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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for IRF3
Z-value: 1.30
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Transcription factors associated with IRF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg19_v2_chr19_-_50168861_50168873 | 0.18 | 3.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_142829162 Show fit | 9.15 |
ENST00000291009.3
|
prolactin-induced protein |
|
| chr1_+_79115503 Show fit | 5.93 |
ENST00000370747.4
ENST00000438486.1 ENST00000545124.1 |
interferon-induced protein 44 |
|
| chr12_+_6561190 Show fit | 5.80 |
ENST00000544021.1
ENST00000266556.7 |
TAP binding protein-like |
|
| chr20_-_25038804 Show fit | 5.67 |
ENST00000323482.4
|
acyl-CoA synthetase short-chain family member 1 |
|
| chr8_+_39770803 Show fit | 4.85 |
ENST00000518237.1
|
indoleamine 2,3-dioxygenase 1 |
|
| chr6_+_32821924 Show fit | 4.62 |
ENST00000374859.2
ENST00000453265.2 |
proteasome (prosome, macropain) subunit, beta type, 9 |
|
| chr4_-_169239921 Show fit | 4.54 |
ENST00000514995.1
ENST00000393743.3 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
|
| chr7_-_122526499 Show fit | 4.41 |
ENST00000412584.2
|
Ca++-dependent secretion activator 2 |
|
| chr19_-_17516449 Show fit | 4.17 |
ENST00000252593.6
|
bone marrow stromal cell antigen 2 |
|
| chr10_+_91087651 Show fit | 3.96 |
ENST00000371818.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.2 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.4 | 9.2 | GO:0070233 | negative regulation of T cell apoptotic process(GO:0070233) |
| 0.1 | 8.6 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.0 | 8.0 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 1.8 | 7.1 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 1.8 | 7.0 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 1.4 | 5.7 | GO:0019413 | acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542) |
| 0.5 | 5.3 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 1.2 | 4.8 | GO:0036269 | swimming behavior(GO:0036269) |
| 1.5 | 4.4 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.7 | 6.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 5.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 5.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.8 | 4.8 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 4.5 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 4.4 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.2 | 4.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 4.3 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 3.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 11.1 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.6 | 9.2 | GO:0019864 | IgG binding(GO:0019864) |
| 0.2 | 6.0 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.1 | 5.7 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.0 | 5.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.6 | 4.8 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 0.0 | 4.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 4.3 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 4.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 5.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 4.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.6 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 8.6 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.4 | 7.0 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.4 | 5.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 4.8 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 4.8 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.1 | 4.3 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.3 | 3.9 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 3.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |