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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HESX1

Z-value: 0.98

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Transcription factors associated with HESX1

Gene Symbol Gene ID Gene Info
HESX1
ENSG00000163666.4 HESX homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HESX1hg19_v2_chr3_-_57233966_57234014-0.355.8e-02Click!

Activity profile of HESX1 motif

Sorted Z-values of HESX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_161337662 6.86 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr11_+_101918153 5.14 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
C11orf70
chromosome 11 open reading frame 70
chr6_+_52285131 5.01 ENST00000433625.2
EFHC1
EF-hand domain (C-terminal) containing 1
chr6_+_116937636 4.07 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A
radial spoke head 4 homolog A (Chlamydomonas)
chr1_-_42921915 3.86 ENST00000372565.3
ENST00000433602.2
ZMYND12
zinc finger, MYND-type containing 12
chr6_+_52285046 3.46 ENST00000371068.5
EFHC1
EF-hand domain (C-terminal) containing 1
chr16_+_19421803 3.41 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr11_+_71791359 2.92 ENST00000419228.1
ENST00000435085.1
ENST00000307198.7
ENST00000538413.1
LRTOMT
leucine rich transmembrane and O-methyltransferase domain containing
chr16_+_4784273 2.92 ENST00000299320.5
ENST00000586724.1
C16orf71
chromosome 16 open reading frame 71
chr8_-_110656995 2.87 ENST00000276646.9
ENST00000533065.1
SYBU
syntabulin (syntaxin-interacting)
chr8_+_120885949 2.74 ENST00000523492.1
ENST00000286234.5
DEPTOR
DEP domain containing MTOR-interacting protein
chr2_-_160654745 2.48 ENST00000259053.4
ENST00000429078.2
CD302
CD302 molecule
chr1_+_15256230 2.41 ENST00000376028.4
ENST00000400798.2
KAZN
kazrin, periplakin interacting protein
chr11_-_5276008 2.11 ENST00000336906.4
HBG2
hemoglobin, gamma G
chr21_+_33784670 2.03 ENST00000300255.2
EVA1C
eva-1 homolog C (C. elegans)
chr2_+_230787213 2.03 ENST00000409992.1
FBXO36
F-box protein 36
chr16_-_84273304 2.01 ENST00000308251.4
ENST00000568181.1
KCNG4
potassium voltage-gated channel, subfamily G, member 4
chr1_+_3614591 1.98 ENST00000378290.4
TP73
tumor protein p73
chr2_+_230787201 1.97 ENST00000283946.3
FBXO36
F-box protein 36
chr5_+_149340282 1.90 ENST00000286298.4
SLC26A2
solute carrier family 26 (anion exchanger), member 2
chr2_+_85981008 1.88 ENST00000306279.3
ATOH8
atonal homolog 8 (Drosophila)
chr7_-_95025661 1.83 ENST00000542556.1
ENST00000265627.5
ENST00000427422.1
ENST00000451904.1
PON1
PON3
paraoxonase 1
paraoxonase 3
chr20_-_40247133 1.71 ENST00000373233.3
ENST00000309279.7
CHD6
chromodomain helicase DNA binding protein 6
chr6_+_116421976 1.70 ENST00000319550.4
ENST00000419791.1
NT5DC1
5'-nucleotidase domain containing 1
chr15_-_89089860 1.61 ENST00000558413.1
ENST00000564406.1
ENST00000268148.8
DET1
de-etiolated homolog 1 (Arabidopsis)
chr2_+_186603355 1.53 ENST00000343098.5
FSIP2
fibrous sheath interacting protein 2
chr2_-_43823093 1.51 ENST00000405006.4
THADA
thyroid adenoma associated
chr9_+_1051481 1.46 ENST00000358146.2
ENST00000259622.6
DMRT2
doublesex and mab-3 related transcription factor 2
chr9_-_123239632 1.45 ENST00000416449.1
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr16_+_4784458 1.44 ENST00000590191.1
C16orf71
chromosome 16 open reading frame 71
chr16_-_1661988 1.43 ENST00000426508.2
IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chr12_-_49582593 1.39 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr19_+_11457232 1.39 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr12_+_131438443 1.37 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr19_+_45312347 1.35 ENST00000270233.6
ENST00000591520.1
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr20_-_34117447 1.34 ENST00000246199.2
ENST00000424444.1
ENST00000374345.4
ENST00000444723.1
C20orf173
chromosome 20 open reading frame 173
chr12_-_121019165 1.34 ENST00000341039.2
ENST00000357500.4
POP5
processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
chr19_-_45579762 1.22 ENST00000303809.2
ZNF296
zinc finger protein 296
chr21_-_34852304 1.19 ENST00000542230.2
TMEM50B
transmembrane protein 50B
chr1_-_169337176 1.15 ENST00000472647.1
ENST00000367811.3
NME7
NME/NM23 family member 7
chr1_+_156338993 1.13 ENST00000368249.1
ENST00000368246.2
ENST00000537040.1
ENST00000400992.2
ENST00000255013.3
ENST00000451864.2
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr17_-_57184260 1.08 ENST00000376149.3
ENST00000393066.3
TRIM37
tripartite motif containing 37
chr6_-_41888814 1.05 ENST00000409060.1
ENST00000265350.4
MED20
mediator complex subunit 20
chr7_-_99679324 1.03 ENST00000292393.5
ENST00000413658.2
ENST00000412947.1
ENST00000441298.1
ENST00000449785.1
ENST00000299667.4
ENST00000424697.1
ZNF3
zinc finger protein 3
chr8_-_97273807 0.98 ENST00000517720.1
ENST00000287025.3
ENST00000523821.1
MTERFD1
MTERF domain containing 1
chr12_-_55367361 0.96 ENST00000532804.1
ENST00000531122.1
ENST00000533446.1
TESPA1
thymocyte expressed, positive selection associated 1
chr5_-_122758994 0.96 ENST00000306467.5
ENST00000515110.1
CEP120
centrosomal protein 120kDa
chr9_+_37079888 0.96 ENST00000429493.1
ENST00000593237.1
ENST00000588557.1
ENST00000430809.1
ENST00000592157.1
RP11-220I1.1
RP11-220I1.1
chr7_+_74508372 0.91 ENST00000356115.5
ENST00000430511.2
ENST00000312575.7
GTF2IRD2B
GTF2I repeat domain containing 2B
chr11_+_73019282 0.91 ENST00000263674.3
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr14_-_70883708 0.88 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr11_-_1629693 0.88 ENST00000399685.1
KRTAP5-3
keratin associated protein 5-3
chr4_+_6784401 0.88 ENST00000425103.1
ENST00000307659.5
KIAA0232
KIAA0232
chr3_-_196695692 0.86 ENST00000412723.1
PIGZ
phosphatidylinositol glycan anchor biosynthesis, class Z
chr17_+_55163075 0.83 ENST00000571629.1
ENST00000570423.1
ENST00000575186.1
ENST00000573085.1
ENST00000572814.1
AKAP1
A kinase (PRKA) anchor protein 1
chr13_-_52378231 0.83 ENST00000280056.2
ENST00000444610.2
DHRS12
dehydrogenase/reductase (SDR family) member 12
chr2_-_43823119 0.82 ENST00000403856.1
ENST00000404790.1
ENST00000405975.2
ENST00000415080.2
THADA
thyroid adenoma associated
chr1_-_109968973 0.81 ENST00000271308.4
ENST00000538610.1
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr10_+_90672113 0.76 ENST00000371922.1
STAMBPL1
STAM binding protein-like 1
chr3_-_51975942 0.76 ENST00000232888.6
RRP9
ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
chr22_+_18632666 0.75 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr2_+_233562015 0.75 ENST00000427233.1
ENST00000373566.3
ENST00000373563.4
ENST00000428883.1
ENST00000456491.1
ENST00000409480.1
ENST00000421433.1
ENST00000425040.1
ENST00000430720.1
ENST00000409547.1
ENST00000423659.1
ENST00000409196.3
ENST00000409451.3
ENST00000429187.1
ENST00000440945.1
GIGYF2
GRB10 interacting GYF protein 2
chr6_-_41888843 0.74 ENST00000434077.1
ENST00000409312.1
MED20
mediator complex subunit 20
chr16_-_70719925 0.74 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr11_+_126139005 0.74 ENST00000263578.5
ENST00000442061.2
ENST00000532125.1
FOXRED1
FAD-dependent oxidoreductase domain containing 1
chr4_-_2264015 0.71 ENST00000337190.2
MXD4
MAX dimerization protein 4
chr6_-_83775489 0.69 ENST00000369747.3
UBE3D
ubiquitin protein ligase E3D
chrX_-_7895479 0.69 ENST00000381042.4
PNPLA4
patatin-like phospholipase domain containing 4
chr9_-_34376851 0.69 ENST00000297625.7
KIAA1161
KIAA1161
chr3_+_195943369 0.68 ENST00000296327.5
SLC51A
solute carrier family 51, alpha subunit
chr6_-_167275991 0.68 ENST00000510118.1
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr10_+_103348031 0.68 ENST00000370151.4
ENST00000370147.1
ENST00000370148.2
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr17_+_36861735 0.67 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr3_+_192958914 0.66 ENST00000264735.2
ENST00000602513.1
HRASLS
HRAS-like suppressor
chr5_-_122759032 0.65 ENST00000510582.3
ENST00000328236.5
ENST00000306481.6
ENST00000508442.2
ENST00000395431.2
CEP120
centrosomal protein 120kDa
chr7_-_74267836 0.59 ENST00000361071.5
ENST00000453619.2
ENST00000417115.2
ENST00000405086.2
GTF2IRD2
GTF2I repeat domain containing 2
chr2_-_89340242 0.57 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr21_+_46020497 0.55 ENST00000380102.2
KRTAP10-7
keratin associated protein 10-7
chr2_+_220071490 0.54 ENST00000409206.1
ENST00000409594.1
ENST00000289528.5
ENST00000422255.1
ENST00000409412.1
ENST00000409097.1
ENST00000409336.1
ENST00000409217.1
ENST00000409319.1
ENST00000444522.2
ZFAND2B
zinc finger, AN1-type domain 2B
chr2_-_89513402 0.54 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chr14_-_25103388 0.53 ENST00000526004.1
ENST00000415355.3
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr16_-_57219966 0.52 ENST00000565760.1
ENST00000309137.8
ENST00000570184.1
ENST00000562324.1
FAM192A
family with sequence similarity 192, member A
chr14_-_90798273 0.51 ENST00000357904.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr4_+_129349188 0.50 ENST00000511497.1
RP11-420A23.1
RP11-420A23.1
chr13_+_108870714 0.49 ENST00000375898.3
ABHD13
abhydrolase domain containing 13
chr2_-_89399845 0.49 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr4_-_89619386 0.48 ENST00000323061.5
NAP1L5
nucleosome assembly protein 1-like 5
chr19_+_46498704 0.48 ENST00000595358.1
ENST00000594672.1
ENST00000536603.1
CCDC61
coiled-coil domain containing 61
chr16_+_66914264 0.45 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr17_-_57184064 0.45 ENST00000262294.7
TRIM37
tripartite motif containing 37
chr4_+_175204818 0.44 ENST00000503780.1
CEP44
centrosomal protein 44kDa
chr13_+_100741269 0.44 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA
propionyl CoA carboxylase, alpha polypeptide
chr11_-_4414880 0.43 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr19_+_38397839 0.43 ENST00000222345.6
SIPA1L3
signal-induced proliferation-associated 1 like 3
chr2_+_90198535 0.42 ENST00000390276.2
IGKV1D-12
immunoglobulin kappa variable 1D-12
chr8_-_145060593 0.42 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
PARP10
poly (ADP-ribose) polymerase family, member 10
chr16_-_57219721 0.42 ENST00000562406.1
ENST00000568671.1
ENST00000567044.1
FAM192A
family with sequence similarity 192, member A
chr14_-_25103472 0.41 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr3_-_131753830 0.41 ENST00000429747.1
CPNE4
copine IV
chr12_-_123717643 0.41 ENST00000541437.1
ENST00000606320.1
MPHOSPH9
M-phase phosphoprotein 9
chr1_+_152658599 0.40 ENST00000368780.3
LCE2B
late cornified envelope 2B
chr7_-_37024665 0.39 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr16_-_57219926 0.39 ENST00000566584.1
ENST00000566481.1
ENST00000566077.1
ENST00000564108.1
ENST00000565458.1
ENST00000566681.1
ENST00000567439.1
FAM192A
family with sequence similarity 192, member A
chr8_+_124084899 0.38 ENST00000287380.1
ENST00000309336.3
ENST00000519418.1
ENST00000327098.5
ENST00000522420.1
ENST00000521676.1
ENST00000378080.2
TBC1D31
TBC1 domain family, member 31
chr8_+_146277764 0.37 ENST00000331434.6
C8orf33
chromosome 8 open reading frame 33
chr17_+_18128896 0.37 ENST00000316843.4
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr3_+_155860751 0.37 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chrX_-_64754611 0.37 ENST00000374807.5
ENST00000374811.3
ENST00000374804.5
ENST00000312391.8
LAS1L
LAS1-like (S. cerevisiae)
chr19_-_39694894 0.37 ENST00000318438.6
SYCN
syncollin
chr5_-_176057518 0.36 ENST00000393693.2
SNCB
synuclein, beta
chr21_+_38445539 0.35 ENST00000418766.1
ENST00000450533.1
ENST00000438055.1
ENST00000355666.1
ENST00000540756.1
ENST00000399010.1
TTC3
tetratricopeptide repeat domain 3
chr20_-_61002584 0.34 ENST00000252998.1
RBBP8NL
RBBP8 N-terminal like
chr17_+_46018872 0.33 ENST00000583599.1
ENST00000434554.2
ENST00000225573.4
ENST00000544840.1
ENST00000534893.1
PNPO
pyridoxamine 5'-phosphate oxidase
chr7_+_1022811 0.31 ENST00000308919.7
CYP2W1
cytochrome P450, family 2, subfamily W, polypeptide 1
chr11_-_126138808 0.29 ENST00000332118.6
ENST00000532259.1
SRPR
signal recognition particle receptor (docking protein)
chr8_+_71581565 0.28 ENST00000408926.3
ENST00000520030.1
XKR9
XK, Kell blood group complex subunit-related family, member 9
chr16_+_1662326 0.28 ENST00000397412.3
CRAMP1L
Crm, cramped-like (Drosophila)
chr2_+_90192768 0.27 ENST00000390275.2
IGKV1D-13
immunoglobulin kappa variable 1D-13
chr8_+_109455845 0.26 ENST00000220853.3
EMC2
ER membrane protein complex subunit 2
chr20_-_5485166 0.26 ENST00000589201.1
ENST00000379053.4
LINC00654
long intergenic non-protein coding RNA 654
chr2_-_96931679 0.26 ENST00000258439.3
ENST00000432959.1
TMEM127
transmembrane protein 127
chr14_-_90798418 0.25 ENST00000354366.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr19_+_41699135 0.25 ENST00000542619.1
ENST00000600561.1
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr15_-_83316711 0.24 ENST00000568128.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr12_-_53228079 0.23 ENST00000330553.5
KRT79
keratin 79
chr1_-_165738072 0.23 ENST00000481278.1
TMCO1
transmembrane and coiled-coil domains 1
chr4_-_175204765 0.23 ENST00000513696.1
ENST00000503293.1
FBXO8
F-box protein 8
chr13_-_108870623 0.23 ENST00000405925.1
LIG4
ligase IV, DNA, ATP-dependent
chr18_+_54318566 0.23 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr2_-_128051670 0.22 ENST00000493187.2
ERCC3
excision repair cross-complementing rodent repair deficiency, complementation group 3
chr6_+_56820018 0.22 ENST00000370746.3
BEND6
BEN domain containing 6
chr5_+_78532003 0.21 ENST00000396137.4
JMY
junction mediating and regulatory protein, p53 cofactor
chr11_+_47586982 0.21 ENST00000426530.2
ENST00000534775.1
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr20_+_47835884 0.21 ENST00000371764.4
DDX27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
chr4_+_15683404 0.21 ENST00000422728.2
FAM200B
family with sequence similarity 200, member B
chr16_-_14724057 0.20 ENST00000539279.1
ENST00000420015.2
ENST00000437198.2
PARN
poly(A)-specific ribonuclease
chr21_-_38445470 0.20 ENST00000399098.1
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr1_-_54637997 0.20 ENST00000536061.1
AL357673.1
CDNA: FLJ21031 fis, clone CAE07336; HCG1780521; Uncharacterized protein
chr21_+_34398153 0.19 ENST00000382357.3
ENST00000430860.1
ENST00000333337.3
OLIG2
oligodendrocyte lineage transcription factor 2
chr4_+_15683369 0.19 ENST00000503617.1
FAM200B
family with sequence similarity 200, member B
chr6_-_42981651 0.19 ENST00000244711.3
MEA1
male-enhanced antigen 1
chr15_+_32322709 0.18 ENST00000455693.2
CHRNA7
cholinergic receptor, nicotinic, alpha 7 (neuronal)
chr10_+_121652204 0.18 ENST00000369075.3
ENST00000543134.1
SEC23IP
SEC23 interacting protein
chr7_+_1022973 0.18 ENST00000340150.6
CYP2W1
cytochrome P450, family 2, subfamily W, polypeptide 1
chr2_+_32502952 0.17 ENST00000238831.4
YIPF4
Yip1 domain family, member 4
chr21_-_38445011 0.17 ENST00000464265.1
ENST00000399102.1
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr11_+_67222818 0.17 ENST00000325656.5
CABP4
calcium binding protein 4
chr1_-_20446020 0.17 ENST00000375105.3
PLA2G2D
phospholipase A2, group IID
chr19_+_19431490 0.16 ENST00000392313.6
ENST00000262815.8
ENST00000609122.1
MAU2
MAU2 sister chromatid cohesion factor
chrX_+_118602363 0.16 ENST00000317881.8
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr6_+_56819773 0.16 ENST00000370750.2
BEND6
BEN domain containing 6
chr18_+_56892724 0.15 ENST00000456142.3
ENST00000530323.1
GRP
gastrin-releasing peptide
chr3_+_178253993 0.15 ENST00000420517.2
ENST00000452583.1
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr10_+_26505594 0.15 ENST00000259271.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr17_-_15168624 0.14 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
PMP22
peripheral myelin protein 22
chr1_-_165738085 0.14 ENST00000464650.1
ENST00000392129.6
TMCO1
transmembrane and coiled-coil domains 1
chr3_+_138153451 0.14 ENST00000389567.4
ENST00000289135.4
ESYT3
extended synaptotagmin-like protein 3
chrX_+_135730373 0.14 ENST00000370628.2
CD40LG
CD40 ligand
chr8_-_101734308 0.13 ENST00000519004.1
ENST00000519363.1
ENST00000520142.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr11_+_47587129 0.13 ENST00000326656.8
ENST00000326674.9
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr2_+_3705785 0.12 ENST00000252505.3
ALLC
allantoicase
chr14_+_45553296 0.12 ENST00000355765.6
ENST00000553605.1
PRPF39
pre-mRNA processing factor 39
chr7_+_99425633 0.12 ENST00000354829.2
ENST00000421837.2
ENST00000417625.1
ENST00000342499.4
ENST00000444905.1
ENST00000415413.1
ENST00000312017.5
ENST00000222382.5
CYP3A43
cytochrome P450, family 3, subfamily A, polypeptide 43
chrX_+_135730297 0.12 ENST00000370629.2
CD40LG
CD40 ligand
chr1_-_16302565 0.11 ENST00000537142.1
ENST00000448462.2
ZBTB17
zinc finger and BTB domain containing 17
chr2_-_197036289 0.11 ENST00000263955.4
STK17B
serine/threonine kinase 17b
chr1_-_1356628 0.10 ENST00000442470.1
ENST00000537107.1
ANKRD65
ankyrin repeat domain 65
chr12_-_54070098 0.10 ENST00000394349.3
ENST00000549164.1
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr12_-_121476750 0.09 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr8_-_101734170 0.09 ENST00000522387.1
ENST00000518196.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr1_+_47799446 0.09 ENST00000371873.5
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr2_+_234216454 0.09 ENST00000447536.1
ENST00000409110.1
SAG
S-antigen; retina and pineal gland (arrestin)
chr19_+_34919257 0.09 ENST00000246548.4
ENST00000590048.2
UBA2
ubiquitin-like modifier activating enzyme 2
chr1_+_46016703 0.09 ENST00000481885.1
ENST00000351829.4
ENST00000471651.1
AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr16_+_56995762 0.08 ENST00000200676.3
ENST00000379780.2
CETP
cholesteryl ester transfer protein, plasma
chr18_-_44702668 0.08 ENST00000256433.3
IER3IP1
immediate early response 3 interacting protein 1
chr7_+_23637118 0.07 ENST00000448353.1
CCDC126
coiled-coil domain containing 126
chr2_-_74875432 0.06 ENST00000536235.1
ENST00000421985.1
M1AP
meiosis 1 associated protein
chr2_-_61765315 0.06 ENST00000406957.1
ENST00000401558.2
XPO1
exportin 1 (CRM1 homolog, yeast)
chr15_+_22892663 0.06 ENST00000313077.7
ENST00000561274.1
ENST00000560848.1
CYFIP1
cytoplasmic FMR1 interacting protein 1
chr20_+_35807512 0.05 ENST00000373622.5
RPN2
ribophorin II
chr6_-_29600832 0.05 ENST00000377016.4
ENST00000376977.3
ENST00000377034.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr4_-_48782259 0.05 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRYL
FRY-like
chr16_-_20367584 0.04 ENST00000570689.1
UMOD
uromodulin
chr7_+_99746514 0.04 ENST00000341942.5
ENST00000441173.1
LAMTOR4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr20_-_62587735 0.03 ENST00000354216.6
ENST00000369892.3
ENST00000358711.3
UCKL1
uridine-cytidine kinase 1-like 1
chr6_-_110797799 0.03 ENST00000456137.2
ENST00000368919.3
ENST00000439654.1
SLC22A16
solute carrier family 22 (organic cation/carnitine transporter), member 16
chr17_+_45286387 0.03 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr21_-_38445443 0.02 ENST00000360525.4
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr22_+_31892373 0.02 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr22_+_19419425 0.02 ENST00000333130.3
MRPL40
mitochondrial ribosomal protein L40
chr4_+_83956237 0.01 ENST00000264389.2
COPS4
COP9 signalosome subunit 4
chr11_+_118443098 0.01 ENST00000392859.3
ENST00000359415.4
ENST00000534182.2
ENST00000264028.4
ARCN1
archain 1
chr15_-_51058005 0.00 ENST00000261854.5
SPPL2A
signal peptide peptidase like 2A
chr20_+_35807449 0.00 ENST00000237530.6
RPN2
ribophorin II
chr5_-_159546396 0.00 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chrX_+_153409678 0.00 ENST00000369951.4
OPN1LW
opsin 1 (cone pigments), long-wave-sensitive

Network of associatons between targets according to the STRING database.

First level regulatory network of HESX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.5 1.5 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.5 1.8 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) phenylpropanoid catabolic process(GO:0046271)
0.4 1.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.2 0.5 GO:0046222 mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376)
0.2 1.5 GO:0061055 myotome development(GO:0061055)
0.2 1.0 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.2 1.9 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2 1.6 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.2 1.7 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 2.9 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 2.7 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 1.3 GO:0009249 protein lipoylation(GO:0009249)
0.1 0.9 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.1 1.5 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 1.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 8.5 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.1 0.4 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 0.4 GO:0010847 regulation of chromatin assembly(GO:0010847) negative regulation of protein import into nucleus, translocation(GO:0033159) protein auto-ADP-ribosylation(GO:0070213)
0.1 2.0 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 2.0 GO:0015671 oxygen transport(GO:0015671)
0.1 1.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 0.9 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 1.9 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 0.7 GO:0021678 third ventricle development(GO:0021678)
0.1 0.3 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.1 0.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.2 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.1 0.4 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.1 4.1 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.2 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.2 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.0 1.3 GO:0097503 sialylation(GO:0097503)
0.0 0.1 GO:0036343 psychomotor behavior(GO:0036343)
0.0 0.4 GO:0006983 ER overload response(GO:0006983)
0.0 0.2 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.3 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.7 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.2 GO:0050893 sensory processing(GO:0050893)
0.0 0.1 GO:0043605 allantoin metabolic process(GO:0000255) cellular amide catabolic process(GO:0043605)
0.0 0.1 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.0 1.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.8 GO:0016246 RNA interference(GO:0016246)
0.0 0.2 GO:0015853 adenine transport(GO:0015853)
0.0 2.5 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.5 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.4 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.4 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.8 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 2.6 GO:0070268 cornification(GO:0070268)
0.0 0.7 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.1 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.0 0.2 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 1.0 GO:0031424 keratinization(GO:0031424)
0.0 0.7 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.7 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0009650 UV protection(GO:0009650)
0.0 0.7 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 0.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0007060 male meiosis chromosome segregation(GO:0007060)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0001534 radial spoke(GO:0001534)
0.2 2.3 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.2 2.9 GO:0097433 dense body(GO:0097433)
0.2 1.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 1.1 GO:1990635 proximal dendrite(GO:1990635)
0.2 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 2.0 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.6 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 1.8 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 8.9 GO:0072686 mitotic spindle(GO:0072686)
0.1 2.4 GO:0030057 desmosome(GO:0030057)
0.1 0.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.5 GO:0005902 microvillus(GO:0005902)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.9 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.0 2.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.0 0.7 GO:0005813 centrosome(GO:0005813)
0.0 0.4 GO:0001533 cornified envelope(GO:0001533)
0.0 0.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.8 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.3 2.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.3 0.9 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.3 1.3 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.2 1.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 2.0 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 0.7 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 0.8 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 2.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.3 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 1.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 2.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.5 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 2.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.4 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.0 0.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.0 0.1 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 0.2 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 1.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.1 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 1.9 GO:0070888 E-box binding(GO:0070888)
0.0 9.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 1.8 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.4 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.5 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.3 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.3 GO:0010181 FMN binding(GO:0010181)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0002046 opsin binding(GO:0002046)
0.0 0.4 GO:0070402 NADPH binding(GO:0070402)
0.0 0.7 GO:0030332 cyclin binding(GO:0030332)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 4.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.4 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 2.3 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.3 PID E2F PATHWAY E2F transcription factor network
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 2.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.1 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.7 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.7 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 2.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 3.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA