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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for HOXC8
Z-value: 1.08
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Transcription factors associated with HOXC8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXC8 | hg19_v2_chr12_+_54402790_54402832 | 0.34 | 6.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_46655538 Show fit | 9.32 |
ENST00000303383.3
|
SHC SH2-domain binding protein 1 |
|
| chr8_-_27695552 Show fit | 5.61 |
ENST00000522944.1
ENST00000301905.4 |
PDZ binding kinase |
|
| chr1_-_153113927 Show fit | 5.58 |
ENST00000368752.4
|
small proline-rich protein 2B |
|
| chr1_+_120839412 Show fit | 5.15 |
ENST00000355228.4
|
family with sequence similarity 72, member B |
|
| chr1_-_153066998 Show fit | 5.06 |
ENST00000368750.3
|
small proline-rich protein 2E |
|
| chr6_+_151646800 Show fit | 4.90 |
ENST00000354675.6
|
A kinase (PRKA) anchor protein 12 |
|
| chr1_-_153085984 Show fit | 4.74 |
ENST00000468739.1
|
small proline-rich protein 2F |
|
| chr1_+_206138884 Show fit | 4.69 |
ENST00000341209.5
ENST00000607379.1 |
family with sequence similarity 72, member A |
|
| chr1_+_45205478 Show fit | 4.65 |
ENST00000452259.1
ENST00000372224.4 |
kinesin family member 2C |
|
| chr17_+_62223320 Show fit | 4.25 |
ENST00000580828.1
ENST00000582965.1 |
small nucleolar RNA, H/ACA box 76 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.2 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 11.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 8.7 | GO:2000177 | regulation of neural precursor cell proliferation(GO:2000177) |
| 0.9 | 8.5 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 7.8 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.5 | 7.6 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.1 | 7.1 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.5 | 6.9 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 6.3 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
| 0.1 | 5.2 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 16.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.4 | 16.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 10.1 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 8.4 | GO:0030496 | midbody(GO:0030496) |
| 0.1 | 5.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.7 | 4.9 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.4 | 4.9 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 4.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 1.5 | 4.5 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.4 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 17.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 10.7 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.2 | 9.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.8 | 8.4 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.4 | 6.9 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 6.6 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.4 | 6.2 | GO:0005549 | odorant binding(GO:0005549) |
| 0.6 | 5.5 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.2 | 5.5 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.1 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 5.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 4.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.3 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 4.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.2 | 3.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 3.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.0 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.3 | 11.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 7.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 7.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 5.6 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 4.9 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 4.5 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 4.4 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.2 | 4.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 4.1 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |