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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for HIC1
Z-value: 0.78
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Transcription factors associated with HIC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC1 | hg19_v2_chr17_+_1958388_1958404, hg19_v2_chr17_+_1959369_1959604 | 0.02 | 9.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_2160611 Show fit | 1.71 |
ENST00000416167.2
|
insulin-like growth factor 2 (somatomedin A) |
|
| chr13_+_110959598 Show fit | 1.11 |
ENST00000360467.5
|
collagen, type IV, alpha 2 |
|
| chr12_+_26274917 Show fit | 1.03 |
ENST00000538142.1
|
sarcospan |
|
| chr18_+_77623668 Show fit | 0.88 |
ENST00000316249.3
|
potassium voltage-gated channel, subfamily G, member 2 |
|
| chr1_+_1551220 Show fit | 0.77 |
ENST00000378712.1
|
mindbomb E3 ubiquitin protein ligase 2 |
|
| chr11_+_120382417 Show fit | 0.75 |
ENST00000527524.2
ENST00000375081.2 |
glutamate receptor, ionotropic, kainate 4 Uncharacterized protein |
|
| chr4_+_3768075 Show fit | 0.75 |
ENST00000509482.1
ENST00000330055.5 |
adrenoceptor alpha 2C |
|
| chr12_-_132905789 Show fit | 0.69 |
ENST00000328957.8
|
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9) |
|
| chr7_+_73082152 Show fit | 0.68 |
ENST00000324941.4
ENST00000451519.1 |
vacuolar protein sorting 37 homolog D (S. cerevisiae) |
|
| chr3_+_52280173 Show fit | 0.67 |
ENST00000296487.4
|
protein phosphatase, Mg2+/Mn2+ dependent, 1M |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.2 | 1.4 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 0.1 | 1.2 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.1 | 1.0 | GO:0060992 | response to fungicide(GO:0060992) |
| 0.1 | 0.9 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.1 | 0.9 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.0 | 0.9 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.2 | 0.8 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.1 | 0.8 | GO:0060179 | male mating behavior(GO:0060179) |
| 0.1 | 0.8 | GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 2.2 | GO:0034705 | potassium channel complex(GO:0034705) |
| 0.2 | 1.3 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.1 | 1.1 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 1.0 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 1.0 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 0.9 | GO:0032059 | muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059) |
| 0.0 | 0.9 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.8 | GO:0098845 | postsynaptic endosome(GO:0098845) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.4 | 1.4 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.1 | 1.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.1 | 1.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 1.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.3 | 1.1 | GO:0003865 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751) |
| 0.0 | 1.1 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 1.0 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.1 | 0.9 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 0.8 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.1 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.9 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 0.7 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.3 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 1.1 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 1.1 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 1.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.9 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |