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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for INSM1

Z-value: 0.93

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Transcription factors associated with INSM1

Gene Symbol Gene ID Gene Info
INSM1
ENSG00000173404.3 INSM transcriptional repressor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
INSM1hg19_v2_chr20_+_20348740_203487650.291.2e-01Click!

Activity profile of INSM1 motif

Sorted Z-values of INSM1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_45722727 4.11 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
C15orf48
chromosome 15 open reading frame 48
chr2_-_72375167 4.02 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr22_+_38071615 3.77 ENST00000215909.5
LGALS1
lectin, galactoside-binding, soluble, 1
chr12_+_70760056 2.40 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr14_+_85996471 2.30 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr17_+_42081914 1.89 ENST00000293404.3
ENST00000589767.1
NAGS
N-acetylglutamate synthase
chr14_+_65879668 1.77 ENST00000553924.1
ENST00000358307.2
ENST00000557338.1
ENST00000554610.1
FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr6_-_41863098 1.70 ENST00000373006.1
USP49
ubiquitin specific peptidase 49
chr15_+_89182178 1.46 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_153750622 1.44 ENST00000532853.1
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr3_+_50192537 1.41 ENST00000002829.3
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr3_+_50192499 1.40 ENST00000413852.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr12_-_6960407 1.27 ENST00000540683.1
ENST00000229265.6
ENST00000535406.1
ENST00000422785.3
CDCA3
cell division cycle associated 3
chr9_+_116263639 1.24 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr9_+_116263778 1.22 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr14_+_65879437 1.17 ENST00000394585.1
FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr11_+_124932955 1.16 ENST00000403796.2
SLC37A2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr14_+_76776957 1.16 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr11_+_124932986 1.13 ENST00000407458.1
ENST00000298280.5
SLC37A2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr16_+_88704978 1.12 ENST00000244241.4
IL17C
interleukin 17C
chr5_-_60140009 1.12 ENST00000505959.1
ELOVL7
ELOVL fatty acid elongase 7
chr11_+_124933191 1.07 ENST00000532000.1
ENST00000308074.4
SLC37A2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr5_-_60140089 1.06 ENST00000507047.1
ENST00000438340.1
ENST00000425382.1
ENST00000508821.1
ELOVL7
ELOVL fatty acid elongase 7
chr12_+_120105558 1.04 ENST00000229328.5
ENST00000541640.1
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr1_-_154943212 1.00 ENST00000368445.5
ENST00000448116.2
ENST00000368449.4
SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr15_+_89181974 0.98 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr14_+_85996507 0.94 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr15_+_90118685 0.92 ENST00000268138.7
TICRR
TOPBP1-interacting checkpoint and replication regulator
chr6_+_31126291 0.91 ENST00000376257.3
ENST00000376255.4
TCF19
transcription factor 19
chr1_-_154943002 0.88 ENST00000606391.1
SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr15_+_90118723 0.87 ENST00000560985.1
TICRR
TOPBP1-interacting checkpoint and replication regulator
chr7_+_86274145 0.82 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
GRM3
glutamate receptor, metabotropic 3
chr18_-_34408802 0.81 ENST00000590842.1
TPGS2
tubulin polyglutamylase complex subunit 2
chr15_-_70388943 0.78 ENST00000559048.1
ENST00000560939.1
ENST00000440567.3
ENST00000557907.1
ENST00000558379.1
ENST00000451782.2
ENST00000559929.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr5_+_154237778 0.77 ENST00000523698.1
ENST00000517876.1
ENST00000520472.1
CNOT8
CCR4-NOT transcription complex, subunit 8
chr1_-_6557156 0.77 ENST00000537245.1
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_+_48972265 0.76 ENST00000452733.2
CYTH2
cytohesin 2
chr19_-_49220084 0.74 ENST00000595591.1
ENST00000356751.4
ENST00000594582.1
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr2_-_74667612 0.73 ENST00000305557.5
ENST00000233330.6
RTKN
rhotekin
chr17_-_36413133 0.72 ENST00000523089.1
ENST00000312412.4
ENST00000520237.1
RP11-1407O15.2
TBC1 domain family member 3
chr1_+_156863470 0.72 ENST00000338302.3
ENST00000455314.1
ENST00000292357.7
PEAR1
platelet endothelial aggregation receptor 1
chr22_+_20105259 0.71 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RANBP1
RAN binding protein 1
chr22_-_30695471 0.70 ENST00000434291.1
RP1-130H16.18
Uncharacterized protein
chr15_+_89182156 0.67 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr8_-_11058847 0.67 ENST00000297303.4
ENST00000416569.2
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr6_-_94129244 0.65 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chrX_+_152907913 0.65 ENST00000370167.4
DUSP9
dual specificity phosphatase 9
chr22_+_37447771 0.65 ENST00000402077.3
ENST00000403888.3
ENST00000456470.1
KCTD17
potassium channel tetramerization domain containing 17
chr17_-_7297833 0.64 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr3_+_185304059 0.62 ENST00000427465.2
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr5_-_11904100 0.62 ENST00000359640.2
CTNND2
catenin (cadherin-associated protein), delta 2
chr2_+_24272543 0.62 ENST00000380991.4
FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr9_-_123691439 0.61 ENST00000540010.1
TRAF1
TNF receptor-associated factor 1
chr1_-_39325431 0.61 ENST00000373001.3
RRAGC
Ras-related GTP binding C
chr2_+_24272576 0.61 ENST00000380986.4
ENST00000452109.1
FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr1_-_6321035 0.61 ENST00000377893.2
GPR153
G protein-coupled receptor 153
chr10_-_103603523 0.59 ENST00000370046.1
KCNIP2
Kv channel interacting protein 2
chr7_+_86273700 0.58 ENST00000546348.1
GRM3
glutamate receptor, metabotropic 3
chr4_-_143767428 0.57 ENST00000513000.1
ENST00000509777.1
ENST00000503927.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr5_-_11904152 0.57 ENST00000304623.8
ENST00000458100.2
CTNND2
catenin (cadherin-associated protein), delta 2
chr4_+_56814968 0.56 ENST00000422247.2
CEP135
centrosomal protein 135kDa
chr7_+_86273952 0.55 ENST00000536043.1
GRM3
glutamate receptor, metabotropic 3
chr17_-_7297519 0.54 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr9_-_37034028 0.53 ENST00000520281.1
ENST00000446742.1
ENST00000522003.1
ENST00000523145.1
ENST00000414447.1
ENST00000377847.2
ENST00000377853.2
ENST00000377852.2
ENST00000523241.1
ENST00000520154.1
ENST00000358127.4
PAX5
paired box 5
chr15_-_43802769 0.53 ENST00000263801.3
TP53BP1
tumor protein p53 binding protein 1
chr1_+_230202936 0.53 ENST00000366672.4
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr19_+_48972459 0.52 ENST00000427476.1
CYTH2
cytohesin 2
chr1_+_2398876 0.51 ENST00000449969.1
PLCH2
phospholipase C, eta 2
chr22_+_20105012 0.46 ENST00000331821.3
ENST00000411892.1
RANBP1
RAN binding protein 1
chr17_-_1389419 0.46 ENST00000575158.1
MYO1C
myosin IC
chr14_+_73563735 0.45 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr17_+_45608430 0.45 ENST00000322157.4
NPEPPS
aminopeptidase puromycin sensitive
chr17_-_1389228 0.45 ENST00000438665.2
MYO1C
myosin IC
chr20_+_44657845 0.45 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr14_-_51297197 0.45 ENST00000382043.4
NIN
ninein (GSK3B interacting protein)
chr19_+_50887585 0.44 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr1_+_65613340 0.43 ENST00000546702.1
AK4
adenylate kinase 4
chr12_-_54779511 0.42 ENST00000551109.1
ENST00000546970.1
ZNF385A
zinc finger protein 385A
chr15_+_27216530 0.42 ENST00000555083.1
GABRG3
gamma-aminobutyric acid (GABA) A receptor, gamma 3
chr12_-_52715179 0.41 ENST00000293670.3
KRT83
keratin 83
chr2_-_72374948 0.40 ENST00000546307.1
ENST00000474509.1
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr3_-_147124547 0.40 ENST00000491672.1
ENST00000383075.3
ZIC4
Zic family member 4
chr10_-_103603677 0.40 ENST00000358038.3
KCNIP2
Kv channel interacting protein 2
chr14_+_106938440 0.40 ENST00000433371.1
ENST00000449670.1
ENST00000334298.3
LINC00221
long intergenic non-protein coding RNA 221
chr11_-_57417405 0.38 ENST00000524669.1
ENST00000300022.3
YPEL4
yippee-like 4 (Drosophila)
chr17_+_27369918 0.38 ENST00000323372.4
PIPOX
pipecolic acid oxidase
chr20_-_45981138 0.38 ENST00000446994.2
ZMYND8
zinc finger, MYND-type containing 8
chr17_-_27507377 0.38 ENST00000531253.1
MYO18A
myosin XVIIIA
chr16_+_610407 0.37 ENST00000409413.3
C16orf11
chromosome 16 open reading frame 11
chr2_-_25475120 0.37 ENST00000380746.4
ENST00000402667.1
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr17_-_27507395 0.36 ENST00000354329.4
ENST00000527372.1
MYO18A
myosin XVIIIA
chr1_-_38230738 0.36 ENST00000427468.2
ENST00000373048.4
ENST00000319637.6
EPHA10
EPH receptor A10
chr12_-_80328700 0.36 ENST00000550107.1
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr1_+_65613217 0.35 ENST00000545314.1
AK4
adenylate kinase 4
chr17_+_45608614 0.35 ENST00000544660.1
NPEPPS
aminopeptidase puromycin sensitive
chr5_-_150466692 0.34 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1
TNFAIP3 interacting protein 1
chr12_+_53773944 0.33 ENST00000551969.1
ENST00000327443.4
SP1
Sp1 transcription factor
chr15_-_74045088 0.33 ENST00000569673.1
C15orf59
chromosome 15 open reading frame 59
chr10_-_104001231 0.33 ENST00000370002.3
PITX3
paired-like homeodomain 3
chr1_+_53098862 0.33 ENST00000517870.1
FAM159A
family with sequence similarity 159, member A
chr7_-_132262060 0.31 ENST00000359827.3
PLXNA4
plexin A4
chr7_-_128694927 0.31 ENST00000471166.1
ENST00000265388.5
TNPO3
transportin 3
chr22_-_20104700 0.30 ENST00000439169.2
ENST00000445045.1
ENST00000404751.3
ENST00000252136.7
ENST00000403707.3
TRMT2A
tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr12_-_118810688 0.29 ENST00000542532.1
ENST00000392533.3
TAOK3
TAO kinase 3
chr6_+_22569784 0.29 ENST00000510882.2
HDGFL1
hepatoma derived growth factor-like 1
chr4_-_120548779 0.29 ENST00000264805.5
PDE5A
phosphodiesterase 5A, cGMP-specific
chr17_-_36762095 0.29 ENST00000578925.1
ENST00000264659.7
SRCIN1
SRC kinase signaling inhibitor 1
chr16_-_30134524 0.28 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
MAPK3
mitogen-activated protein kinase 3
chr18_-_34409116 0.28 ENST00000334295.4
TPGS2
tubulin polyglutamylase complex subunit 2
chr12_-_58131931 0.28 ENST00000547588.1
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_+_117049445 0.28 ENST00000324225.4
ENST00000532960.1
SIDT2
SID1 transmembrane family, member 2
chr7_-_128695147 0.27 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
TNPO3
transportin 3
chr6_+_56819895 0.27 ENST00000370748.3
BEND6
BEN domain containing 6
chr18_+_34409069 0.27 ENST00000543923.1
ENST00000280020.5
ENST00000435985.2
ENST00000592521.1
ENST00000587139.1
KIAA1328
KIAA1328
chr22_+_20104947 0.27 ENST00000402752.1
RANBP1
RAN binding protein 1
chr5_+_60933634 0.27 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr1_+_54411715 0.26 ENST00000371370.3
ENST00000371368.1
LRRC42
leucine rich repeat containing 42
chr22_+_44351419 0.26 ENST00000396202.3
SAMM50
SAMM50 sorting and assembly machinery component
chr8_-_120685608 0.26 ENST00000427067.2
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr17_+_34058639 0.26 ENST00000268864.3
RASL10B
RAS-like, family 10, member B
chr10_-_103603568 0.25 ENST00000356640.2
KCNIP2
Kv channel interacting protein 2
chr14_-_85996332 0.25 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr13_+_47127293 0.25 ENST00000311191.6
LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr19_-_38916802 0.25 ENST00000587738.1
RASGRP4
RAS guanyl releasing protein 4
chr5_+_154238096 0.24 ENST00000517568.1
ENST00000524105.1
ENST00000285896.6
CNOT8
CCR4-NOT transcription complex, subunit 8
chr11_-_64014379 0.24 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_+_153191706 0.24 ENST00000288670.9
FMNL2
formin-like 2
chr11_-_40314652 0.23 ENST00000527150.1
LRRC4C
leucine rich repeat containing 4C
chr19_+_35630022 0.23 ENST00000589209.1
FXYD1
FXYD domain containing ion transport regulator 1
chr8_-_67525524 0.22 ENST00000517885.1
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr3_+_10857885 0.22 ENST00000254488.2
ENST00000454147.1
SLC6A11
solute carrier family 6 (neurotransmitter transporter), member 11
chr8_+_28174649 0.22 ENST00000301908.3
PNOC
prepronociceptin
chrX_-_41782249 0.22 ENST00000442742.2
ENST00000421587.2
ENST00000378166.4
ENST00000318588.9
ENST00000361962.4
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr18_-_34408693 0.22 ENST00000587382.1
ENST00000589049.1
ENST00000587129.1
TPGS2
tubulin polyglutamylase complex subunit 2
chr4_+_619347 0.21 ENST00000255622.6
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr3_+_35681081 0.21 ENST00000428373.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr13_-_52027134 0.21 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chrX_+_146993449 0.20 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr5_+_154238042 0.20 ENST00000519211.1
ENST00000522458.1
ENST00000519903.1
ENST00000521450.1
ENST00000403027.2
CNOT8
CCR4-NOT transcription complex, subunit 8
chr12_+_113860160 0.20 ENST00000553248.1
ENST00000345635.4
ENST00000547802.1
SDSL
serine dehydratase-like
chr12_+_113860042 0.20 ENST00000403593.4
SDSL
serine dehydratase-like
chr11_-_65430554 0.20 ENST00000308639.9
ENST00000406246.3
RELA
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr17_-_4890919 0.20 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
CAMTA2
calmodulin binding transcription activator 2
chr21_-_46707793 0.19 ENST00000331343.7
ENST00000349485.5
POFUT2
protein O-fucosyltransferase 2
chr17_-_42441204 0.19 ENST00000293443.7
FAM171A2
family with sequence similarity 171, member A2
chr11_+_8704748 0.19 ENST00000526562.1
ENST00000525981.1
RPL27A
ribosomal protein L27a
chr9_+_136243264 0.18 ENST00000371955.1
C9orf96
chromosome 9 open reading frame 96
chr19_+_10196981 0.18 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chrX_+_146993534 0.18 ENST00000334557.6
ENST00000439526.2
ENST00000370475.4
FMR1
fragile X mental retardation 1
chr5_+_154238149 0.18 ENST00000519430.1
ENST00000520671.1
ENST00000521583.1
ENST00000518028.1
ENST00000519404.1
ENST00000519394.1
ENST00000518775.1
CNOT8
CCR4-NOT transcription complex, subunit 8
chrX_-_153095945 0.18 ENST00000164640.4
PDZD4
PDZ domain containing 4
chr1_-_205325850 0.17 ENST00000537168.1
KLHDC8A
kelch domain containing 8A
chr17_+_52978185 0.17 ENST00000572405.1
ENST00000572158.1
ENST00000540336.1
ENST00000572298.1
ENST00000536554.1
ENST00000575333.1
ENST00000570499.1
ENST00000572576.1
TOM1L1
target of myb1 (chicken)-like 1
chr13_-_36871886 0.17 ENST00000491049.2
ENST00000503173.1
ENST00000239860.6
ENST00000379862.2
ENST00000239859.7
ENST00000379864.2
ENST00000510088.1
ENST00000554962.1
ENST00000511166.1
CCDC169
SOHLH2
CCDC169-SOHLH2
coiled-coil domain containing 169
spermatogenesis and oogenesis specific basic helix-loop-helix 2
CCDC169-SOHLH2 readthrough
chr8_-_67525473 0.17 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr6_-_53530474 0.16 ENST00000370905.3
KLHL31
kelch-like family member 31
chr6_-_38607673 0.16 ENST00000481247.1
BTBD9
BTB (POZ) domain containing 9
chr9_-_136242956 0.16 ENST00000371989.3
ENST00000485435.2
SURF4
surfeit 4
chr19_-_38916839 0.16 ENST00000433821.2
ENST00000426920.2
ENST00000587753.1
ENST00000454404.2
ENST00000293062.9
RASGRP4
RAS guanyl releasing protein 4
chr11_+_46383121 0.16 ENST00000454345.1
DGKZ
diacylglycerol kinase, zeta
chrX_-_51812268 0.16 ENST00000486010.1
ENST00000497164.1
ENST00000360134.6
ENST00000485287.1
ENST00000335504.5
ENST00000431659.1
MAGED4B
melanoma antigen family D, 4B
chr10_+_91061712 0.16 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr3_-_69062764 0.15 ENST00000295571.5
EOGT
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr1_+_168148273 0.15 ENST00000367830.3
TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr17_-_46623441 0.15 ENST00000330070.4
HOXB2
homeobox B2
chr4_+_56815102 0.14 ENST00000257287.4
CEP135
centrosomal protein 135kDa
chr11_+_58346584 0.14 ENST00000316059.6
ZFP91
ZFP91 zinc finger protein
chr1_-_85725316 0.14 ENST00000344356.5
ENST00000471115.1
C1orf52
chromosome 1 open reading frame 52
chr14_-_104313824 0.14 ENST00000553739.1
ENST00000202556.9
PPP1R13B
protein phosphatase 1, regulatory subunit 13B
chr9_+_136243117 0.14 ENST00000426926.2
ENST00000371957.3
C9orf96
chromosome 9 open reading frame 96
chr7_-_15726296 0.13 ENST00000262041.5
MEOX2
mesenchyme homeobox 2
chr20_+_48807351 0.13 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr18_-_34408902 0.13 ENST00000593035.1
ENST00000383056.3
ENST00000588909.1
ENST00000590337.1
TPGS2
tubulin polyglutamylase complex subunit 2
chr9_+_37650945 0.12 ENST00000377765.3
FRMPD1
FERM and PDZ domain containing 1
chr6_-_9933500 0.12 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr19_+_54695098 0.12 ENST00000396388.2
TSEN34
TSEN34 tRNA splicing endonuclease subunit
chr19_-_38916822 0.12 ENST00000586305.1
RASGRP4
RAS guanyl releasing protein 4
chr3_+_185303962 0.11 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr21_+_46020497 0.11 ENST00000380102.2
KRTAP10-7
keratin associated protein 10-7
chr12_-_72057571 0.10 ENST00000548100.1
ZFC3H1
zinc finger, C3H1-type containing
chr19_+_42817450 0.10 ENST00000301204.3
TMEM145
transmembrane protein 145
chr1_+_154474689 0.10 ENST00000368482.4
TDRD10
tudor domain containing 10
chr17_+_7211280 0.10 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
EIF5A
eukaryotic translation initiation factor 5A
chr10_+_134258649 0.10 ENST00000392630.3
ENST00000321248.2
C10orf91
chromosome 10 open reading frame 91
chr9_-_34637718 0.10 ENST00000378892.1
ENST00000277010.4
SIGMAR1
sigma non-opioid intracellular receptor 1
chr3_+_195413160 0.09 ENST00000599448.1
LINC00969
long intergenic non-protein coding RNA 969
chr17_-_73389854 0.09 ENST00000578961.1
ENST00000392564.1
ENST00000582582.1
GRB2
growth factor receptor-bound protein 2
chr19_-_12780211 0.09 ENST00000597961.1
ENST00000598732.1
ENST00000222190.5
CTD-2192J16.24
WDR83OS
Uncharacterized protein
WD repeat domain 83 opposite strand
chr19_-_48894104 0.09 ENST00000597017.1
KDELR1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr1_-_154474589 0.09 ENST00000304760.2
SHE
Src homology 2 domain containing E
chr11_+_120207787 0.09 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr2_+_207139367 0.09 ENST00000374423.3
ZDBF2
zinc finger, DBF-type containing 2
chr19_-_19626351 0.09 ENST00000585580.3
TSSK6
testis-specific serine kinase 6
chr17_-_46667594 0.08 ENST00000476342.1
ENST00000460160.1
ENST00000472863.1
HOXB3
homeobox B3
chrX_+_51927919 0.08 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr17_+_52978156 0.08 ENST00000348161.4
TOM1L1
target of myb1 (chicken)-like 1
chr21_-_46238034 0.08 ENST00000332859.6
SUMO3
small ubiquitin-like modifier 3
chr6_+_108881012 0.08 ENST00000343882.6
FOXO3
forkhead box O3
chr8_-_145550571 0.08 ENST00000332324.4
DGAT1
diacylglycerol O-acyltransferase 1
chr17_+_52978107 0.08 ENST00000445275.2
TOM1L1
target of myb1 (chicken)-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of INSM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:2001035 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
1.0 2.9 GO:0036071 N-glycan fucosylation(GO:0036071)
0.8 3.8 GO:0002317 plasma cell differentiation(GO:0002317)
0.6 3.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.5 3.2 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.4 1.7 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.4 1.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.4 2.8 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.3 3.4 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.2 0.7 GO:1903028 positive regulation of opsonization(GO:1903028)
0.2 2.2 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 1.9 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 1.8 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.2 3.6 GO:0005513 detection of calcium ion(GO:0005513)
0.2 1.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.2 0.9 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.5 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 2.0 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 0.4 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.7 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.1 0.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 1.2 GO:0019227 neuronal action potential propagation(GO:0019227) positive regulation of axon regeneration(GO:0048680) action potential propagation(GO:0098870)
0.1 0.3 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.1 0.3 GO:0021644 vagus nerve morphogenesis(GO:0021644) chemorepulsion of branchiomotor axon(GO:0021793)
0.1 1.1 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.1 0.3 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.1 0.3 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 0.4 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.7 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.8 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 0.4 GO:0019474 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.1 0.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 1.0 GO:0035878 nail development(GO:0035878)
0.1 3.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.7 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.4 GO:1903758 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 0.4 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.1 0.2 GO:0014040 positive regulation of Schwann cell differentiation(GO:0014040)
0.1 1.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.3 GO:0000189 MAPK import into nucleus(GO:0000189) regulation of Golgi inheritance(GO:0090170)
0.0 0.7 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 1.9 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0 0.3 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0 0.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.5 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.0 0.3 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 1.4 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.3 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.2 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.5 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.6 GO:1903432 regulation of TORC1 signaling(GO:1903432)
0.0 0.1 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.0 0.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0021546 rhombomere development(GO:0021546) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.8 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.6 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 0.1 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.8 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.1 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.0 GO:0061183 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183)
0.0 0.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.2 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.2 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0070435 Shc-EGFR complex(GO:0070435)
0.2 0.9 GO:0045160 myosin I complex(GO:0045160)
0.1 1.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.4 GO:0019034 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.4 GO:0032039 integrator complex(GO:0032039)
0.1 0.6 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.2 GO:0071159 NF-kappaB complex(GO:0071159)
0.0 1.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 3.1 GO:0015030 Cajal body(GO:0015030)
0.0 0.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 3.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 5.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.7 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 3.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.4 GO:0001741 XY body(GO:0001741)
0.0 0.2 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 6.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0008859 exoribonuclease II activity(GO:0008859)
1.0 2.9 GO:0046921 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.9 3.8 GO:0030395 lactose binding(GO:0030395)
0.9 4.4 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.5 3.4 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.4 6.7 GO:0045499 chemorepellent activity(GO:0045499)
0.4 2.0 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.4 1.9 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.3 1.9 GO:0048408 epidermal growth factor binding(GO:0048408)
0.2 1.2 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.2 2.2 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 0.8 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 1.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.4 GO:0004794 L-threonine ammonia-lyase activity(GO:0004794)
0.1 0.7 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.6 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 1.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 0.5 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 2.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.3 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 1.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.4 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 1.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.4 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.6 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.2 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.0 0.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0005046 KDEL sequence binding(GO:0005046)
0.0 0.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.7 GO:0043531 ADP binding(GO:0043531)
0.0 0.4 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.1 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 4.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.4 PID ARF 3PATHWAY Arf1 pathway
0.0 2.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.9 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 3.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID E2F PATHWAY E2F transcription factor network
0.0 1.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.5 PID ATM PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 2.9 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 2.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 4.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.0 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 3.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.2 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR