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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HOXB13

Z-value: 0.45

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.7 homeobox B13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_468065580.038.7e-01Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_86376081 2.57 ENST00000285379.5
CA2
carbonic anhydrase II
chr11_-_102826434 1.52 ENST00000340273.4
ENST00000260302.3
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr9_+_125133315 1.51 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_+_84630645 1.41 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_190044480 1.35 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr17_-_39538550 0.98 ENST00000394001.1
KRT34
keratin 34
chr5_+_135496675 0.83 ENST00000507637.1
SMAD5
SMAD family member 5
chr16_-_2205352 0.82 ENST00000563192.1
RP11-304L19.5
RP11-304L19.5
chr6_+_122793058 0.81 ENST00000392491.2
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr1_+_84630053 0.81 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_-_145214893 0.78 ENST00000394450.2
PRELID2
PRELI domain containing 2
chr19_+_1440838 0.75 ENST00000594262.1
AC027307.3
Uncharacterized protein
chr7_-_50860565 0.62 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr1_-_45956800 0.61 ENST00000538496.1
TESK2
testis-specific kinase 2
chr9_+_125132803 0.60 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr7_+_35756092 0.56 ENST00000458087.3
AC018647.3
AC018647.3
chr15_-_55541227 0.54 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr1_-_155880672 0.53 ENST00000609492.1
ENST00000368322.3
RIT1
Ras-like without CAAX 1
chr19_+_35634146 0.52 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
FXYD7
FXYD domain containing ion transport regulator 7
chr14_+_76776957 0.50 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chrM_-_14670 0.41 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr19_+_56154913 0.41 ENST00000270451.5
ENST00000588537.1
ZNF581
zinc finger protein 581
chr6_-_27782548 0.37 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr14_-_72458326 0.36 ENST00000542853.1
AC005477.1
AC005477.1
chr5_-_145214848 0.34 ENST00000505416.1
ENST00000334744.4
ENST00000358004.2
ENST00000511435.1
PRELID2
PRELI domain containing 2
chr7_+_132937820 0.33 ENST00000393161.2
ENST00000253861.4
EXOC4
exocyst complex component 4
chr1_+_84630367 0.32 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_-_52715179 0.31 ENST00000293670.3
KRT83
keratin 83
chr11_+_63606373 0.30 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
MARK2
MAP/microtubule affinity-regulating kinase 2
chr8_+_97597148 0.29 ENST00000521590.1
SDC2
syndecan 2
chr1_-_45956822 0.29 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr17_-_73663168 0.28 ENST00000578201.1
ENST00000423245.2
RECQL5
RecQ protein-like 5
chr13_-_103719196 0.27 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr4_-_69111401 0.27 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr16_-_80926457 0.27 ENST00000563626.1
ENST00000562231.1
RP11-314O13.1
RP11-314O13.1
chr1_-_149783914 0.27 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
HIST2H2BF
histone cluster 2, H2bf
chr6_-_43021612 0.26 ENST00000535468.1
CUL7
cullin 7
chr13_-_45768841 0.23 ENST00000379108.1
KCTD4
potassium channel tetramerization domain containing 4
chr1_+_23037323 0.21 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
EPHB2
EPH receptor B2
chrX_+_115301975 0.20 ENST00000371906.4
AGTR2
angiotensin II receptor, type 2
chr1_+_52682052 0.18 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr6_+_27782788 0.18 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr3_+_68053359 0.18 ENST00000478136.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr12_+_8309630 0.17 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr8_+_77593448 0.16 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr17_-_39646116 0.16 ENST00000328119.6
KRT36
keratin 36
chr19_+_48497962 0.16 ENST00000596043.1
ENST00000597519.1
ELSPBP1
epididymal sperm binding protein 1
chr4_-_164534657 0.16 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr8_+_77593474 0.15 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr1_+_110993795 0.14 ENST00000271331.3
PROK1
prokineticin 1
chr19_+_48497901 0.14 ENST00000339841.2
ELSPBP1
epididymal sperm binding protein 1
chr16_-_71610985 0.14 ENST00000355962.4
TAT
tyrosine aminotransferase
chr14_-_51027838 0.14 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr5_-_126409159 0.14 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr15_+_71839566 0.13 ENST00000357769.4
THSD4
thrombospondin, type I, domain containing 4
chr3_-_150690786 0.12 ENST00000327047.1
CLRN1
clarin 1
chr16_+_30669720 0.11 ENST00000356166.6
FBRS
fibrosin
chr2_+_67624430 0.11 ENST00000272342.5
ETAA1
Ewing tumor-associated antigen 1
chr6_-_116833500 0.09 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr17_-_73663245 0.09 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
RECQL5
RecQ protein-like 5
chr1_-_151148492 0.09 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr11_+_118401706 0.08 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
TMEM25
transmembrane protein 25
chr19_-_5903714 0.08 ENST00000586349.1
ENST00000585661.1
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000252675.5
AC024592.12
NDUFA11
FUT5
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr9_-_14180778 0.08 ENST00000380924.1
ENST00000543693.1
NFIB
nuclear factor I/B
chr2_-_175629135 0.07 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr16_-_24942273 0.07 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr13_+_28813645 0.06 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr16_+_2205755 0.06 ENST00000326181.6
TRAF7
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
chr2_-_175629164 0.06 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr16_-_24942411 0.05 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr4_+_68424434 0.03 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr12_+_70219052 0.02 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr3_+_89156674 0.01 ENST00000336596.2
EPHA3
EPH receptor A3

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0042938 dipeptide transport(GO:0042938)
0.5 1.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.4 2.5 GO:0097338 response to clozapine(GO:0097338)
0.2 0.5 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.8 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 0.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 2.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.2 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.1 1.5 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.3 GO:0008218 bioluminescence(GO:0008218)
0.0 0.8 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.6 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.3 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.2 GO:1904783 positive regulation of NMDA glutamate receptor activity(GO:1904783)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 1.1 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 1.5 GO:0070268 cornification(GO:0070268)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 2.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:1990393 3M complex(GO:1990393)
0.0 0.8 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 2.7 GO:0005902 microvillus(GO:0005902)
0.0 2.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.3 2.6 GO:0004064 arylesterase activity(GO:0004064)
0.2 1.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 2.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.8 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.8 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.2 GO:0004945 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.5 GO:0005518 collagen binding(GO:0005518)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.8 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.9 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 2.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP