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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ISX

Z-value: 0.45

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Transcription factors associated with ISX

Gene Symbol Gene ID Gene Info
ISX
ENSG00000175329.8 intestine specific homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISXhg19_v2_chr22_+_35462129_35462156-0.048.2e-01Click!

Activity profile of ISX motif

Sorted Z-values of ISX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_153044083 1.27 ENST00000341611.2
SPRR2B
small proline-rich protein 2B
chr1_+_206138457 1.07 ENST00000367128.3
ENST00000431655.2
FAM72A
family with sequence similarity 72, member A
chr1_-_143913143 1.06 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chr1_+_120839005 1.04 ENST00000369390.3
ENST00000452190.1
FAM72B
family with sequence similarity 72, member B
chr1_-_197115818 1.01 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr6_+_31126291 0.91 ENST00000376257.3
ENST00000376255.4
TCF19
transcription factor 19
chr16_+_2479390 0.89 ENST00000397066.4
CCNF
cyclin F
chr20_+_44441271 0.79 ENST00000335046.3
ENST00000243893.6
UBE2C
ubiquitin-conjugating enzyme E2C
chr5_+_159848807 0.74 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr20_+_44441215 0.73 ENST00000356455.4
ENST00000405520.1
UBE2C
ubiquitin-conjugating enzyme E2C
chr22_-_24303340 0.72 ENST00000404172.3
ENST00000290765.4
GSTT2B
glutathione S-transferase theta 2B (gene/pseudogene)
chr10_+_91461337 0.72 ENST00000260753.4
ENST00000416354.1
ENST00000394289.2
ENST00000371728.3
KIF20B
kinesin family member 20B
chr22_+_24322322 0.72 ENST00000215780.5
ENST00000402588.3
GSTT2
glutathione S-transferase theta 2
chr20_+_44441304 0.71 ENST00000352551.5
UBE2C
ubiquitin-conjugating enzyme E2C
chr6_+_34204642 0.71 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr3_-_149095652 0.71 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr4_-_48018580 0.70 ENST00000514170.1
CNGA1
cyclic nucleotide gated channel alpha 1
chr19_-_36001113 0.57 ENST00000434389.1
DMKN
dermokine
chr11_+_33061543 0.57 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chr4_-_174255536 0.56 ENST00000446922.2
HMGB2
high mobility group box 2
chr17_+_59489112 0.56 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr12_+_122688090 0.53 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr17_+_40610862 0.53 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr12_-_10022735 0.51 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr11_-_111741994 0.49 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr12_-_10978957 0.48 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr1_-_161208013 0.48 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr1_-_159915386 0.47 ENST00000361509.3
ENST00000368094.1
IGSF9
immunoglobulin superfamily, member 9
chr22_-_32766972 0.46 ENST00000382084.4
ENST00000382086.2
RFPL3S
RFPL3 antisense
chr16_+_12059050 0.45 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr6_-_111927062 0.43 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr17_-_57229155 0.43 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr6_+_53948328 0.43 ENST00000370876.2
MLIP
muscular LMNA-interacting protein
chr22_+_24309089 0.40 ENST00000215770.5
DDTL
D-dopachrome tautomerase-like
chr2_-_89247338 0.39 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr5_+_159848854 0.38 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
PTTG1
pituitary tumor-transforming 1
chr2_-_89292422 0.35 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr22_-_32767017 0.34 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr17_-_7307358 0.33 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr6_+_73076432 0.32 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr1_+_155278625 0.32 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr17_+_42786051 0.31 ENST00000315005.3
DBF4B
DBF4 homolog B (S. cerevisiae)
chr17_-_40829026 0.31 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr14_+_32798547 0.31 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr10_+_103986085 0.31 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr22_-_29137771 0.31 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr1_+_209602156 0.30 ENST00000429156.1
ENST00000366437.3
ENST00000603283.1
ENST00000431096.1
MIR205HG
MIR205 host gene (non-protein coding)
chr6_-_33860521 0.30 ENST00000525746.1
ENST00000531046.1
LINC01016
long intergenic non-protein coding RNA 1016
chr17_-_40828969 0.30 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr1_+_155278539 0.30 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr1_+_87595433 0.29 ENST00000469312.2
ENST00000490006.2
RP5-1052I5.1
long intergenic non-protein coding RNA 1140
chr14_-_81425828 0.28 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr22_-_24316648 0.28 ENST00000403754.3
ENST00000430101.2
ENST00000398344.4
DDT
D-dopachrome tautomerase
chr9_+_136501478 0.28 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr4_+_87515454 0.28 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chr19_-_14785622 0.27 ENST00000443157.2
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chrX_+_44703249 0.27 ENST00000339042.4
DUSP21
dual specificity phosphatase 21
chr14_+_57671888 0.27 ENST00000391612.1
AL391152.1
AL391152.1
chr22_-_50523760 0.27 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr3_+_51851612 0.26 ENST00000456080.1
IQCF3
IQ motif containing F3
chr7_+_144052381 0.26 ENST00000498580.1
ENST00000056217.5
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr14_-_94789663 0.25 ENST00000557225.1
ENST00000341584.3
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr6_+_30687978 0.25 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr8_+_7783859 0.25 ENST00000400120.3
ZNF705B
zinc finger protein 705B
chr11_+_55578854 0.25 ENST00000333973.2
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr1_-_150849047 0.24 ENST00000354396.2
ENST00000505755.1
ARNT
aryl hydrocarbon receptor nuclear translocator
chr11_+_75526212 0.24 ENST00000356136.3
UVRAG
UV radiation resistance associated
chr8_+_22132847 0.24 ENST00000521356.1
PIWIL2
piwi-like RNA-mediated gene silencing 2
chr1_-_20250110 0.23 ENST00000375116.3
PLA2G2E
phospholipase A2, group IIE
chr19_-_14785674 0.23 ENST00000253673.5
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr17_-_40337470 0.22 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr11_+_95523621 0.22 ENST00000325542.5
ENST00000325486.5
ENST00000544522.1
ENST00000541365.1
CEP57
centrosomal protein 57kDa
chr6_+_160542821 0.22 ENST00000366963.4
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr14_+_32798462 0.22 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr9_-_132383055 0.22 ENST00000372478.4
C9orf50
chromosome 9 open reading frame 50
chr17_-_27418537 0.22 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr17_-_77005801 0.21 ENST00000392446.5
CANT1
calcium activated nucleotidase 1
chr1_-_43833628 0.21 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr6_+_29795595 0.21 ENST00000360323.6
ENST00000376818.3
ENST00000376815.3
HLA-G
major histocompatibility complex, class I, G
chr8_-_7243080 0.21 ENST00000400156.4
ZNF705G
zinc finger protein 705G
chr1_-_150849174 0.21 ENST00000515192.1
ARNT
aryl hydrocarbon receptor nuclear translocator
chr17_-_2966901 0.21 ENST00000575751.1
OR1D5
olfactory receptor, family 1, subfamily D, member 5
chr17_-_18266765 0.21 ENST00000354098.3
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr4_+_48018781 0.21 ENST00000295461.5
NIPAL1
NIPA-like domain containing 1
chr11_-_121986923 0.20 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr12_+_26348246 0.20 ENST00000422622.2
SSPN
sarcospan
chr5_+_150226085 0.19 ENST00000522154.1
IRGM
immunity-related GTPase family, M
chr10_+_135160844 0.19 ENST00000423766.1
ENST00000458230.1
PRAP1
proline-rich acidic protein 1
chr6_-_111927449 0.19 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr17_+_46970178 0.19 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr11_-_13484713 0.19 ENST00000526841.1
ENST00000529708.1
ENST00000278174.5
ENST00000528120.1
BTBD10
BTB (POZ) domain containing 10
chrX_+_43515467 0.19 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr6_+_160542870 0.19 ENST00000324965.4
ENST00000457470.2
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr12_-_22063787 0.18 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr20_-_50722183 0.18 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr20_-_50418947 0.18 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chrY_+_14813160 0.18 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr21_+_35014783 0.18 ENST00000381291.4
ENST00000381285.4
ENST00000399367.3
ENST00000399352.1
ENST00000399355.2
ENST00000399349.1
ITSN1
intersectin 1 (SH3 domain protein)
chr7_+_50348268 0.17 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr17_+_46970127 0.17 ENST00000355938.5
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr19_+_12902289 0.17 ENST00000302754.4
JUNB
jun B proto-oncogene
chr22_+_40322623 0.17 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr20_-_50418972 0.17 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr5_-_82969405 0.17 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr22_+_40322595 0.17 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chr17_+_46970134 0.16 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr3_+_28390637 0.16 ENST00000420223.1
ENST00000383768.2
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr14_+_70233810 0.16 ENST00000394366.2
ENST00000553548.1
ENST00000553369.1
ENST00000557154.1
ENST00000451983.2
ENST00000553635.1
SRSF5
serine/arginine-rich splicing factor 5
chr4_-_186733363 0.15 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
SORBS2
sorbin and SH3 domain containing 2
chr2_+_124782857 0.15 ENST00000431078.1
CNTNAP5
contactin associated protein-like 5
chr11_+_119205222 0.15 ENST00000311413.4
RNF26
ring finger protein 26
chr15_+_58430567 0.15 ENST00000536493.1
AQP9
aquaporin 9
chr10_-_105110831 0.15 ENST00000337211.4
PCGF6
polycomb group ring finger 6
chr8_+_50824233 0.14 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr2_+_204571375 0.14 ENST00000374478.4
CD28
CD28 molecule
chr15_+_58430368 0.14 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr5_-_177580855 0.14 ENST00000514354.1
ENST00000511078.1
NHP2
NHP2 ribonucleoprotein
chr10_+_124913793 0.14 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3
BUB3 mitotic checkpoint protein
chr6_+_36165133 0.14 ENST00000446974.1
ENST00000454960.1
BRPF3
bromodomain and PHD finger containing, 3
chr17_-_45266542 0.14 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr4_-_177190364 0.14 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr9_-_4666421 0.13 ENST00000381895.5
SPATA6L
spermatogenesis associated 6-like
chr14_+_22670455 0.13 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr2_+_90248739 0.13 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr2_-_198540719 0.13 ENST00000295049.4
RFTN2
raftlin family member 2
chr17_-_18266797 0.13 ENST00000316694.3
ENST00000539052.1
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr7_+_115862858 0.13 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr20_+_24449821 0.13 ENST00000376862.3
SYNDIG1
synapse differentiation inducing 1
chr19_+_50270219 0.12 ENST00000354293.5
ENST00000359032.5
AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr12_-_50790267 0.12 ENST00000327337.5
ENST00000543111.1
FAM186A
family with sequence similarity 186, member A
chr17_-_18266660 0.12 ENST00000582653.1
ENST00000352886.6
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr19_+_1275917 0.12 ENST00000469144.1
C19orf24
chromosome 19 open reading frame 24
chr16_-_31106211 0.12 ENST00000532364.1
ENST00000529564.1
ENST00000319788.7
ENST00000354895.4
ENST00000394975.2
RP11-196G11.1
VKORC1
Uncharacterized protein
vitamin K epoxide reductase complex, subunit 1
chr4_+_144303093 0.11 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr6_-_10115007 0.11 ENST00000485268.1
OFCC1
orofacial cleft 1 candidate 1
chr14_-_73925225 0.11 ENST00000356296.4
ENST00000355058.3
ENST00000359560.3
ENST00000557597.1
ENST00000554394.1
ENST00000555238.1
ENST00000535282.1
ENST00000555987.1
ENST00000555394.1
ENST00000554546.1
NUMB
numb homolog (Drosophila)
chr16_-_31106048 0.11 ENST00000300851.6
VKORC1
vitamin K epoxide reductase complex, subunit 1
chrX_+_37639302 0.11 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr10_-_104001231 0.11 ENST00000370002.3
PITX3
paired-like homeodomain 3
chr10_+_114206956 0.11 ENST00000432306.1
ENST00000393077.2
VTI1A
vesicle transport through interaction with t-SNAREs 1A
chr12_+_16500037 0.10 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr10_-_56560939 0.10 ENST00000373955.1
PCDH15
protocadherin-related 15
chr17_+_45286706 0.10 ENST00000393450.1
ENST00000572303.1
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr13_+_38923959 0.10 ENST00000379649.1
ENST00000239878.4
ENST00000437952.1
ENST00000379641.1
UFM1
ubiquitin-fold modifier 1
chr7_-_92107229 0.10 ENST00000603053.1
ERVW-1
endogenous retrovirus group W, member 1
chr16_-_31105870 0.09 ENST00000394971.3
VKORC1
vitamin K epoxide reductase complex, subunit 1
chr14_-_24711470 0.09 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr1_-_68698222 0.09 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr8_+_92261516 0.09 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr5_-_159546396 0.09 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr4_-_174255400 0.09 ENST00000506267.1
HMGB2
high mobility group box 2
chr22_+_46476192 0.09 ENST00000443490.1
FLJ27365
hsa-mir-4763
chr15_-_75199213 0.09 ENST00000562698.1
FAM219B
family with sequence similarity 219, member B
chr6_+_28317685 0.09 ENST00000252211.2
ENST00000341464.5
ENST00000377255.3
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr3_+_37284668 0.09 ENST00000361924.2
ENST00000444882.1
ENST00000356847.4
ENST00000450863.2
ENST00000429018.1
GOLGA4
golgin A4
chr2_+_242089833 0.09 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr19_-_3557570 0.09 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr17_+_73452545 0.08 ENST00000314256.7
KIAA0195
KIAA0195
chr2_+_172778952 0.08 ENST00000392584.1
ENST00000264108.4
HAT1
histone acetyltransferase 1
chr4_-_100242549 0.08 ENST00000305046.8
ENST00000394887.3
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr19_+_4153598 0.08 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr9_+_34646624 0.08 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr2_-_183387064 0.08 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr8_+_21881636 0.08 ENST00000520125.1
ENST00000521157.1
ENST00000397940.1
ENST00000522813.1
NPM2
nucleophosmin/nucleoplasmin 2
chr12_+_16500599 0.08 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr10_-_99447024 0.08 ENST00000370626.3
AVPI1
arginine vasopressin-induced 1
chr5_+_140557371 0.08 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr11_-_13517565 0.07 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr6_+_3259148 0.07 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr3_+_111393501 0.07 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr10_-_1095050 0.07 ENST00000381344.3
IDI1
isopentenyl-diphosphate delta isomerase 1
chr1_-_68698197 0.07 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr22_+_17956618 0.07 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chrX_-_139587225 0.07 ENST00000370536.2
SOX3
SRY (sex determining region Y)-box 3
chr10_+_99205959 0.07 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chrX_+_77166172 0.07 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr1_-_150849208 0.07 ENST00000358595.5
ARNT
aryl hydrocarbon receptor nuclear translocator
chr1_+_151735431 0.07 ENST00000321531.5
ENST00000315067.8
OAZ3
ornithine decarboxylase antizyme 3
chr14_-_20801427 0.06 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
CCNB1IP1
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr5_-_177580933 0.06 ENST00000274606.3
NHP2
NHP2 ribonucleoprotein
chr17_+_39394250 0.06 ENST00000254072.6
KRTAP9-8
keratin associated protein 9-8
chr17_+_73452695 0.06 ENST00000582186.1
ENST00000582455.1
ENST00000581252.1
ENST00000579208.1
KIAA0195
KIAA0195
chr5_-_177580777 0.06 ENST00000314397.4
NHP2
NHP2 ribonucleoprotein
chr3_-_151034734 0.06 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr10_+_99205894 0.06 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr1_+_220267429 0.06 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr6_-_119256279 0.06 ENST00000316068.3
MCM9
minichromosome maintenance complex component 9
chr17_+_45286387 0.06 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr22_+_21400229 0.06 ENST00000342608.4
ENST00000543388.1
ENST00000442047.1
AC002472.13
Leucine-rich repeat-containing protein LOC400891
chr16_-_58585513 0.06 ENST00000245138.4
ENST00000567285.1
CNOT1
CCR4-NOT transcription complex, subunit 1
chr16_+_89160217 0.06 ENST00000317447.4
ENST00000537290.1
ACSF3
acyl-CoA synthetase family member 3
chr20_+_9494987 0.06 ENST00000427562.2
ENST00000246070.2
LAMP5
lysosomal-associated membrane protein family, member 5
chr14_+_104182061 0.06 ENST00000216602.6
ZFYVE21
zinc finger, FYVE domain containing 21
chr10_+_124914285 0.05 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr6_-_135271260 0.05 ENST00000265605.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr3_+_113775576 0.05 ENST00000485050.1
ENST00000281273.4
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr6_-_135271219 0.05 ENST00000367847.2
ENST00000367845.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr3_-_15563229 0.05 ENST00000383786.5
ENST00000383787.2
ENST00000383785.2
ENST00000383788.5
ENST00000603808.1
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr10_+_124913930 0.05 ENST00000368858.5
BUB3
BUB3 mitotic checkpoint protein
chr2_-_3521518 0.05 ENST00000382093.5
ADI1
acireductone dioxygenase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ISX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 2.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.2 0.7 GO:1903436 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.2 0.5 GO:1904481 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.1 0.7 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.5 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 0.6 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 0.3 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.6 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.2 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.3 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.1 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.7 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.5 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.4 GO:0048241 epinephrine transport(GO:0048241)
0.0 0.9 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.0 0.4 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.5 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.0 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.5 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.3 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.0 0.1 GO:0030860 neuroblast division in subventricular zone(GO:0021849) regulation of polarized epithelial cell differentiation(GO:0030860)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.1 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.3 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.2 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.0 0.1 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.5 GO:0050776 regulation of immune response(GO:0050776)
0.0 0.3 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.1 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 1.3 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.0 0.1 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 0.5 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:0042574 retinal metabolic process(GO:0042574) 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.7 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.6 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.1 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 1.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0032596 protein transport into membrane raft(GO:0032596)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.2 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.0 0.0 GO:0043605 cellular amide catabolic process(GO:0043605)
0.0 0.0 GO:0097051 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233) regulation of endoplasmic reticulum tubular network organization(GO:1903371)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.3 GO:1990923 PET complex(GO:1990923)
0.1 0.2 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.1 2.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.2 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.1 0.7 GO:1990023 contractile ring(GO:0070938) mitotic spindle midzone(GO:1990023)
0.0 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.3 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.1 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.0 0.1 GO:0036338 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 1.3 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.5 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 0.5 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.7 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.1 0.6 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.4 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.1 0.5 GO:0070905 serine binding(GO:0070905)
0.1 0.5 GO:0004882 androgen receptor activity(GO:0004882)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 0.3 GO:0033981 D-dopachrome decarboxylase activity(GO:0033981)
0.1 0.3 GO:0034584 piRNA binding(GO:0034584)
0.1 0.3 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.1 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.5 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.7 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 2.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.2 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 1.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.0 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769)
0.0 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.0 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.0 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.6 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.5 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.1 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0 0.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen