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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for IRX3

Z-value: 0.83

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Transcription factors associated with IRX3

Gene Symbol Gene ID Gene Info
IRX3
ENSG00000177508.11 iroquois homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX3hg19_v2_chr16_-_54320675_543207150.077.2e-01Click!

Activity profile of IRX3 motif

Sorted Z-values of IRX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_69681710 2.40 ENST00000265403.7
ENST00000458688.2
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B10
chr2_-_89545079 1.59 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr4_+_70861647 1.48 ENST00000246895.4
ENST00000381060.2
STATH
statherin
chr19_-_9092018 1.38 ENST00000397910.4
MUC16
mucin 16, cell surface associated
chr12_-_91573132 1.33 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr13_-_20080080 1.29 ENST00000400103.2
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr10_+_118305435 1.29 ENST00000369221.2
PNLIP
pancreatic lipase
chr4_+_69962185 1.28 ENST00000305231.7
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr10_+_118187379 1.27 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chr12_-_91574142 1.22 ENST00000547937.1
DCN
decorin
chr12_-_10282836 1.17 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr4_-_70725856 1.16 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr9_+_105757590 1.16 ENST00000374798.3
ENST00000487798.1
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr19_-_22379753 1.15 ENST00000397121.2
ZNF676
zinc finger protein 676
chr2_+_89975669 1.15 ENST00000474213.1
IGKV2D-30
immunoglobulin kappa variable 2D-30
chr4_-_70080449 1.14 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chrX_-_15620192 1.07 ENST00000427411.1
ACE2
angiotensin I converting enzyme 2
chr13_+_25254545 1.05 ENST00000218548.6
ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr4_+_70146217 1.04 ENST00000335568.5
ENST00000511240.1
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr12_-_10282681 1.03 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr12_-_10282742 0.97 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr16_+_19421803 0.94 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr6_-_52705641 0.93 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr13_+_25254693 0.91 ENST00000381946.3
ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr5_+_140235469 0.91 ENST00000506939.2
ENST00000307360.5
PCDHA10
protocadherin alpha 10
chr12_+_21207503 0.85 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr10_+_95326416 0.84 ENST00000371481.4
ENST00000371483.4
ENST00000604414.1
FFAR4
free fatty acid receptor 4
chr12_-_91573316 0.84 ENST00000393155.1
DCN
decorin
chr4_+_69962212 0.82 ENST00000508661.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr9_+_90112767 0.79 ENST00000408954.3
DAPK1
death-associated protein kinase 1
chr7_-_99573640 0.77 ENST00000411734.1
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr12_+_69742121 0.76 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr5_+_147443534 0.75 ENST00000398454.1
ENST00000359874.3
ENST00000508733.1
ENST00000256084.7
SPINK5
serine peptidase inhibitor, Kazal type 5
chr16_-_20709066 0.70 ENST00000520010.1
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr7_-_99573677 0.70 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr1_-_31902614 0.68 ENST00000596131.1
AC114494.1
HCG1787699; Uncharacterized protein
chr11_+_27062502 0.68 ENST00000263182.3
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr11_-_111782484 0.67 ENST00000533971.1
CRYAB
crystallin, alpha B
chr11_+_27076764 0.67 ENST00000525090.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr14_-_106453155 0.67 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr5_+_140220769 0.66 ENST00000531613.1
ENST00000378123.3
PCDHA8
protocadherin alpha 8
chr11_-_111782696 0.65 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chr22_-_18923655 0.64 ENST00000438924.1
ENST00000457083.1
ENST00000420436.1
ENST00000334029.2
ENST00000357068.6
PRODH
proline dehydrogenase (oxidase) 1
chr4_-_170924888 0.63 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chr19_+_50691437 0.63 ENST00000598205.1
MYH14
myosin, heavy chain 14, non-muscle
chr8_+_84824920 0.60 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr7_+_13141097 0.60 ENST00000411542.1
AC011288.2
AC011288.2
chr12_-_127174806 0.58 ENST00000545853.1
ENST00000537478.1
RP11-407A16.3
RP11-407A16.3
chr2_-_16804320 0.58 ENST00000355549.2
FAM49A
family with sequence similarity 49, member A
chr12_-_71182695 0.57 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr17_+_34639793 0.57 ENST00000394465.2
ENST00000394463.2
ENST00000378342.4
CCL4L2
chemokine (C-C motif) ligand 4-like 2
chr6_+_29407083 0.56 ENST00000444197.2
OR10C1
olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
chr3_-_127541194 0.55 ENST00000453507.2
MGLL
monoglyceride lipase
chr12_-_10605929 0.55 ENST00000347831.5
ENST00000359151.3
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr4_+_41361616 0.55 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr7_+_80267973 0.54 ENST00000394788.3
ENST00000447544.2
CD36
CD36 molecule (thrombospondin receptor)
chr21_-_43528548 0.53 ENST00000329015.2
C21orf128
chromosome 21 open reading frame 128
chr6_-_47009996 0.53 ENST00000371243.2
GPR110
G protein-coupled receptor 110
chr11_+_57365150 0.52 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr9_-_21975088 0.52 ENST00000304494.5
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr8_+_120885949 0.52 ENST00000523492.1
ENST00000286234.5
DEPTOR
DEP domain containing MTOR-interacting protein
chr20_-_13971255 0.52 ENST00000284951.5
ENST00000378072.5
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr12_-_13248598 0.51 ENST00000337630.6
ENST00000545699.1
GSG1
germ cell associated 1
chr2_+_106679690 0.51 ENST00000409944.1
C2orf40
chromosome 2 open reading frame 40
chr12_-_91546926 0.49 ENST00000550758.1
DCN
decorin
chr11_-_63330842 0.49 ENST00000255695.1
HRASLS2
HRAS-like suppressor 2
chr9_-_37465396 0.49 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr22_+_23161491 0.49 ENST00000390316.2
IGLV3-9
immunoglobulin lambda variable 3-9 (gene/pseudogene)
chr20_+_2276639 0.49 ENST00000381458.5
TGM3
transglutaminase 3
chr13_-_46716969 0.49 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_+_29542557 0.49 ENST00000550906.1
OVCH1-AS1
OVCH1 antisense RNA 1
chr18_+_9885961 0.48 ENST00000306084.6
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr3_-_185270383 0.48 ENST00000296252.4
LIPH
lipase, member H
chr2_-_88125471 0.48 ENST00000398146.3
RGPD2
RANBP2-like and GRIP domain containing 2
chr19_-_44388116 0.47 ENST00000587539.1
ZNF404
zinc finger protein 404
chr21_-_33975547 0.47 ENST00000431599.1
C21orf59
chromosome 21 open reading frame 59
chr10_+_82009466 0.46 ENST00000356374.4
AL359195.1
Uncharacterized protein; cDNA FLJ46261 fis, clone TESTI4025062
chr1_-_46598284 0.46 ENST00000423209.1
ENST00000262741.5
PIK3R3
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr14_-_106926724 0.45 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr1_-_46598371 0.45 ENST00000372006.1
ENST00000425892.1
ENST00000420542.1
ENST00000354242.4
ENST00000340332.6
PIK3R3
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr4_-_103998439 0.45 ENST00000503230.1
ENST00000503818.1
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr17_-_9683238 0.45 ENST00000571771.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr1_-_152086556 0.44 ENST00000368804.1
TCHH
trichohyalin
chr16_+_20775358 0.43 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr13_+_97928395 0.43 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr19_+_53761545 0.42 ENST00000341702.3
VN1R2
vomeronasal 1 receptor 2
chr22_-_36556821 0.42 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr13_+_113030625 0.42 ENST00000283550.3
SPACA7
sperm acrosome associated 7
chr19_-_10491130 0.41 ENST00000530829.1
ENST00000529370.1
TYK2
tyrosine kinase 2
chr4_-_103997862 0.41 ENST00000394785.3
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr6_-_35765088 0.41 ENST00000259938.2
CLPS
colipase, pancreatic
chr22_+_51176624 0.41 ENST00000216139.5
ENST00000529621.1
ACR
acrosin
chr7_-_92777606 0.40 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr7_-_16921601 0.40 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
AGR3
anterior gradient 3
chr1_+_220863187 0.39 ENST00000294889.5
C1orf115
chromosome 1 open reading frame 115
chr11_-_49230184 0.39 ENST00000340334.7
ENST00000256999.2
FOLH1
folate hydrolase (prostate-specific membrane antigen) 1
chrX_-_77150911 0.39 ENST00000373336.3
MAGT1
magnesium transporter 1
chr19_-_54974894 0.39 ENST00000333834.4
LENG9
leukocyte receptor cluster (LRC) member 9
chr20_-_18477862 0.38 ENST00000337227.4
RBBP9
retinoblastoma binding protein 9
chr11_-_27384737 0.38 ENST00000317945.6
CCDC34
coiled-coil domain containing 34
chr10_-_101841588 0.38 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr1_+_145524891 0.38 ENST00000369304.3
ITGA10
integrin, alpha 10
chr11_+_60048053 0.37 ENST00000337908.4
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4A
chr4_-_84035905 0.37 ENST00000311507.4
PLAC8
placenta-specific 8
chr6_+_131958436 0.36 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr8_+_9009296 0.36 ENST00000521718.1
RP11-10A14.4
Uncharacterized protein
chr13_-_38172863 0.36 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr5_+_175490540 0.36 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr3_+_51895621 0.36 ENST00000333127.3
IQCF2
IQ motif containing F2
chr11_-_26588634 0.35 ENST00000436318.2
ENST00000281268.8
MUC15
mucin 15, cell surface associated
chr3_-_185270342 0.35 ENST00000424591.2
LIPH
lipase, member H
chr9_+_130026756 0.34 ENST00000314904.5
ENST00000373387.4
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr3_-_127441406 0.34 ENST00000487473.1
ENST00000484451.1
MGLL
monoglyceride lipase
chr15_-_56757329 0.34 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr14_+_22636283 0.34 ENST00000557168.1
TRAV30
T cell receptor alpha variable 30
chr12_+_56114189 0.34 ENST00000548082.1
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr21_-_43816052 0.33 ENST00000398405.1
TMPRSS3
transmembrane protease, serine 3
chr12_+_20963632 0.33 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr4_+_41540160 0.33 ENST00000503057.1
ENST00000511496.1
LIMCH1
LIM and calponin homology domains 1
chr5_+_94727048 0.33 ENST00000283357.5
FAM81B
family with sequence similarity 81, member B
chr8_+_9009202 0.32 ENST00000518496.1
RP11-10A14.4
Uncharacterized protein
chr8_+_52730143 0.32 ENST00000415643.1
AC090186.1
Uncharacterized protein
chr3_-_151102529 0.32 ENST00000302632.3
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr9_+_99690592 0.32 ENST00000354649.3
NUTM2G
NUT family member 2G
chr2_+_101591314 0.31 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr10_-_96829246 0.31 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr16_+_56995854 0.31 ENST00000566128.1
CETP
cholesteryl ester transfer protein, plasma
chr15_-_81616446 0.31 ENST00000302824.6
STARD5
StAR-related lipid transfer (START) domain containing 5
chr6_-_32920794 0.31 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr12_-_91348949 0.31 ENST00000358859.2
CCER1
coiled-coil glutamate-rich protein 1
chr17_-_34207295 0.31 ENST00000463941.1
ENST00000293272.3
CCL5
chemokine (C-C motif) ligand 5
chr3_-_151047327 0.30 ENST00000325602.5
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr16_-_72206034 0.30 ENST00000537465.1
ENST00000237353.10
PMFBP1
polyamine modulated factor 1 binding protein 1
chr12_+_56114151 0.30 ENST00000547072.1
ENST00000552930.1
ENST00000257895.5
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr14_-_106963409 0.29 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr10_+_96698406 0.29 ENST00000260682.6
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr10_+_91092241 0.29 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_+_53528659 0.29 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr2_-_8464760 0.29 ENST00000430192.1
LINC00299
long intergenic non-protein coding RNA 299
chr7_-_112430427 0.29 ENST00000449743.1
ENST00000441474.1
ENST00000454074.1
ENST00000447395.1
TMEM168
transmembrane protein 168
chr1_+_202317815 0.29 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr16_+_78056412 0.29 ENST00000299642.4
ENST00000575655.1
CLEC3A
C-type lectin domain family 3, member A
chr8_-_16043780 0.28 ENST00000445506.2
MSR1
macrophage scavenger receptor 1
chr1_-_89488510 0.28 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr3_+_8543533 0.28 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr8_+_12803176 0.28 ENST00000524591.2
KIAA1456
KIAA1456
chr19_-_40596828 0.28 ENST00000414720.2
ENST00000455521.1
ENST00000340963.5
ENST00000595773.1
ZNF780A
zinc finger protein 780A
chr5_-_131879205 0.28 ENST00000231454.1
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr4_-_103998060 0.28 ENST00000339611.4
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr1_+_160709076 0.28 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr2_-_233415220 0.28 ENST00000408957.3
TIGD1
tigger transposable element derived 1
chr12_+_8309630 0.27 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr14_-_23624511 0.27 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr7_-_111202511 0.27 ENST00000452895.1
ENST00000452753.1
ENST00000331762.3
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr1_-_161337662 0.27 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr1_+_160709055 0.27 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr7_+_37960163 0.27 ENST00000199448.4
ENST00000559325.1
ENST00000423717.1
EPDR1
ependymin related 1
chr2_-_158300556 0.27 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr5_-_177207634 0.27 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chr8_+_7801144 0.27 ENST00000443676.1
ZNF705B
zinc finger protein 705B
chr1_-_112032284 0.27 ENST00000414219.1
ADORA3
adenosine A3 receptor
chr17_-_26127525 0.26 ENST00000313735.6
NOS2
nitric oxide synthase 2, inducible
chr2_-_228497888 0.26 ENST00000264387.4
ENST00000409066.1
C2orf83
chromosome 2 open reading frame 83
chr9_-_136203235 0.26 ENST00000372022.4
SURF6
surfeit 6
chr16_-_67224002 0.26 ENST00000563889.1
ENST00000564418.1
ENST00000545725.2
ENST00000314586.6
EXOC3L1
exocyst complex component 3-like 1
chr3_+_142838091 0.26 ENST00000309575.3
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr9_-_97356075 0.26 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr17_+_56232494 0.26 ENST00000268912.5
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr13_+_76362974 0.25 ENST00000497947.2
LMO7
LIM domain 7
chr14_-_106471723 0.25 ENST00000390595.2
IGHV1-3
immunoglobulin heavy variable 1-3
chr1_-_213020991 0.25 ENST00000332912.3
C1orf227
chromosome 1 open reading frame 227
chr19_+_55281260 0.25 ENST00000336077.6
ENST00000291633.7
KIR2DL1
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
chr10_+_29577974 0.25 ENST00000375500.3
LYZL1
lysozyme-like 1
chr13_+_21714653 0.25 ENST00000382533.4
SAP18
Sin3A-associated protein, 18kDa
chr3_-_74570291 0.25 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr1_+_87012753 0.25 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr15_-_22473353 0.24 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr5_-_146302078 0.24 ENST00000508545.2
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr2_+_234545148 0.24 ENST00000373445.1
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr12_+_10365404 0.24 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr12_+_55248289 0.24 ENST00000308796.6
MUCL1
mucin-like 1
chr14_+_100485712 0.24 ENST00000544450.2
EVL
Enah/Vasp-like
chr17_-_61905005 0.24 ENST00000584574.1
ENST00000585145.1
ENST00000427159.2
FTSJ3
FtsJ homolog 3 (E. coli)
chr16_-_3493528 0.23 ENST00000301744.4
ZNF597
zinc finger protein 597
chr1_+_26644441 0.23 ENST00000374213.2
CD52
CD52 molecule
chr1_+_160709029 0.23 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr14_-_51562745 0.23 ENST00000298355.3
TRIM9
tripartite motif containing 9
chr1_+_15668240 0.23 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr8_+_24151620 0.22 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr5_-_147211226 0.22 ENST00000296695.5
SPINK1
serine peptidase inhibitor, Kazal type 1
chr1_-_227505289 0.22 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr14_-_71001708 0.22 ENST00000256389.3
ADAM20
ADAM metallopeptidase domain 20
chrX_+_65382381 0.22 ENST00000519389.1
HEPH
hephaestin
chr2_-_231090344 0.22 ENST00000540870.1
ENST00000416610.1
SP110
SP110 nuclear body protein
chr1_-_112106578 0.22 ENST00000369717.4
ADORA3
adenosine A3 receptor
chr20_+_54933971 0.21 ENST00000371384.3
ENST00000437418.1
FAM210B
family with sequence similarity 210, member B
chr11_-_65150103 0.21 ENST00000294187.6
ENST00000398802.1
ENST00000360662.3
ENST00000377152.2
ENST00000530936.1
SLC25A45
solute carrier family 25, member 45
chr1_+_202431859 0.21 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr17_-_42327236 0.21 ENST00000399246.2
AC003102.1
AC003102.1
chr2_+_217735493 0.21 ENST00000456163.1
AC007557.1
HCG1816075; Uncharacterized protein

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0006711 estrogen catabolic process(GO:0006711)
0.2 3.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 0.7 GO:0018874 benzoate metabolic process(GO:0018874)
0.2 1.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.2 0.5 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.2 3.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 1.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.6 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.1 0.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 1.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.4 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 1.5 GO:0046541 saliva secretion(GO:0046541)
0.1 2.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.7 GO:1900425 regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) negative regulation of defense response to bacterium(GO:1900425)
0.1 1.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.3 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1 0.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.3 GO:0002818 intracellular defense response(GO:0002818)
0.1 2.0 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 0.6 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.2 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 0.3 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.5 GO:0072564 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.3 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 0.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.2 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.1 0.4 GO:0030070 insulin processing(GO:0030070)
0.1 1.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.4 GO:0032571 response to vitamin K(GO:0032571) bone regeneration(GO:1990523)
0.1 0.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 0.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 1.3 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.1 0.3 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 0.2 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.1 0.4 GO:0019236 response to pheromone(GO:0019236)
0.1 0.3 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.1 0.4 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.2 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.3 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.6 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.3 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.3 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 0.2 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.8 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.5 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:1990180 mitochondrial tRNA 3'-end processing(GO:1990180)
0.0 0.5 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.2 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 0.2 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 0.1 GO:1902616 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 0.1 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.1 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0016095 polyprenol catabolic process(GO:0016095)
0.0 0.5 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 4.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.1 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.1 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.9 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.3 GO:0035376 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0 0.5 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.5 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 0.4 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.5 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.2 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.0 0.1 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.1 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.0 0.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:0071048 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.5 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.1 GO:1903487 regulation of lactation(GO:1903487)
0.0 2.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.1 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 1.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.1 GO:1990927 negative regulation of synaptic vesicle recycling(GO:1903422) negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.0 0.2 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.3 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.3 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.4 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.0 0.1 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.9 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.2 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0070374 positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.0 0.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.1 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.6 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.0 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.5 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 0.0 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.0 0.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.0 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.1 GO:0009743 response to carbohydrate(GO:0009743)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.0 GO:0080154 regulation of fertilization(GO:0080154)
0.0 0.1 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.1 GO:0030593 neutrophil chemotaxis(GO:0030593) granulocyte chemotaxis(GO:0071621)
0.0 0.1 GO:0043691 reverse cholesterol transport(GO:0043691)
0.0 0.5 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.1 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.0 GO:1903936 response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.0 0.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.1 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.4 1.2 GO:0033150 cytoskeletal calyx(GO:0033150)
0.3 4.0 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 0.4 GO:0043159 acrosomal matrix(GO:0043159)
0.1 0.4 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 0.6 GO:0097513 myosin II filament(GO:0097513)
0.1 0.7 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 1.3 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.3 GO:0001652 granular component(GO:0001652)
0.0 0.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.5 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.1 GO:0098855 HCN channel complex(GO:0098855)
0.0 0.1 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 1.1 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.6 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.9 GO:0001533 cornified envelope(GO:0001533)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 0.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0046848 hydroxyapatite binding(GO:0046848)
0.5 2.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.3 1.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.3 1.3 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.3 1.1 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.2 7.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 1.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.2 0.6 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.2 1.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 3.9 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 1.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 0.6 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 0.6 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 0.3 GO:0017129 triglyceride binding(GO:0017129)
0.1 0.4 GO:0004040 amidase activity(GO:0004040)
0.1 0.4 GO:1904492 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)
0.1 0.3 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.1 1.5 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.3 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 2.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.4 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.8 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 1.4 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 0.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.3 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 0.4 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 3.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 1.2 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.3 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.5 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.6 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.1 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.2 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576)
0.0 0.4 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0035671 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0001147 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.4 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.2 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.1 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 1.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.0 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.2 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.1 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.1 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 2.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.1 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.2 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.0 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.0 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.2 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 4.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.0 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 4.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 1.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.0 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 2.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 1.3 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.7 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.5 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules