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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HOXB5

Z-value: 0.67

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.5 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_466713230.251.8e-01Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_133097902 5.77 ENST00000262283.5
OC90
Otoconin-90
chr19_-_16045220 3.62 ENST00000326742.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr17_+_46970178 0.96 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr17_+_46970134 0.94 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr19_-_50143452 0.92 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr17_+_46970127 0.89 ENST00000355938.5
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr12_+_56915776 0.79 ENST00000550726.1
ENST00000542360.1
RBMS2
RNA binding motif, single stranded interacting protein 2
chr16_-_84651647 0.76 ENST00000564057.1
COTL1
coactosin-like 1 (Dictyostelium)
chr3_-_195538760 0.74 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr12_+_56915713 0.64 ENST00000262031.5
ENST00000552247.2
RBMS2
RNA binding motif, single stranded interacting protein 2
chr12_+_66217911 0.61 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr10_-_103603523 0.60 ENST00000370046.1
KCNIP2
Kv channel interacting protein 2
chr3_-_195538728 0.58 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chrX_+_135230712 0.53 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr1_+_4714792 0.53 ENST00000378190.3
AJAP1
adherens junctions associated protein 1
chr3_-_164914640 0.50 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr11_-_125648690 0.50 ENST00000436890.2
ENST00000358524.3
PATE2
prostate and testis expressed 2
chr15_-_75017711 0.43 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chrX_+_47077632 0.43 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr6_+_121756809 0.42 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr7_-_102252038 0.41 ENST00000461209.1
RASA4
RAS p21 protein activator 4
chr16_+_31539197 0.40 ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr1_+_155579979 0.40 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr2_-_47168850 0.36 ENST00000409207.1
MCFD2
multiple coagulation factor deficiency 2
chrM_+_12331 0.34 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr3_-_127541194 0.34 ENST00000453507.2
MGLL
monoglyceride lipase
chr1_-_161193349 0.34 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr6_-_29395509 0.32 ENST00000377147.2
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr2_-_47168906 0.32 ENST00000444761.2
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2
chr6_-_29396243 0.30 ENST00000377148.1
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr17_-_17140436 0.30 ENST00000285071.4
ENST00000389169.5
ENST00000417064.1
FLCN
folliculin
chr3_-_128186091 0.28 ENST00000319153.3
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr1_+_154975110 0.27 ENST00000535420.1
ENST00000368426.3
ZBTB7B
zinc finger and BTB domain containing 7B
chr3_+_51422478 0.27 ENST00000528157.1
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr15_+_74218787 0.25 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chrX_+_48380205 0.24 ENST00000446158.1
ENST00000414061.1
EBP
emopamil binding protein (sterol isomerase)
chr13_-_64650144 0.24 ENST00000456627.1
LINC00355
long intergenic non-protein coding RNA 355
chr7_+_5322561 0.22 ENST00000396872.3
ENST00000444741.1
ENST00000297195.4
ENST00000406453.3
SLC29A4
solute carrier family 29 (equilibrative nucleoside transporter), member 4
chrX_-_139587225 0.22 ENST00000370536.2
SOX3
SRY (sex determining region Y)-box 3
chr11_-_57089671 0.21 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr18_-_33077556 0.21 ENST00000589273.1
ENST00000586489.1
INO80C
INO80 complex subunit C
chr2_+_17721920 0.21 ENST00000295156.4
VSNL1
visinin-like 1
chr3_+_45986511 0.21 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr6_-_31869769 0.20 ENST00000375527.2
ZBTB12
zinc finger and BTB domain containing 12
chr12_-_53614155 0.20 ENST00000543726.1
RARG
retinoic acid receptor, gamma
chr16_-_30102547 0.19 ENST00000279386.2
TBX6
T-box 6
chr1_+_41157421 0.19 ENST00000372654.1
NFYC
nuclear transcription factor Y, gamma
chr17_-_42143963 0.18 ENST00000585388.1
ENST00000293406.3
LSM12
LSM12 homolog (S. cerevisiae)
chr6_-_97285336 0.18 ENST00000229955.3
ENST00000417980.1
GPR63
G protein-coupled receptor 63
chr10_-_103603568 0.18 ENST00000356640.2
KCNIP2
Kv channel interacting protein 2
chr12_-_53614043 0.17 ENST00000338561.5
RARG
retinoic acid receptor, gamma
chr1_+_116915855 0.17 ENST00000295598.5
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr14_+_21945335 0.15 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX4
TOX high mobility group box family member 4
chr11_-_35440579 0.15 ENST00000606205.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_+_167525277 0.14 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr7_+_120969045 0.14 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr16_-_58004992 0.13 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1
cyclic nucleotide gated channel beta 1
chr20_-_6034672 0.13 ENST00000378858.4
LRRN4
leucine rich repeat neuronal 4
chr1_+_162351503 0.13 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr2_-_188430478 0.13 ENST00000421427.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr1_+_146373546 0.13 ENST00000446760.2
NBPF12
neuroblastoma breakpoint family, member 12
chr17_+_6679528 0.13 ENST00000321535.4
FBXO39
F-box protein 39
chr17_+_2496971 0.12 ENST00000397195.5
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr1_+_41157361 0.11 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
NFYC
nuclear transcription factor Y, gamma
chr20_-_3687775 0.11 ENST00000344754.4
ENST00000202578.4
SIGLEC1
sialic acid binding Ig-like lectin 1, sialoadhesin
chr6_-_32820529 0.10 ENST00000425148.2
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_-_52715179 0.09 ENST00000293670.3
KRT83
keratin 83
chr1_+_206317450 0.09 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
CTSE
cathepsin E
chr13_-_54706954 0.08 ENST00000606706.1
ENST00000607494.1
ENST00000427299.2
ENST00000423442.2
ENST00000451744.1
LINC00458
long intergenic non-protein coding RNA 458
chr19_-_12267524 0.08 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
ZNF625
zinc finger protein 625
chr9_+_4662282 0.08 ENST00000381883.2
PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
chr12_-_56101647 0.08 ENST00000347027.6
ENST00000257879.6
ENST00000257880.7
ENST00000394230.2
ENST00000394229.2
ITGA7
integrin, alpha 7
chr8_+_118147498 0.07 ENST00000519688.1
ENST00000456015.2
SLC30A8
solute carrier family 30 (zinc transporter), member 8
chr7_+_130020932 0.06 ENST00000484324.1
CPA1
carboxypeptidase A1 (pancreatic)
chr15_-_49103235 0.06 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr16_-_30381580 0.06 ENST00000409939.3
TBC1D10B
TBC1 domain family, member 10B
chr11_+_4664650 0.05 ENST00000396952.5
OR51E1
olfactory receptor, family 51, subfamily E, member 1
chr12_+_53693466 0.05 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10
chr17_-_29233769 0.04 ENST00000581216.1
TEFM
transcription elongation factor, mitochondrial
chr7_+_155090271 0.04 ENST00000476756.1
INSIG1
insulin induced gene 1
chr17_-_29233221 0.03 ENST00000580840.1
TEFM
transcription elongation factor, mitochondrial
chr4_-_68620053 0.03 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr20_-_48184638 0.03 ENST00000244043.4
PTGIS
prostaglandin I2 (prostacyclin) synthase
chr3_+_130613226 0.03 ENST00000509662.1
ENST00000328560.8
ENST00000428331.2
ENST00000359644.3
ENST00000422190.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chrX_+_103411189 0.02 ENST00000493442.1
FAM199X
family with sequence similarity 199, X-linked
chr5_-_35048047 0.02 ENST00000231420.6
AGXT2
alanine--glyoxylate aminotransferase 2
chr1_-_119530428 0.02 ENST00000369429.3
TBX15
T-box 15
chr5_+_149569520 0.02 ENST00000230671.2
ENST00000524041.1
SLC6A7
solute carrier family 6 (neurotransmitter transporter), member 7
chr6_-_31509714 0.02 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr1_+_41157671 0.01 ENST00000534399.1
ENST00000372653.1
NFYC
nuclear transcription factor Y, gamma
chr1_-_155658518 0.01 ENST00000404643.1
ENST00000359205.5
ENST00000407221.1
YY1AP1
YY1 associated protein 1
chr8_-_93107827 0.00 ENST00000520724.1
ENST00000518844.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.2 0.5 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.2 0.6 GO:2000685 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.1 0.4 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.1 0.4 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.1 5.8 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 0.3 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 2.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.3 GO:2001170 negative regulation of energy homeostasis(GO:2000506) negative regulation of ATP biosynthetic process(GO:2001170)
0.1 0.4 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.3 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 1.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.2 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.2 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.1 GO:0046967 cytosol to ER transport(GO:0046967)
0.0 0.2 GO:0090032 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.0 0.1 GO:0046469 platelet activating factor metabolic process(GO:0046469)
0.0 0.9 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.4 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.8 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.4 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.0 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.3 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.0 0.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.3 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.2 GO:1901642 nucleoside transmembrane transport(GO:1901642)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)
0.0 0.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.3 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.2 0.6 GO:0035501 MH1 domain binding(GO:0035501)
0.1 5.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 2.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.4 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.1 0.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 3.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.4 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.3 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.1 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.0 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.1 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.2 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 4.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis