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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ISL1

Z-value: 0.48

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Transcription factors associated with ISL1

Gene Symbol Gene ID Gene Info
ISL1
ENSG00000016082.10 ISL LIM homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL1hg19_v2_chr5_+_50678921_50678921-0.232.2e-01Click!

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_102668879 1.24 ENST00000315274.6
MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr8_+_26371763 0.87 ENST00000521913.1
DPYSL2
dihydropyrimidinase-like 2
chrX_+_135252050 0.83 ENST00000449474.1
ENST00000345434.3
FHL1
four and a half LIM domains 1
chr12_-_30887948 0.78 ENST00000433722.2
CAPRIN2
caprin family member 2
chr19_-_50143452 0.77 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chrX_+_135251835 0.75 ENST00000456445.1
FHL1
four and a half LIM domains 1
chrX_+_135251783 0.74 ENST00000394153.2
FHL1
four and a half LIM domains 1
chr5_+_137203465 0.68 ENST00000239926.4
MYOT
myotilin
chrX_+_79675965 0.54 ENST00000308293.5
FAM46D
family with sequence similarity 46, member D
chr2_-_208030647 0.52 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr6_+_167704838 0.51 ENST00000366829.2
UNC93A
unc-93 homolog A (C. elegans)
chr11_+_60995849 0.50 ENST00000537932.1
PGA4
pepsinogen 4, group I (pepsinogen A)
chr4_+_8201091 0.48 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr22_+_40390930 0.47 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr10_-_17659234 0.46 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr11_-_107729887 0.46 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr6_+_167704798 0.45 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr2_+_211421262 0.42 ENST00000233072.5
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr9_-_113761720 0.41 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1
chr16_-_67517716 0.41 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr3_+_121774202 0.41 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr10_+_17270214 0.41 ENST00000544301.1
VIM
vimentin
chr10_-_17659357 0.40 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr17_-_57229155 0.39 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr1_+_82266053 0.38 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr3_+_158787041 0.38 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr12_-_28124903 0.38 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr6_+_35996859 0.38 ENST00000472333.1
MAPK14
mitogen-activated protein kinase 14
chr1_-_114430169 0.37 ENST00000393316.3
BCL2L15
BCL2-like 15
chr3_-_149095652 0.37 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr18_+_21529811 0.37 ENST00000588004.1
LAMA3
laminin, alpha 3
chr9_+_131084846 0.36 ENST00000608951.1
COQ4
coenzyme Q4
chr7_+_20687017 0.35 ENST00000258738.6
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr2_+_158114051 0.35 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr12_+_1099675 0.34 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr13_-_99667960 0.31 ENST00000448493.2
DOCK9
dedicator of cytokinesis 9
chr2_+_219472637 0.30 ENST00000417849.1
PLCD4
phospholipase C, delta 4
chr7_+_13141097 0.30 ENST00000411542.1
AC011288.2
AC011288.2
chr5_+_137203557 0.30 ENST00000515645.1
MYOT
myotilin
chr10_-_95241951 0.30 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr15_-_55541227 0.29 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr10_-_95242044 0.29 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr2_+_28618532 0.29 ENST00000545753.1
FOSL2
FOS-like antigen 2
chr8_+_42873548 0.28 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr11_-_66496430 0.26 ENST00000533211.1
SPTBN2
spectrin, beta, non-erythrocytic 2
chr4_-_77328458 0.25 ENST00000388914.3
ENST00000434846.2
CCDC158
coiled-coil domain containing 158
chr17_-_64225508 0.25 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr14_+_37126765 0.24 ENST00000402703.2
PAX9
paired box 9
chr12_+_96883347 0.24 ENST00000524981.4
ENST00000298953.3
C12orf55
chromosome 12 open reading frame 55
chr2_-_89247338 0.24 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr3_-_185538849 0.23 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr15_-_72767490 0.23 ENST00000565181.1
RP11-1007O24.3
RP11-1007O24.3
chr1_-_197169672 0.23 ENST00000367405.4
ZBTB41
zinc finger and BTB domain containing 41
chr3_-_27498235 0.23 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr1_-_119682812 0.23 ENST00000537870.1
WARS2
tryptophanyl tRNA synthetase 2, mitochondrial
chr5_+_137203541 0.23 ENST00000421631.2
MYOT
myotilin
chr16_+_2198604 0.22 ENST00000210187.6
RAB26
RAB26, member RAS oncogene family
chr20_-_25320367 0.22 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chr2_-_220034712 0.22 ENST00000409370.2
ENST00000430764.1
ENST00000409878.3
SLC23A3
solute carrier family 23, member 3
chr1_-_157670647 0.22 ENST00000368184.3
FCRL3
Fc receptor-like 3
chr1_+_15986364 0.21 ENST00000345034.1
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr5_+_34757309 0.21 ENST00000397449.1
RAI14
retinoic acid induced 14
chr8_+_70404996 0.21 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr18_+_616672 0.21 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr4_+_169418255 0.21 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chrX_+_49832231 0.20 ENST00000376108.3
CLCN5
chloride channel, voltage-sensitive 5
chr1_+_3773825 0.20 ENST00000378209.3
ENST00000338895.3
ENST00000378212.2
ENST00000341385.3
DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr12_+_93096759 0.20 ENST00000544406.2
C12orf74
chromosome 12 open reading frame 74
chr19_+_39687596 0.20 ENST00000339852.4
NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr1_-_100598444 0.20 ENST00000535161.1
ENST00000287482.5
SASS6
spindle assembly 6 homolog (C. elegans)
chr11_+_30252549 0.20 ENST00000254122.3
ENST00000417547.1
FSHB
follicle stimulating hormone, beta polypeptide
chr3_-_113897899 0.19 ENST00000383673.2
ENST00000295881.7
DRD3
dopamine receptor D3
chr10_+_135340859 0.19 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr2_+_202937972 0.19 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr20_+_60174827 0.18 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr22_-_36784035 0.18 ENST00000216181.5
MYH9
myosin, heavy chain 9, non-muscle
chr12_+_93096619 0.18 ENST00000397833.3
C12orf74
chromosome 12 open reading frame 74
chr8_+_26247878 0.18 ENST00000518611.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr4_-_186877806 0.18 ENST00000355634.5
SORBS2
sorbin and SH3 domain containing 2
chr7_-_122342988 0.18 ENST00000434824.1
RNF148
ring finger protein 148
chr6_+_31707725 0.17 ENST00000375755.3
ENST00000375742.3
ENST00000375750.3
ENST00000425703.1
ENST00000534153.4
ENST00000375703.3
ENST00000375740.3
MSH5
mutS homolog 5
chr13_-_52027134 0.17 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr7_+_99724317 0.17 ENST00000398075.2
ENST00000421390.1
MBLAC1
metallo-beta-lactamase domain containing 1
chr11_+_120973375 0.16 ENST00000264037.2
TECTA
tectorin alpha
chr4_+_169418195 0.16 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr9_-_134585221 0.15 ENST00000372190.3
ENST00000427994.1
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr18_+_616711 0.15 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr7_-_122342966 0.15 ENST00000447240.1
RNF148
ring finger protein 148
chr1_+_150980889 0.15 ENST00000450884.1
ENST00000271620.3
ENST00000271619.8
ENST00000368937.1
ENST00000431193.1
ENST00000368936.1
PRUNE
prune exopolyphosphatase
chr15_-_43594453 0.15 ENST00000452443.2
TGM7
transglutaminase 7
chr6_+_168418553 0.15 ENST00000354419.2
ENST00000351261.3
KIF25
kinesin family member 25
chr10_-_115613828 0.14 ENST00000361384.2
DCLRE1A
DNA cross-link repair 1A
chr2_+_171034646 0.14 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr13_-_99910673 0.14 ENST00000397473.2
ENST00000397470.2
GPR18
G protein-coupled receptor 18
chr3_-_33686925 0.14 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr8_-_7220490 0.14 ENST00000400078.2
ZNF705G
zinc finger protein 705G
chr5_+_32710736 0.14 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr7_+_93535817 0.14 ENST00000248572.5
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr9_+_27109133 0.14 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr11_+_64018955 0.14 ENST00000279230.6
ENST00000540288.1
ENST00000325234.5
PLCB3
phospholipase C, beta 3 (phosphatidylinositol-specific)
chrX_+_65382433 0.14 ENST00000374727.3
HEPH
hephaestin
chr17_-_2996290 0.14 ENST00000331459.1
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chrX_-_15683147 0.14 ENST00000380342.3
TMEM27
transmembrane protein 27
chr12_-_53012343 0.14 ENST00000305748.3
KRT73
keratin 73
chr5_+_135468516 0.14 ENST00000507118.1
ENST00000511116.1
ENST00000545279.1
ENST00000545620.1
SMAD5
SMAD family member 5
chr5_+_32788945 0.14 ENST00000326958.1
AC026703.1
AC026703.1
chr3_+_151451707 0.13 ENST00000356517.3
AADACL2
arylacetamide deacetylase-like 2
chr9_+_131084815 0.13 ENST00000300452.3
ENST00000609948.1
COQ4
coenzyme Q4
chr2_+_207804278 0.13 ENST00000272852.3
CPO
carboxypeptidase O
chr15_+_48498480 0.13 ENST00000380993.3
ENST00000396577.3
SLC12A1
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr4_-_87281196 0.13 ENST00000359221.3
MAPK10
mitogen-activated protein kinase 10
chr14_+_62585332 0.13 ENST00000554895.1
LINC00643
long intergenic non-protein coding RNA 643
chr17_+_1933404 0.13 ENST00000263083.6
ENST00000571418.1
DPH1
diphthamide biosynthesis 1
chr8_-_131399110 0.13 ENST00000521426.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr6_-_117150198 0.13 ENST00000310357.3
ENST00000368549.3
ENST00000530250.1
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr8_+_53850991 0.13 ENST00000331251.3
NPBWR1
neuropeptides B/W receptor 1
chr12_-_11139511 0.13 ENST00000506868.1
TAS2R50
taste receptor, type 2, member 50
chr17_+_35732916 0.12 ENST00000586700.1
C17orf78
chromosome 17 open reading frame 78
chr8_-_70016408 0.12 ENST00000518540.1
RP11-600K15.1
RP11-600K15.1
chr4_+_118955500 0.12 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr17_+_35732955 0.12 ENST00000300618.4
C17orf78
chromosome 17 open reading frame 78
chr6_-_138820624 0.11 ENST00000343505.5
NHSL1
NHS-like 1
chrX_-_30327495 0.11 ENST00000453287.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr3_+_38307293 0.11 ENST00000311856.4
SLC22A13
solute carrier family 22 (organic anion/urate transporter), member 13
chr7_+_150811705 0.11 ENST00000335367.3
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr2_-_158345462 0.11 ENST00000439355.1
ENST00000540637.1
CYTIP
cytohesin 1 interacting protein
chr5_-_94417314 0.11 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr5_+_52856456 0.11 ENST00000296684.5
ENST00000506765.1
NDUFS4
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
chr13_+_28527647 0.11 ENST00000567234.1
LINC00543
long intergenic non-protein coding RNA 543
chr4_-_87281224 0.11 ENST00000395169.3
ENST00000395161.2
MAPK10
mitogen-activated protein kinase 10
chr1_+_223101757 0.11 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr17_-_15501932 0.11 ENST00000583965.1
CDRT1
CMT1A duplicated region transcript 1
chr5_-_102455801 0.11 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr20_-_48732472 0.11 ENST00000340309.3
ENST00000415862.2
ENST00000371677.3
ENST00000420027.2
UBE2V1
ubiquitin-conjugating enzyme E2 variant 1
chr12_+_81110684 0.10 ENST00000228644.3
MYF5
myogenic factor 5
chr5_+_169659950 0.10 ENST00000593851.1
C5orf58
chromosome 5 open reading frame 58
chr12_+_54402790 0.10 ENST00000040584.4
HOXC8
homeobox C8
chr1_-_154458520 0.10 ENST00000486773.1
SHE
Src homology 2 domain containing E
chr1_-_156217875 0.10 ENST00000292291.5
PAQR6
progestin and adipoQ receptor family member VI
chr19_-_42806842 0.10 ENST00000596265.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr1_+_206972215 0.10 ENST00000340758.2
IL19
interleukin 19
chr12_-_53045948 0.10 ENST00000309680.3
KRT2
keratin 2
chr15_-_62937380 0.10 ENST00000560347.1
ENST00000558940.1
RP11-625H11.1
Uncharacterized protein
chr1_-_95391315 0.10 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chr1_+_100111479 0.10 ENST00000263174.4
PALMD
palmdelphin
chr3_+_57875738 0.09 ENST00000417128.1
ENST00000438794.1
SLMAP
sarcolemma associated protein
chr1_+_156024525 0.09 ENST00000368305.4
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chrX_-_92928557 0.09 ENST00000373079.3
ENST00000475430.2
NAP1L3
nucleosome assembly protein 1-like 3
chr6_-_128222103 0.09 ENST00000434358.1
ENST00000543064.1
ENST00000368248.2
THEMIS
thymocyte selection associated
chr22_+_30279144 0.09 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr1_-_156217822 0.09 ENST00000368270.1
PAQR6
progestin and adipoQ receptor family member VI
chr13_-_103719196 0.09 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr18_-_5544241 0.09 ENST00000341928.2
ENST00000540638.2
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr14_+_20811766 0.09 ENST00000250416.5
ENST00000527915.1
PARP2
poly (ADP-ribose) polymerase 2
chr1_+_156024552 0.09 ENST00000368304.5
ENST00000368302.3
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr3_-_33686743 0.09 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr6_+_155537771 0.09 ENST00000275246.7
TIAM2
T-cell lymphoma invasion and metastasis 2
chr2_+_172543919 0.08 ENST00000452242.1
ENST00000340296.4
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr19_+_13842559 0.08 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chr7_+_93535866 0.08 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr12_-_6484376 0.08 ENST00000360168.3
ENST00000358945.3
SCNN1A
sodium channel, non-voltage-gated 1 alpha subunit
chr8_-_19540266 0.08 ENST00000311540.4
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr3_-_138312971 0.08 ENST00000485115.1
ENST00000484888.1
ENST00000468900.1
ENST00000542237.1
ENST00000481834.1
CEP70
centrosomal protein 70kDa
chrX_-_49965663 0.08 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
AKAP4
A kinase (PRKA) anchor protein 4
chr14_-_60337684 0.08 ENST00000267484.5
RTN1
reticulon 1
chr12_-_24102576 0.07 ENST00000537393.1
ENST00000309359.1
ENST00000381381.2
ENST00000451604.2
SOX5
SRY (sex determining region Y)-box 5
chr6_+_108977520 0.07 ENST00000540898.1
FOXO3
forkhead box O3
chr15_+_59279851 0.07 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr8_-_19540086 0.07 ENST00000332246.6
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr13_-_45768841 0.07 ENST00000379108.1
KCTD4
potassium channel tetramerization domain containing 4
chr12_-_6484715 0.07 ENST00000228916.2
SCNN1A
sodium channel, non-voltage-gated 1 alpha subunit
chrX_+_10031499 0.07 ENST00000454666.1
WWC3
WWC family member 3
chr11_+_128563652 0.07 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr6_+_31515337 0.07 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr2_+_99758161 0.07 ENST00000409684.1
C2ORF15
Uncharacterized protein C2orf15
chr4_+_74347400 0.07 ENST00000226355.3
AFM
afamin
chr1_+_113217043 0.07 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr6_+_116575329 0.07 ENST00000430252.2
ENST00000540275.1
ENST00000448740.2
DSE
RP3-486I3.7
dermatan sulfate epimerase
RP3-486I3.7
chr11_-_62783303 0.06 ENST00000336232.2
ENST00000430500.2
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr1_+_113217073 0.06 ENST00000369645.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr11_-_62783276 0.06 ENST00000535878.1
ENST00000545207.1
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr3_-_49066811 0.06 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr21_-_42219065 0.06 ENST00000400454.1
DSCAM
Down syndrome cell adhesion molecule
chr3_-_192445289 0.06 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12
fibroblast growth factor 12
chr7_+_90012986 0.06 ENST00000416322.1
CLDN12
claudin 12
chr6_+_132455118 0.05 ENST00000458028.1
LINC01013
long intergenic non-protein coding RNA 1013
chr19_-_22806764 0.05 ENST00000598042.1
AC011516.2
AC011516.2
chr20_+_36405665 0.05 ENST00000373469.1
CTNNBL1
catenin, beta like 1
chr6_+_144904334 0.05 ENST00000367526.4
UTRN
utrophin
chr1_-_108231101 0.05 ENST00000544443.1
ENST00000415432.2
VAV3
vav 3 guanine nucleotide exchange factor
chr22_-_43355858 0.05 ENST00000402229.1
ENST00000407585.1
ENST00000453079.1
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr20_+_42136308 0.05 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr4_-_186877502 0.05 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2
sorbin and SH3 domain containing 2
chr19_-_17488143 0.05 ENST00000599426.1
ENST00000252590.4
PLVAP
plasmalemma vesicle associated protein
chr4_-_168155169 0.04 ENST00000534949.1
ENST00000535728.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr21_-_47575481 0.04 ENST00000291670.5
ENST00000397748.1
ENST00000359679.2
ENST00000355384.2
ENST00000397746.3
ENST00000397743.1
FTCD
formimidoyltransferase cyclodeaminase
chr3_-_100712292 0.04 ENST00000495063.1
ENST00000530539.1
ABI3BP
ABI family, member 3 (NESH) binding protein
chr7_+_20686946 0.04 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr9_+_37667978 0.04 ENST00000539465.1
FRMPD1
FERM and PDZ domain containing 1
chr5_+_32711419 0.04 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.4 GO:0071400 cellular response to oleic acid(GO:0071400)
0.1 0.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.4 GO:0048749 compound eye development(GO:0048749)
0.1 0.4 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.2 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.2 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.6 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.4 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.8 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.2 GO:0010193 response to ozone(GO:0010193)
0.0 1.2 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 0.1 GO:1904562 phosphatidylinositol 5-phosphate metabolic process(GO:1904562)
0.0 0.2 GO:1903923 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 2.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.1 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.0 0.2 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.2 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 1.0 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.8 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.5 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.2 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.2 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.4 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.2 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.0 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.1 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.4 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.2 GO:0097513 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.0 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.4 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.4 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.4 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.4 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 1.6 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.0 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 1.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.5 GO:0005452 inorganic anion exchanger activity(GO:0005452)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.7 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation