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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HNF1A_HNF1B

Z-value: 0.95

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
HNF1A
ENSG00000135100.13 HNF1 homeobox A
HNF1B
ENSG00000108753.8 HNF1 homeobox B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416437_121416479-0.393.1e-02Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_110723134 4.26 ENST00000510800.1
ENST00000512148.1
CFI
complement factor I
chr4_-_110723194 4.25 ENST00000394635.3
CFI
complement factor I
chr4_-_110723335 3.89 ENST00000394634.2
CFI
complement factor I
chrX_-_15619076 2.66 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr19_+_50016610 2.57 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_-_35195338 2.46 ENST00000509839.1
PRLR
prolactin receptor
chr3_-_74570291 1.83 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr20_-_7921090 1.74 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr17_-_202579 1.68 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
RPH3AL
rabphilin 3A-like (without C2 domains)
chr16_+_20775358 1.66 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr17_+_4692230 1.63 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr19_+_50016411 1.62 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr7_+_141695671 1.52 ENST00000497673.1
ENST00000475668.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr7_+_141695633 1.51 ENST00000549489.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr22_+_31003133 1.49 ENST00000405742.3
TCN2
transcobalamin II
chr6_-_29013017 1.47 ENST00000377175.1
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr22_+_31003190 1.44 ENST00000407817.3
TCN2
transcobalamin II
chr14_-_94854926 1.36 ENST00000402629.1
ENST00000556091.1
ENST00000554720.1
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr7_-_50633078 1.36 ENST00000444124.2
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr8_-_95220775 1.35 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr22_-_32651326 1.35 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr22_+_31002779 1.34 ENST00000215838.3
TCN2
transcobalamin II
chr1_+_162351503 1.29 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr13_+_96085847 1.23 ENST00000376873.3
CLDN10
claudin 10
chr1_+_18807424 1.18 ENST00000400664.1
KLHDC7A
kelch domain containing 7A
chrX_-_105282712 1.08 ENST00000372563.1
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr12_+_109785708 1.01 ENST00000310903.5
MYO1H
myosin IH
chr17_+_26800756 1.00 ENST00000537681.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr17_+_35732955 0.99 ENST00000300618.4
C17orf78
chromosome 17 open reading frame 78
chr17_+_26800648 0.99 ENST00000545060.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr17_+_35732916 0.97 ENST00000586700.1
C17orf78
chromosome 17 open reading frame 78
chr17_+_26800296 0.93 ENST00000444914.3
ENST00000314669.5
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr22_-_30968813 0.92 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr13_-_103719196 0.91 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr17_+_68071458 0.88 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 0.86 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr16_+_21244986 0.81 ENST00000311620.5
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr3_-_157221380 0.80 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr12_-_91574142 0.78 ENST00000547937.1
DCN
decorin
chr9_-_123812542 0.76 ENST00000223642.1
C5
complement component 5
chr3_-_157221357 0.73 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr5_-_61031495 0.72 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
CTD-2170G1.2
chr1_+_104293028 0.72 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr16_-_55909255 0.70 ENST00000290567.9
CES5A
carboxylesterase 5A
chr16_-_55909272 0.70 ENST00000319165.9
CES5A
carboxylesterase 5A
chr16_-_55909211 0.70 ENST00000520435.1
CES5A
carboxylesterase 5A
chr6_-_25930819 0.69 ENST00000360488.3
SLC17A2
solute carrier family 17, member 2
chr6_-_25930904 0.64 ENST00000377850.3
SLC17A2
solute carrier family 17, member 2
chr1_-_197036364 0.63 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr17_-_26733179 0.63 ENST00000440501.1
ENST00000321666.5
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr2_-_228244013 0.62 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr8_-_87242589 0.61 ENST00000419776.2
ENST00000297524.3
SLC7A13
solute carrier family 7 (anionic amino acid transporter), member 13
chr6_+_126070726 0.61 ENST00000368364.3
HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr6_-_52628271 0.59 ENST00000493422.1
GSTA2
glutathione S-transferase alpha 2
chr6_-_51952418 0.57 ENST00000371117.3
PKHD1
polycystic kidney and hepatic disease 1 (autosomal recessive)
chr1_-_168464875 0.57 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr16_-_57831914 0.56 ENST00000421376.2
KIFC3
kinesin family member C3
chr4_-_76944621 0.55 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr2_-_55920952 0.55 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr1_+_104159999 0.55 ENST00000414303.2
ENST00000423678.1
AMY2A
amylase, alpha 2A (pancreatic)
chr10_+_45406627 0.54 ENST00000389583.4
TMEM72
transmembrane protein 72
chr6_+_54172653 0.54 ENST00000370869.3
TINAG
tubulointerstitial nephritis antigen
chr6_-_51952367 0.52 ENST00000340994.4
PKHD1
polycystic kidney and hepatic disease 1 (autosomal recessive)
chr2_+_38177575 0.49 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr10_-_61495760 0.48 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr4_-_100212132 0.48 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr4_+_3443614 0.47 ENST00000382774.3
ENST00000511533.1
HGFAC
HGF activator
chr6_+_12717892 0.47 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr6_-_154751629 0.47 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr8_-_108510224 0.45 ENST00000517746.1
ENST00000297450.3
ANGPT1
angiopoietin 1
chr6_+_54173227 0.45 ENST00000259782.4
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr8_-_70745575 0.45 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr2_+_133174147 0.45 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr11_-_65149422 0.44 ENST00000526432.1
ENST00000527174.1
SLC25A45
solute carrier family 25, member 45
chr3_+_183948161 0.44 ENST00000426955.2
VWA5B2
von Willebrand factor A domain containing 5B2
chr4_+_155484155 0.43 ENST00000509493.1
FGB
fibrinogen beta chain
chr4_-_70518941 0.42 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr2_-_158300556 0.42 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr3_-_137834436 0.41 ENST00000327532.2
ENST00000467030.1
DZIP1L
DAZ interacting zinc finger protein 1-like
chr8_+_104892639 0.40 ENST00000436393.2
RIMS2
regulating synaptic membrane exocytosis 2
chr15_-_99057551 0.40 ENST00000558256.1
FAM169B
family with sequence similarity 169, member B
chr22_-_30970560 0.39 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr5_-_111093167 0.39 ENST00000446294.2
ENST00000419114.2
NREP
neuronal regeneration related protein
chr3_-_164796269 0.38 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr17_+_1646130 0.37 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr7_-_155601766 0.37 ENST00000430104.1
SHH
sonic hedgehog
chr1_+_207277590 0.37 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr12_+_20963647 0.36 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr14_+_39703112 0.36 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr2_+_115219171 0.36 ENST00000409163.1
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr5_+_140571902 0.35 ENST00000239446.4
PCDHB10
protocadherin beta 10
chr4_+_71494461 0.35 ENST00000396073.3
ENAM
enamelin
chr6_+_131571535 0.34 ENST00000474850.2
AKAP7
A kinase (PRKA) anchor protein 7
chr16_-_69385681 0.34 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr12_+_20963632 0.33 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr19_+_41305085 0.33 ENST00000303961.4
EGLN2
egl-9 family hypoxia-inducible factor 2
chr17_+_79953310 0.31 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr11_+_46740730 0.31 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2
coagulation factor II (thrombin)
chr1_-_42630389 0.31 ENST00000357001.2
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr8_+_21911054 0.31 ENST00000519850.1
ENST00000381470.3
DMTN
dematin actin binding protein
chr4_-_1166954 0.31 ENST00000514490.1
ENST00000431380.1
ENST00000503765.1
SPON2
spondin 2, extracellular matrix protein
chr9_-_94712434 0.31 ENST00000375708.3
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr19_+_11350278 0.31 ENST00000252453.8
C19orf80
chromosome 19 open reading frame 80
chr6_+_47624172 0.30 ENST00000507065.1
ENST00000296862.1
GPR111
G protein-coupled receptor 111
chr16_-_57831676 0.30 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
KIFC3
kinesin family member C3
chr2_-_88427568 0.30 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr8_-_17752996 0.29 ENST00000381841.2
ENST00000427924.1
FGL1
fibrinogen-like 1
chr9_+_130860583 0.29 ENST00000373064.5
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr1_-_110284384 0.27 ENST00000540225.1
GSTM3
glutathione S-transferase mu 3 (brain)
chr1_+_119911425 0.27 ENST00000361035.4
ENST00000325945.3
HAO2
hydroxyacid oxidase 2 (long chain)
chr3_-_49466686 0.27 ENST00000273598.3
ENST00000436744.2
NICN1
nicolin 1
chr6_-_25874440 0.27 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr11_+_560956 0.27 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr9_+_130860810 0.26 ENST00000433501.1
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr14_-_57960545 0.26 ENST00000526336.1
ENST00000216445.3
C14orf105
chromosome 14 open reading frame 105
chr12_-_8693469 0.25 ENST00000545274.1
ENST00000446457.2
CLEC4E
C-type lectin domain family 4, member E
chr12_+_40787194 0.24 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr5_-_10761206 0.24 ENST00000432074.2
ENST00000230895.6
DAP
death-associated protein
chr5_+_67586465 0.24 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_+_186383741 0.24 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr12_-_39837192 0.22 ENST00000361961.3
ENST00000395670.3
KIF21A
kinesin family member 21A
chr7_-_47579188 0.21 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr12_+_100867486 0.21 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr1_+_36789335 0.21 ENST00000373137.2
RP11-268J15.5
RP11-268J15.5
chr3_+_185431080 0.20 ENST00000296270.1
C3orf65
chromosome 3 open reading frame 65
chr2_-_47572105 0.20 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
AC073283.4
chr3_-_169587621 0.20 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr12_+_60058458 0.20 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr16_+_20775024 0.19 ENST00000289416.5
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr11_-_117695449 0.19 ENST00000292079.2
FXYD2
FXYD domain containing ion transport regulator 2
chr12_+_100897130 0.19 ENST00000551379.1
ENST00000188403.7
ENST00000551184.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr10_-_38146510 0.19 ENST00000395867.3
ZNF248
zinc finger protein 248
chr4_+_100495864 0.18 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr11_-_128894053 0.18 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr4_-_987164 0.17 ENST00000398520.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr2_-_162931052 0.17 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr19_-_49565254 0.17 ENST00000593537.1
NTF4
neurotrophin 4
chr6_-_116833500 0.17 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr11_+_2405833 0.16 ENST00000527343.1
ENST00000464784.2
CD81
CD81 molecule
chr12_-_91546926 0.16 ENST00000550758.1
DCN
decorin
chr20_+_43029911 0.16 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr22_-_38506619 0.15 ENST00000332536.5
ENST00000381669.3
BAIAP2L2
BAI1-associated protein 2-like 2
chr16_-_15474904 0.15 ENST00000534094.1
NPIPA5
nuclear pore complex interacting protein family, member A5
chr14_+_21156915 0.15 ENST00000397990.4
ENST00000555597.1
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr2_+_234668894 0.15 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr7_-_6098770 0.14 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
EIF2AK1
eukaryotic translation initiation factor 2-alpha kinase 1
chr4_+_187187337 0.14 ENST00000492972.2
F11
coagulation factor XI
chr14_+_95027772 0.14 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr9_+_82186872 0.13 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr10_-_128359074 0.13 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr4_+_159443090 0.13 ENST00000343542.5
ENST00000470033.1
RXFP1
relaxin/insulin-like family peptide receptor 1
chr11_+_64358686 0.13 ENST00000473690.1
SLC22A12
solute carrier family 22 (organic anion/urate transporter), member 12
chr10_+_111765562 0.12 ENST00000360162.3
ADD3
adducin 3 (gamma)
chr4_-_74486109 0.12 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr12_-_76879852 0.12 ENST00000548341.1
OSBPL8
oxysterol binding protein-like 8
chr17_+_41052808 0.11 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr18_+_5748793 0.11 ENST00000566533.1
ENST00000562452.2
RP11-945C19.1
RP11-945C19.1
chr19_-_42133420 0.11 ENST00000221954.2
ENST00000600925.1
CEACAM4
carcinoembryonic antigen-related cell adhesion molecule 4
chr11_-_111649015 0.11 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr6_-_161085291 0.11 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr11_-_83393457 0.11 ENST00000404783.3
DLG2
discs, large homolog 2 (Drosophila)
chr4_-_74486347 0.11 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr3_+_180319918 0.10 ENST00000296015.4
ENST00000491380.1
ENST00000412756.2
ENST00000382584.4
TTC14
tetratricopeptide repeat domain 14
chr3_+_66271410 0.10 ENST00000336733.6
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr13_+_27825706 0.10 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
RPL21
ribosomal protein L21
chr2_+_109223595 0.10 ENST00000410093.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr4_-_166034029 0.10 ENST00000306480.6
TMEM192
transmembrane protein 192
chr4_+_74269956 0.10 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr17_+_48823896 0.10 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr10_-_52645379 0.09 ENST00000395489.2
A1CF
APOBEC1 complementation factor
chr5_+_140772381 0.09 ENST00000398604.2
PCDHGA8
protocadherin gamma subfamily A, 8
chr3_+_75955817 0.09 ENST00000487694.3
ENST00000602589.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr6_+_25754927 0.09 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr1_-_159684371 0.08 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr7_-_87856280 0.08 ENST00000490437.1
ENST00000431660.1
SRI
sorcin
chr8_-_87755878 0.08 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr7_-_87856303 0.08 ENST00000394641.3
SRI
sorcin
chr7_+_152456829 0.08 ENST00000377776.3
ENST00000256001.8
ENST00000397282.2
ACTR3B
ARP3 actin-related protein 3 homolog B (yeast)
chr16_-_20587599 0.08 ENST00000566384.1
ENST00000565232.1
ENST00000567001.1
ENST00000565322.1
ENST00000569344.1
ENST00000329697.6
ENST00000414188.2
ENST00000568882.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chrX_+_36254051 0.07 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr10_-_72648541 0.07 ENST00000299299.3
PCBD1
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr10_-_52645416 0.07 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr11_+_20620946 0.07 ENST00000525748.1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr22_+_32439019 0.07 ENST00000266088.4
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr14_+_24590560 0.07 ENST00000558325.1
RP11-468E2.6
RP11-468E2.6
chr12_+_100867694 0.07 ENST00000392986.3
ENST00000549996.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr2_+_234637754 0.07 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr8_+_42873548 0.07 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr9_+_82186682 0.06 ENST00000376552.2
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_+_76540386 0.06 ENST00000328299.3
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr4_-_102267953 0.06 ENST00000523694.2
ENST00000507176.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_-_107596910 0.05 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635
long intergenic non-protein coding RNA 635
chr2_+_234526272 0.05 ENST00000373450.4
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr16_+_89696692 0.05 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chr20_+_57414743 0.05 ENST00000313949.7
GNAS
GNAS complex locus
chr16_+_20462783 0.05 ENST00000574251.1
ENST00000576361.1
ENST00000417235.2
ENST00000573854.1
ENST00000424070.1
ENST00000536134.1
ENST00000219054.6
ENST00000575690.1
ENST00000571894.1
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr18_-_48346415 0.05 ENST00000431965.2
ENST00000436348.2
MRO
maestro
chr3_+_107318157 0.05 ENST00000406780.1
BBX
bobby sox homolog (Drosophila)
chr2_+_234627424 0.04 ENST00000373409.3
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr12_-_102874378 0.04 ENST00000456098.1
IGF1
insulin-like growth factor 1 (somatomedin C)

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0000023 maltose metabolic process(GO:0000023)
0.5 2.7 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.5 4.2 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.5 1.4 GO:0052314 phytoalexin metabolic process(GO:0052314)
0.4 4.3 GO:0015889 cobalamin transport(GO:0015889)
0.4 2.5 GO:0038161 prolactin signaling pathway(GO:0038161)
0.3 1.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.3 0.8 GO:1904106 protein localization to microvillus(GO:1904106)
0.2 0.6 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.2 1.6 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 0.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 0.5 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.2 0.6 GO:0051958 methotrexate transport(GO:0051958)
0.2 0.5 GO:0001079 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.2 0.8 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 1.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.4 GO:0060738 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738) negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1 0.3 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 13.2 GO:0030449 regulation of complement activation(GO:0030449)
0.1 1.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.4 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.5 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.4 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.1 1.6 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.6 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950) regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.3 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.1 0.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.3 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 0.3 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.4 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.1 GO:0052331 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.0 GO:0006789 bilirubin conjugation(GO:0006789)
0.0 0.2 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 1.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 1.3 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.2 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 0.1 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.5 GO:0015866 ADP transport(GO:0015866)
0.0 0.3 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.5 GO:0006069 ethanol oxidation(GO:0006069)
0.0 1.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.1 GO:0016999 antibiotic metabolic process(GO:0016999)
0.0 1.1 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.2 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.6 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 1.4 GO:0006953 acute-phase response(GO:0006953)
0.0 0.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 2.3 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 0.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.6 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 1.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.2 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.2 GO:0034378 chylomicron assembly(GO:0034378)
0.0 2.0 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.9 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.9 GO:0005915 zonula adherens(GO:0005915)
0.1 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 1.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0036028 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 2.5 GO:0031904 endosome lumen(GO:0031904)
0.0 2.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 4.3 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0034358 protein-lipid complex(GO:0032994) plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.0 2.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.2 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.7 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.9 GO:0005902 microvillus(GO:0005902)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.4 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.2 GO:0019770 IgG receptor activity(GO:0019770)
1.0 2.9 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.9 3.6 GO:0016160 amylase activity(GO:0016160)
0.7 2.0 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.5 2.5 GO:0004925 prolactin receptor activity(GO:0004925)
0.4 4.3 GO:0031419 cobalamin binding(GO:0031419)
0.4 2.6 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.3 1.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.2 2.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.2 0.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 1.3 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.2 13.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 0.6 GO:0015350 methotrexate transporter activity(GO:0015350)
0.2 0.5 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.2 0.6 GO:0035939 microsatellite binding(GO:0035939)
0.2 1.7 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 0.4 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 1.6 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 0.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.5 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.3 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.3 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.3 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.4 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.3 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.5 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.3 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.2 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.1 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 1.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.8 GO:0008009 chemokine activity(GO:0008009)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 0.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.9 GO:0002020 protease binding(GO:0002020)
0.0 0.2 GO:1990459 transferrin receptor binding(GO:1990459)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.5 PID E2F PATHWAY E2F transcription factor network
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.5 12.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 3.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.9 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 1.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis