17_-_79849438 0.43 ENST00000331204.4
ENST00000505490.2
ALYREF
Aly/REF export factor
chr2_-_47143160 0.43 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr10_-_99447024 0.42 ENST00000370626.3
AVPI1
arginine vasopressin-induced 1
chr13_+_52158610 0.42 ENST00000298125.5
WDFY2
WD repeat and FYVE domain containing 2
chr19_+_4402659 0.41 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr14_-_91282726 0.41 ENST00000328459.6
ENST00000357056.2
TTC7B
tetratricopeptide repeat domain 7B
chr8_-_145515055 0.41 ENST00000526552.1
ENST00000529231.1
ENST00000307404.5
BOP1
block of proliferation 1
chr5_+_149737202 0.41 ENST00000451292.1
ENST00000377797.3
ENST00000445265.2
ENST00000323668.7
ENST00000439160.2
ENST00000394269.3
ENST00000427724.2
ENST00000504761.2
ENST00000513346.1
ENST00000515516.1
TCOF1
Treacher Collins-Franceschetti syndrome 1
chr10_-_75634219 0.41 ENST00000305762.7
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr12_+_96588279 0.40 ENST00000552142.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr2_-_47142884 0.40 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr2_+_208576355 0.40 ENST00000420822.1
ENST00000295414.3
ENST00000339882.5
CCNYL1
cyclin Y-like 1
chr1_-_43424500 0.40 ENST00000415851.2
ENST00000426263.3
ENST00000372500.3
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr5_+_612387 0.39 ENST00000264935.5
ENST00000444221.1
CEP72
centrosomal protein 72kDa
chr2_+_204193149 0.39 ENST00000422511.2
ABI2
abl-interactor 2
chr11_+_65029233 0.39 ENST00000265465.3
POLA2
polymerase (DNA directed), alpha 2, accessory subunit
chr11_+_124932955 0.38 ENST00000403796.2
SLC37A2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr12_-_53614155 0.38 ENST00000543726.1
RARG
retinoic acid receptor, gamma
chr14_+_100070869 0.38 ENST00000502101.2
RP11-543C4.1
RP11-543C4.1
chr2_-_101925055 0.38 ENST00000295317.3
RNF149
ring finger protein 149
chr10_+_74033672 0.37 ENST00000307365.3
DDIT4
DNA-damage-inducible transcript 4
chr3_-_179169330 0.37 ENST00000232564.3
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr5_-_180632147 0.37 ENST00000274773.7
TRIM7
tripartite motif containing 7
chr6_+_20403997 0.37 ENST00000535432.1
E2F3
E2F transcription factor 3
chr1_+_44444865 0.37 ENST00000372324.1
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr12_-_113909877 0.37 ENST00000261731.3
LHX5
LIM homeobox 5
chr20_+_6748311 0.37 ENST00000378827.4
BMP2
bone morphogenetic protein 2
chr9_-_126692386 0.37 ENST00000373624.2
ENST00000394219.3
ENST00000373620.3
ENST00000394215.2
ENST00000373618.1
DENND1A
DENN/MADD domain containing 1A
chr11_+_124932986 0.37 ENST00000407458.1
ENST00000298280.5
SLC37A2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr15_+_89182178 0.37 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr8_+_41386761 0.37 ENST00000523277.2
GINS4
GINS complex subunit 4 (Sld5 homolog)
chr12_-_53614043 0.36 ENST00000338561.5
RARG
retinoic acid receptor, gamma
chr9_+_4490394 0.36 ENST00000262352.3
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr14_-_100070363 0.36 ENST00000380243.4
CCDC85C
coiled-coil domain containing 85C
chr14_-_53162361 0.36 ENST00000395686.3
ERO1L
ERO1-like (S. cerevisiae)
chr16_+_72127461 0.35 ENST00000268482.3
ENST00000566794.1
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr16_+_72127670 0.35 ENST00000536867.1
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr6_+_43738444 0.35 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
VEGFA
vascular endothelial growth factor A
chr10_+_75936444 0.35 ENST00000372734.3
ENST00000541550.1
ADK
adenosine kinase
chr11_+_124933191 0.35 ENST00000532000.1
ENST00000308074.4
SLC37A2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr1_+_44401479 0.35 ENST00000438616.3
ARTN
artemin
chr2_+_113239710 0.35 ENST00000233336.6
TTL
tubulin tyrosine ligase
chr12_+_49761147 0.35 ENST00000549298.1
SPATS2
spermatogenesis associated, serine-rich 2
chr8_+_145515263 0.35 ENST00000528838.1
HSF1
heat shock transcription factor 1
chr8_+_124428959 0.34 ENST00000287387.2
ENST00000523984.1
WDYHV1
WDYHV motif containing 1
chr8_+_22298578 0.34 ENST00000240139.5
ENST00000289963.8
ENST00000397775.3
PPP3CC
protein phosphatase 3, catalytic subunit, gamma isozyme
chr5_-_132112907 0.34 ENST00000458488.2
SEPT8
septin 8
chr19_-_8373173 0.34 ENST00000537716.2
ENST00000301458.5
CD320
CD320 molecule
chr22_+_38302285 0.34 ENST00000215957.6
MICALL1
MICAL-like 1
chr15_-_63674218 0.34 ENST00000178638.3
CA12
carbonic anhydrase XII
chr11_-_134093827 0.34 ENST00000534548.2
NCAPD3
non-SMC condensin II complex, subunit D3
chr10_-_105110831 0.33 ENST00000337211.4
PCGF6
polycomb group ring finger 6
chr3_+_51422478 0.33 ENST00000528157.1
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr17_-_7297519 0.33 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr3_+_182971583 0.33 ENST00000460419.1
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr3_-_179754556 0.33 ENST00000263962.8
PEX5L
peroxisomal biogenesis factor 5-like
chr10_-_105110890 0.33 ENST00000369847.3
PCGF6
polycomb group ring finger 6
chr5_-_132112921 0.33 ENST00000378721.4
ENST00000378701.1
SEPT8
septin 8
chr12_-_106641728 0.33 ENST00000378026.4
CKAP4
cytoskeleton-associated protein 4
chr5_-_172662303 0.33 ENST00000517440.1
ENST00000329198.4
NKX2-5
NK2 homeobox 5
chr6_-_105850937 0.33 ENST00000369110.3
PREP
prolyl endopeptidase
chr18_+_48086440 0.32 ENST00000400384.2
ENST00000540640.1
ENST00000592595.1
MAPK4
mitogen-activated protein kinase 4
chr1_-_154946825 0.32 ENST00000368453.4
ENST00000368450.1
ENST00000366442.2
SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr11_+_63580855 0.32 ENST00000294244.4
C11orf84
chromosome 11 open reading frame 84
chr21_-_47648665 0.32 ENST00000450351.1
ENST00000522411.1
ENST00000356396.4
ENST00000397728.3
ENST00000457828.2
LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr12_+_121416437 0.32 ENST00000402929.1
ENST00000535955.1
ENST00000538626.1
ENST00000543427.1
HNF1A
HNF1 homeobox A
chr18_+_12308231 0.32 ENST00000590103.1
ENST00000591909.1
ENST00000586653.1
ENST00000592683.1
ENST00000590967.1
ENST00000591208.1
ENST00000591463.1
TUBB6
tubulin, beta 6 class V
chr6_-_45345597 0.32 ENST00000371460.1
ENST00000371459.1
SUPT3H
suppressor of Ty 3 homolog (S. cerevisiae)
chr20_+_23471727 0.31 ENST00000449810.1
ENST00000246012.1
CST8
cystatin 8 (cystatin-related epididymal specific)
chr11_+_86748863 0.31 ENST00000340353.7
TMEM135
transmembrane protein 135
chr19_+_10982336 0.31 ENST00000344150.4
CARM1
coactivator-associated arginine methyltransferase 1
chr17_-_74722536 0.31 ENST00000585429.1
JMJD6
jumonji domain containing 6
chr6_+_43739697 0.31 ENST00000230480.6
VEGFA
vascular endothelial growth factor A
chr5_+_6633534 0.31 ENST00000537411.1
ENST00000538824.1
SRD5A1
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
chr2_-_86116093 0.31 ENST00000377332.3
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr19_-_14201776 0.31 ENST00000269724.5
SAMD1
sterile alpha motif domain containing 1
chr19_-_14629224 0.30 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr9_+_101867387 0.30 ENST00000374990.2
ENST00000552516.1
TGFBR1
transforming growth factor, beta receptor 1
chr3_-_127541679 0.30 ENST00000265052.5
MGLL
monoglyceride lipase
chr18_+_77794358 0.30 ENST00000306735.5
RBFA
ribosome binding factor A (putative)
chr16_+_16043406 0.30 ENST00000399410.3
ENST00000399408.2
ENST00000346370.5
ENST00000351154.5
ENST00000345148.5
ENST00000349029.5
ABCC1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
chr6_-_10419871 0.30 ENST00000319516.4
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr10_-_121302195 0.30 ENST00000369103.2
RGS10
regulator of G-protein signaling 10
chr8_+_31496809 0.30 ENST00000518104.1
ENST00000519301.1
NRG1
neuregulin 1
chr19_+_33071974 0.29 ENST00000590247.2
ENST00000419343.3
ENST00000592786.1
ENST00000379316.3
PDCD5
programmed cell death 5
chr19_-_48673552 0.29 ENST00000536218.1
ENST00000596549.1
LIG1
ligase I, DNA, ATP-dependent
chr8_+_95653427 0.29 ENST00000454170.2
ESRP1
epithelial splicing regulatory protein 1
chr18_+_77794446 0.29 ENST00000262197.7
RBFA
ribosome binding factor A (putative)
chr8_+_142138711 0.29 ENST00000518347.1
ENST00000262585.2
ENST00000424248.1
ENST00000519811.1
ENST00000520986.1
ENST00000523058.1
DENND3
DENN/MADD domain containing 3
chr1_-_8086343 0.29 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
ERRFI1
ERBB receptor feedback inhibitor 1
chr4_+_57302297 0.29 ENST00000399688.3
ENST00000512576.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr19_+_50887585 0.29 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr5_+_157158205 0.29 ENST00000231198.7
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr17_-_56565736 0.29 ENST00000323777.3
HSF5
heat shock transcription factor family member 5
chr18_+_12947981 0.29 ENST00000262124.11
SEH1L
SEH1-like (S. cerevisiae)
chr19_+_39616410 0.29 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chrX_-_107018969 0.28 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr21_-_40032581 0.28 ENST00000398919.2
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr1_+_154947148 0.28 ENST00000368436.1
ENST00000308987.5
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr13_+_21277482 0.28 ENST00000304920.3
IL17D
interleukin 17D
chr10_+_3109695 0.28 ENST00000381125.4
PFKP
phosphofructokinase, platelet
chr1_+_154947126 0.28 ENST00000368439.1
CKS1B
CDC28 protein kinase regulatory subunit 1B
chrX_-_153285395 0.28 ENST00000369980.3
IRAK1
interleukin-1 receptor-associated kinase 1
chr8_+_32406179 0.28 ENST00000405005.3
NRG1
neuregulin 1
chr8_+_95653302 0.28 ENST00000423620.2
ENST00000433389.2
ESRP1
epithelial splicing regulatory protein 1
chr19_-_14628645 0.28 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.7 2.0 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.6 1.9 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.6 1.9 GO:0071789 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.6 1.8 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.6 2.3 GO:0046102 inosine metabolic process(GO:0046102)
0.4 1.3 GO:0015728 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.3 0.8 GO:0035623 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.3 0.8 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.2 0.7 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.2 0.7 GO:0006597 spermine biosynthetic process(GO:0006597)
0.2 0.7 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 0.7 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.2 0.6 GO:0008355 olfactory learning(GO:0008355)
0.2 1.6 GO:0007498 mesoderm development(GO:0007498)
0.2 0.6 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 1.5 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.2 0.9 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 0.9 GO:0003342 proepicardium development(GO:0003342) septum transversum development(GO:0003343)
0.2 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.2 0.5 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.2 1.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.2 0.6 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.2 2.5 GO:0060019 radial glial cell differentiation(GO:0060019)
0.2 0.8 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.2 0.6 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 0.7 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430) Harderian gland development(GO:0070384)
0.1 0.4 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.6 GO:0009224 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 0.4 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.1 1.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 1.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.8 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 0.4 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 2.1 GO:0051639 actin filament network formation(GO:0051639)
0.1 1.4 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.4 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.1 0.5 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1 0.5 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.3 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.1 0.6 GO:0072144 glomerular mesangial cell development(GO:0072144)
0.1 0.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.4 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.1 1.1 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.8 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.1 0.6 GO:1901909 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 1.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.5 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.4 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.4 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.1 0.7 GO:0071494 cellular response to UV-C(GO:0071494)
0.1 0.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.3 GO:0035674 tricarboxylic acid transmembrane transport(GO:0035674)
0.1 1.8 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.3 GO:0042214 terpene metabolic process(GO:0042214) phytoalexin metabolic process(GO:0052314)
0.1 0.6 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.6 GO:0060992 response to fungicide(GO:0060992)
0.1 0.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 0.2 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.1 0.2 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.2 GO:0098502 DNA dephosphorylation(GO:0098502)
0.1 0.7 GO:1904783 positive regulation of NMDA glutamate receptor activity(GO:1904783)
0.1 0.2 GO:1990086 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) lens fiber cell apoptotic process(GO:1990086)
0.1 0.3 GO:0003404 optic vesicle morphogenesis(GO:0003404) optic cup structural organization(GO:0003409)
0.1 0.4 GO:0032526 response to retinoic acid(GO:0032526)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.7 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 1.9 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 0.3 GO:0061146 Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
0.1 0.2 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.1 0.2 GO:1902490 regulation of sperm capacitation(GO:1902490)
0.1 0.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 0.3 GO:0031296 B cell costimulation(GO:0031296)
0.1 0.2 GO:0021722 pons maturation(GO:0021586) superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.3 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.1 0.2 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 2.9 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.3 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.1 0.2 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.2 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.1 0.5 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 0.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.2 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.1 0.4 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 0.4 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.1 0.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.2 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.1 0.2 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0 0.3 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.3 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.4 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.3 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.4 GO:0000101 sulfur amino acid transport(GO:0000101)
0.0 0.3 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.0 0.1 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.0 0.2 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.6 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.4 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0061009 cardiac cell fate determination(GO:0060913) common bile duct development(GO:0061009) gall bladder development(GO:0061010)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:1901078 negative regulation of relaxation of muscle(GO:1901078)
0.0 0.2 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499)
0.0 0.1 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.4 GO:1904779 regulation of protein localization to centrosome(GO:1904779)
0.0 2.2 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.4 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.0 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0 0.1 GO:0036337 Fas signaling pathway(GO:0036337)
0.0 0.4 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.0 0.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.0 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.0 0.2 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.6 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 0.3 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616) lung vasculature development(GO:0060426) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.0 0.0 GO:0034333 cell-substrate adherens junction assembly(GO:0007045) adherens junction assembly(GO:0034333) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109) regulation of adherens junction organization(GO:1903391)
0.0 0.2 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.0 0.4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.5 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.8 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.2 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0 0.4 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 1.2 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.5 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.6 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.3 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.7 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.1 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.1 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 0.1 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.0 0.1 GO:0002461 tolerance induction dependent upon immune response(GO:0002461)
0.0 0.4 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.0 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.1 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.4 GO:0045820 negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198)
0.0 0.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.1 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.0 0.1 GO:0060921 sinoatrial node development(GO:0003163) sinoatrial node cell differentiation(GO:0060921) sinoatrial node cell development(GO:0060931)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.3 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.4 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.1 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 0.5 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.0 0.8 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.8 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 0.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.2 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.1 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.2 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.2 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.2 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.0 GO:1900195 positive regulation of oocyte maturation(GO:1900195)
0.0 0.1 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.2 GO:0002666 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) positive regulation of T cell tolerance induction(GO:0002666) immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.2 GO:0002097 tRNA wobble base modification(GO:0002097)
0.0 0.2 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.1 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 0.2 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.0 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.0 0.1 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.3 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.2 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.0 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.0 GO:2000830 vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.2 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.6 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.0 GO:0010269 response to selenium ion(GO:0010269)
0.0 0.4 GO:0030517 negative regulation of axon extension(GO:0030517)
0.0 0.2 GO:0051823 regulation of synapse structural plasticity(GO:0051823) positive regulation of synapse maturation(GO:0090129)
0.0 0.1 GO:1990314 cellular response to insulin-like growth factor stimulus(GO:1990314)
0.0 0.5 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.0 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.0 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.0 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.0 1.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 0.1 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 0.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.6 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0060312 regulation of blood vessel remodeling(GO:0060312)
0.0 0.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.2 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.5 0.5 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.2 1.0 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 1.1 GO:0070876 SOSS complex(GO:0070876)
0.2 1.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 2.8 GO:0045120 pronucleus(GO:0045120)
0.2 1.6 GO:0000796 condensin complex(GO:0000796)
0.1 0.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.4 GO:0042565 RNA nuclear export complex(GO:0042565)
0.1 0.5 GO:0000811 GINS complex(GO:0000811)
0.1 0.5 GO:0071001 U4/U6 snRNP(GO:0071001)
0.1 0.4 GO:0045160 myosin I complex(GO:0045160)
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.4 GO:0042555 MCM complex(GO:0042555)
0.1 1.4 GO:0031209 SCAR complex(GO:0031209)
0.1 0.5 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 0.2 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.9 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.1 1.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.2 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.3 GO:0070435 Shc-EGFR complex(GO:0070435)
0.1 0.5 GO:0070852 cell body fiber(GO:0070852)
0.1 0.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.0 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 1.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 4.4 GO:0005901 caveola(GO:0005901)
0.0 0.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.5 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 2.2 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.3 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 0.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.9 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.5 GO:0046540 U5 snRNP(GO:0005682) U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 1.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.0 GO:0000125 PCAF complex(GO:0000125)
0.0 0.2 GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.0 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.0 0.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0042599 lamellar body(GO:0042599)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.1 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0070025 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.6 1.8 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.4 1.3 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.4 1.5 GO:0038025 reelin receptor activity(GO:0038025)
0.3 0.9 GO:0008859 exoribonuclease II activity(GO:0008859)
0.3 0.8 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.2 1.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 0.7 GO:0003883 CTP synthase activity(GO:0003883)
0.2 0.7 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.2 2.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 0.6 GO:0015235 cobalamin transporter activity(GO:0015235)
0.2 0.8 GO:0004461 lactose synthase activity(GO:0004461)
0.2 0.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 3.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 1.1 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.2 0.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 1.3 GO:0043426 MRF binding(GO:0043426)
0.1 0.4 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.1 0.4 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.1 0.5 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1 2.0 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 0.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.7 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.3 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.5 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 1.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 1.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.3 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 0.6 GO:0052841 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1 0.4 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.1 0.3 GO:0097677 STAT family protein binding(GO:0097677)
0.1 0.7 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 0.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.2 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.4 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.1 0.2 GO:0098808 mRNA cap binding(GO:0098808)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.3 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 0.5 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 0.3 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.1 1.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.6 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 2.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.5 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 0.2 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.1 0.3 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.2 GO:0070984 SET domain binding(GO:0070984)
0.0 0.1 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.0 0.5 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.7 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.3 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.3 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.7 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.3 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.3 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.5 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.2 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.3 GO:0050733 RS domain binding(GO:0050733)
0.0 0.4 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.3 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.1 GO:0001632 leukotriene B4 receptor activity(GO:0001632)
0.0 0.2 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.7 GO:0008432 JUN kinase binding(GO:0008432)
0.0 1.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.2 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.4 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0050815 phosphoserine binding(GO:0050815) phosphothreonine binding(GO:0050816)
0.0 0.9 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 1.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.3 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.5 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.1 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.0 0.4 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.1 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.1 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.9 GO:0019894 kinesin binding(GO:0019894)
0.0 0.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.2 GO:0005542 folic acid binding(GO:0005542)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.0 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 1.6 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 0.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0016866 intramolecular transferase activity(GO:0016866)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 1.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.8 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.9 PID AURORA B PATHWAY Aurora B signaling
0.0 1.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID ATR PATHWAY ATR signaling pathway
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.2 PID EPO PATHWAY EPO signaling pathway
0.0 0.8 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.4 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 0.4 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.9 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 1.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 1.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.5 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 0.8 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 0.8 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.6 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.0 0.9 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.5 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.2 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.5 REACTOME OPSINS Genes involved in Opsins
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.1 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.5 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.5 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.4 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.1 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.4 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.3 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis