ISMARA results: IKZF1

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for IKZF1

Z-value: 2.21

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Transcription factors associated with IKZF1

Gene Symbol	Gene ID	Gene Info
IKZF1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000185811.12	IKAROS family zinc finger 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IKZF1	hg19_v2_chr7_+_50348268_50348366	0.54	2.0e-03	Click!

Activity profile of IKZF1 motif

Sorted Z-values of IKZF1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_51487282 Show fit	21.56	ENST00000595820.1 ENST00000597707.1 ENST00000336317.4	KLK7 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 7
chr19_-_51466681 Show fit	16.79	ENST00000456750.2	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6
chr19_-_51456198 Show fit	15.79	ENST00000594846.1	KLK5 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 5
chr19_-_51456344 Show fit	14.26	ENST00000336334.3 ENST00000593428.1	KLK5 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 5
chr19_-_51456321 Show fit	13.85	ENST00000391809.2	KLK5 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 5
chr22_+_31488433 Show fit	13.72	ENST00000455608.1	SMTN Ensembl NCBI GeneCards UniProt NextProt Show fit	smoothelin
chr19_-_51471381 Show fit	13.61	ENST00000594641.1	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6
chr12_-_57630873 Show fit	12.71	ENST00000556732.1	NDUFA4L2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr19_-_51471362 Show fit	12.01	ENST00000376853.4 ENST00000424910.2	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6
chr15_-_90039805 Show fit	10.15	ENST00000544600.1 ENST00000268122.4	RHCG Ensembl NCBI GeneCards UniProt NextProt Show fit	Rh family, C glycoprotein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of IKZF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	82.8	GO:0070268	cornification(GO:0070268)
12.0	72.3	GO:0002803	positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
2.4	52.3	GO:0016540	protein autoprocessing(GO:0016540)
3.9	31.4	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
1.1	28.5	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.9	26.8	GO:0031581	hemidesmosome assembly(GO:0031581)
0.2	23.4	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
1.0	22.2	GO:0032060	bleb assembly(GO:0032060)
1.0	21.0	GO:0071803	positive regulation of podosome assembly(GO:0071803)
1.0	19.1	GO:0000022	mitotic spindle elongation(GO:0000022)

Showing 1 to 10 of 1,613 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	91.7	GO:0005615	extracellular space(GO:0005615)
10.3	72.3	GO:0097209	epidermal lamellar body(GO:0097209)
0.2	66.4	GO:0030027	lamellipodium(GO:0030027)
0.9	61.0	GO:0001533	cornified envelope(GO:0001533)
0.1	52.2	GO:0005925	focal adhesion(GO:0005925)
2.2	41.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
1.2	29.2	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.1	26.5	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.2	24.1	GO:0005882	intermediate filament(GO:0005882)
0.6	22.6	GO:0035371	microtubule plus-end(GO:0035371)

Showing 1 to 10 of 496 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	185.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.6	68.8	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	53.2	GO:0045296	cadherin binding(GO:0045296)
0.2	44.9	GO:0051015	actin filament binding(GO:0051015)
0.1	38.3	GO:0005096	GTPase activator activity(GO:0005096)
0.2	35.2	GO:0030674	protein binding, bridging(GO:0030674)
0.2	31.3	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.7	26.0	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.3	23.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.5	20.7	GO:0005504	fatty acid binding(GO:0005504)

Showing 1 to 10 of 891 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	73.6	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.2	70.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	50.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.7	49.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.5	37.7	PID AURORA B PATHWAY	Aurora B signaling
1.5	20.7	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4	19.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4	19.6	PID IFNG PATHWAY	IFN-gamma pathway
0.3	18.4	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.4	18.2	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling

Showing 1 to 10 of 138 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	62.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	34.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.3	30.9	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
1.3	26.6	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.5	23.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.2	22.6	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.6	22.5	REACTOME KINESINS	Genes involved in Kinesins
0.5	21.6	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
1.3	21.5	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.6	20.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions

Showing 1 to 10 of 221 entries

Results for IKZF1

Z-value: 2.21

Motif logo

Transcription factors associated with IKZF1

Activity-expression correlation:

Activity profile of IKZF1 motif

Sorted Z-values of IKZF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IKZF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: