ISMARA results: IRF7

Project

Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

Navigation

Downloads

Results for IRF7

Z-value: 0.83

Motif logo

Transcription factors associated with IRF7

Gene Symbol	Gene ID	Gene Info
IRF7 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000185507.15	interferon regulatory factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF7	hg19_v2_chr11_-_615570_615728	0.01	9.4e-01	Click!

Activity profile of IRF7 motif

Sorted Z-values of IRF7 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_39770803 Show fit	4.18	ENST00000518237.1	IDO1 Ensembl NCBI GeneCards UniProt NextProt Show fit	indoleamine 2,3-dioxygenase 1
chr1_-_207119738 Show fit	2.44	ENST00000356495.4	PIGR Ensembl NCBI GeneCards UniProt NextProt Show fit	polymeric immunoglobulin receptor
chr16_-_21289627 Show fit	2.40	ENST00000396023.2 ENST00000415987.2	CRYM Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, mu
chr4_+_70861647 Show fit	2.25	ENST00000246895.4 ENST00000381060.2	STATH Ensembl NCBI GeneCards UniProt NextProt Show fit	statherin
chr6_+_32821924 Show fit	1.97	ENST00000374859.2 ENST00000453265.2	PSMB9 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_29527702 Show fit	1.96	ENST00000377050.4	UBD Ensembl NCBI GeneCards UniProt NextProt Show fit	ubiquitin D
chr10_+_51549498 Show fit	1.96	ENST00000358559.2 ENST00000298239.6	MSMB Ensembl NCBI GeneCards UniProt NextProt Show fit	microseminoprotein, beta-
chr5_+_96212185 Show fit	1.87	ENST00000379904.4	ERAP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	endoplasmic reticulum aminopeptidase 2
chr5_+_96211643 Show fit	1.87	ENST00000437043.3 ENST00000510373.1	ERAP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	endoplasmic reticulum aminopeptidase 2
chr1_+_79115503 Show fit	1.84	ENST00000370747.4 ENST00000438486.1 ENST00000545124.1	IFI44 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon-induced protein 44

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	4.2	GO:0036269	swimming behavior(GO:0036269)
0.3	4.2	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2	3.7	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	3.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	3.6	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.3	3.5	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3	2.9	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.7	2.8	GO:0034343	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.5	2.4	GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.2	2.4	GO:0070327	thyroid hormone transport(GO:0070327)

Showing 1 to 10 of 195 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.4	GO:0035577	azurophil granule membrane(GO:0035577)
0.7	4.2	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.3	4.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.3	3.0	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	2.3	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	1.5	GO:0016235	aggresome(GO:0016235)
0.1	1.2	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	1.2	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.2	1.0	GO:0070826	paraferritin complex(GO:0070826)
0.0	1.0	GO:0031092	platelet alpha granule membrane(GO:0031092)

Showing 1 to 10 of 69 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.9	GO:0050840	extracellular matrix binding(GO:0050840)
1.4	4.2	GO:0033754	indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0	4.0	GO:0003727	single-stranded RNA binding(GO:0003727)
0.2	3.7	GO:0038187	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1	2.8	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.1	2.8	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6	2.4	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3	2.4	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.7	2.2	GO:0046848	hydroxyapatite binding(GO:0046848)
0.6	2.2	GO:0004031	aldehyde oxidase activity(GO:0004031)

Showing 1 to 10 of 129 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	1.5	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	1.2	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	1.1	PID ATR PATHWAY	ATR signaling pathway
0.0	0.8	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.8	PID FOXO PATHWAY	FoxO family signaling
0.0	0.8	PID CDC42 PATHWAY	CDC42 signaling events
0.0	0.8	PID BMP PATHWAY	BMP receptor signaling
0.0	0.7	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Showing 1 to 10 of 20 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.8	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.2	4.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	4.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.2	4.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	2.9	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	2.6	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	1.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.1	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	1.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway

Showing 1 to 10 of 43 entries

Results for IRF7

Z-value: 0.83

Motif logo

Transcription factors associated with IRF7

Activity-expression correlation:

Activity profile of IRF7 motif

Sorted Z-values of IRF7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: