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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for IRF6_IRF4_IRF5

Z-value: 0.84

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Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol Gene ID Gene Info
ENSG00000117595.6 interferon regulatory factor 6
ENSG00000137265.10 interferon regulatory factor 4
ENSG00000128604.14 interferon regulatory factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF6hg19_v2_chr1_-_209979375_209979389-0.461.1e-02Click!
IRF5hg19_v2_chr7_+_128577972_128578047-0.202.8e-01Click!
IRF4hg19_v2_chr6_+_391739_391759-0.029.3e-01Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_32526299 5.41 ENST00000379882.1
ENST00000379883.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_-_32526184 5.26 ENST00000545044.1
ENST00000379868.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr15_-_45670924 3.15 ENST00000396659.3
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr21_+_42733870 2.17 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
myxovirus (influenza virus) resistance 2 (mouse)
chr2_-_7005785 2.04 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr5_-_35938674 1.73 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
calcyphosine-like
chr21_+_42792442 1.61 ENST00000398600.2
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_57335280 1.60 ENST00000287156.4
ubiquitin-conjugating enzyme E2L 6
chr17_+_6659153 1.58 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XIAP associated factor 1
chr1_-_207119738 1.58 ENST00000356495.4
polymeric immunoglobulin receptor
chr21_+_42798094 1.37 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr19_-_3029011 1.31 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr14_-_61190754 1.24 ENST00000216513.4
SIX homeobox 4
chr8_+_8559406 1.23 ENST00000519106.1
claudin 23
chr12_+_113344582 1.21 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_+_78769549 1.20 ENST00000370758.1
prostaglandin F receptor (FP)
chr11_-_86383650 1.17 ENST00000526944.1
ENST00000530335.1
ENST00000543262.1
ENST00000524826.1
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr12_+_46123682 1.15 ENST00000422737.1
AT rich interactive domain 2 (ARID, RFX-like)
chr17_+_18380051 1.12 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
lectin, galactoside-binding, soluble, 9C
chr11_-_65548265 1.08 ENST00000532090.2
adaptor-related protein complex 5, beta 1 subunit
chr6_+_32605195 1.00 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chr17_-_20370847 1.00 ENST00000423676.3
ENST00000324290.5
lectin, galactoside-binding, soluble, 9B
chr20_-_25038804 0.95 ENST00000323482.4
acyl-CoA synthetase short-chain family member 1
chr8_+_39770803 0.93 ENST00000518237.1
indoleamine 2,3-dioxygenase 1
chr1_+_948803 0.92 ENST00000379389.4
ISG15 ubiquitin-like modifier
chr5_-_35230434 0.86 ENST00000504500.1
prolactin receptor
chr17_+_25958174 0.86 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
lectin, galactoside-binding, soluble, 9
chr20_-_20033052 0.84 ENST00000536226.1
crooked neck pre-mRNA splicing factor 1
chr3_+_100328433 0.83 ENST00000273352.3
G protein-coupled receptor 128
chr9_-_21995249 0.82 ENST00000494262.1
cyclin-dependent kinase inhibitor 2A
chr22_+_23487513 0.77 ENST00000263116.2
ENST00000341989.4
RAB36, member RAS oncogene family
chr3_-_146262637 0.75 ENST00000472349.1
ENST00000342435.4
phospholipid scramblase 1
chr1_+_236687881 0.68 ENST00000526634.1
lectin, galactoside-binding, soluble, 8
chr3_-_146262428 0.66 ENST00000486631.1
phospholipid scramblase 1
chrM_+_9207 0.66 ENST00000362079.2
mitochondrially encoded cytochrome c oxidase III
chr19_+_12273866 0.66 ENST00000425827.1
ENST00000439995.1
ENST00000343979.4
ENST00000398616.2
ENST00000418338.1
zinc finger protein 136
chr7_-_138794394 0.66 ENST00000242351.5
ENST00000471652.1
zinc finger CCCH-type, antiviral 1
chr7_+_12250886 0.63 ENST00000444443.1
ENST00000396667.3
transmembrane protein 106B
chr3_-_146262293 0.60 ENST00000448205.1
phospholipid scramblase 1
chr3_-_146262352 0.58 ENST00000462666.1
phospholipid scramblase 1
chr6_+_89791507 0.58 ENST00000354922.3
proline-rich nuclear receptor coactivator 1
chr11_-_86383157 0.58 ENST00000393324.3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr16_+_29127282 0.58 ENST00000562902.1
RP11-426C22.5
chr12_+_46123448 0.58 ENST00000334344.6
AT rich interactive domain 2 (ARID, RFX-like)
chr2_+_7017796 0.56 ENST00000382040.3
radical S-adenosyl methionine domain containing 2
chr5_-_139943830 0.55 ENST00000412920.3
ENST00000511201.2
ENST00000356738.2
ENST00000354402.5
ENST00000358580.5
ENST00000508496.2
amyloid beta (A4) precursor protein-binding, family B, member 3
chr14_+_105267250 0.54 ENST00000342537.7
zinc finger and BTB domain containing 42
chr10_+_91174314 0.49 ENST00000371795.4
interferon-induced protein with tetratricopeptide repeats 5
chr20_-_45318230 0.49 ENST00000372114.3
TP53 regulating kinase
chr19_-_57183114 0.48 ENST00000537055.2
ENST00000601659.1
zinc finger protein 835
chr3_-_146262365 0.48 ENST00000448787.2
phospholipid scramblase 1
chr2_-_55920952 0.47 ENST00000447944.2
polyribonucleotide nucleotidyltransferase 1
chr20_-_45061695 0.46 ENST00000445496.2
engulfment and cell motility 2
chr4_-_100575781 0.46 ENST00000511828.1
Protein LOC285556
chr1_+_179262905 0.45 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
sterol O-acyltransferase 1
chr15_-_75748115 0.44 ENST00000360439.4
SIN3 transcription regulator family member A
chr2_+_208423840 0.44 ENST00000539789.1
cAMP responsive element binding protein 1
chr17_-_4167142 0.44 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ankyrin repeat and FYVE domain containing 1
chr2_+_113299990 0.43 ENST00000537335.1
ENST00000417433.2
polymerase (RNA) I polypeptide B, 128kDa
chr19_-_17516449 0.43 ENST00000252593.6
bone marrow stromal cell antigen 2
chr3_+_187086120 0.42 ENST00000259030.2
receptor (chemosensory) transporter protein 4
chr7_+_12250833 0.42 ENST00000396668.3
transmembrane protein 106B
chr6_+_32605134 0.40 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
major histocompatibility complex, class II, DQ alpha 1
chr17_+_4643337 0.40 ENST00000592813.1
zinc finger, MYND-type containing 15
chr11_-_47736896 0.40 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
ATP/GTP binding protein-like 2
chr19_-_36705547 0.40 ENST00000304116.5
zinc finger protein 565
chr11_-_321050 0.38 ENST00000399808.4
interferon induced transmembrane protein 3
chr3_-_182880541 0.38 ENST00000470251.1
ENST00000265598.3
lysosomal-associated membrane protein 3
chr10_+_91061712 0.37 ENST00000371826.3
interferon-induced protein with tetratricopeptide repeats 2
chr16_-_67970990 0.37 ENST00000358514.4
proteasome (prosome, macropain) subunit, beta type, 10
chr6_-_27799305 0.37 ENST00000357549.2
histone cluster 1, H4k
chr19_+_10196981 0.37 ENST00000591813.1
chromosome 19 open reading frame 66
chr11_+_100862811 0.35 ENST00000303130.2
transmembrane protein 133
chr9_-_100881466 0.35 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
tripartite motif containing 14
chr9_-_21995300 0.35 ENST00000498628.2
cyclin-dependent kinase inhibitor 2A
chr17_-_30185946 0.34 ENST00000579741.1
coordinator of PRMT5, differentiation stimulator
chr19_+_10196781 0.33 ENST00000253110.11
chromosome 19 open reading frame 66
chrM_+_10053 0.32 ENST00000361227.2
mitochondrially encoded NADH dehydrogenase 3
chr1_+_179050512 0.32 ENST00000367627.3
torsin family 3, member A
chr18_+_3466248 0.31 ENST00000581029.1
ENST00000581442.1
ENST00000579007.1
RP11-838N2.4
chr4_-_88141755 0.31 ENST00000273963.5
kelch-like family member 8
chr11_-_321340 0.31 ENST00000526811.1
interferon induced transmembrane protein 3
chr6_+_126070726 0.31 ENST00000368364.3
hes-related family bHLH transcription factor with YRPW motif 2
chr14_-_102552659 0.30 ENST00000441629.2
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr17_-_38083843 0.30 ENST00000304046.2
ENST00000579695.1
ORM1-like 3 (S. cerevisiae)
chr4_+_190992387 0.30 ENST00000554906.2
ENST00000553820.2
double homeobox 4 like 7
chrX_-_8139308 0.30 ENST00000317103.4
variable charge, X-linked 2
chr15_-_52263937 0.29 ENST00000315141.5
ENST00000299601.5
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr3_-_146262488 0.29 ENST00000487389.1
phospholipid scramblase 1
chr22_-_31688381 0.29 ENST00000487265.2
phosphoinositide-3-kinase interacting protein 1
chr1_-_151319710 0.29 ENST00000290524.4
ENST00000437327.1
ENST00000452513.2
ENST00000368870.2
ENST00000452671.2
regulatory factor X, 5 (influences HLA class II expression)
chr22_-_31688431 0.29 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
phosphoinositide-3-kinase interacting protein 1
chr12_-_56753858 0.29 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
signal transducer and activator of transcription 2, 113kDa
chr7_-_95064264 0.28 ENST00000536183.1
ENST00000433091.2
ENST00000222572.3
paraoxonase 2
chr15_+_90895471 0.28 ENST00000354377.3
ENST00000379090.5
zinc finger protein 774
chr3_-_46037299 0.27 ENST00000296137.2
FYVE and coiled-coil domain containing 1
chr7_-_77045617 0.26 ENST00000257626.7
gamma-secretase activating protein
chr4_-_88141615 0.26 ENST00000545252.1
ENST00000425278.2
ENST00000498875.2
kelch-like family member 8
chr9_-_33264676 0.25 ENST00000472232.3
ENST00000379704.2
BCL2-associated athanogene
chr7_+_148823485 0.25 ENST00000426851.2
zinc finger protein 398
chr4_-_11431188 0.25 ENST00000510712.1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr6_+_20534672 0.24 ENST00000274695.4
ENST00000378624.4
CDK5 regulatory subunit associated protein 1-like 1
chr17_-_56595196 0.24 ENST00000579921.1
ENST00000579925.1
ENST00000323456.5
myotubularin related protein 4
chr17_-_30185971 0.24 ENST00000378634.2
coordinator of PRMT5, differentiation stimulator
chr1_-_54355430 0.24 ENST00000371399.1
ENST00000072644.1
ENST00000412288.1
Yip1 domain family, member 1
chr4_-_118006697 0.24 ENST00000310754.4
translocation associated membrane protein 1-like 1
chr2_-_220252603 0.22 ENST00000322176.7
ENST00000273075.4
aspartyl aminopeptidase
chr8_+_13424352 0.22 ENST00000297324.4
chromosome 8 open reading frame 48
chr12_+_121131970 0.22 ENST00000535656.1
malectin
chr3_-_180707466 0.22 ENST00000491873.1
ENST00000486355.1
ENST00000382564.2
DnaJ (Hsp40) homolog, subfamily C, member 19
chr11_+_5710919 0.21 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr15_-_89764929 0.21 ENST00000268125.5
retinaldehyde binding protein 1
chr14_+_89029253 0.21 ENST00000251038.5
ENST00000359301.3
ENST00000302216.8
zinc finger CCCH-type containing 14
chr1_-_168464875 0.21 ENST00000422253.1
RP5-968D22.3
chr13_+_51483814 0.21 ENST00000336617.3
ENST00000422660.1
ribonuclease H2, subunit B
chr13_-_100624012 0.20 ENST00000267294.4
Zic family member 5
chr16_+_30751953 0.20 ENST00000483578.1
RP11-2C24.4
chrX_-_139587225 0.20 ENST00000370536.2
SRY (sex determining region Y)-box 3
chr12_-_122712038 0.20 ENST00000413918.1
ENST00000443649.3
diablo, IAP-binding mitochondrial protein
chr2_+_32390925 0.20 ENST00000440718.1
ENST00000379343.2
ENST00000282587.5
ENST00000435660.1
ENST00000538303.1
ENST00000357055.3
ENST00000406369.1
solute carrier family 30 (zinc transporter), member 6
chr11_-_126138808 0.20 ENST00000332118.6
ENST00000532259.1
signal recognition particle receptor (docking protein)
chr13_-_41768654 0.19 ENST00000379483.3
kelch repeat and BTB (POZ) domain containing 7
chr2_-_75938115 0.19 ENST00000321027.3
GC-rich sequence DNA-binding factor 2
chrX_-_77041685 0.19 ENST00000373344.5
ENST00000395603.3
alpha thalassemia/mental retardation syndrome X-linked
chr15_+_83478370 0.18 ENST00000286760.4
WAS protein homolog associated with actin, golgi membranes and microtubules
chr7_+_37960163 0.18 ENST00000199448.4
ENST00000559325.1
ENST00000423717.1
ependymin related 1
chr19_+_18942720 0.18 ENST00000262803.5
UPF1 regulator of nonsense transcripts homolog (yeast)
chr16_+_53133070 0.18 ENST00000565832.1
chromodomain helicase DNA binding protein 9
chr1_+_241695424 0.18 ENST00000366558.3
ENST00000366559.4
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr7_-_98467629 0.17 ENST00000339375.4
transmembrane protein 130
chr7_+_151038850 0.17 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
negative regulator of ubiquitin-like proteins 1
chr7_-_98467543 0.17 ENST00000345589.4
transmembrane protein 130
chr15_-_29561979 0.16 ENST00000332303.4
necdin-like 2
chr11_-_77790865 0.16 ENST00000534029.1
ENST00000525085.1
ENST00000527806.1
ENST00000528164.1
ENST00000528251.1
ENST00000530054.1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NDUFC2-KCTD14 readthrough
chr4_+_86396265 0.16 ENST00000395184.1
Rho GTPase activating protein 24
chr5_+_140772381 0.16 ENST00000398604.2
protocadherin gamma subfamily A, 8
chr7_-_98467489 0.16 ENST00000416379.2
transmembrane protein 130
chr3_+_45429998 0.16 ENST00000265537.3
ENST00000415258.1
ENST00000431023.1
ENST00000414984.1
leucyl-tRNA synthetase 2, mitochondrial
chr2_-_158184211 0.15 ENST00000397283.2
ermin, ERM-like protein
chr14_-_70883708 0.15 ENST00000256366.4
synaptojanin 2 binding protein
chr2_-_191878681 0.15 ENST00000409465.1
signal transducer and activator of transcription 1, 91kDa
chr22_-_31885727 0.15 ENST00000330125.5
ENST00000344710.5
ENST00000397518.1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr1_-_224033596 0.15 ENST00000391878.2
ENST00000343537.7
tumor protein p53 binding protein, 2
chr7_+_142985308 0.15 ENST00000310447.5
caspase 2, apoptosis-related cysteine peptidase
chr2_+_120770645 0.14 ENST00000443902.2
erythrocyte membrane protein band 4.1 like 5
chr3_-_179169181 0.14 ENST00000497513.1
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr17_-_26898516 0.14 ENST00000543734.1
ENST00000395346.2
phosphatidylinositol glycan anchor biosynthesis, class S
chr2_-_198299726 0.14 ENST00000409915.4
ENST00000487698.1
ENST00000414963.2
ENST00000335508.6
splicing factor 3b, subunit 1, 155kDa
chr1_+_179051160 0.14 ENST00000367625.4
ENST00000352445.6
torsin family 3, member A
chr19_+_18942761 0.14 ENST00000599848.1
UPF1 regulator of nonsense transcripts homolog (yeast)
chr19_+_52264104 0.14 ENST00000340023.6
formyl peptide receptor 2
chr10_+_123923205 0.14 ENST00000369004.3
ENST00000260733.3
transforming, acidic coiled-coil containing protein 2
chr12_+_52643077 0.14 ENST00000553310.2
ENST00000544024.1
keratin 86
chr10_+_135192695 0.14 ENST00000368539.4
ENST00000278060.5
ENST00000357296.3
polyamine oxidase (exo-N4-amino)
chr2_-_163175133 0.14 ENST00000421365.2
ENST00000263642.2
interferon induced with helicase C domain 1
chr4_+_86396321 0.14 ENST00000503995.1
Rho GTPase activating protein 24
chrX_-_48755030 0.14 ENST00000490755.2
ENST00000465150.2
ENST00000495490.2
translocase of inner mitochondrial membrane 17 homolog B (yeast)
chr15_+_28624878 0.14 ENST00000450328.2
golgin A8 family, member F
chr19_-_52511334 0.13 ENST00000602063.1
ENST00000597747.1
ENST00000594083.1
ENST00000593650.1
ENST00000599631.1
ENST00000598071.1
ENST00000601178.1
ENST00000376716.5
ENST00000391795.3
zinc finger protein 615
chr10_+_135192782 0.13 ENST00000480071.2
polyamine oxidase (exo-N4-amino)
chr7_-_138794081 0.13 ENST00000464606.1
zinc finger CCCH-type, antiviral 1
chr1_-_154580616 0.13 ENST00000368474.4
adenosine deaminase, RNA-specific
chr19_-_47616992 0.13 ENST00000253048.5
zinc finger CCCH-type containing 4
chr1_+_221051699 0.13 ENST00000366903.6
H2.0-like homeobox
chr15_+_76352178 0.13 ENST00000388942.3
chromosome 15 open reading frame 27
chr7_+_106809406 0.13 ENST00000468410.1
ENST00000478930.1
ENST00000464009.1
ENST00000222574.4
HMG-box transcription factor 1
chr12_-_51664058 0.13 ENST00000605627.1
small cell adhesion glycoprotein
chr13_-_43566301 0.13 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
epithelial stromal interaction 1 (breast)
chr1_+_177140633 0.13 ENST00000361539.4
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr5_+_118407053 0.13 ENST00000311085.8
ENST00000539542.1
Dmx-like 1
chr6_+_3118926 0.13 ENST00000380379.5
biphenyl hydrolase-like (serine hydrolase)
chr19_-_15544099 0.12 ENST00000599910.2
widely interspaced zinc finger motifs
chrX_+_23801280 0.12 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
spermidine/spermine N1-acetyltransferase 1
chr7_-_100895414 0.12 ENST00000435848.1
ENST00000474120.1
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
chr9_+_82188077 0.12 ENST00000425506.1
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr19_-_9546177 0.12 ENST00000592292.1
ENST00000588221.1
zinc finger protein 266
chr14_+_89029336 0.12 ENST00000556945.1
ENST00000556158.1
ENST00000557607.1
zinc finger CCCH-type containing 14
chr19_+_52264449 0.12 ENST00000599326.1
ENST00000598953.1
formyl peptide receptor 2
chr3_-_142166846 0.12 ENST00000463916.1
ENST00000544157.1
5'-3' exoribonuclease 1
chr7_-_142176790 0.11 ENST00000390369.2
T cell receptor beta variable 7-4 (gene/pseudogene)
chr19_+_36705504 0.11 ENST00000456324.1
zinc finger protein 146
chr1_+_241695670 0.11 ENST00000366557.4
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr14_-_94942577 0.11 ENST00000424550.2
ENST00000337425.5
ENST00000546329.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
chr19_+_42300548 0.11 ENST00000344550.4
carcinoembryonic antigen-related cell adhesion molecule 3
chr19_-_50528584 0.11 ENST00000594092.1
ENST00000443401.2
ENST00000594948.1
ENST00000377011.2
ENST00000593919.1
ENST00000601324.1
ENST00000316763.3
ENST00000601341.1
ENST00000600259.1
vaccinia related kinase 3
chr5_-_11904152 0.11 ENST00000304623.8
ENST00000458100.2
catenin (cadherin-associated protein), delta 2
chr19_-_9546227 0.11 ENST00000361451.2
ENST00000361151.1
zinc finger protein 266
chr17_+_39845134 0.11 ENST00000591776.1
ENST00000469257.1
eukaryotic translation initiation factor 1
chr16_+_89642120 0.11 ENST00000268720.5
ENST00000319518.8
copine VII
chr15_+_74287035 0.11 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
promyelocytic leukemia
chr12_+_4758264 0.11 ENST00000266544.5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr13_-_76056250 0.11 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1 domain family, member 4
chr19_+_42300369 0.11 ENST00000357396.3
ENST00000221999.4
carcinoembryonic antigen-related cell adhesion molecule 3
chr1_-_8000872 0.11 ENST00000377507.3
tumor necrosis factor receptor superfamily, member 9
chr12_+_129028500 0.11 ENST00000315208.8
transmembrane protein 132C
chrX_+_65382381 0.10 ENST00000519389.1
hephaestin
chr3_+_9958870 0.10 ENST00000413608.1
interleukin 17 receptor C
chr5_+_180257951 0.10 ENST00000501855.2
long intergenic non-protein coding RNA 847
chr2_-_160473114 0.10 ENST00000392783.2
bromodomain adjacent to zinc finger domain, 2B
chr17_-_40264692 0.10 ENST00000591220.1
ENST00000251642.3
DEXH (Asp-Glu-X-His) box polypeptide 58

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.8 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.7 2.0 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.5 5.2 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.4 1.2 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.4 3.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.3 1.6 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.3 0.9 GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.3 3.2 GO:0006600 creatine metabolic process(GO:0006600)
0.3 2.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.2 1.0 GO:0019541 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.2 0.9 GO:0036269 swimming behavior(GO:0036269)
0.2 1.7 GO:0072592 oxygen metabolic process(GO:0072592)
0.2 0.5 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.1 0.9 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.4 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
0.1 0.7 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.1 1.2 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 0.6 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.6 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.1 0.4 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.1 0.4 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.3 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
0.1 0.3 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.1 0.3 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.1 0.4 GO:0009447 putrescine catabolic process(GO:0009447)
0.1 1.2 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 1.4 GO:0060982 coronary artery morphogenesis(GO:0060982)
0.1 0.9 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.4 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.3 GO:0043335 protein unfolding(GO:0043335)
0.1 2.5 GO:0035456 response to interferon-beta(GO:0035456)
0.1 0.4 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1 0.4 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.1 0.2 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.1 0.6 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.6 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 0.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.2 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.1 GO:1904579 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.0 0.3 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.4 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.5 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.0 0.1 GO:0032899 regulation of neurotrophin production(GO:0032899)
0.0 1.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.1 GO:0032242 regulation of nucleoside transport(GO:0032242) positive regulation of necroptotic process(GO:0060545)
0.0 0.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.1 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.2 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.3 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.1 GO:2001183 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.3 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.0 0.2 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.2 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 1.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.0 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.3 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.0 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.0 0.2 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.3 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.1 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.9 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.0 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.1 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.4 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.8 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.1 1.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.3 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.4 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.4 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.2 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 11.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.7 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.1 GO:0043291 RAVE complex(GO:0043291)
0.0 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 3.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.8 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 2.2 GO:0005643 nuclear pore(GO:0005643)
0.0 1.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 1.1 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.6 GO:0031904 endosome lumen(GO:0031904)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0009041 uridylate kinase activity(GO:0009041)
0.4 1.2 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.3 0.9 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.3 1.7 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 1.6 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 1.6 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.2 0.6 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 1.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 3.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 0.9 GO:0004925 prolactin receptor activity(GO:0004925)
0.2 0.9 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 1.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 3.2 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.3 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1 12.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 0.3 GO:0005124 scavenger receptor binding(GO:0005124)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.8 GO:0031386 protein tag(GO:0031386)
0.1 0.4 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 0.3 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 1.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.3 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.3 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 5.5 GO:0003924 GTPase activity(GO:0003924)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.1 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.4 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 3.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.4 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.5 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 1.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 8.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 3.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.2 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle