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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for IRF2_STAT2_IRF8_IRF1
Z-value: 2.40
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Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000168310.6 | interferon regulatory factor 2 | |
| ENSG00000170581.9 | signal transducer and activator of transcription 2 | |
| ENSG00000140968.6 | interferon regulatory factor 8 | |
| ENSG00000125347.9 | interferon regulatory factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | 0.88 | 2.2e-10 | Click! |
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | 0.53 | 2.4e-03 | Click! |
| IRF8 | hg19_v2_chr16_+_85942594_85942635 | 0.14 | 4.7e-01 | Click! |
| IRF2 | hg19_v2_chr4_-_185395672_185395734 | 0.12 | 5.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 34.7 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 5.8 | 23.1 | GO:0036269 | swimming behavior(GO:0036269) |
| 5.5 | 21.8 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 1.9 | 20.8 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 1.6 | 20.4 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 1.8 | 17.8 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 5.1 | 15.2 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 3.8 | 15.2 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 3.0 | 15.2 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 2.4 | 12.0 | GO:0070842 | aggresome assembly(GO:0070842) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 45.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 3.3 | 30.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.3 | 27.6 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 20.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 3.3 | 19.9 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 12.3 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.0 | 11.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.2 | 11.5 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 10.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 9.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 48.8 | GO:0005525 | GTP binding(GO:0005525) |
| 0.3 | 42.0 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 1.0 | 30.7 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 7.7 | 23.1 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 1.9 | 15.3 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 3.8 | 15.2 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.6 | 12.0 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 10.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 9.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 1.2 | 8.7 | GO:0046979 | TAP2 binding(GO:0046979) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 7.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 7.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 6.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 3.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 2.8 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 2.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 97.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.4 | 30.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 1.2 | 25.0 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 1.1 | 21.3 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.3 | 14.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.6 | 8.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.5 | 8.1 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 5.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 4.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.1 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |