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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for IRX6_IRX4

Z-value: 0.36

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 iroquois homeobox 6
IRX4
ENSG00000113430.5 iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.222.4e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_777118 1.19 ENST00000562141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr3_-_9994021 0.93 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr1_+_63989004 0.87 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr11_+_6897856 0.87 ENST00000379829.2
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr21_-_34185944 0.74 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr16_+_777246 0.67 ENST00000561546.1
ENST00000564545.1
ENST00000389703.3
ENST00000567414.1
ENST00000568141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr16_+_776936 0.57 ENST00000549114.1
ENST00000341413.4
ENST00000562187.1
ENST00000564537.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr8_+_67976593 0.51 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr20_+_11008408 0.50 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr12_+_32655110 0.50 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr12_-_10282836 0.47 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr4_+_41361616 0.43 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr7_-_16844611 0.41 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr1_+_170904612 0.40 ENST00000367759.4
ENST00000367758.3
MROH9
maestro heat-like repeat family member 9
chr6_-_52705641 0.40 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr12_-_10282681 0.32 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr12_-_10282742 0.31 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr3_+_171561127 0.31 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr13_-_41768654 0.26 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chrX_+_36254051 0.26 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr6_+_140175987 0.25 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr8_-_17555164 0.24 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr17_-_42327236 0.23 ENST00000399246.2
AC003102.1
AC003102.1
chr3_+_53528659 0.23 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr21_-_34185989 0.22 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr6_+_116691001 0.22 ENST00000537543.1
DSE
dermatan sulfate epimerase
chr20_+_43990576 0.20 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr10_+_90660832 0.20 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr18_-_47376197 0.17 ENST00000592688.1
MYO5B
myosin VB
chr2_+_113670548 0.16 ENST00000263326.3
ENST00000352179.3
ENST00000349806.3
ENST00000353225.3
IL37
interleukin 37
chr7_-_92855762 0.15 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr15_+_41057818 0.15 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr10_+_118350522 0.14 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr19_-_54974894 0.14 ENST00000333834.4
LENG9
leukocyte receptor cluster (LRC) member 9
chr4_+_130017268 0.14 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr17_-_47723943 0.14 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chr15_+_66585879 0.13 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr2_+_113829895 0.13 ENST00000393197.2
IL1F10
interleukin 1 family, member 10 (theta)
chr20_+_10199468 0.13 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr10_+_118350468 0.13 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr15_+_66585555 0.12 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr9_-_37465396 0.12 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr19_+_50691437 0.11 ENST00000598205.1
MYH14
myosin, heavy chain 14, non-muscle
chr11_-_35547572 0.11 ENST00000378880.2
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr17_-_29641084 0.11 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr16_+_21689835 0.10 ENST00000286149.4
ENST00000388958.3
OTOA
otoancorin
chr14_+_56127989 0.09 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr8_+_84824920 0.09 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr4_+_71458012 0.08 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr2_+_133874577 0.06 ENST00000596384.1
AC011755.1
HCG2006742; Protein LOC100996685
chr9_-_27573651 0.05 ENST00000379995.1
ENST00000379997.3
C9orf72
chromosome 9 open reading frame 72
chr21_-_34186006 0.05 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr4_+_71457970 0.05 ENST00000322937.6
AMBN
ameloblastin (enamel matrix protein)
chr12_-_88423164 0.05 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chrX_-_15333736 0.04 ENST00000380470.3
ASB11
ankyrin repeat and SOCS box containing 11
chr4_+_113558612 0.04 ENST00000505034.1
ENST00000324052.6
LARP7
La ribonucleoprotein domain family, member 7
chr1_+_53308398 0.04 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chrX_+_15767971 0.03 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr5_+_175490540 0.03 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr12_+_5541267 0.02 ENST00000423158.3
NTF3
neurotrophin 3
chr3_-_168865522 0.02 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr8_-_67976509 0.01 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr5_+_59783540 0.01 ENST00000515734.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr6_-_49834240 0.01 ENST00000335847.4
CRISP1
cysteine-rich secretory protein 1
chr2_-_231989808 0.01 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr6_-_49834209 0.01 ENST00000507853.1
CRISP1
cysteine-rich secretory protein 1
chr1_-_3566590 0.01 ENST00000424367.1
ENST00000378322.3
WRAP73
WD repeat containing, antisense to TP73
chrX_-_19988382 0.00 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 1.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0043105 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.1 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.2 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.2 GO:0032439 endosome localization(GO:0032439)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 1.1 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.2 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)