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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for HOXB2_UNCX_HOXD3
Z-value: 0.58
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Transcription factors associated with HOXB2_UNCX_HOXD3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD3 | hg19_v2_chr2_+_177015122_177015122 | -0.10 | 5.9e-01 | Click! |
| HOXB2 | hg19_v2_chr17_-_46623441_46623441 | -0.02 | 9.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_217804661 Show fit | 1.63 |
ENST00000366933.4
|
spermatogenesis associated 17 |
|
| chr12_+_7013897 Show fit | 1.61 |
ENST00000007969.8
ENST00000323702.5 |
leucine rich repeat containing 23 |
|
| chr12_+_7014064 Show fit | 1.59 |
ENST00000443597.2
|
leucine rich repeat containing 23 |
|
| chr3_-_141747950 Show fit | 1.35 |
ENST00000497579.1
|
transcription factor Dp-2 (E2F dimerization partner 2) |
|
| chrX_-_13835147 Show fit | 1.35 |
ENST00000493677.1
ENST00000355135.2 |
glycoprotein M6B |
|
| chr5_+_68860949 Show fit | 1.28 |
ENST00000507595.1
|
general transcription factor IIH, polypeptide 2C |
|
| chr6_-_76072719 Show fit | 1.19 |
ENST00000370020.1
|
filamin A interacting protein 1 |
|
| chr16_+_53133070 Show fit | 1.11 |
ENST00000565832.1
|
chromodomain helicase DNA binding protein 9 |
|
| chr8_-_10512569 Show fit | 1.06 |
ENST00000382483.3
|
retinitis pigmentosa 1-like 1 |
|
| chr6_+_153552455 Show fit | 0.96 |
ENST00000392385.2
|
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB2_UNCX_HOXD3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 2.1 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.1 | 1.9 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 1.5 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 1.5 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 1.4 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.0 | 1.4 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.1 | 1.3 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.1 | 1.0 | GO:0034144 | negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) |
| 0.1 | 1.0 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 2.2 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.4 | 1.7 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.0 | 1.7 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.0 | 1.5 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 1.3 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 1.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 1.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 1.1 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 1.1 | GO:0036038 | MKS complex(GO:0036038) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.1 | 1.5 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 1.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 1.0 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 1.0 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.8 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.0 | 0.8 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 0.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.8 | GO:0001948 | glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394) |
| 0.2 | 0.7 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 0.3 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.2 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.1 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.2 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.1 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.1 | 0.8 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.7 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 0.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |