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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HLF_TEF

Z-value: 0.70

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Transcription factors associated with HLF_TEF

Gene Symbol Gene ID Gene Info
HLF
ENSG00000108924.9 HLF transcription factor, PAR bZIP family member
TEF
ENSG00000167074.10 TEF transcription factor, PAR bZIP family member

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TEFhg19_v2_chr22_+_41763274_41763337,
hg19_v2_chr22_+_41777927_41777971		0.346.4e-02Click!
HLFhg19_v2_chr17_+_53344945_533449770.202.9e-01Click!

Activity profile of HLF_TEF motif

Sorted Z-values of HLF_TEF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_33759854 1.92 ENST00000216968.4
PROCR
protein C receptor, endothelial
chr1_+_7844312 1.83 ENST00000377541.1
PER3
period circadian clock 3
chr14_+_78227105 1.65 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
C14orf178
chromosome 14 open reading frame 178
chr2_-_113594279 1.61 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr17_-_41623691 1.49 ENST00000545954.1
ETV4
ets variant 4
chr17_-_41623075 1.41 ENST00000545089.1
ETV4
ets variant 4
chr19_-_35992780 1.25 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
DMKN
dermokine
chr17_-_41623259 1.12 ENST00000538265.1
ENST00000591713.1
ETV4
ets variant 4
chr2_-_31637560 1.10 ENST00000379416.3
XDH
xanthine dehydrogenase
chr1_-_244013384 1.06 ENST00000366539.1
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr17_-_41623716 1.05 ENST00000319349.5
ETV4
ets variant 4
chr5_-_140013275 1.05 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14
CD14 molecule
chr17_-_41623009 0.99 ENST00000393664.2
ETV4
ets variant 4
chr12_-_71031185 0.98 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr7_-_83824169 0.90 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr8_-_6735451 0.90 ENST00000297439.3
DEFB1
defensin, beta 1
chr9_+_101705893 0.88 ENST00000375001.3
COL15A1
collagen, type XV, alpha 1
chr3_-_48130707 0.82 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chr9_-_123639304 0.78 ENST00000436309.1
PHF19
PHD finger protein 19
chr17_+_73089382 0.76 ENST00000538213.2
ENST00000584118.1
SLC16A5
solute carrier family 16 (monocarboxylate transporter), member 5
chr3_+_154797877 0.71 ENST00000462745.1
ENST00000493237.1
MME
membrane metallo-endopeptidase
chr4_+_75230853 0.70 ENST00000244869.2
EREG
epiregulin
chr17_+_39975455 0.70 ENST00000455106.1
FKBP10
FK506 binding protein 10, 65 kDa
chr1_+_174933899 0.70 ENST00000367688.3
RABGAP1L
RAB GTPase activating protein 1-like
chr5_+_150404904 0.69 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr2_+_113885138 0.68 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr7_+_23145884 0.68 ENST00000409689.1
ENST00000410047.1
KLHL7
kelch-like family member 7
chr14_+_96722152 0.67 ENST00000216629.6
BDKRB1
bradykinin receptor B1
chr1_+_45212051 0.65 ENST00000372222.3
KIF2C
kinesin family member 2C
chr18_+_32621324 0.65 ENST00000300249.5
ENST00000538170.2
ENST00000588910.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_+_45212074 0.63 ENST00000372217.1
KIF2C
kinesin family member 2C
chr1_-_226496772 0.60 ENST00000359525.2
ENST00000460719.1
LIN9
lin-9 homolog (C. elegans)
chr11_+_35201826 0.59 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr11_-_33795893 0.57 ENST00000526785.1
ENST00000534136.1
ENST00000265651.3
ENST00000530401.1
ENST00000448981.2
FBXO3
F-box protein 3
chr16_+_70680439 0.56 ENST00000288098.2
IL34
interleukin 34
chr9_-_123639445 0.56 ENST00000312189.6
PHF19
PHD finger protein 19
chr3_-_48130314 0.55 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr3_-_99595037 0.52 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr9_-_123639600 0.52 ENST00000373896.3
PHF19
PHD finger protein 19
chr4_-_76928641 0.50 ENST00000264888.5
CXCL9
chemokine (C-X-C motif) ligand 9
chr14_+_102276192 0.47 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr15_+_81293254 0.46 ENST00000267984.2
MESDC1
mesoderm development candidate 1
chr7_+_23146271 0.46 ENST00000545771.1
KLHL7
kelch-like family member 7
chr11_-_105948129 0.43 ENST00000526793.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr9_+_71820057 0.42 ENST00000539225.1
TJP2
tight junction protein 2
chr2_+_192543153 0.41 ENST00000425611.2
NABP1
nucleic acid binding protein 1
chr12_+_93963590 0.39 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr1_+_115572415 0.39 ENST00000256592.1
TSHB
thyroid stimulating hormone, beta
chr6_+_53948328 0.39 ENST00000370876.2
MLIP
muscular LMNA-interacting protein
chr3_-_99594948 0.39 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr4_-_21950356 0.39 ENST00000447367.2
ENST00000382152.2
KCNIP4
Kv channel interacting protein 4
chr11_-_62313090 0.39 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr9_+_71819927 0.38 ENST00000535702.1
TJP2
tight junction protein 2
chr4_+_118955500 0.38 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr12_-_53074182 0.38 ENST00000252244.3
KRT1
keratin 1
chrX_-_33229636 0.38 ENST00000357033.4
DMD
dystrophin
chr18_+_21032781 0.36 ENST00000339486.3
RIOK3
RIO kinase 3
chr11_-_105948040 0.36 ENST00000534815.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr12_+_57624119 0.35 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr7_+_90032667 0.35 ENST00000496677.1
ENST00000287916.4
ENST00000535571.1
ENST00000394604.1
ENST00000394605.2
CLDN12
claudin 12
chr4_+_144257915 0.35 ENST00000262995.4
GAB1
GRB2-associated binding protein 1
chr14_+_96722539 0.35 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr5_+_95998070 0.34 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
CAST
calpastatin
chr10_-_14372870 0.34 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr5_+_95997769 0.34 ENST00000338252.3
ENST00000508830.1
CAST
calpastatin
chr1_-_226496898 0.33 ENST00000481685.1
LIN9
lin-9 homolog (C. elegans)
chr12_+_57623477 0.32 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_-_71031220 0.32 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr17_-_39538550 0.32 ENST00000394001.1
KRT34
keratin 34
chr12_+_57623869 0.31 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_57624085 0.31 ENST00000553474.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_161207953 0.31 ENST00000367982.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr20_+_37209820 0.30 ENST00000537425.1
ENST00000373348.3
ENST00000416116.1
ADIG
adipogenin
chr3_+_182983090 0.30 ENST00000465010.1
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr9_-_95298314 0.30 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr1_-_161208013 0.29 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr11_+_69061594 0.28 ENST00000441339.2
ENST00000308946.3
ENST00000535407.1
MYEOV
myeloma overexpressed
chr3_+_158787041 0.27 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr16_-_30102547 0.27 ENST00000279386.2
TBX6
T-box 6
chr2_-_101925055 0.26 ENST00000295317.3
RNF149
ring finger protein 149
chr13_-_46626847 0.26 ENST00000242848.4
ENST00000282007.3
ZC3H13
zinc finger CCCH-type containing 13
chr6_-_46459099 0.26 ENST00000371374.1
RCAN2
regulator of calcineurin 2
chr1_-_161207986 0.25 ENST00000506209.1
ENST00000367980.2
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr3_-_196910721 0.25 ENST00000443183.1
DLG1
discs, large homolog 1 (Drosophila)
chr10_+_94050913 0.24 ENST00000358935.2
MARCH5
membrane-associated ring finger (C3HC4) 5
chr16_-_20367584 0.24 ENST00000570689.1
UMOD
uromodulin
chr8_-_27469196 0.24 ENST00000546343.1
ENST00000560566.1
CLU
clusterin
chr8_+_70404996 0.24 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr7_-_37026108 0.23 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr1_+_65730385 0.23 ENST00000263441.7
ENST00000395325.3
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr20_+_16729003 0.23 ENST00000246081.2
OTOR
otoraplin
chr6_-_30043539 0.23 ENST00000376751.3
ENST00000244360.6
RNF39
ring finger protein 39
chr3_-_58200398 0.23 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
DNASE1L3
deoxyribonuclease I-like 3
chr1_-_114430169 0.23 ENST00000393316.3
BCL2L15
BCL2-like 15
chr14_+_65453432 0.23 ENST00000246166.2
FNTB
farnesyltransferase, CAAX box, beta
chr1_-_161207875 0.23 ENST00000512372.1
ENST00000437437.2
ENST00000442691.2
ENST00000412844.2
ENST00000428574.2
ENST00000505005.1
ENST00000508740.1
ENST00000508387.1
ENST00000504010.1
ENST00000511676.1
ENST00000502985.1
ENST00000367981.3
ENST00000515621.1
ENST00000511944.1
ENST00000511748.1
ENST00000367984.4
ENST00000367985.3
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr5_-_147162263 0.22 ENST00000333010.6
ENST00000265272.5
JAKMIP2
janus kinase and microtubule interacting protein 2
chr13_-_33780133 0.22 ENST00000399365.3
STARD13
StAR-related lipid transfer (START) domain containing 13
chr17_-_39306054 0.22 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chr17_-_76124711 0.22 ENST00000306591.7
ENST00000590602.1
TMC6
transmembrane channel-like 6
chr19_-_2042065 0.22 ENST00000591588.1
ENST00000591142.1
MKNK2
MAP kinase interacting serine/threonine kinase 2
chr12_-_54758251 0.21 ENST00000267015.3
ENST00000551809.1
GPR84
G protein-coupled receptor 84
chr6_+_24126350 0.21 ENST00000378491.4
ENST00000378478.1
ENST00000378477.2
NRSN1
neurensin 1
chr8_+_90914073 0.21 ENST00000297438.2
OSGIN2
oxidative stress induced growth inhibitor family member 2
chr14_-_72458326 0.21 ENST00000542853.1
AC005477.1
AC005477.1
chr17_-_76124812 0.21 ENST00000592063.1
ENST00000589271.1
ENST00000322933.4
ENST00000589553.1
TMC6
transmembrane channel-like 6
chr5_-_179050066 0.21 ENST00000329433.6
ENST00000510411.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr5_-_146435694 0.20 ENST00000356826.3
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr17_+_11501816 0.20 ENST00000454412.2
DNAH9
dynein, axonemal, heavy chain 9
chr12_-_75603643 0.20 ENST00000549446.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr1_+_92632542 0.20 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr16_+_3507985 0.20 ENST00000421765.3
ENST00000360862.5
ENST00000414063.2
ENST00000610180.1
ENST00000608993.1
NAA60
NAA60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
N-alpha-acetyltransferase 60
chr3_+_101504200 0.20 ENST00000422132.1
NXPE3
neurexophilin and PC-esterase domain family, member 3
chr12_-_88423164 0.19 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chr12_-_75603482 0.19 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr8_+_77318769 0.19 ENST00000518732.1
RP11-706J10.1
long intergenic non-protein coding RNA 1111
chr2_-_201936302 0.19 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr16_+_3508063 0.18 ENST00000576787.1
ENST00000572942.1
ENST00000576916.1
ENST00000575076.1
ENST00000572131.1
NAA60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr7_-_80141328 0.18 ENST00000398291.3
GNAT3
guanine nucleotide binding protein, alpha transducing 3
chr22_+_41487711 0.18 ENST00000263253.7
EP300
E1A binding protein p300
chr5_-_114505624 0.17 ENST00000513154.1
TRIM36
tripartite motif containing 36
chr5_+_95997918 0.17 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
CAST
calpastatin
chr7_+_20687017 0.17 ENST00000258738.6
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr1_+_161087873 0.17 ENST00000368009.2
ENST00000368007.4
ENST00000368008.1
ENST00000392190.5
NIT1
nitrilase 1
chr4_+_96012614 0.17 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr9_+_110045537 0.16 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr4_+_144258021 0.16 ENST00000262994.4
GAB1
GRB2-associated binding protein 1
chr10_-_82049424 0.16 ENST00000372213.3
MAT1A
methionine adenosyltransferase I, alpha
chr12_-_120966943 0.16 ENST00000552443.1
ENST00000547736.1
ENST00000445328.2
ENST00000547943.1
ENST00000288532.6
COQ5
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
chr1_-_114429997 0.15 ENST00000471267.1
ENST00000393320.3
BCL2L15
BCL2-like 15
chr17_-_73851285 0.15 ENST00000589642.1
ENST00000593002.1
ENST00000590221.1
ENST00000344296.4
ENST00000587374.1
ENST00000585462.1
ENST00000433525.2
ENST00000254806.3
WBP2
WW domain binding protein 2
chr8_+_68864330 0.15 ENST00000288368.4
PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chrX_+_41306575 0.14 ENST00000342595.2
ENST00000378220.1
NYX
nyctalopin
chr11_+_62495997 0.14 ENST00000316461.4
TTC9C
tetratricopeptide repeat domain 9C
chr22_-_29457832 0.14 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr21_-_30365136 0.13 ENST00000361371.5
ENST00000389194.2
ENST00000389195.2
LTN1
listerin E3 ubiquitin protein ligase 1
chr3_+_148447887 0.13 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
AGTR1
angiotensin II receptor, type 1
chr1_+_65613513 0.13 ENST00000395334.2
AK4
adenylate kinase 4
chr7_+_120629653 0.13 ENST00000450913.2
ENST00000340646.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr6_-_31940065 0.13 ENST00000375349.3
ENST00000337523.5
DXO
decapping exoribonuclease
chr5_+_34757309 0.12 ENST00000397449.1
RAI14
retinoic acid induced 14
chr20_-_49547731 0.12 ENST00000396029.3
ADNP
activity-dependent neuroprotector homeobox
chr8_+_7801144 0.12 ENST00000443676.1
ZNF705B
zinc finger protein 705B
chr12_-_113574028 0.11 ENST00000546530.1
ENST00000261729.5
RASAL1
RAS protein activator like 1 (GAP1 like)
chr4_-_96470350 0.11 ENST00000504962.1
ENST00000453304.1
ENST00000506749.1
UNC5C
unc-5 homolog C (C. elegans)
chr9_-_32552551 0.11 ENST00000360538.2
ENST00000379858.1
TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr22_-_29711704 0.11 ENST00000216101.6
RASL10A
RAS-like, family 10, member A
chr6_-_64029879 0.11 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr14_+_102276132 0.11 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr22_-_30867973 0.10 ENST00000402286.1
ENST00000401751.1
ENST00000539629.1
ENST00000403066.1
ENST00000215812.4
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr20_-_56285595 0.10 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr4_-_153274078 0.10 ENST00000263981.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr1_-_101491319 0.09 ENST00000342173.7
ENST00000488176.1
ENST00000370109.3
DPH5
diphthamide biosynthesis 5
chr3_+_157154578 0.09 ENST00000295927.3
PTX3
pentraxin 3, long
chr19_-_3985455 0.09 ENST00000309311.6
EEF2
eukaryotic translation elongation factor 2
chr15_+_58430567 0.09 ENST00000536493.1
AQP9
aquaporin 9
chr7_+_135347215 0.09 ENST00000507606.1
C7orf73
chromosome 7 open reading frame 73
chr14_+_60715928 0.08 ENST00000395076.4
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr2_-_112614424 0.08 ENST00000427997.1
ANAPC1
anaphase promoting complex subunit 1
chr3_+_186330712 0.08 ENST00000411641.2
ENST00000273784.5
AHSG
alpha-2-HS-glycoprotein
chr15_+_58430368 0.08 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr20_-_49547910 0.08 ENST00000396032.3
ADNP
activity-dependent neuroprotector homeobox
chr13_+_23755099 0.08 ENST00000537476.1
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr1_+_11249398 0.07 ENST00000376819.3
ANGPTL7
angiopoietin-like 7
chr4_+_110354928 0.07 ENST00000504968.2
ENST00000399100.2
ENST00000265175.5
SEC24B
SEC24 family member B
chr4_+_187187337 0.07 ENST00000492972.2
F11
coagulation factor XI
chr13_-_21634421 0.06 ENST00000542899.1
LATS2
large tumor suppressor kinase 2
chr1_+_75594119 0.06 ENST00000294638.5
LHX8
LIM homeobox 8
chr1_-_150552006 0.06 ENST00000307940.3
ENST00000369026.2
MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr9_+_27524283 0.06 ENST00000276943.2
IFNK
interferon, kappa
chr6_+_72926145 0.06 ENST00000425662.2
ENST00000453976.2
RIMS1
regulating synaptic membrane exocytosis 1
chr7_+_44646162 0.06 ENST00000439616.2
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr20_+_2082494 0.06 ENST00000246032.3
STK35
serine/threonine kinase 35
chr2_+_103378472 0.06 ENST00000412401.2
TMEM182
transmembrane protein 182
chr11_-_72145426 0.06 ENST00000535990.1
ENST00000437826.2
ENST00000340729.5
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr6_-_116447283 0.05 ENST00000452729.1
ENST00000243222.4
COL10A1
collagen, type X, alpha 1
chr8_+_50824233 0.05 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr8_+_42396936 0.05 ENST00000416469.2
SMIM19
small integral membrane protein 19
chr8_+_24298597 0.05 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr14_+_93260642 0.05 ENST00000355976.2
GOLGA5
golgin A5
chr7_+_20686946 0.05 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr12_-_68619586 0.05 ENST00000229134.4
IL26
interleukin 26
chr10_-_94050820 0.05 ENST00000265997.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr19_+_50922187 0.04 ENST00000595883.1
ENST00000597855.1
ENST00000596074.1
ENST00000439922.2
ENST00000594685.1
ENST00000270632.7
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr8_+_107738240 0.04 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr19_+_33865218 0.04 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr10_+_18629628 0.04 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr18_+_77160282 0.04 ENST00000318065.5
ENST00000545796.1
ENST00000592223.1
ENST00000329101.4
ENST00000586434.1
NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr2_+_191208196 0.04 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
INPP1
inositol polyphosphate-1-phosphatase
chr6_+_36238237 0.04 ENST00000457797.1
ENST00000394571.2
PNPLA1
patatin-like phospholipase domain containing 1
chr7_+_100210133 0.04 ENST00000393950.2
ENST00000424091.2
MOSPD3
motile sperm domain containing 3
chr21_+_45138941 0.04 ENST00000398081.1
ENST00000468090.1
ENST00000291565.4
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr2_-_214014959 0.04 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
IKZF2
IKAROS family zinc finger 2 (Helios)
chr8_+_24298531 0.04 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr3_-_10547192 0.04 ENST00000360273.2
ENST00000343816.4
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_154377669 0.04 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr1_+_25757376 0.03 ENST00000399766.3
ENST00000399763.3
ENST00000374343.4
TMEM57
transmembrane protein 57
chr1_-_72566613 0.03 ENST00000306821.3
NEGR1
neuronal growth regulator 1
chr19_-_4065730 0.03 ENST00000601588.1
ZBTB7A
zinc finger and BTB domain containing 7A
chr11_-_14993819 0.03 ENST00000396372.2
ENST00000361010.3
ENST00000359642.3
ENST00000331587.4
CALCA
calcitonin-related polypeptide alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of HLF_TEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.3 1.1 GO:0046110 xanthine metabolic process(GO:0046110)
0.3 1.0 GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.2 0.7 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.2 0.7 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.2 1.4 GO:0051012 microtubule sliding(GO:0051012)
0.2 0.9 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.2 1.3 GO:1903575 cornified envelope assembly(GO:1903575)
0.2 1.3 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.2 0.9 GO:0048880 sensory system development(GO:0048880)
0.2 1.9 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 0.7 GO:0046449 creatinine metabolic process(GO:0046449) cellular response to UV-A(GO:0071492)
0.1 1.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.7 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 0.4 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 0.3 GO:0070884 calcineurin-NFAT signaling cascade(GO:0033173) regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 0.8 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 0.6 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 1.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.5 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.8 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 0.4 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 1.8 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 0.4 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.2 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.3 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.2 GO:0048749 compound eye development(GO:0048749)
0.0 0.2 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.4 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.2 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.2 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.2 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.6 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.2 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 1.0 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 1.9 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.2 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.1 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.0 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.2 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.0 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.1 GO:0061518 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.0 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.0 0.5 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.1 GO:0001828 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.3 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.2 GO:0090344 negative regulation of cell aging(GO:0090344)
0.0 0.2 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.0 0.4 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.0 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0 0.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845) retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.9 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.2 GO:0001502 cartilage condensation(GO:0001502)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:1990742 microvesicle(GO:1990742)
0.2 1.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 1.3 GO:0070552 BRISC complex(GO:0070552)
0.1 0.9 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.1 0.6 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.4 GO:0070876 SOSS complex(GO:0070876)
0.1 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 1.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.9 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.2 GO:0043219 lateral loop(GO:0043219)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 1.9 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.4 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004947 bradykinin receptor activity(GO:0004947)
0.3 0.9 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 0.7 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.2 1.0 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.2 1.3 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 1.1 GO:0004882 androgen receptor activity(GO:0004882)
0.1 0.8 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 1.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 1.1 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.1 0.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.3 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 1.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.6 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.7 GO:0008430 selenium binding(GO:0008430)
0.1 0.2 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 1.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.1 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.0 0.4 GO:0089720 caspase binding(GO:0089720)
0.0 0.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 1.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.4 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.0 GO:0031403 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 6.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.0 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 6.1 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.2 PID AURORA B PATHWAY Aurora B signaling
0.0 0.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.5 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.5 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.0 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.8 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 2.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.9 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.7 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins