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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HMBOX1

Z-value: 0.82

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Transcription factors associated with HMBOX1

Gene Symbol Gene ID Gene Info
HMBOX1
ENSG00000147421.13 homeobox containing 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMBOX1hg19_v2_chr8_+_28747884_287479380.631.8e-04Click!

Activity profile of HMBOX1 motif

Sorted Z-values of HMBOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_25348007 4.35 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
CASC1
cancer susceptibility candidate 1
chr6_+_88117683 3.77 ENST00000369562.4
C6ORF165
UPF0704 protein C6orf165
chr6_+_112408768 3.45 ENST00000368656.2
ENST00000604268.1
FAM229B
family with sequence similarity 229, member B
chr9_-_117111222 2.58 ENST00000374079.4
AKNA
AT-hook transcription factor
chr4_+_9172135 2.29 ENST00000512047.1
FAM90A26
family with sequence similarity 90, member A26
chr6_-_52668605 2.21 ENST00000334575.5
GSTA1
glutathione S-transferase alpha 1
chr13_+_24144509 2.10 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr14_+_75536335 1.97 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr14_+_75536280 1.92 ENST00000238686.8
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr1_-_169396666 1.83 ENST00000456107.1
ENST00000367805.3
CCDC181
coiled-coil domain containing 181
chr21_-_46340884 1.80 ENST00000302347.5
ENST00000517819.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_61293021 1.80 ENST00000402291.1
KIAA1841
KIAA1841
chr20_+_43211149 1.69 ENST00000372886.1
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr1_-_169396646 1.68 ENST00000367806.3
CCDC181
coiled-coil domain containing 181
chr1_+_174844645 1.64 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chr8_+_67976593 1.62 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr3_-_57530051 1.61 ENST00000311202.6
ENST00000351747.2
ENST00000495027.1
ENST00000389536.4
DNAH12
dynein, axonemal, heavy chain 12
chr2_-_220110187 1.53 ENST00000295759.7
ENST00000392089.2
GLB1L
galactosidase, beta 1-like
chr2_-_220110111 1.53 ENST00000428427.1
ENST00000356283.3
ENST00000432839.1
ENST00000424620.1
GLB1L
galactosidase, beta 1-like
chrX_-_10851762 1.52 ENST00000380785.1
ENST00000380787.1
MID1
midline 1 (Opitz/BBB syndrome)
chr2_-_62081148 1.51 ENST00000404929.1
FAM161A
family with sequence similarity 161, member A
chr2_-_62081254 1.50 ENST00000405894.3
FAM161A
family with sequence similarity 161, member A
chr4_+_36283213 1.41 ENST00000357504.3
DTHD1
death domain containing 1
chr12_-_56236734 1.40 ENST00000548629.1
MMP19
matrix metallopeptidase 19
chr12_-_113658892 1.38 ENST00000299732.2
ENST00000416617.2
IQCD
IQ motif containing D
chr7_-_120498357 1.36 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12
tetraspanin 12
chr22_-_37172111 1.27 ENST00000417951.2
ENST00000430701.1
ENST00000433985.2
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr11_+_100862811 1.25 ENST00000303130.2
TMEM133
transmembrane protein 133
chr7_+_100728720 1.23 ENST00000306085.6
ENST00000412507.1
TRIM56
tripartite motif containing 56
chr22_-_37172191 1.23 ENST00000340630.5
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr18_-_53253323 1.20 ENST00000540999.1
ENST00000563888.2
TCF4
transcription factor 4
chr14_+_45431379 1.15 ENST00000361577.3
ENST00000361462.2
ENST00000382233.2
FAM179B
family with sequence similarity 179, member B
chr17_+_26800648 1.13 ENST00000545060.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr1_-_217311090 1.13 ENST00000493603.1
ENST00000366940.2
ESRRG
estrogen-related receptor gamma
chr17_+_26800756 1.12 ENST00000537681.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr8_-_28347737 1.10 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
FBXO16
F-box protein 16
chr6_+_30951487 1.09 ENST00000486149.2
ENST00000376296.3
MUC21
mucin 21, cell surface associated
chr1_-_86861660 1.07 ENST00000486215.1
ODF2L
outer dense fiber of sperm tails 2-like
chrX_+_16964985 1.03 ENST00000303843.7
REPS2
RALBP1 associated Eps domain containing 2
chr6_-_52710893 1.02 ENST00000284562.2
GSTA5
glutathione S-transferase alpha 5
chr17_+_26800296 0.99 ENST00000444914.3
ENST00000314669.5
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr10_-_112678904 0.96 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBIP1
BBSome interacting protein 1
chr1_-_150669500 0.93 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr4_-_110723134 0.91 ENST00000510800.1
ENST00000512148.1
CFI
complement factor I
chr1_+_153940713 0.90 ENST00000368601.1
ENST00000368603.1
ENST00000368600.3
CREB3L4
cAMP responsive element binding protein 3-like 4
chr1_-_217250231 0.89 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr4_-_110723194 0.89 ENST00000394635.3
CFI
complement factor I
chr14_+_50999744 0.85 ENST00000441560.2
ATL1
atlastin GTPase 1
chr14_-_89878369 0.85 ENST00000553840.1
ENST00000556916.1
FOXN3
forkhead box N3
chrX_-_10588459 0.81 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr5_+_140254884 0.77 ENST00000398631.2
PCDHA12
protocadherin alpha 12
chr1_+_27561007 0.77 ENST00000319394.3
WDTC1
WD and tetratricopeptide repeats 1
chr6_+_27114861 0.75 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chr6_-_165989936 0.74 ENST00000354448.4
PDE10A
phosphodiesterase 10A
chr6_-_52628271 0.73 ENST00000493422.1
GSTA2
glutathione S-transferase alpha 2
chr1_-_86861936 0.69 ENST00000394733.2
ENST00000359242.3
ENST00000294678.2
ENST00000479890.1
ENST00000317336.7
ENST00000370567.1
ENST00000394731.1
ENST00000478286.2
ENST00000370566.3
ODF2L
outer dense fiber of sperm tails 2-like
chrX_-_10588595 0.68 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr6_+_46097711 0.66 ENST00000321037.4
ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
chr17_+_48172639 0.65 ENST00000503176.1
ENST00000503614.1
PDK2
pyruvate dehydrogenase kinase, isozyme 2
chrX_-_115594160 0.63 ENST00000371894.4
CXorf61
cancer/testis antigen 83
chr6_-_15586238 0.63 ENST00000462989.2
DTNBP1
dystrobrevin binding protein 1
chr2_+_24714729 0.62 ENST00000406961.1
ENST00000405141.1
NCOA1
nuclear receptor coactivator 1
chr15_+_75639296 0.57 ENST00000564500.1
ENST00000355059.4
ENST00000566752.1
NEIL1
nei endonuclease VIII-like 1 (E. coli)
chr3_-_69101461 0.56 ENST00000543976.1
TMF1
TATA element modulatory factor 1
chr1_+_109255279 0.56 ENST00000370017.3
FNDC7
fibronectin type III domain containing 7
chr3_-_69101413 0.56 ENST00000398559.2
TMF1
TATA element modulatory factor 1
chr16_-_30597000 0.55 ENST00000470110.1
ENST00000395216.2
ZNF785
zinc finger protein 785
chr2_-_197226875 0.54 ENST00000409111.1
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr7_-_47579188 0.53 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr3_+_52444651 0.52 ENST00000327906.3
PHF7
PHD finger protein 7
chr1_+_222988464 0.52 ENST00000420335.1
RP11-452F19.3
RP11-452F19.3
chr1_+_222988363 0.50 ENST00000450784.1
ENST00000426045.1
ENST00000457955.1
ENST00000444858.1
ENST00000435378.1
ENST00000441676.1
RP11-452F19.3
RP11-452F19.3
chr12_-_56727676 0.48 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr4_+_25915896 0.46 ENST00000514384.1
SMIM20
small integral membrane protein 20
chr4_+_25915822 0.46 ENST00000506197.2
SMIM20
small integral membrane protein 20
chr12_+_94071341 0.45 ENST00000542893.2
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr10_-_112678976 0.45 ENST00000448814.1
BBIP1
BBSome interacting protein 1
chr11_+_19798964 0.44 ENST00000527559.2
NAV2
neuron navigator 2
chr1_+_27561104 0.44 ENST00000361771.3
WDTC1
WD and tetratricopeptide repeats 1
chr2_+_128458514 0.43 ENST00000310981.4
SFT2D3
SFT2 domain containing 3
chr8_+_27491572 0.43 ENST00000301904.3
SCARA3
scavenger receptor class A, member 3
chr3_+_69928256 0.43 ENST00000394355.2
MITF
microphthalmia-associated transcription factor
chr2_+_127413481 0.43 ENST00000259254.4
GYPC
glycophorin C (Gerbich blood group)
chr17_-_56609302 0.43 ENST00000581607.1
ENST00000317256.6
ENST00000426861.1
ENST00000580809.1
ENST00000577729.1
ENST00000583291.1
SEPT4
septin 4
chr17_-_29641084 0.43 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chrX_+_70586140 0.42 ENST00000276072.3
TAF1
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
chrX_+_70752917 0.41 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr5_+_131705438 0.41 ENST00000245407.3
SLC22A5
solute carrier family 22 (organic cation/carnitine transporter), member 5
chr20_+_42187682 0.40 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr12_-_56727487 0.39 ENST00000548043.1
ENST00000425394.2
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr11_-_5207612 0.39 ENST00000380367.1
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr10_+_24755416 0.38 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr17_-_62493131 0.38 ENST00000539111.2
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
chr1_-_93257951 0.37 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr8_+_120885949 0.37 ENST00000523492.1
ENST00000286234.5
DEPTOR
DEP domain containing MTOR-interacting protein
chr1_+_109632425 0.36 ENST00000338272.8
TMEM167B
transmembrane protein 167B
chr9_+_33290491 0.36 ENST00000379540.3
ENST00000379521.4
ENST00000318524.6
NFX1
nuclear transcription factor, X-box binding 1
chr1_+_206643787 0.36 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr19_-_7553852 0.36 ENST00000593547.1
PEX11G
peroxisomal biogenesis factor 11 gamma
chr14_+_56078695 0.35 ENST00000416613.1
KTN1
kinectin 1 (kinesin receptor)
chr14_-_23755297 0.35 ENST00000357460.5
HOMEZ
homeobox and leucine zipper encoding
chr12_+_104982622 0.33 ENST00000549016.1
CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr6_-_112408661 0.33 ENST00000368662.5
TUBE1
tubulin, epsilon 1
chr2_+_68384976 0.33 ENST00000263657.2
PNO1
partner of NOB1 homolog (S. cerevisiae)
chr12_-_54673871 0.33 ENST00000209875.4
CBX5
chromobox homolog 5
chr5_+_178977546 0.33 ENST00000319449.4
ENST00000377001.2
RUFY1
RUN and FYVE domain containing 1
chrX_+_22291065 0.32 ENST00000323684.1
ZNF645
zinc finger protein 645
chr17_-_27621125 0.31 ENST00000579665.1
ENST00000225388.4
NUFIP2
nuclear fragile X mental retardation protein interacting protein 2
chr10_+_89419370 0.31 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chrX_-_99987088 0.31 ENST00000372981.1
ENST00000263033.5
SYTL4
synaptotagmin-like 4
chr13_+_111365602 0.31 ENST00000333219.7
ING1
inhibitor of growth family, member 1
chr18_-_19283649 0.30 ENST00000584464.1
ENST00000578270.1
ABHD3
abhydrolase domain containing 3
chr5_+_173316341 0.30 ENST00000520867.1
ENST00000334035.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr3_+_38347427 0.30 ENST00000273173.4
SLC22A14
solute carrier family 22, member 14
chr14_+_105331596 0.30 ENST00000556508.1
ENST00000414716.3
ENST00000453495.1
ENST00000418279.1
CEP170B
centrosomal protein 170B
chr1_+_151043070 0.30 ENST00000368918.3
ENST00000368917.1
GABPB2
GA binding protein transcription factor, beta subunit 2
chr20_+_42187608 0.30 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr19_-_7553889 0.30 ENST00000221480.1
PEX11G
peroxisomal biogenesis factor 11 gamma
chr5_+_110559603 0.29 ENST00000512453.1
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr2_+_109335929 0.29 ENST00000283195.6
RANBP2
RAN binding protein 2
chr10_+_115312766 0.29 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr11_-_124981475 0.28 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr4_-_186877502 0.28 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2
sorbin and SH3 domain containing 2
chr19_+_41699135 0.28 ENST00000542619.1
ENST00000600561.1
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr1_-_159046617 0.27 ENST00000368130.4
AIM2
absent in melanoma 2
chr18_-_32870148 0.27 ENST00000589178.1
ENST00000333206.5
ENST00000592278.1
ENST00000592211.1
ENST00000420878.3
ENST00000383091.2
ENST00000586922.2
ZSCAN30
RP11-158H5.7
zinc finger and SCAN domain containing 30
RP11-158H5.7
chr1_+_198126093 0.26 ENST00000367385.4
ENST00000442588.1
ENST00000538004.1
NEK7
NIMA-related kinase 7
chr6_-_26199471 0.26 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr9_-_101984184 0.26 ENST00000476832.1
ALG2
ALG2, alpha-1,3/1,6-mannosyltransferase
chr3_+_37035289 0.25 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr1_+_196743943 0.25 ENST00000471440.2
ENST00000391985.3
CFHR3
complement factor H-related 3
chr1_+_100436065 0.24 ENST00000370153.1
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr14_+_32030582 0.24 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr8_-_38326139 0.24 ENST00000335922.5
ENST00000532791.1
ENST00000397091.5
FGFR1
fibroblast growth factor receptor 1
chr19_-_53238260 0.24 ENST00000453741.2
ENST00000602162.1
ENST00000601643.1
ENST00000596702.1
ENST00000600943.1
ENST00000543227.1
ENST00000540744.1
ZNF611
zinc finger protein 611
chr20_-_54580523 0.24 ENST00000064571.2
CBLN4
cerebellin 4 precursor
chr11_-_59950519 0.23 ENST00000528851.1
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr8_-_95220775 0.23 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr11_-_47447970 0.23 ENST00000298852.3
ENST00000530912.1
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr11_+_17281900 0.23 ENST00000530527.1
NUCB2
nucleobindin 2
chrX_+_70586082 0.23 ENST00000373790.4
ENST00000449580.1
ENST00000423759.1
TAF1
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
chr11_-_62572901 0.23 ENST00000439713.2
ENST00000531131.1
ENST00000530875.1
ENST00000531709.2
ENST00000294172.2
NXF1
nuclear RNA export factor 1
chr3_-_151176497 0.23 ENST00000282466.3
IGSF10
immunoglobulin superfamily, member 10
chr11_-_59950486 0.22 ENST00000426738.2
ENST00000533023.1
ENST00000420732.2
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr7_-_22234381 0.22 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr12_+_51633061 0.22 ENST00000551313.1
DAZAP2
DAZ associated protein 2
chr14_+_31028329 0.21 ENST00000206595.6
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr11_-_46638720 0.20 ENST00000326737.3
HARBI1
harbinger transposase derived 1
chrM_+_5824 0.20 ENST00000361624.2
MT-CO1
mitochondrially encoded cytochrome c oxidase I
chr1_-_160549235 0.19 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84
CD84 molecule
chr3_-_12587055 0.19 ENST00000564146.3
C3orf83
chromosome 3 open reading frame 83
chr12_-_122018859 0.18 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
KDM2B
lysine (K)-specific demethylase 2B
chr12_+_49121213 0.17 ENST00000548380.1
LINC00935
long intergenic non-protein coding RNA 935
chr1_+_196743912 0.17 ENST00000367425.4
CFHR3
complement factor H-related 3
chr12_+_4758264 0.17 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chrX_+_70752945 0.17 ENST00000373701.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr3_-_45837959 0.16 ENST00000353278.4
ENST00000456124.2
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr12_-_53715328 0.16 ENST00000547757.1
ENST00000394384.3
ENST00000209873.4
AAAS
achalasia, adrenocortical insufficiency, alacrimia
chr10_+_35484793 0.16 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr6_+_30585486 0.16 ENST00000259873.4
ENST00000506373.2
MRPS18B
mitochondrial ribosomal protein S18B
chr14_+_31028348 0.16 ENST00000550944.1
ENST00000438909.2
ENST00000553504.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr8_-_116504448 0.15 ENST00000518018.1
TRPS1
trichorhinophalangeal syndrome I
chr5_-_133968459 0.15 ENST00000505758.1
ENST00000439578.1
ENST00000502286.1
SAR1B
SAR1 homolog B (S. cerevisiae)
chr11_-_111649015 0.15 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr17_-_55822653 0.14 ENST00000299415.2
AC007431.1
coiled-coil domain containing 182
chr17_-_29641104 0.14 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr6_+_29364416 0.14 ENST00000383555.2
OR12D2
olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
chr19_+_57019212 0.14 ENST00000308031.5
ENST00000591537.1
ZNF471
zinc finger protein 471
chr11_+_34643600 0.14 ENST00000530286.1
ENST00000533754.1
EHF
ets homologous factor
chr2_+_106468204 0.13 ENST00000425756.1
ENST00000393349.2
NCK2
NCK adaptor protein 2
chr5_-_39074479 0.13 ENST00000514735.1
ENST00000296782.5
ENST00000357387.3
RICTOR
RPTOR independent companion of MTOR, complex 2
chr14_+_37641012 0.13 ENST00000556667.1
SLC25A21-AS1
SLC25A21 antisense RNA 1
chr17_+_3118915 0.13 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr8_+_107738240 0.13 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr6_-_26199499 0.13 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr11_+_10772534 0.13 ENST00000361367.2
CTR9
CTR9, Paf1/RNA polymerase II complex component
chr4_-_69434245 0.13 ENST00000317746.2
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr1_+_206643806 0.13 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr4_-_47465666 0.13 ENST00000381571.4
COMMD8
COMM domain containing 8
chr9_-_114246635 0.13 ENST00000338205.5
KIAA0368
KIAA0368
chr7_+_101460882 0.13 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr19_-_56826157 0.12 ENST00000592509.1
ENST00000592679.1
ENST00000588442.1
ENST00000593106.1
ENST00000587492.1
ENST00000254165.3
ZSCAN5A
zinc finger and SCAN domain containing 5A
chr3_-_57326704 0.12 ENST00000487349.1
ENST00000389601.3
ASB14
ankyrin repeat and SOCS box containing 14
chr14_-_45431091 0.12 ENST00000579157.1
ENST00000396128.4
ENST00000556500.1
KLHL28
kelch-like family member 28
chr2_-_3521518 0.12 ENST00000382093.5
ADI1
acireductone dioxygenase 1
chrX_+_135730373 0.11 ENST00000370628.2
CD40LG
CD40 ligand
chrX_+_66764375 0.11 ENST00000374690.3
AR
androgen receptor
chr1_-_149982624 0.11 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chrX_+_135730297 0.11 ENST00000370629.2
CD40LG
CD40 ligand
chr1_+_175036966 0.11 ENST00000239462.4
TNN
tenascin N
chr5_+_138629417 0.11 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
MATR3
matrin 3
chr2_-_86948245 0.11 ENST00000439940.2
ENST00000604011.1
CHMP3
RNF103-CHMP3
charged multivesicular body protein 3
RNF103-CHMP3 readthrough
chr19_+_50084561 0.11 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr3_-_126327398 0.11 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr1_+_24286287 0.10 ENST00000334351.7
ENST00000374468.1
PNRC2
proline-rich nuclear receptor coactivator 2
chr12_+_28343365 0.10 ENST00000545336.1
CCDC91
coiled-coil domain containing 91
chr19_+_50353944 0.09 ENST00000594151.1
ENST00000600603.1
ENST00000601638.1
ENST00000221557.9
PTOV1
prostate tumor overexpressed 1
chr13_-_77901177 0.09 ENST00000407578.2
ENST00000357337.6
ENST00000360084.5
MYCBP2
MYC binding protein 2, E3 ubiquitin protein ligase
chr13_-_67802549 0.09 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr1_-_154832316 0.09 ENST00000361147.4
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of HMBOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:2000845 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.2 0.9 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 3.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 0.6 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.2 1.4 GO:0001554 luteolysis(GO:0001554)
0.1 1.4 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.6 GO:0036369 transcription factor catabolic process(GO:0036369)
0.1 2.2 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 0.7 GO:0044375 regulation of peroxisome size(GO:0044375)
0.1 0.4 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 1.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.2 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.1 1.0 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 0.2 GO:1990569 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.1 0.3 GO:0000103 sulfate assimilation(GO:0000103)
0.1 2.5 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.1 0.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 1.5 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 0.2 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.4 GO:0021564 vagus nerve development(GO:0021564)
0.1 1.2 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.6 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 0.4 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.2 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.4 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.0 0.1 GO:1903465 vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.0 0.4 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.1 GO:2001162 regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.0 0.6 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.9 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 1.4 GO:0010842 retina layer formation(GO:0010842)
0.0 0.8 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.1 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 2.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.7 GO:0046130 purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0 0.3 GO:0070269 pyroptosis(GO:0070269)
0.0 1.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.1 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.0 0.5 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.4 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.1 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0 0.7 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.2 GO:0015824 proline transport(GO:0015824)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 1.2 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.4 GO:0009650 UV protection(GO:0009650)
0.0 0.1 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 2.7 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 1.0 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.3 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.5 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.0 GO:0051180 vitamin transport(GO:0051180)
0.0 0.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.7 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 1.8 GO:0001942 hair follicle development(GO:0001942)
0.0 1.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.3 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.8 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.5 GO:0002177 manchette(GO:0002177)
0.2 1.8 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.2 0.9 GO:0031251 PAN complex(GO:0031251)
0.2 0.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.4 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.1 1.4 GO:0034464 BBSome(GO:0034464)
0.1 2.2 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.2 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.8 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 3.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.4 GO:0097227 sperm annulus(GO:0097227)
0.0 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.6 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 2.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.6 GO:0030286 dynein complex(GO:0030286)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.1 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.0 1.1 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.3 3.1 GO:0004565 beta-galactosidase activity(GO:0004565)
0.3 2.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 1.8 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.2 0.5 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.2 0.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.6 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.1 0.6 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 0.7 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 0.3 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 0.3 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 1.2 GO:0001083 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.4 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.2 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.1 0.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 2.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 1.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.3 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.6 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 1.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.5 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 1.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.0 0.5 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 2.6 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0004882 androgen receptor activity(GO:0004882)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.3 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.4 GO:0004364 glutathione transferase activity(GO:0004364)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 2.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.1 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 4.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 1.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection