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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HOXB4_LHX9

Z-value: 0.85

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Transcription factors associated with HOXB4_LHX9

Gene Symbol Gene ID Gene Info
HOXB4
ENSG00000182742.5 homeobox B4
LHX9
ENSG00000143355.11 LIM homeobox 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX9hg19_v2_chr1_+_197886461_1978865580.441.6e-02Click!
HOXB4hg19_v2_chr17_-_46657473_466574730.412.3e-02Click!

Activity profile of HOXB4_LHX9 motif

Sorted Z-values of HOXB4_LHX9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_105845674 4.66 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr4_-_39033963 4.09 ENST00000381938.3
TMEM156
transmembrane protein 156
chr11_-_107729887 3.90 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr2_+_102953608 3.74 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr10_+_6779326 3.56 ENST00000417112.1
RP11-554I8.2
RP11-554I8.2
chr2_-_161056762 3.33 ENST00000428609.2
ENST00000409967.2
ITGB6
integrin, beta 6
chr12_-_10978957 3.28 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr19_-_36001113 3.02 ENST00000434389.1
DMKN
dermokine
chr12_-_8803128 2.88 ENST00000543467.1
MFAP5
microfibrillar associated protein 5
chr2_-_161056802 2.83 ENST00000283249.2
ENST00000409872.1
ITGB6
integrin, beta 6
chr9_+_125133315 2.73 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_+_33061543 2.72 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chrX_+_43515467 2.60 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr12_-_10022735 2.36 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr11_-_121986923 2.32 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr7_+_134528635 2.25 ENST00000445569.2
CALD1
caldesmon 1
chr6_+_130339710 2.23 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr3_-_149095652 2.22 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr4_-_159956333 2.21 ENST00000434826.2
C4orf45
chromosome 4 open reading frame 45
chr18_+_29027696 2.18 ENST00000257189.4
DSG3
desmoglein 3
chr4_-_57547870 2.15 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr16_-_30122717 2.03 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr4_+_86525299 1.93 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr2_+_90211643 1.81 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr1_+_62439037 1.74 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr9_-_77567743 1.72 ENST00000376854.5
C9orf40
chromosome 9 open reading frame 40
chr8_-_125577940 1.71 ENST00000519168.1
ENST00000395508.2
MTSS1
metastasis suppressor 1
chr9_+_125132803 1.70 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_95640218 1.69 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484
zinc finger protein 484
chr2_+_182850743 1.68 ENST00000409702.1
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr14_-_67878917 1.66 ENST00000216446.4
PLEK2
pleckstrin 2
chr1_-_197115818 1.65 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr7_-_107642348 1.64 ENST00000393561.1
LAMB1
laminin, beta 1
chr4_+_169418255 1.56 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr4_-_39979576 1.53 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr2_+_102456277 1.52 ENST00000421882.1
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr18_+_21452964 1.50 ENST00000587184.1
LAMA3
laminin, alpha 3
chr14_+_56584414 1.49 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr9_+_124329336 1.49 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr6_+_42584847 1.47 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr12_-_22063787 1.45 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr12_+_26348582 1.43 ENST00000535504.1
SSPN
sarcospan
chr11_-_55703876 1.42 ENST00000301532.3
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr18_+_21452804 1.30 ENST00000269217.6
LAMA3
laminin, alpha 3
chr6_+_34204642 1.29 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr12_+_26348246 1.29 ENST00000422622.2
SSPN
sarcospan
chr12_+_26348429 1.28 ENST00000242729.2
SSPN
sarcospan
chr2_-_40680578 1.28 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr6_+_114178512 1.26 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr15_+_67418047 1.23 ENST00000540846.2
SMAD3
SMAD family member 3
chr7_+_107224364 1.23 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr4_-_109541539 1.21 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr2_+_90077680 1.17 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr14_-_106494587 1.16 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr11_+_35201826 1.16 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr20_-_56265680 1.15 ENST00000414037.1
PMEPA1
prostate transmembrane protein, androgen induced 1
chr2_+_90273679 1.14 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr5_+_89770664 1.13 ENST00000503973.1
ENST00000399107.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr11_-_104827425 1.12 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr5_+_89770696 1.09 ENST00000504930.1
ENST00000514483.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr6_-_82957433 1.08 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr2_+_182850551 1.08 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chrX_-_77225135 1.07 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr11_-_5323226 1.07 ENST00000380224.1
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr14_+_24641062 1.07 ENST00000311457.3
ENST00000557806.1
ENST00000559919.1
REC8
REC8 meiotic recombination protein
chr14_+_31046959 1.04 ENST00000547532.1
ENST00000555429.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr17_-_45266542 1.03 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr17_+_33914460 1.01 ENST00000537622.2
AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr1_+_152784447 0.98 ENST00000360090.3
LCE1B
late cornified envelope 1B
chr2_-_89327228 0.98 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr7_+_134430212 0.97 ENST00000436461.2
CALD1
caldesmon 1
chrX_-_100662881 0.97 ENST00000218516.3
GLA
galactosidase, alpha
chr4_-_103997862 0.97 ENST00000394785.3
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr15_+_94899183 0.94 ENST00000557742.1
MCTP2
multiple C2 domains, transmembrane 2
chr22_+_46476192 0.92 ENST00000443490.1
FLJ27365
hsa-mir-4763
chr17_-_57229155 0.92 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr4_+_72897521 0.88 ENST00000308744.6
ENST00000344413.5
NPFFR2
neuropeptide FF receptor 2
chr6_+_47749718 0.87 ENST00000489301.2
ENST00000371211.2
ENST00000393699.2
OPN5
opsin 5
chr11_+_133938820 0.86 ENST00000299106.4
ENST00000529443.2
JAM3
junctional adhesion molecule 3
chr7_-_144435985 0.85 ENST00000549981.1
TPK1
thiamin pyrophosphokinase 1
chr5_-_125930929 0.84 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr2_-_130031335 0.83 ENST00000375987.3
AC079586.1
AC079586.1
chr2_-_89385283 0.82 ENST00000390252.2
IGKV3-15
immunoglobulin kappa variable 3-15
chr1_-_67266939 0.82 ENST00000304526.2
INSL5
insulin-like 5
chr1_+_155278625 0.80 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr19_-_3557570 0.80 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr14_-_106552755 0.79 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr2_+_234637754 0.78 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chrX_-_18690210 0.77 ENST00000379984.3
RS1
retinoschisin 1
chr1_-_201140673 0.77 ENST00000367333.2
TMEM9
transmembrane protein 9
chr7_-_87342564 0.77 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr4_-_120243545 0.77 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chrX_+_44703249 0.76 ENST00000339042.4
DUSP21
dual specificity phosphatase 21
chr14_+_22670455 0.76 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chrX_-_21676442 0.76 ENST00000379499.2
KLHL34
kelch-like family member 34
chr20_+_30697298 0.76 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr1_+_155278539 0.75 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr2_-_88285309 0.74 ENST00000420840.2
RGPD2
RANBP2-like and GRIP domain containing 2
chr4_-_69111401 0.73 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr18_-_24443151 0.73 ENST00000440832.3
AQP4
aquaporin 4
chr14_+_103851712 0.73 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr13_-_24007815 0.73 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr14_+_35591858 0.72 ENST00000603544.1
KIAA0391
KIAA0391
chr3_-_185538849 0.72 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr5_+_57787254 0.72 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GAPT
GRB2-binding adaptor protein, transmembrane
chr17_-_39743139 0.71 ENST00000167586.6
KRT14
keratin 14
chr1_+_115572415 0.70 ENST00000256592.1
TSHB
thyroid stimulating hormone, beta
chr11_-_14913190 0.70 ENST00000532378.1
CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr10_+_18549645 0.69 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr11_+_55594695 0.68 ENST00000378397.1
OR5L2
olfactory receptor, family 5, subfamily L, member 2
chr4_-_90757364 0.68 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chrX_+_37639302 0.68 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr3_-_141747950 0.68 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr10_+_696000 0.67 ENST00000381489.5
PRR26
proline rich 26
chrX_-_71458802 0.66 ENST00000373657.1
ENST00000334463.3
ERCC6L
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
chr13_+_32313658 0.66 ENST00000380314.1
ENST00000298386.2
RXFP2
relaxin/insulin-like family peptide receptor 2
chr1_+_225600404 0.66 ENST00000366845.2
AC092811.1
AC092811.1
chr4_+_71091786 0.65 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr6_+_29079668 0.65 ENST00000377169.1
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr4_+_169552748 0.65 ENST00000504519.1
ENST00000512127.1
PALLD
palladin, cytoskeletal associated protein
chr3_+_139063372 0.65 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr3_-_20053741 0.64 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr17_+_33914276 0.63 ENST00000592545.1
ENST00000538556.1
ENST00000312678.8
ENST00000589344.1
AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr4_-_185275104 0.61 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr5_-_16916624 0.60 ENST00000513882.1
MYO10
myosin X
chr4_+_119810134 0.60 ENST00000434046.2
SYNPO2
synaptopodin 2
chr13_-_36050819 0.59 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr4_-_103749205 0.59 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chrX_+_7137475 0.59 ENST00000217961.4
STS
steroid sulfatase (microsomal), isozyme S
chr3_+_111718173 0.59 ENST00000494932.1
TAGLN3
transgelin 3
chr11_+_89764274 0.58 ENST00000448984.1
ENST00000432771.1
TRIM49C
tripartite motif containing 49C
chr8_-_42623747 0.58 ENST00000534622.1
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr8_-_49833978 0.58 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr2_+_219472488 0.57 ENST00000450993.2
PLCD4
phospholipase C, delta 4
chr14_-_106668095 0.57 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr8_-_30670384 0.56 ENST00000221138.4
ENST00000518243.1
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr4_+_169418195 0.56 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr12_+_8309630 0.56 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr15_-_91565743 0.56 ENST00000535843.1
VPS33B
vacuolar protein sorting 33 homolog B (yeast)
chr4_-_103749179 0.55 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr14_-_72458326 0.55 ENST00000542853.1
AC005477.1
AC005477.1
chr10_+_5135981 0.54 ENST00000380554.3
AKR1C3
aldo-keto reductase family 1, member C3
chr15_+_66679155 0.54 ENST00000307102.5
MAP2K1
mitogen-activated protein kinase kinase 1
chr7_+_115862858 0.54 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr15_-_20193370 0.54 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr15_-_25823938 0.53 ENST00000422117.1
AC124997.1
AC124997.1
chr10_-_58120996 0.52 ENST00000361148.6
ENST00000395405.1
ENST00000373944.3
ZWINT
ZW10 interacting kinetochore protein
chr1_-_211307404 0.52 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr6_+_29429217 0.52 ENST00000396792.2
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr18_-_44181442 0.51 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr4_-_103998439 0.51 ENST00000503230.1
ENST00000503818.1
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chrX_-_100872911 0.51 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr4_+_156587853 0.50 ENST00000506455.1
ENST00000511108.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr7_-_111032971 0.50 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr15_-_91565770 0.50 ENST00000535906.1
ENST00000333371.3
VPS33B
vacuolar protein sorting 33 homolog B (yeast)
chr4_-_119759795 0.50 ENST00000419654.2
SEC24D
SEC24 family member D
chr17_+_39394250 0.50 ENST00000254072.6
KRTAP9-8
keratin associated protein 9-8
chr14_-_39639523 0.50 ENST00000330149.5
ENST00000554018.1
ENST00000347691.5
TRAPPC6B
trafficking protein particle complex 6B
chr3_-_164796269 0.49 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr17_-_72772462 0.48 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr11_-_89541743 0.48 ENST00000329758.1
TRIM49
tripartite motif containing 49
chr19_-_36304201 0.48 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr11_-_117186946 0.48 ENST00000313005.6
ENST00000528053.1
BACE1
beta-site APP-cleaving enzyme 1
chr19_-_44388116 0.47 ENST00000587539.1
ZNF404
zinc finger protein 404
chr8_-_49834299 0.47 ENST00000396822.1
SNAI2
snail family zinc finger 2
chrX_+_1710484 0.47 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr2_-_225811747 0.47 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr14_-_51027838 0.46 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr9_-_21482312 0.46 ENST00000448696.3
IFNE
interferon, epsilon
chr16_+_33204980 0.46 ENST00000561509.1
TP53TG3C
TP53 target 3C
chr14_+_32798547 0.46 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr2_-_101925055 0.46 ENST00000295317.3
RNF149
ring finger protein 149
chr5_+_66300446 0.45 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_157963063 0.45 ENST00000360089.4
ENST00000368173.3
ENST00000392272.2
KIRREL
kin of IRRE like (Drosophila)
chr14_+_35591928 0.45 ENST00000605870.1
ENST00000557404.3
KIAA0391
KIAA0391
chr7_+_23145884 0.45 ENST00000409689.1
ENST00000410047.1
KLHL7
kelch-like family member 7
chr20_-_1447467 0.44 ENST00000353088.2
ENST00000350991.4
NSFL1C
NSFL1 (p97) cofactor (p47)
chrX_+_13671225 0.44 ENST00000545566.1
ENST00000544987.1
ENST00000314720.4
TCEANC
transcription elongation factor A (SII) N-terminal and central domain containing
chr5_-_176889381 0.44 ENST00000393563.4
ENST00000512501.1
DBN1
drebrin 1
chrX_+_120181457 0.44 ENST00000328078.1
GLUD2
glutamate dehydrogenase 2
chr2_+_102615416 0.43 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr4_-_103749313 0.43 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr22_-_32766972 0.43 ENST00000382084.4
ENST00000382086.2
RFPL3S
RFPL3 antisense
chr3_+_111718036 0.43 ENST00000455401.2
TAGLN3
transgelin 3
chr14_-_107049312 0.42 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr7_+_141438118 0.42 ENST00000265304.6
ENST00000498107.1
ENST00000467681.1
ENST00000465582.1
ENST00000463093.1
SSBP1
single-stranded DNA binding protein 1, mitochondrial
chr9_-_77643307 0.42 ENST00000376834.3
ENST00000376830.3
C9orf41
chromosome 9 open reading frame 41
chr6_-_38670897 0.42 ENST00000373365.4
GLO1
glyoxalase I
chr2_-_15701422 0.42 ENST00000441750.1
ENST00000281513.5
NBAS
neuroblastoma amplified sequence
chr2_+_87565634 0.42 ENST00000421835.2
IGKV3OR2-268
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr14_+_95027772 0.42 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr1_-_198509804 0.42 ENST00000489986.1
ENST00000367382.1
ATP6V1G3
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
chr6_+_129204337 0.42 ENST00000421865.2
LAMA2
laminin, alpha 2
chr1_+_161691353 0.42 ENST00000367948.2
FCRLB
Fc receptor-like B
chr2_+_90248739 0.41 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr14_+_35591735 0.41 ENST00000604948.1
ENST00000605201.1
ENST00000250377.7
ENST00000321130.10
ENST00000534898.4
KIAA0391
KIAA0391
chr2_-_90538397 0.41 ENST00000443397.3
RP11-685N3.1
Uncharacterized protein
chr11_+_59522837 0.41 ENST00000437946.2
STX3
syntaxin 3
chr11_+_12766583 0.40 ENST00000361985.2
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr18_-_51751132 0.40 ENST00000256429.3
MBD2
methyl-CpG binding domain protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB4_LHX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.7 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.6 6.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.5 1.6 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.5 3.0 GO:1903575 cornified envelope assembly(GO:1903575)
0.4 1.6 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.4 1.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3 1.6 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.3 1.6 GO:0033384 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.3 1.5 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 1.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.3 1.7 GO:0030035 microspike assembly(GO:0030035)
0.3 8.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 0.8 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.3 5.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 1.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.3 1.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.2 1.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 1.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 1.8 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.2 0.8 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.2 0.9 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.2 0.9 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.2 1.1 GO:0070889 platelet alpha granule organization(GO:0070889)
0.2 1.6 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.2 0.7 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.2 2.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 0.5 GO:0061300 cerebellum vasculature development(GO:0061300)
0.2 2.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 0.8 GO:0070980 biphenyl catabolic process(GO:0070980)
0.1 1.2 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.7 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 0.7 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 0.7 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1 1.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 0.4 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 1.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 2.8 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.3 GO:1904956 neural crest cell fate commitment(GO:0014034) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.1 0.8 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.1 0.4 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 0.6 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.1 1.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.9 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 1.0 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.4 GO:0006772 thiamine metabolic process(GO:0006772)
0.1 0.8 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.5 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.1 1.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.4 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.1 0.5 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 0.4 GO:0061107 seminal vesicle development(GO:0061107)
0.1 3.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 2.1 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 2.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.1 GO:0070432 regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.1 1.1 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.5 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.3 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 1.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 2.9 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 0.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.4 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 2.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 0.4 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.1 2.2 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.8 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 0.2 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.1 0.2 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 1.0 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.3 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.1 1.3 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.3 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 2.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.4 GO:0009438 methylglyoxal metabolic process(GO:0009438)
0.0 0.4 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.4 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.4 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 6.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.8 GO:0009642 response to light intensity(GO:0009642)
0.0 4.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.4 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.0 0.2 GO:0006203 dGTP catabolic process(GO:0006203)
0.0 0.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.2 GO:0014901 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.0 0.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.6 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.9 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 1.5 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:1900112 regulation of histone H3-K9 trimethylation(GO:1900112)
0.0 0.8 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.0 0.2 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.4 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.7 GO:0006833 water transport(GO:0006833)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0003162 atrioventricular node development(GO:0003162)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.7 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.7 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.2 GO:0046425 regulation of JAK-STAT cascade(GO:0046425) regulation of STAT cascade(GO:1904892)
0.0 0.7 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.6 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.3 GO:0046606 negative regulation of centrosome cycle(GO:0046606)
0.0 0.2 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.2 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) chromatin silencing at telomere(GO:0006348) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.2 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.8 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.7 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 0.3 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.2 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.1 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 2.9 GO:0031424 keratinization(GO:0031424)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.9 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.2 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 6.8 GO:0006936 muscle contraction(GO:0006936)
0.0 0.1 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.4 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 0.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 1.1 GO:0051283 release of sequestered calcium ion into cytosol(GO:0051209) negative regulation of sequestering of calcium ion(GO:0051283)
0.0 0.0 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.4 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 0.5 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.4 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 1.7 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.9 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.1 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.4 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.4 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 0.3 GO:0006625 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.5 1.6 GO:0005607 laminin-2 complex(GO:0005607)
0.5 1.5 GO:1990032 parallel fiber(GO:1990032)
0.4 2.8 GO:0005610 laminin-5 complex(GO:0005610)
0.3 1.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 1.5 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.3 1.1 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.3 1.6 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.2 3.2 GO:0030478 actin cap(GO:0030478)
0.2 4.7 GO:0030056 hemidesmosome(GO:0030056)
0.2 1.6 GO:0036449 microtubule minus-end(GO:0036449)
0.2 0.7 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.2 0.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.2 1.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 1.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.4 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.4 GO:0036024 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 1.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 2.9 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 4.1 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.4 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.1 0.8 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.3 GO:0005873 plus-end kinesin complex(GO:0005873)
0.1 0.3 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 3.0 GO:0030057 desmosome(GO:0030057)
0.1 0.3 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 2.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 2.8 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.7 GO:0070852 cell body fiber(GO:0070852)
0.1 1.6 GO:0036020 endolysosome membrane(GO:0036020)
0.1 0.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 5.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.8 GO:0002102 podosome(GO:0002102)
0.0 0.6 GO:0005869 dynactin complex(GO:0005869)
0.0 0.7 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.6 GO:0032433 filopodium tip(GO:0032433)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.3 GO:0031526 brush border membrane(GO:0031526)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 1.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.7 GO:0031092 nuclear outer membrane(GO:0005640) platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0005921 gap junction(GO:0005921)
0.0 0.6 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:0043204 perikaryon(GO:0043204)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.4 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 4.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0005605 basal lamina(GO:0005605)
0.0 0.4 GO:0001533 cornified envelope(GO:0001533)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 1.9 GO:0072562 blood microparticle(GO:0072562)
0.0 2.7 GO:0005741 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0002113 interleukin-33 binding(GO:0002113)
1.1 4.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.5 1.5 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.4 1.8 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.3 2.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 1.6 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.3 1.9 GO:0070728 leucine binding(GO:0070728)
0.3 1.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.3 1.1 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 1.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 1.0 GO:0016936 galactoside binding(GO:0016936)
0.2 1.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 2.8 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 1.5 GO:0004111 creatine kinase activity(GO:0004111)
0.2 1.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.2 0.7 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.2 0.5 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.2 0.5 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.2 0.8 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 3.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.7 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.5 GO:0047023 androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.1 0.9 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 2.1 GO:0005549 odorant binding(GO:0005549)
0.1 0.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 3.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.8 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.7 GO:1990254 keratin filament binding(GO:1990254)
0.1 3.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.4 GO:0004802 transketolase activity(GO:0004802)
0.1 0.4 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1 0.7 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.4 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 1.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.6 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 1.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.6 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.2 GO:0035539 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
0.1 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.1 GO:0046978 peptide antigen-transporting ATPase activity(GO:0015433) TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.1 0.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 1.1 GO:0050700 CARD domain binding(GO:0050700)
0.1 5.7 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0032190 acrosin binding(GO:0032190)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.8 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.7 GO:0015250 water channel activity(GO:0015250)
0.0 2.2 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 3.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.7 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.4 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 7.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.3 GO:0089720 caspase binding(GO:0089720)
0.0 1.6 GO:0050699 WW domain binding(GO:0050699)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 2.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 1.3 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.6 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.6 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.9 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.2 GO:0030547 receptor inhibitor activity(GO:0030547)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.5 GO:0017022 myosin binding(GO:0017022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 6.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 4.7 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.9 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 3.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.1 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.4 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.1 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.5 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.6 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.8 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.5 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 0.6 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 1.0 REACTOME OPSINS Genes involved in Opsins
0.1 1.6 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 9.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 7.8 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 1.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.9 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 0.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 0.5 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 5.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 3.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 4.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.7 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 1.5 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.4 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.8 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 1.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.7 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 0.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 2.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 2.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors