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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HMGA2

Z-value: 0.46

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.9 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218598_66218678-0.752.1e-06Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_34397800 1.97 ENST00000297623.2
C9orf24
chromosome 9 open reading frame 24
chr1_+_196621156 1.21 ENST00000359637.2
CFH
complement factor H
chr11_+_73661364 0.94 ENST00000339764.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr10_-_129691195 0.93 ENST00000368671.3
CLRN3
clarin 3
chr5_+_36608422 0.92 ENST00000381918.3
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_52705641 0.88 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr1_+_196621002 0.86 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr2_+_120436733 0.80 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
TMEM177
transmembrane protein 177
chr6_-_32908792 0.70 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr12_+_113587558 0.60 ENST00000335621.6
CCDC42B
coiled-coil domain containing 42B
chr17_-_30186328 0.53 ENST00000302362.6
COPRS
coordinator of PRMT5, differentiation stimulator
chr19_-_11457162 0.49 ENST00000590482.1
TMEM205
transmembrane protein 205
chr19_-_11457082 0.48 ENST00000587948.1
TMEM205
transmembrane protein 205
chrX_-_7895479 0.47 ENST00000381042.4
PNPLA4
patatin-like phospholipase domain containing 4
chr19_-_11456722 0.47 ENST00000354882.5
TMEM205
transmembrane protein 205
chrX_-_7895755 0.46 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
PNPLA4
patatin-like phospholipase domain containing 4
chr19_-_11456905 0.44 ENST00000588560.1
ENST00000592952.1
TMEM205
transmembrane protein 205
chr6_-_52926539 0.43 ENST00000350082.5
ENST00000356971.3
ICK
intestinal cell (MAK-like) kinase
chr1_+_2487800 0.42 ENST00000355716.4
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr19_-_11456872 0.40 ENST00000586218.1
TMEM205
transmembrane protein 205
chr17_-_38911580 0.40 ENST00000312150.4
KRT25
keratin 25
chr13_+_51483814 0.37 ENST00000336617.3
ENST00000422660.1
RNASEH2B
ribonuclease H2, subunit B
chr19_-_36297632 0.37 ENST00000588266.2
PRODH2
proline dehydrogenase (oxidase) 2
chr15_+_88120158 0.34 ENST00000560153.1
LINC00052
long intergenic non-protein coding RNA 52
chr9_+_42704004 0.32 ENST00000457288.1
CBWD7
COBW domain containing 7
chr7_+_80275953 0.32 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chr16_+_66442411 0.32 ENST00000499966.1
LINC00920
long intergenic non-protein coding RNA 920
chr18_-_21017817 0.31 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
TMEM241
transmembrane protein 241
chr2_-_216257849 0.30 ENST00000456923.1
FN1
fibronectin 1
chr9_+_108463234 0.30 ENST00000374688.1
TMEM38B
transmembrane protein 38B
chr20_+_48884002 0.30 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3
RP11-290F20.3
chr15_+_43885252 0.28 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr6_-_32908765 0.27 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr9_+_2157655 0.27 ENST00000452193.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr18_+_11851383 0.25 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr7_-_102985035 0.25 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr15_+_43985084 0.25 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr19_+_11457175 0.25 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr2_+_170683942 0.24 ENST00000272793.5
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr3_-_157221380 0.24 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_+_123110302 0.24 ENST00000368440.4
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr1_+_227751231 0.24 ENST00000343776.5
ENST00000608949.1
ENST00000397097.3
ZNF678
zinc finger protein 678
chr6_-_127664736 0.24 ENST00000368291.2
ENST00000309620.9
ENST00000454859.3
ECHDC1
enoyl CoA hydratase domain containing 1
chr2_+_170683979 0.22 ENST00000418381.1
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr3_-_157221357 0.20 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr2_+_220143989 0.20 ENST00000336576.5
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr10_-_62332357 0.20 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr14_+_88852059 0.19 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr17_-_26220366 0.19 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9
RP1-66C13.4
LYR motif containing 9
Uncharacterized protein
chr3_+_106959530 0.19 ENST00000466734.1
ENST00000463143.1
ENST00000490441.1
LINC00883
long intergenic non-protein coding RNA 883
chr10_+_35456444 0.18 ENST00000361599.4
CREM
cAMP responsive element modulator
chr7_-_102985288 0.18 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr17_-_48785216 0.18 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr5_-_135290705 0.17 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr7_+_80267973 0.17 ENST00000394788.3
ENST00000447544.2
CD36
CD36 molecule (thrombospondin receptor)
chr12_+_21207503 0.16 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr6_-_127664683 0.16 ENST00000528402.1
ENST00000454591.2
ECHDC1
enoyl CoA hydratase domain containing 1
chr4_+_25378912 0.15 ENST00000510092.1
ENST00000505991.1
ANAPC4
anaphase promoting complex subunit 4
chr6_+_88106840 0.15 ENST00000369570.4
C6orf164
chromosome 6 open reading frame 164
chr5_+_150827143 0.15 ENST00000243389.3
ENST00000517945.1
ENST00000521925.1
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chrX_-_23926004 0.15 ENST00000379226.4
ENST00000379220.3
APOO
apolipoprotein O
chr9_-_115480303 0.14 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
INIP
INTS3 and NABP interacting protein
chr11_-_130786400 0.14 ENST00000265909.4
SNX19
sorting nexin 19
chrX_-_77150911 0.14 ENST00000373336.3
MAGT1
magnesium transporter 1
chr9_+_104296122 0.11 ENST00000389120.3
RNF20
ring finger protein 20, E3 ubiquitin protein ligase
chr12_-_21757774 0.11 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)
chr6_+_111580508 0.11 ENST00000368847.4
KIAA1919
KIAA1919
chr2_+_177134201 0.10 ENST00000452865.1
MTX2
metaxin 2
chr4_+_184826418 0.10 ENST00000308497.4
ENST00000438269.1
STOX2
storkhead box 2
chr4_+_40058411 0.09 ENST00000261435.6
ENST00000515550.1
N4BP2
NEDD4 binding protein 2
chr2_-_183387430 0.09 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr11_-_130786333 0.09 ENST00000533214.1
ENST00000528555.1
ENST00000530356.1
ENST00000539184.1
SNX19
sorting nexin 19
chr2_-_180610767 0.09 ENST00000409343.1
ZNF385B
zinc finger protein 385B
chr12_-_122751002 0.09 ENST00000267199.4
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr2_-_89266286 0.09 ENST00000464162.1
IGKV1-6
immunoglobulin kappa variable 1-6
chr11_+_67250490 0.08 ENST00000528641.2
ENST00000279146.3
AIP
aryl hydrocarbon receptor interacting protein
chr12_-_10541575 0.08 ENST00000540818.1
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chrX_-_71792477 0.08 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr11_+_60260248 0.07 ENST00000526784.1
ENST00000016913.4
ENST00000537076.1
ENST00000530007.1
MS4A12
membrane-spanning 4-domains, subfamily A, member 12
chrX_-_77150985 0.07 ENST00000358075.6
MAGT1
magnesium transporter 1
chr5_-_102455801 0.06 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr2_+_177134134 0.06 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr1_+_55464600 0.06 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr3_+_137728842 0.05 ENST00000183605.5
CLDN18
claudin 18
chr15_+_30427352 0.05 ENST00000569052.1
GOLGA8T
golgin A8 family, member T
chr15_+_30375158 0.04 ENST00000341650.6
ENST00000567927.1
GOLGA8J
golgin A8 family, member J
chr2_+_235887329 0.04 ENST00000409212.1
ENST00000344528.4
ENST00000444916.1
SH3BP4
SH3-domain binding protein 4
chr3_+_186501336 0.04 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr2_-_183387283 0.04 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr12_-_10573149 0.04 ENST00000381904.2
ENST00000381903.2
ENST00000396439.2
KLRC3
killer cell lectin-like receptor subfamily C, member 3
chr12_-_122750957 0.04 ENST00000451053.2
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr14_+_37641012 0.03 ENST00000556667.1
SLC25A21-AS1
SLC25A21 antisense RNA 1
chr6_-_29324054 0.02 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr3_+_193853927 0.02 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr6_+_116892641 0.02 ENST00000487832.2
ENST00000518117.1
RWDD1
RWD domain containing 1
chr9_-_34729457 0.02 ENST00000378788.3
FAM205A
family with sequence similarity 205, member A
chr17_-_4607335 0.01 ENST00000570571.1
ENST00000575101.1
ENST00000436683.2
ENST00000574876.1
PELP1
proline, glutamate and leucine rich protein 1
chr19_-_38146289 0.01 ENST00000392144.1
ENST00000591444.1
ENST00000351218.2
ENST00000587809.1
ZFP30
ZFP30 zinc finger protein
chr12_+_69979113 0.01 ENST00000299300.6
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr20_-_31989307 0.01 ENST00000473997.1
ENST00000544843.1
ENST00000346416.2
ENST00000357886.4
ENST00000339269.5
CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr19_-_12267524 0.01 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
ZNF625
zinc finger protein 625
chr12_+_69979210 0.00 ENST00000544368.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr10_-_36813162 0.00 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.2 0.9 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.9 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 0.4 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 0.4 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 0.3 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 2.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.3 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 0.5 GO:0072564 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.4 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.2 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.0 0.5 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.1 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.1 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.9 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.3 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.2 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.4 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.1 GO:0051344 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 0.4 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.5 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.3 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 0.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 2.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 1.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters