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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for HIC2
Z-value: 1.50
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Transcription factors associated with HIC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC2 | hg19_v2_chr22_+_21771656_21771693 | 0.32 | 8.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51487282 Show fit | 5.54 |
ENST00000595820.1
ENST00000597707.1 ENST00000336317.4 |
kallikrein-related peptidase 7 |
|
| chr15_+_90728145 Show fit | 4.13 |
ENST00000561085.1
ENST00000379122.3 ENST00000332496.6 |
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B |
|
| chr4_+_4388805 Show fit | 3.64 |
ENST00000504171.1
|
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA. |
|
| chr1_+_32042131 Show fit | 3.25 |
ENST00000271064.7
ENST00000537531.1 |
tubulointerstitial nephritis antigen-like 1 |
|
| chr1_+_17531614 Show fit | 3.15 |
ENST00000375471.4
|
peptidyl arginine deiminase, type I |
|
| chr9_+_33750515 Show fit | 3.09 |
ENST00000361005.5
|
protease, serine, 3 |
|
| chr12_-_52845910 Show fit | 3.07 |
ENST00000252252.3
|
keratin 6B |
|
| chr1_+_32042105 Show fit | 3.03 |
ENST00000457433.2
ENST00000441210.2 |
tubulointerstitial nephritis antigen-like 1 |
|
| chr22_-_20367797 Show fit | 2.87 |
ENST00000424787.2
|
gamma-glutamyltransferase light chain 3 |
|
| chr19_-_51487071 Show fit | 2.82 |
ENST00000391807.1
ENST00000593904.1 |
kallikrein-related peptidase 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | GO:0070268 | cornification(GO:0070268) |
| 0.6 | 8.5 | GO:0035878 | nail development(GO:0035878) |
| 1.4 | 8.4 | GO:0002760 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.3 | 6.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.6 | 6.1 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.3 | 6.0 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.2 | 5.6 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.6 | 5.4 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.1 | 5.4 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.1 | 5.1 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 8.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.4 | 8.5 | GO:0030056 | hemidesmosome(GO:0030056) |
| 1.2 | 8.4 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 8.4 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 6.5 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 5.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 5.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 5.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.6 | 4.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 8.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 8.4 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 8.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 7.8 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.2 | 6.1 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.3 | 6.0 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.2 | 5.3 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 5.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.2 | 4.9 | GO:0008431 | vitamin E binding(GO:0008431) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 14.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 10.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 9.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 7.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 6.6 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 5.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 5.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 5.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.8 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.3 | 7.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 6.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 6.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 5.8 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 5.1 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.2 | 4.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 4.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 4.1 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 3.4 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |