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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for IRF3

Z-value: 1.30

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50168861_501688730.183.4e-01Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_142829162 9.15 ENST00000291009.3
PIP
prolactin-induced protein
chr1_+_79115503 5.93 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr12_+_6561190 5.80 ENST00000544021.1
ENST00000266556.7
TAPBPL
TAP binding protein-like
chr20_-_25038804 5.67 ENST00000323482.4
ACSS1
acyl-CoA synthetase short-chain family member 1
chr8_+_39770803 4.85 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr6_+_32821924 4.62 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr4_-_169239921 4.54 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_-_122526499 4.41 ENST00000412584.2
CADPS2
Ca++-dependent secretion activator 2
chr19_-_17516449 4.17 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr10_+_91087651 3.96 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr7_-_122526799 3.56 ENST00000334010.7
ENST00000313070.7
CADPS2
Ca++-dependent secretion activator 2
chr21_+_42792442 3.36 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chrX_+_57313113 3.28 ENST00000374900.4
FAAH2
fatty acid amide hydrolase 2
chr10_+_91092241 3.26 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_948803 3.11 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr7_+_100728720 3.04 ENST00000306085.6
ENST00000412507.1
TRIM56
tripartite motif containing 56
chr9_-_32526299 2.99 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_+_69240302 2.98 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr9_-_32526184 2.88 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr16_+_58283814 2.80 ENST00000443128.2
ENST00000219299.4
CCDC113
coiled-coil domain containing 113
chr9_+_74764340 2.72 ENST00000376986.1
ENST00000358399.3
GDA
guanine deaminase
chr17_+_6659153 2.67 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr17_-_40264692 2.59 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr4_-_156875003 2.57 ENST00000433477.3
CTSO
cathepsin O
chr12_+_12223867 2.36 ENST00000308721.5
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr22_-_36556821 2.34 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr19_+_18284477 2.32 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr20_-_47894569 2.29 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
ZNFX1
zinc finger, NFX1-type containing 1
chr11_-_57335280 2.28 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr2_-_157198860 2.27 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr19_+_50431959 2.24 ENST00000595125.1
ATF5
activating transcription factor 5
chr12_+_113416265 2.05 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chrX_+_77154935 1.95 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr14_+_73525144 1.95 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr10_+_91061712 1.94 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr9_-_90589586 1.94 ENST00000325303.8
ENST00000375883.3
CDK20
cyclin-dependent kinase 20
chr2_+_163175394 1.93 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr6_+_26440700 1.87 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr19_-_47735918 1.84 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr17_+_21729899 1.82 ENST00000583708.1
UBBP4
ubiquitin B pseudogene 4
chr5_-_77656175 1.79 ENST00000513755.1
ENST00000421004.3
CTD-2037K23.2
CTD-2037K23.2
chr3_-_53079281 1.78 ENST00000394750.1
SFMBT1
Scm-like with four mbt domains 1
chr6_+_26365443 1.73 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr9_-_90589402 1.70 ENST00000375871.4
ENST00000605159.1
ENST00000336654.5
CDK20
cyclin-dependent kinase 20
chr1_+_210502238 1.65 ENST00000545154.1
ENST00000537898.1
ENST00000391905.3
ENST00000545781.1
ENST00000261458.3
ENST00000308852.6
HHAT
hedgehog acyltransferase
chr1_+_110577229 1.59 ENST00000369795.3
ENST00000369794.2
STRIP1
striatin interacting protein 1
chr6_+_26402465 1.57 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr2_-_231084820 1.56 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr14_+_73525265 1.55 ENST00000525161.1
RBM25
RNA binding motif protein 25
chr15_-_62352570 1.54 ENST00000261517.5
ENST00000395896.4
ENST00000395898.3
VPS13C
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr2_+_69240415 1.45 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr3_-_172241250 1.45 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr16_-_67970990 1.41 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr19_+_50432400 1.41 ENST00000423777.2
ENST00000600336.1
ENST00000597227.1
ATF5
activating transcription factor 5
chr11_-_124190184 1.39 ENST00000357438.2
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr7_-_92777606 1.39 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr17_-_61517572 1.39 ENST00000582997.1
CYB561
cytochrome b561
chr2_+_127413704 1.38 ENST00000409836.3
GYPC
glycophorin C (Gerbich blood group)
chr2_-_231084617 1.30 ENST00000409815.2
SP110
SP110 nuclear body protein
chr14_-_70883708 1.28 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr2_+_127413677 1.27 ENST00000356887.7
GYPC
glycophorin C (Gerbich blood group)
chr1_+_151129103 1.23 ENST00000368910.3
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr4_+_156587853 1.22 ENST00000506455.1
ENST00000511108.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr3_+_187086120 1.22 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr9_+_74764278 1.21 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr2_+_127413481 1.20 ENST00000259254.4
GYPC
glycophorin C (Gerbich blood group)
chr5_-_96143602 1.19 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1
endoplasmic reticulum aminopeptidase 1
chr9_-_140082983 1.19 ENST00000323927.2
ANAPC2
anaphase promoting complex subunit 2
chr12_+_133613878 1.17 ENST00000392319.2
ENST00000543758.1
ZNF84
zinc finger protein 84
chr2_-_163175133 1.15 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr12_+_133614119 1.14 ENST00000327668.7
ZNF84
zinc finger protein 84
chr3_-_125803105 1.14 ENST00000346785.5
ENST00000315891.6
SLC41A3
solute carrier family 41, member 3
chr10_-_120355149 1.11 ENST00000239032.2
PRLHR
prolactin releasing hormone receptor
chr19_+_10196781 1.09 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr6_+_26402517 1.08 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr10_+_48355024 1.04 ENST00000395702.2
ENST00000442001.1
ENST00000433077.1
ENST00000436850.1
ENST00000494156.1
ENST00000586537.1
ZNF488
zinc finger protein 488
chr1_-_89664595 1.03 ENST00000355754.6
GBP4
guanylate binding protein 4
chr11_-_4414880 1.01 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr6_-_28226984 1.01 ENST00000423974.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr12_+_4758264 1.00 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr4_+_156588115 1.00 ENST00000455639.2
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr4_+_156588350 0.99 ENST00000296518.7
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr10_-_135187193 0.98 ENST00000368547.3
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr14_+_73525229 0.98 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr4_+_156588249 0.97 ENST00000393832.3
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr17_+_25958174 0.97 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_154580616 0.96 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr22_+_18632666 0.94 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr3_+_122399444 0.92 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr12_+_133613937 0.91 ENST00000539354.1
ENST00000542874.1
ENST00000438628.2
ZNF84
zinc finger protein 84
chr6_-_30181133 0.91 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chr17_+_36861735 0.90 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr19_+_17516531 0.90 ENST00000528911.1
ENST00000528604.1
ENST00000595892.1
ENST00000500836.2
ENST00000598546.1
ENST00000600369.1
ENST00000598356.1
ENST00000594426.1
MVB12A
CTD-2521M24.9
multivesicular body subunit 12A
CTD-2521M24.9
chr21_-_43346790 0.90 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chr6_-_30181156 0.89 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr2_-_220252603 0.83 ENST00000322176.7
ENST00000273075.4
DNPEP
aspartyl aminopeptidase
chr5_-_180288248 0.80 ENST00000512132.1
ENST00000506439.1
ENST00000502412.1
ENST00000359141.6
ZFP62
ZFP62 zinc finger protein
chr9_-_95087838 0.78 ENST00000442668.2
ENST00000421075.2
ENST00000536624.1
NOL8
nucleolar protein 8
chr9_-_95087604 0.78 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
NOL8
nucleolar protein 8
chr14_+_24605389 0.78 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr6_-_36355513 0.77 ENST00000340181.4
ENST00000373737.4
ETV7
ets variant 7
chr16_+_75681650 0.74 ENST00000300086.4
TERF2IP
telomeric repeat binding factor 2, interacting protein
chr14_-_91976794 0.74 ENST00000555462.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr20_-_20033052 0.73 ENST00000536226.1
CRNKL1
crooked neck pre-mRNA splicing factor 1
chr15_-_88799948 0.71 ENST00000394480.2
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr12_-_54582655 0.70 ENST00000504338.1
ENST00000514685.1
ENST00000504797.1
ENST00000513838.1
ENST00000505128.1
ENST00000337581.3
ENST00000503306.1
ENST00000243112.5
ENST00000514196.1
ENST00000506169.1
ENST00000507904.1
ENST00000508394.2
SMUG1
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr11_-_796197 0.70 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr12_+_12224331 0.70 ENST00000396367.1
ENST00000266434.4
ENST00000396369.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr14_-_24615805 0.70 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_-_231084659 0.68 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr4_-_87855851 0.66 ENST00000473559.1
C4orf36
chromosome 4 open reading frame 36
chr10_+_92980517 0.63 ENST00000336126.5
PCGF5
polycomb group ring finger 5
chr3_-_125802765 0.62 ENST00000514891.1
ENST00000512470.1
ENST00000504035.1
ENST00000360370.4
ENST00000513723.1
ENST00000510651.1
ENST00000514333.1
SLC41A3
solute carrier family 41, member 3
chr14_+_24605361 0.61 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr16_-_29874462 0.60 ENST00000566113.1
ENST00000569956.1
ENST00000570016.1
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr17_+_21730180 0.60 ENST00000584398.1
UBBP4
ubiquitin B pseudogene 4
chr8_+_145438870 0.58 ENST00000527931.1
FAM203B
family with sequence similarity 203, member B
chr7_+_134832808 0.58 ENST00000275767.3
TMEM140
transmembrane protein 140
chr16_+_29127282 0.57 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chr1_-_159046617 0.53 ENST00000368130.4
AIM2
absent in melanoma 2
chr12_-_322821 0.51 ENST00000359674.4
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chrX_+_80457442 0.50 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr8_+_22446763 0.50 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
AC037459.4
Uncharacterized protein
chr10_-_49701686 0.49 ENST00000417247.2
ARHGAP22
Rho GTPase activating protein 22
chr19_+_49977818 0.46 ENST00000594009.1
ENST00000595510.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr14_-_24615523 0.46 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_+_118230287 0.45 ENST00000252108.3
ENST00000431736.2
UBE4A
ubiquitination factor E4A
chr19_+_10196981 0.44 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr10_-_22292675 0.44 ENST00000376946.1
DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chrX_+_119384607 0.44 ENST00000326624.2
ENST00000557385.1
ZBTB33
zinc finger and BTB domain containing 33
chrX_-_48937531 0.44 ENST00000473974.1
ENST00000475880.1
ENST00000396681.4
ENST00000553851.1
ENST00000471338.1
ENST00000476728.1
ENST00000376368.2
ENST00000485908.1
ENST00000376372.3
ENST00000376358.3
WDR45
AF196779.12
WD repeat domain 45
WD repeat domain phosphoinositide-interacting protein 4
chr4_+_144434584 0.43 ENST00000283131.3
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr10_+_35416223 0.42 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM
cAMP responsive element modulator
chr20_-_43589109 0.41 ENST00000372813.3
TOMM34
translocase of outer mitochondrial membrane 34
chr12_-_8218997 0.41 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr7_-_138794394 0.41 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr20_+_388791 0.39 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr4_+_130017268 0.39 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr22_-_36635684 0.39 ENST00000358502.5
APOL2
apolipoprotein L, 2
chrX_+_52920336 0.38 ENST00000452154.2
FAM156B
family with sequence similarity 156, member B
chr1_-_11042094 0.37 ENST00000377004.4
ENST00000377008.4
C1orf127
chromosome 1 open reading frame 127
chr15_+_45003675 0.37 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr2_+_113672770 0.35 ENST00000311328.2
IL37
interleukin 37
chr10_+_35415978 0.33 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chr5_+_140749803 0.32 ENST00000576222.1
PCDHGB3
protocadherin gamma subfamily B, 3
chr3_+_184529948 0.28 ENST00000436792.2
ENST00000446204.2
ENST00000422105.1
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr3_+_184529929 0.28 ENST00000287546.4
ENST00000437079.3
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr2_+_99771418 0.28 ENST00000393473.2
ENST00000393477.3
ENST00000393474.3
ENST00000340066.1
ENST00000393471.2
ENST00000449211.1
ENST00000434566.1
ENST00000410042.1
LIPT1
MRPL30
lipoyltransferase 1
39S ribosomal protein L30, mitochondrial
chr6_-_32821599 0.27 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_28193037 0.27 ENST00000531981.1
ENST00000425468.2
ENST00000252207.5
ENST00000531979.1
ENST00000527436.1
ZSCAN9
zinc finger and SCAN domain containing 9
chr6_+_42018251 0.26 ENST00000372978.3
ENST00000494547.1
ENST00000456846.2
ENST00000372982.4
ENST00000472818.1
ENST00000372977.3
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr19_+_49977466 0.26 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr1_-_182558374 0.25 ENST00000367559.3
ENST00000539397.1
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr14_-_20881579 0.22 ENST00000556935.1
ENST00000262715.5
ENST00000556549.1
TEP1
telomerase-associated protein 1
chr22_+_36044411 0.21 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr9_-_100954910 0.20 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr9_+_140083099 0.20 ENST00000322310.5
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr16_-_29874211 0.19 ENST00000563415.1
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr10_+_115439630 0.18 ENST00000369318.3
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr10_+_115439282 0.17 ENST00000369321.2
ENST00000345633.4
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr10_+_115439699 0.17 ENST00000369315.1
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr4_+_156587979 0.16 ENST00000511507.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr20_-_47894936 0.14 ENST00000371754.4
ZNFX1
zinc finger, NFX1-type containing 1
chr3_-_27764190 0.13 ENST00000537516.1
EOMES
eomesodermin
chr6_+_42018614 0.13 ENST00000465926.1
ENST00000482432.1
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr1_+_236557569 0.11 ENST00000334232.4
EDARADD
EDAR-associated death domain
chr12_+_129028500 0.11 ENST00000315208.8
TMEM132C
transmembrane protein 132C
chr2_+_219125714 0.10 ENST00000522678.1
ENST00000519574.1
ENST00000521462.1
GPBAR1
G protein-coupled bile acid receptor 1
chr4_+_100495864 0.10 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr8_-_67525473 0.09 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr3_+_63897605 0.09 ENST00000487717.1
ATXN7
ataxin 7
chr3_-_160283348 0.08 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr15_+_64428529 0.08 ENST00000560861.1
SNX1
sorting nexin 1
chr9_+_95087766 0.07 ENST00000375587.3
CENPP
centromere protein P
chr6_-_711395 0.05 ENST00000606285.1
RP11-532F6.3
RP11-532F6.3
chr16_-_29875057 0.04 ENST00000219789.6
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr10_-_14996017 0.01 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
DCLRE1C
DNA cross-link repair 1C
chr4_-_74847800 0.01 ENST00000296029.3
PF4
platelet factor 4
chr12_-_127256772 0.01 ENST00000536517.1
LINC00944
long intergenic non-protein coding RNA 944
chr14_+_35452104 0.00 ENST00000216774.6
ENST00000546080.1
SRP54
signal recognition particle 54kDa
chr6_-_36355486 0.00 ENST00000538992.1
ETV7
ets variant 7

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.8 7.0 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
1.5 4.4 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
1.4 5.7 GO:0019413 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
1.4 4.2 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
1.4 4.1 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
1.2 4.8 GO:0036269 swimming behavior(GO:0036269)
1.0 8.0 GO:1990504 dense core granule exocytosis(GO:1990504)
0.8 3.9 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.8 2.3 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.7 4.3 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.7 9.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.5 5.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.5 1.5 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.4 0.4 GO:0034761 positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.4 9.2 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.3 1.0 GO:0032831 natural killer cell tolerance induction(GO:0002519) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.3 1.0 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.3 3.4 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.3 1.0 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.2 0.7 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.2 1.9 GO:0018377 protein myristoylation(GO:0018377)
0.2 0.7 GO:0048687 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.2 3.7 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.2 4.4 GO:0072643 interferon-gamma secretion(GO:0072643)
0.2 0.7 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.2 1.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.2 1.6 GO:1902570 protein localization to nucleolus(GO:1902570)
0.1 1.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 8.6 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 3.2 GO:0035456 response to interferon-beta(GO:0035456)
0.1 2.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 3.3 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 0.4 GO:0019075 virus maturation(GO:0019075)
0.1 0.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.1 0.5 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1 3.6 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.1 1.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 3.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 3.0 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 0.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.1 0.2 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 1.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 3.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 3.3 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 1.0 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.7 GO:0045008 depyrimidination(GO:0045008)
0.0 0.5 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 1.0 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0 0.8 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.0 1.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 1.8 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.3 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.4 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.5 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 2.3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.4 GO:0022900 electron transport chain(GO:0022900)
0.0 1.4 GO:0009615 response to virus(GO:0009615)
0.0 0.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.3 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.8 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.7 6.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 2.5 GO:0008537 proteasome activator complex(GO:0008537)
0.2 1.0 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 4.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 4.4 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.4 GO:0031213 RSF complex(GO:0031213)
0.1 0.7 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.1 0.6 GO:0033263 CORVET complex(GO:0033263)
0.1 2.0 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.7 GO:0030870 Mre11 complex(GO:0030870)
0.1 2.8 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.4 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.5 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 3.6 GO:0005771 multivesicular body(GO:0005771)
0.0 1.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 5.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 5.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 3.3 GO:0005811 lipid particle(GO:0005811)
0.0 3.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 9.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 4.5 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.9 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 4.3 GO:0005681 spliceosomal complex(GO:0005681)
0.0 1.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
1.2 3.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.1 5.7 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.6 9.2 GO:0019864 IgG binding(GO:0019864)
0.3 1.4 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.3 2.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 1.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.3 0.8 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.3 2.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.3 3.1 GO:0031386 protein tag(GO:0031386)
0.2 6.0 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.0 GO:0048030 disaccharide binding(GO:0048030)
0.2 0.7 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.2 4.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 4.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.7 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.1 1.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 12.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 2.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.5 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.1 1.4 GO:0005549 odorant binding(GO:0005549)
0.1 1.0 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.1 0.3 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.1 2.9 GO:0019239 deaminase activity(GO:0019239)
0.1 2.0 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.7 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 1.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 4.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0046979 TAP2 binding(GO:0046979)
0.0 1.6 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.4 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 1.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 3.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0038181 bile acid receptor activity(GO:0038181)
0.0 1.7 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 5.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.8 GO:0051117 ATPase binding(GO:0051117)
0.0 2.4 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 3.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 11.1 GO:0008270 zinc ion binding(GO:0008270)
0.0 3.4 GO:0008017 microtubule binding(GO:0008017)
0.0 0.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 4.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 2.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 5.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 7.0 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.3 3.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 4.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 18.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 8.6 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 4.3 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 4.8 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.2 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 3.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.5 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 2.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes