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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for IRX3
Z-value: 0.83
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Transcription factors associated with IRX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX3 | hg19_v2_chr16_-_54320675_54320715 | 0.07 | 7.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_69681710 Show fit | 2.40 |
ENST00000265403.7
ENST00000458688.2 |
UDP glucuronosyltransferase 2 family, polypeptide B10 |
|
| chr2_-_89545079 Show fit | 1.59 |
ENST00000468494.1
|
immunoglobulin kappa variable 2-30 |
|
| chr4_+_70861647 Show fit | 1.48 |
ENST00000246895.4
ENST00000381060.2 |
statherin |
|
| chr19_-_9092018 Show fit | 1.38 |
ENST00000397910.4
|
mucin 16, cell surface associated |
|
| chr12_-_91573132 Show fit | 1.33 |
ENST00000550563.1
ENST00000546370.1 |
decorin |
|
| chr13_-_20080080 Show fit | 1.29 |
ENST00000400103.2
|
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 |
|
| chr10_+_118305435 Show fit | 1.29 |
ENST00000369221.2
|
pancreatic lipase |
|
| chr4_+_69962185 Show fit | 1.28 |
ENST00000305231.7
|
UDP glucuronosyltransferase 2 family, polypeptide B7 |
|
| chr10_+_118187379 Show fit | 1.27 |
ENST00000369230.3
|
pancreatic lipase-related protein 3 |
|
| chr12_-_91574142 Show fit | 1.22 |
ENST00000547937.1
|
decorin |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 3.7 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 3.2 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.1 | 2.3 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 2.1 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 2.0 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
| 0.5 | 1.5 | GO:0006711 | estrogen catabolic process(GO:0006711) |
| 0.1 | 1.5 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.1 | 1.5 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.1 | 1.3 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 2.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 2.0 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.0 | 1.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 1.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.4 | 1.2 | GO:0033150 | cytoskeletal calyx(GO:0033150) |
| 0.0 | 1.1 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 1.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.9 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.1 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 3.9 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.0 | 3.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 2.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 2.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.5 | 2.0 | GO:0008900 | hydrogen:potassium-exchanging ATPase activity(GO:0008900) |
| 0.5 | 1.5 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.1 | 1.5 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.1 | 1.4 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.3 | 1.3 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.0 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.8 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.6 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.4 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.3 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 4.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 2.3 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 2.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.7 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 1.4 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 1.3 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 1.2 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.0 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |