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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HES7_HES5

Z-value: 0.78

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Transcription factors associated with HES7_HES5

Gene Symbol Gene ID Gene Info
HES7
ENSG00000179111.4 hes family bHLH transcription factor 7
HES5
ENSG00000197921.5 hes family bHLH transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HES7hg19_v2_chr17_-_8027402_80274320.431.8e-02Click!
HES5hg19_v2_chr1_-_2461684_24617100.135.0e-01Click!

Activity profile of HES7_HES5 motif

Sorted Z-values of HES7_HES5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_42694732 7.08 ENST00000398646.3
FAM3B
family with sequence similarity 3, member B
chr13_+_35516390 6.74 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
NBEA
neurobeachin
chr7_-_73184588 3.86 ENST00000395145.2
CLDN3
claudin 3
chr1_-_109655377 3.50 ENST00000369948.3
C1orf194
chromosome 1 open reading frame 194
chr9_+_92219919 2.32 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr17_+_48172639 2.24 ENST00000503176.1
ENST00000503614.1
PDK2
pyruvate dehydrogenase kinase, isozyme 2
chr11_-_119066545 2.23 ENST00000415318.1
CCDC153
coiled-coil domain containing 153
chr5_-_54529415 2.07 ENST00000282572.4
CCNO
cyclin O
chr22_-_31741757 2.04 ENST00000215919.3
PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr19_+_13106383 2.03 ENST00000397661.2
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_-_220108309 2.01 ENST00000409640.1
GLB1L
galactosidase, beta 1-like
chr19_+_35168633 1.84 ENST00000505365.2
ZNF302
zinc finger protein 302
chr21_-_46330545 1.77 ENST00000320216.6
ENST00000397852.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr3_-_125820348 1.49 ENST00000509064.1
ENST00000508835.1
SLC41A3
solute carrier family 41, member 3
chr17_-_5015129 1.46 ENST00000575898.1
ENST00000416429.2
ZNF232
zinc finger protein 232
chr11_-_63376013 1.38 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr20_-_2821271 1.34 ENST00000448755.1
ENST00000360652.2
PCED1A
PC-esterase domain containing 1A
chr11_-_26593649 1.33 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr1_+_28261492 1.27 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr17_-_40346477 1.20 ENST00000593209.1
ENST00000587427.1
ENST00000588352.1
ENST00000414034.3
ENST00000590249.1
GHDC
GH3 domain containing
chr17_-_17109579 1.20 ENST00000321560.3
PLD6
phospholipase D family, member 6
chr16_-_5115913 1.19 ENST00000474471.3
C16orf89
chromosome 16 open reading frame 89
chr11_+_35684288 1.19 ENST00000299413.5
TRIM44
tripartite motif containing 44
chr1_+_28261621 1.18 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr3_-_151102529 1.17 ENST00000302632.3
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr3_+_49027308 1.10 ENST00000383729.4
ENST00000343546.4
P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr5_+_78532003 1.09 ENST00000396137.4
JMY
junction mediating and regulatory protein, p53 cofactor
chr11_+_60197040 1.06 ENST00000300190.2
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr2_-_86564776 1.04 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1
receptor accessory protein 1
chr17_+_40440481 0.94 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A
signal transducer and activator of transcription 5A
chr7_+_148959262 0.93 ENST00000434415.1
ZNF783
zinc finger family member 783
chr4_+_6202448 0.92 ENST00000508601.1
RP11-586D19.1
RP11-586D19.1
chr9_-_100395756 0.91 ENST00000341170.4
ENST00000354801.2
TSTD2
thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
chr3_-_25824925 0.90 ENST00000396649.3
ENST00000428257.1
ENST00000280700.5
NGLY1
N-glycanase 1
chr20_+_55966444 0.89 ENST00000356208.5
ENST00000440234.2
RBM38
RNA binding motif protein 38
chr3_-_149510553 0.88 ENST00000462519.2
ENST00000446160.1
ENST00000383050.3
ANKUB1
ankyrin repeat and ubiquitin domain containing 1
chr4_-_144940477 0.81 ENST00000513128.1
ENST00000429670.2
ENST00000502664.1
GYPB
glycophorin B (MNS blood group)
chr17_-_1531635 0.80 ENST00000571650.1
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr11_-_26593677 0.80 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr7_+_99933730 0.79 ENST00000610247.1
PILRB
paired immunoglobin-like type 2 receptor beta
chr7_+_23637118 0.79 ENST00000448353.1
CCDC126
coiled-coil domain containing 126
chr7_+_23636992 0.79 ENST00000307471.3
ENST00000409765.1
CCDC126
coiled-coil domain containing 126
chr17_-_62084241 0.75 ENST00000449662.2
ICAM2
intercellular adhesion molecule 2
chr16_+_3550924 0.75 ENST00000576634.1
ENST00000574369.1
ENST00000341633.5
ENST00000417763.2
ENST00000571025.1
CLUAP1
clusterin associated protein 1
chr4_+_1003742 0.74 ENST00000398484.2
FGFRL1
fibroblast growth factor receptor-like 1
chr22_+_22681656 0.74 ENST00000390291.2
IGLV1-50
immunoglobulin lambda variable 1-50 (non-functional)
chr2_+_149402553 0.72 ENST00000258484.6
ENST00000409654.1
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr1_+_45140360 0.71 ENST00000418644.1
ENST00000458657.2
ENST00000441519.1
ENST00000535358.1
ENST00000445071.1
C1orf228
chromosome 1 open reading frame 228
chr11_+_60197069 0.71 ENST00000528905.1
ENST00000528093.1
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr13_+_115079949 0.71 ENST00000361283.1
CHAMP1
chromosome alignment maintaining phosphoprotein 1
chr11_+_537494 0.70 ENST00000270115.7
LRRC56
leucine rich repeat containing 56
chr22_+_41777927 0.70 ENST00000266304.4
TEF
thyrotrophic embryonic factor
chr22_+_24891210 0.67 ENST00000382760.2
UPB1
ureidopropionase, beta
chr1_-_1293904 0.67 ENST00000309212.6
ENST00000342753.4
ENST00000445648.2
MXRA8
matrix-remodelling associated 8
chr21_-_33985127 0.66 ENST00000290155.3
C21orf59
chromosome 21 open reading frame 59
chr4_-_170924888 0.66 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chr15_-_57025759 0.64 ENST00000267807.7
ZNF280D
zinc finger protein 280D
chr11_-_6440624 0.63 ENST00000311051.3
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr17_-_61523622 0.62 ENST00000448884.2
ENST00000582297.1
ENST00000582034.1
ENST00000578072.1
ENST00000360793.3
CYB561
cytochrome b561
chr4_+_113152978 0.61 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr16_-_67969888 0.60 ENST00000574576.2
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr17_-_61523535 0.58 ENST00000584031.1
ENST00000392976.1
CYB561
cytochrome b561
chr10_+_131265443 0.57 ENST00000306010.7
MGMT
O-6-methylguanine-DNA methyltransferase
chr7_+_75027418 0.57 ENST00000447409.2
TRIM73
tripartite motif containing 73
chr4_+_76439665 0.56 ENST00000508105.1
ENST00000311638.3
ENST00000380837.3
ENST00000507556.1
ENST00000504190.1
ENST00000507885.1
ENST00000502620.1
ENST00000514480.1
THAP6
THAP domain containing 6
chr4_-_18023350 0.56 ENST00000539056.1
ENST00000382226.5
ENST00000326877.4
LCORL
ligand dependent nuclear receptor corepressor-like
chr4_+_113152881 0.53 ENST00000274000.5
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr8_+_145437880 0.52 ENST00000377406.4
FAM203B
family with sequence similarity 203, member B
chr12_+_112204691 0.52 ENST00000416293.3
ENST00000261733.2
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
chr16_-_21416640 0.51 ENST00000542817.1
NPIPB3
nuclear pore complex interacting protein family, member B3
chr1_+_152658599 0.49 ENST00000368780.3
LCE2B
late cornified envelope 2B
chr1_+_210111570 0.49 ENST00000367019.1
ENST00000472886.1
SYT14
synaptotagmin XIV
chr10_+_22605374 0.47 ENST00000448361.1
COMMD3
COMM domain containing 3
chr9_-_136203235 0.46 ENST00000372022.4
SURF6
surfeit 6
chr20_+_35201857 0.45 ENST00000373874.2
TGIF2
TGFB-induced factor homeobox 2
chr22_-_24181174 0.45 ENST00000318109.7
ENST00000406855.3
ENST00000404056.1
ENST00000476077.1
DERL3
derlin 3
chr12_-_49318715 0.45 ENST00000444214.2
FKBP11
FK506 binding protein 11, 19 kDa
chr20_-_44993012 0.45 ENST00000372229.1
ENST00000372230.5
ENST00000543605.1
ENST00000243896.2
ENST00000317734.8
SLC35C2
solute carrier family 35 (GDP-fucose transporter), member C2
chr10_+_180405 0.44 ENST00000439456.1
ENST00000397962.3
ENST00000309776.4
ENST00000381602.4
ZMYND11
zinc finger, MYND-type containing 11
chr16_-_21849091 0.43 ENST00000537951.1
NPIPB4
nuclear pore complex interacting protein family, member B4
chr11_+_67776012 0.42 ENST00000539229.1
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr2_+_61372226 0.42 ENST00000426997.1
C2orf74
chromosome 2 open reading frame 74
chr1_+_150254936 0.41 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
C1orf51
chromosome 1 open reading frame 51
chr9_-_139658965 0.41 ENST00000316144.5
LCN15
lipocalin 15
chr5_+_95066823 0.41 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr2_+_74648848 0.40 ENST00000409791.1
ENST00000426787.1
ENST00000348227.4
WDR54
WD repeat domain 54
chr1_+_166958497 0.40 ENST00000367870.2
MAEL
maelstrom spermatogenic transposon silencer
chr10_+_49514698 0.40 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
MAPK8
mitogen-activated protein kinase 8
chr17_-_35969409 0.39 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
SYNRG
synergin, gamma
chr16_-_30237150 0.39 ENST00000543463.1
RP11-347C12.1
Putative NPIP-like protein LOC613037
chr11_+_9595180 0.38 ENST00000450114.2
WEE1
WEE1 G2 checkpoint kinase
chr7_-_72437484 0.38 ENST00000395244.1
TRIM74
tripartite motif containing 74
chr17_+_46048376 0.38 ENST00000338399.4
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr19_+_37837185 0.37 ENST00000541583.2
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr10_+_22605304 0.36 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr1_+_44457261 0.35 ENST00000372318.3
CCDC24
coiled-coil domain containing 24
chr7_+_99214559 0.35 ENST00000394152.2
ENST00000431485.2
ZSCAN25
zinc finger and SCAN domain containing 25
chr21_+_45432174 0.35 ENST00000380221.3
ENST00000291574.4
TRAPPC10
trafficking protein particle complex 10
chr2_-_198299726 0.34 ENST00000409915.4
ENST00000487698.1
ENST00000414963.2
ENST00000335508.6
SF3B1
splicing factor 3b, subunit 1, 155kDa
chr7_-_130598059 0.34 ENST00000432045.2
MIR29B1
microRNA 29a
chr1_+_231114795 0.34 ENST00000310256.2
ENST00000366658.2
ENST00000450711.1
ENST00000435927.1
ARV1
ARV1 homolog (S. cerevisiae)
chr1_+_28261533 0.34 ENST00000411604.1
ENST00000373888.4
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr7_+_101460882 0.33 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr2_+_27665232 0.33 ENST00000543753.1
ENST00000288873.3
KRTCAP3
keratinocyte associated protein 3
chr15_+_22833395 0.33 ENST00000283645.4
TUBGCP5
tubulin, gamma complex associated protein 5
chr9_+_131451480 0.31 ENST00000322030.8
SET
SET nuclear oncogene
chr15_-_29561979 0.31 ENST00000332303.4
NDNL2
necdin-like 2
chr13_+_43597269 0.31 ENST00000379221.2
DNAJC15
DnaJ (Hsp40) homolog, subfamily C, member 15
chr1_+_210111534 0.30 ENST00000422431.1
ENST00000534859.1
ENST00000399639.2
ENST00000537238.1
SYT14
synaptotagmin XIV
chr2_-_3523507 0.29 ENST00000327435.6
ADI1
acireductone dioxygenase 1
chr5_+_152870106 0.28 ENST00000285900.5
GRIA1
glutamate receptor, ionotropic, AMPA 1
chr16_+_5121814 0.27 ENST00000262374.5
ENST00000586840.1
ALG1
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr4_-_76439483 0.26 ENST00000380840.2
ENST00000513257.1
ENST00000507014.1
RCHY1
ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
chr2_+_27665289 0.26 ENST00000407293.1
KRTCAP3
keratinocyte associated protein 3
chr17_-_47492236 0.25 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
PHB
prohibitin
chr9_+_100395891 0.25 ENST00000375147.3
NCBP1
nuclear cap binding protein subunit 1, 80kDa
chrX_-_20159934 0.23 ENST00000379593.1
ENST00000379607.5
EIF1AX
eukaryotic translation initiation factor 1A, X-linked
chr18_+_11752040 0.23 ENST00000423027.3
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr8_-_65711310 0.23 ENST00000310193.3
CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1
chr12_+_52345448 0.23 ENST00000257963.4
ENST00000541224.1
ENST00000426655.2
ENST00000536420.1
ENST00000415850.2
ACVR1B
activin A receptor, type IB
chrX_-_16887963 0.23 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr13_+_115047097 0.21 ENST00000351487.5
UPF3A
UPF3 regulator of nonsense transcripts homolog A (yeast)
chr20_+_35201993 0.21 ENST00000373872.4
TGIF2
TGFB-induced factor homeobox 2
chr19_+_58095501 0.21 ENST00000536878.2
ENST00000597850.1
ENST00000597219.1
ENST00000598689.1
ENST00000599456.1
ENST00000307468.4
ZIK1
zinc finger protein interacting with K protein 1
chr19_+_50691437 0.19 ENST00000598205.1
MYH14
myosin, heavy chain 14, non-muscle
chr12_-_91348949 0.19 ENST00000358859.2
CCER1
coiled-coil glutamate-rich protein 1
chr7_+_44788430 0.19 ENST00000457123.1
ENST00000309315.4
ZMIZ2
zinc finger, MIZ-type containing 2
chr8_+_104033277 0.19 ENST00000518857.1
ENST00000395862.3
ATP6V1C1
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
chr12_+_133066137 0.18 ENST00000434748.2
FBRSL1
fibrosin-like 1
chr16_+_333152 0.18 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
PDIA2
protein disulfide isomerase family A, member 2
chr2_+_25264933 0.18 ENST00000401432.3
ENST00000403714.3
EFR3B
EFR3 homolog B (S. cerevisiae)
chr12_-_76953453 0.17 ENST00000549570.1
OSBPL8
oxysterol binding protein-like 8
chr8_+_17780346 0.16 ENST00000325083.8
PCM1
pericentriolar material 1
chr16_+_29127282 0.16 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chr19_+_24009879 0.16 ENST00000354585.4
RPSAP58
ribosomal protein SA pseudogene 58
chr10_+_72194585 0.16 ENST00000420338.2
AC022532.1
Uncharacterized protein
chr3_-_50329990 0.16 ENST00000417626.2
IFRD2
interferon-related developmental regulator 2
chr17_-_79791118 0.15 ENST00000576431.1
ENST00000575061.1
ENST00000455127.2
ENST00000572645.1
ENST00000538396.1
ENST00000573478.1
FAM195B
family with sequence similarity 195, member B
chr3_-_50329835 0.14 ENST00000429673.2
IFRD2
interferon-related developmental regulator 2
chr17_-_73874654 0.14 ENST00000254816.2
TRIM47
tripartite motif containing 47
chr1_+_160765919 0.13 ENST00000341032.4
ENST00000368041.2
ENST00000368040.1
LY9
lymphocyte antigen 9
chr4_-_135248604 0.13 ENST00000515491.1
ENST00000504728.1
ENST00000506638.1
RP11-400D2.2
RP11-400D2.2
chr14_+_65879668 0.13 ENST00000553924.1
ENST00000358307.2
ENST00000557338.1
ENST00000554610.1
FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr6_-_114292449 0.12 ENST00000519065.1
HDAC2
histone deacetylase 2
chr4_-_76439596 0.11 ENST00000451788.1
ENST00000512706.1
RCHY1
ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
chr17_-_41465674 0.11 ENST00000592135.1
ENST00000587874.1
ENST00000588654.1
ENST00000592094.1
LINC00910
long intergenic non-protein coding RNA 910
chr1_+_160765884 0.11 ENST00000392203.4
LY9
lymphocyte antigen 9
chr1_+_160765860 0.10 ENST00000368037.5
LY9
lymphocyte antigen 9
chr10_-_71169031 0.10 ENST00000373307.1
TACR2
tachykinin receptor 2
chr6_-_114292284 0.10 ENST00000520895.1
ENST00000521163.1
ENST00000524334.1
ENST00000368632.2
ENST00000398283.2
HDAC2
histone deacetylase 2
chr16_+_222846 0.09 ENST00000251595.6
ENST00000397806.1
HBA2
hemoglobin, alpha 2
chr17_-_47492164 0.08 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
PHB
prohibitin
chr14_-_77737543 0.08 ENST00000298352.4
NGB
neuroglobin
chr22_-_21984282 0.08 ENST00000398873.3
ENST00000292778.6
YDJC
YdjC homolog (bacterial)
chr5_-_114598548 0.08 ENST00000379615.3
ENST00000419445.1
PGGT1B
protein geranylgeranyltransferase type I, beta subunit
chr3_+_38080691 0.08 ENST00000308059.6
ENST00000346219.3
ENST00000452631.2
DLEC1
deleted in lung and esophageal cancer 1
chr19_-_52511334 0.08 ENST00000602063.1
ENST00000597747.1
ENST00000594083.1
ENST00000593650.1
ENST00000599631.1
ENST00000598071.1
ENST00000601178.1
ENST00000376716.5
ENST00000391795.3
ZNF615
zinc finger protein 615
chr14_+_65878565 0.07 ENST00000556518.1
ENST00000557164.1
FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr12_+_27175476 0.07 ENST00000546323.1
ENST00000282892.3
MED21
mediator complex subunit 21
chr4_-_6692246 0.07 ENST00000499502.2
RP11-539L10.2
RP11-539L10.2
chr5_+_112227311 0.07 ENST00000391338.1
ZRSR1
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1
chr16_-_48419361 0.07 ENST00000394725.2
SIAH1
siah E3 ubiquitin protein ligase 1
chr5_-_130500922 0.07 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
HINT1
histidine triad nucleotide binding protein 1
chr1_+_150293973 0.07 ENST00000414970.2
ENST00000543398.1
PRPF3
pre-mRNA processing factor 3
chr1_+_150293921 0.06 ENST00000324862.6
PRPF3
pre-mRNA processing factor 3
chr9_+_100174344 0.06 ENST00000422139.2
TDRD7
tudor domain containing 7
chr16_+_770975 0.06 ENST00000569529.1
ENST00000564000.1
ENST00000219535.3
FAM173A
family with sequence similarity 173, member A
chr12_-_76953513 0.05 ENST00000547540.1
OSBPL8
oxysterol binding protein-like 8
chr22_+_18560675 0.05 ENST00000329627.7
PEX26
peroxisomal biogenesis factor 26
chr15_+_68871569 0.05 ENST00000566799.1
CORO2B
coronin, actin binding protein, 2B
chrX_-_149106653 0.05 ENST00000462691.1
ENST00000370404.1
ENST00000483447.1
ENST00000370409.3
CXorf40B
chromosome X open reading frame 40B
chr12_+_49621658 0.04 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr1_-_166944561 0.04 ENST00000271417.3
ILDR2
immunoglobulin-like domain containing receptor 2
chr8_+_17780483 0.04 ENST00000517730.1
ENST00000518537.1
ENST00000523055.1
ENST00000519253.1
PCM1
pericentriolar material 1
chr15_-_65477637 0.04 ENST00000300107.3
CLPX
caseinolytic mitochondrial matrix peptidase chaperone subunit
chr19_-_55954230 0.04 ENST00000376325.4
SHISA7
shisa family member 7
chr6_-_74161977 0.04 ENST00000370318.1
ENST00000370315.3
MB21D1
Mab-21 domain containing 1
chr8_+_104033296 0.03 ENST00000521514.1
ENST00000518738.1
ATP6V1C1
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
chr14_+_39735411 0.03 ENST00000603904.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr15_+_22833482 0.02 ENST00000453949.2
TUBGCP5
tubulin, gamma complex associated protein 5
chr9_+_131549483 0.01 ENST00000372648.5
ENST00000539497.1
TBC1D13
TBC1 domain family, member 13
chrX_-_152736013 0.01 ENST00000330912.2
ENST00000338525.2
ENST00000334497.2
ENST00000370232.1
ENST00000370212.3
ENST00000370211.4
TREX2
HAUS7
three prime repair exonuclease 2
HAUS augmin-like complex, subunit 7

Network of associatons between targets according to the STRING database.

First level regulatory network of HES7_HES5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.2 0.9 GO:0000255 allantoin metabolic process(GO:0000255)
0.2 1.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 2.8 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 0.6 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.2 1.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 0.7 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 1.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.4 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 2.2 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 3.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 1.2 GO:0010635 regulation of mitochondrial fusion(GO:0010635)
0.1 2.3 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 1.8 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 0.3 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1 0.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 0.3 GO:0045917 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.1 0.3 GO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902957)
0.1 0.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 1.0 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.4 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.5 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.2 GO:0061198 fungiform papilla formation(GO:0061198)
0.0 0.7 GO:0060539 diaphragm development(GO:0060539)
0.0 0.6 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.2 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.7 GO:0060856 establishment of blood-brain barrier(GO:0060856)
0.0 0.4 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.9 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.4 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781)
0.0 0.9 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057) negative regulation of luteinizing hormone secretion(GO:0033685)
0.0 2.1 GO:0006284 base-excision repair(GO:0006284)
0.0 0.3 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.8 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.2 GO:0031053 primary miRNA processing(GO:0031053)
0.0 2.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.1 GO:0036071 N-glycan fucosylation(GO:0036071)
0.0 6.5 GO:0030073 insulin secretion(GO:0030073)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.3 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 1.1 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.8 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 0.4 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.8 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.4 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.2 GO:0006413 translational initiation(GO:0006413)
0.0 1.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 1.8 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.1 0.4 GO:0030849 autosome(GO:0030849)
0.1 3.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.5 GO:0001652 granular component(GO:0001652)
0.1 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.6 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.1 0.6 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.1 0.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.5 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 1.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.4 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.0 0.2 GO:0097513 myosin II filament(GO:0097513)
0.0 0.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0 0.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.6 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 7.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 2.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.2 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.3 1.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.3 1.1 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.3 1.4 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.3 1.6 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.3 1.0 GO:0031849 olfactory receptor binding(GO:0031849)
0.3 2.1 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.2 2.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 1.8 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 1.8 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.1 0.4 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 1.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.3 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.1 0.9 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.6 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 0.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.3 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 1.1 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.6 GO:0048156 tau protein binding(GO:0048156)
0.0 0.2 GO:0031543 peptidyl-proline dioxygenase activity(GO:0031543) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.1 GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 6.3 GO:0005125 cytokine activity(GO:0005125)
0.0 0.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 2.0 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 2.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 2.1 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 3.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 1.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 2.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 2.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL