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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for HOXB6_PRRX2
Z-value: 0.97
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Transcription factors associated with HOXB6_PRRX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRRX2 | hg19_v2_chr9_+_132427883_132427951 | -0.22 | 2.5e-01 | Click! |
| HOXB6 | hg19_v2_chr17_-_46682321_46682362 | 0.11 | 5.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_135251783 Show fit | 3.59 |
ENST00000394153.2
|
four and a half LIM domains 1 |
|
| chrX_+_135252050 Show fit | 3.31 |
ENST00000449474.1
ENST00000345434.3 |
four and a half LIM domains 1 |
|
| chrX_+_135251835 Show fit | 3.31 |
ENST00000456445.1
|
four and a half LIM domains 1 |
|
| chrX_+_135279179 Show fit | 3.11 |
ENST00000370676.3
|
four and a half LIM domains 1 |
|
| chr1_+_50569575 Show fit | 2.76 |
ENST00000371827.1
|
ELAV like neuron-specific RNA binding protein 4 |
|
| chr2_-_161056762 Show fit | 2.47 |
ENST00000428609.2
ENST00000409967.2 |
integrin, beta 6 |
|
| chr12_-_122240792 Show fit | 2.44 |
ENST00000545885.1
ENST00000542933.1 ENST00000428029.2 ENST00000541694.1 ENST00000536662.1 ENST00000535643.1 ENST00000541657.1 |
AC084018.1 ras homolog family member F (in filopodia) |
|
| chr2_-_216257849 Show fit | 2.40 |
ENST00000456923.1
|
fibronectin 1 |
|
| chr2_+_54785485 Show fit | 2.35 |
ENST00000333896.5
|
spectrin, beta, non-erythrocytic 1 |
|
| chr12_-_89746173 Show fit | 2.23 |
ENST00000308385.6
|
dual specificity phosphatase 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB6_PRRX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.3 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.1 | 6.9 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.1 | 4.8 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.4 | 3.9 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 0.7 | 2.9 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.1 | 2.7 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.3 | 2.6 | GO:2000543 | positive regulation of gastrulation(GO:2000543) |
| 0.8 | 2.4 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.2 | 2.3 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.7 | 2.2 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 5.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 5.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 4.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.3 | 3.9 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.1 | 3.9 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.3 | 3.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 3.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.8 | 3.3 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.4 | 2.9 | GO:0032437 | cuticular plate(GO:0032437) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.6 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 5.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 4.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 4.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 4.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 4.0 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 3.9 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 3.9 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 3.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 3.2 | GO:0030506 | ankyrin binding(GO:0030506) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.9 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 3.6 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 3.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 3.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 3.0 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 2.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 2.6 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.3 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 4.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 4.0 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 3.2 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 2.9 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 2.9 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 2.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |