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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HOXD1

Z-value: 0.50

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
ENSG00000128645.11 homeobox D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg19_v2_chr2_+_177053307_177053402-0.301.1e-01Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_101918153 3.46 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
chromosome 11 open reading frame 70
chr13_+_36050881 2.81 ENST00000537702.1
neurobeachin
chr2_+_228736335 2.43 ENST00000440997.1
ENST00000545118.1
dynein assembly factor with WDR repeat domains 1
chr11_+_71900703 1.87 ENST00000393681.2
folate receptor 1 (adult)
chr11_+_71900572 1.82 ENST00000312293.4
folate receptor 1 (adult)
chr11_-_26593779 1.69 ENST00000529533.1
mucin 15, cell surface associated
chr11_-_26593649 1.19 ENST00000455601.2
mucin 15, cell surface associated
chr5_-_96478466 1.10 ENST00000274382.4
Lix1 homolog (chicken)
chr11_-_26593677 1.05 ENST00000527569.1
mucin 15, cell surface associated
chr4_-_25865159 1.05 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr7_+_133812052 0.96 ENST00000285928.2
leucine-rich repeats and guanylate kinase domain containing
chr14_+_74034310 0.83 ENST00000538782.1
acyl-CoA thioesterase 2
chr20_-_50418972 0.83 ENST00000395997.3
spalt-like transcription factor 4
chr20_-_50418947 0.78 ENST00000371539.3
spalt-like transcription factor 4
chr7_+_99717230 0.76 ENST00000262932.3
canopy FGF signaling regulator 4
chrX_+_77154935 0.72 ENST00000481445.1
cytochrome c oxidase subunit VIIb
chrX_+_77166172 0.70 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATPase, Cu++ transporting, alpha polypeptide
chr9_-_5339873 0.69 ENST00000223862.1
ENST00000223858.4
relaxin 1
chr20_+_43990576 0.66 ENST00000372727.1
ENST00000414310.1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr20_-_50419055 0.65 ENST00000217086.4
spalt-like transcription factor 4
chr4_-_74486109 0.61 ENST00000395777.2
Ras association (RalGDS/AF-6) domain family member 6
chr15_-_37393406 0.60 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr4_-_138453559 0.57 ENST00000511115.1
protocadherin 18
chr12_+_109577202 0.52 ENST00000377848.3
ENST00000377854.5
acetyl-CoA carboxylase beta
chr12_-_23737534 0.52 ENST00000396007.2
SRY (sex determining region Y)-box 5
chr16_+_53133070 0.47 ENST00000565832.1
chromodomain helicase DNA binding protein 9
chr4_-_74486347 0.41 ENST00000342081.3
Ras association (RalGDS/AF-6) domain family member 6
chr1_-_151431647 0.39 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
pogo transposable element with ZNF domain
chr4_-_150736962 0.39 ENST00000502345.1
ENST00000510975.1
ENST00000511993.1
RP11-526A4.1
chr7_-_73256838 0.38 ENST00000297873.4
Williams Beuren syndrome chromosome region 27
chr10_-_27529486 0.36 ENST00000375888.1
acyl-CoA binding domain containing 5
chr4_+_113568207 0.35 ENST00000511529.1
La ribonucleoprotein domain family, member 7
chr3_+_2933893 0.34 ENST00000397459.2
contactin 4
chr19_+_50016610 0.33 ENST00000596975.1
Fc fragment of IgG, receptor, transporter, alpha
chr10_-_72142345 0.33 ENST00000373224.1
ENST00000446961.1
ENST00000358141.2
ENST00000357631.2
leucine rich repeat containing 20
chr11_-_62521614 0.33 ENST00000527994.1
ENST00000394807.3
zinc finger and BTB domain containing 3
chr11_-_102651343 0.32 ENST00000279441.4
ENST00000539681.1
matrix metallopeptidase 10 (stromelysin 2)
chr1_-_151431909 0.30 ENST00000361398.3
ENST00000271715.2
pogo transposable element with ZNF domain
chr13_+_78315295 0.30 ENST00000351546.3
SLAIN motif family, member 1
chr5_-_20575959 0.25 ENST00000507958.1
cadherin 18, type 2
chr11_+_73498898 0.21 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
mitochondrial ribosomal protein L48
chr4_-_74486217 0.20 ENST00000335049.5
ENST00000307439.5
Ras association (RalGDS/AF-6) domain family member 6
chr1_-_232651312 0.19 ENST00000262861.4
signal-induced proliferation-associated 1 like 2
chr3_+_111717600 0.17 ENST00000273368.4
transgelin 3
chr11_-_95657231 0.16 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
myotubularin related protein 2
chr3_-_126327398 0.15 ENST00000383572.2
thioredoxin reductase 3 neighbor
chr7_-_99717463 0.15 ENST00000437822.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr3_+_111717511 0.15 ENST00000478951.1
ENST00000393917.2
transgelin 3
chr3_-_191000172 0.15 ENST00000427544.2
urotensin 2B
chr17_+_18086392 0.14 ENST00000541285.1
alkB, alkylation repair homolog 5 (E. coli)
chr1_-_190446759 0.13 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr4_-_138453606 0.12 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
protocadherin 18
chr3_+_111718036 0.12 ENST00000455401.2
transgelin 3
chr12_+_29376673 0.12 ENST00000547116.1
fatty acyl CoA reductase 2
chr8_+_55528627 0.12 ENST00000220676.1
retinitis pigmentosa 1 (autosomal dominant)
chr4_+_86748898 0.12 ENST00000509300.1
Rho GTPase activating protein 24
chr12_+_29376592 0.11 ENST00000182377.4
fatty acyl CoA reductase 2
chr1_-_112032284 0.11 ENST00000414219.1
adenosine A3 receptor
chr2_+_54350316 0.11 ENST00000606865.1
acylphosphatase 2, muscle type
chr4_+_86749045 0.10 ENST00000514229.1
Rho GTPase activating protein 24
chr7_-_99716952 0.09 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_+_148737562 0.08 ENST00000274569.4
prenylcysteine oxidase 1 like
chr7_+_148287657 0.08 ENST00000307003.2
chromosome 7 open reading frame 33
chr11_-_71823796 0.07 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
anaphase promoting complex subunit 15
chr5_+_63802109 0.06 ENST00000334025.2
regulator of G-protein signaling 7 binding protein
chr3_+_111718173 0.06 ENST00000494932.1
transgelin 3
chr11_-_71823266 0.06 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
anaphase promoting complex subunit 15
chr17_-_10372875 0.05 ENST00000255381.2
myosin, heavy chain 4, skeletal muscle
chr18_-_33709268 0.04 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
solute carrier family 39 (zinc transporter), member 6
chr11_-_71823715 0.03 ENST00000545944.1
ENST00000502597.2
anaphase promoting complex subunit 15
chr2_+_135596180 0.02 ENST00000283054.4
ENST00000392928.1
aminocarboxymuconate semialdehyde decarboxylase
chr1_-_92952433 0.02 ENST00000294702.5
growth factor independent 1 transcription repressor
chr5_+_66300446 0.01 ENST00000261569.7
microtubule associated serine/threonine kinase family member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.2 0.7 GO:0071284 cellular response to lead ion(GO:0071284)
0.2 2.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.5 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.1 0.5 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 3.9 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.7 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.2 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.3 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.8 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 1.1 GO:0097352 autophagosome maturation(GO:0097352)
0.0 2.4 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 1.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.3 GO:0007158 neuron cell-cell adhesion(GO:0007158)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 1.0 GO:0002177 manchette(GO:0002177)
0.0 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 3.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 2.3 GO:0000792 heterochromatin(GO:0000792)
0.0 0.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.2 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 3.4 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0061714 folic acid receptor activity(GO:0061714)
0.2 0.7 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.5 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.3 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases