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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ID4_TCF4_SNAI2
Z-value: 2.26
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Transcription factors associated with ID4_TCF4_SNAI2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000172201.6 | inhibitor of DNA binding 4, HLH protein | |
| ENSG00000196628.9 | transcription factor 4 | |
| ENSG00000019549.4 | snail family transcriptional repressor 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ID4 | hg19_v2_chr6_+_19837592_19837621 | 0.93 | 2.6e-13 | Click! |
| TCF4 | hg19_v2_chr18_-_53303123_53303190 | 0.85 | 3.2e-09 | Click! |
| SNAI2 | hg19_v2_chr8_-_49833978_49833996, hg19_v2_chr8_-_49834299_49834446 | -0.81 | 7.2e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ID4_TCF4_SNAI2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 48.3 | GO:2000768 | glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 1.4 | 44.0 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 3.6 | 36.4 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.4 | 30.9 | GO:0001895 | retina homeostasis(GO:0001895) |
| 4.0 | 20.2 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 1.8 | 20.2 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.5 | 18.1 | GO:0003341 | cilium movement(GO:0003341) |
| 0.3 | 18.1 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.2 | 17.0 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.7 | 16.2 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 56.3 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 2.6 | 47.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.2 | 27.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.0 | 21.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.6 | 17.1 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.2 | 16.3 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.4 | 15.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 14.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 13.1 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.2 | 12.3 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 53.9 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 24.2 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 5.3 | 21.3 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.9 | 20.7 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.9 | 17.7 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.4 | 16.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.4 | 14.6 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 2.6 | 12.8 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.1 | 11.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 11.0 | GO:0070840 | dynein complex binding(GO:0070840) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 34.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 14.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 12.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 10.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 7.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 6.9 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.5 | 5.9 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 5.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.4 | 5.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.4 | 5.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 24.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.2 | 22.3 | REACTOME SIGNALING BY NOTCH1 | Genes involved in Signaling by NOTCH1 |
| 0.0 | 18.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.7 | 15.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 15.0 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.4 | 14.8 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.8 | 14.5 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.4 | 14.4 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 1.2 | 13.0 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.2 | 10.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |