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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for JUND

Z-value: 0.87

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Transcription factors associated with JUND

Gene Symbol Gene ID Gene Info
JUND
ENSG00000130522.4 JunD proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
JUNDhg19_v2_chr19_-_18391708_183917390.164.0e-01Click!

Activity profile of JUND motif

Sorted Z-values of JUND motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_102826434 2.87 ENST00000340273.4
ENST00000260302.3
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr5_-_140013275 2.31 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14
CD14 molecule
chrY_+_15016725 2.11 ENST00000336079.3
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr11_-_82708519 2.04 ENST00000534301.1
RAB30
RAB30, member RAS oncogene family
chr15_-_74504597 1.95 ENST00000416286.3
STRA6
stimulated by retinoic acid 6
chr15_-_74504560 1.87 ENST00000449139.2
STRA6
stimulated by retinoic acid 6
chr22_-_37545972 1.51 ENST00000216223.5
IL2RB
interleukin 2 receptor, beta
chr12_-_95009837 1.35 ENST00000551457.1
TMCC3
transmembrane and coiled-coil domain family 3
chr1_-_153348067 1.34 ENST00000368737.3
S100A12
S100 calcium binding protein A12
chr22_+_31488433 1.33 ENST00000455608.1
SMTN
smoothelin
chr3_-_169587621 1.28 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr7_+_79998864 1.23 ENST00000435819.1
CD36
CD36 molecule (thrombospondin receptor)
chr10_+_17270214 1.19 ENST00000544301.1
VIM
vimentin
chr15_+_89182178 1.16 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr3_-_48632593 1.14 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr5_-_60140009 1.09 ENST00000505959.1
ELOVL7
ELOVL fatty acid elongase 7
chr5_-_60140089 1.09 ENST00000507047.1
ENST00000438340.1
ENST00000425382.1
ENST00000508821.1
ELOVL7
ELOVL fatty acid elongase 7
chr17_+_25799008 1.04 ENST00000583370.1
ENST00000398988.3
ENST00000268763.6
KSR1
kinase suppressor of ras 1
chr8_-_135522425 0.91 ENST00000521673.1
ZFAT
zinc finger and AT hook domain containing
chr15_+_89182156 0.90 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 0.90 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr8_-_27472198 0.76 ENST00000519472.1
ENST00000523589.1
ENST00000522413.1
ENST00000523396.1
ENST00000560366.1
CLU
clusterin
chr4_-_104119528 0.75 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr20_-_62129163 0.75 ENST00000298049.7
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr6_-_32145861 0.71 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr9_-_127263265 0.68 ENST00000373587.3
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr6_-_44281043 0.68 ENST00000244571.4
AARS2
alanyl-tRNA synthetase 2, mitochondrial
chr10_+_120116527 0.67 ENST00000445161.1
LINC00867
long intergenic non-protein coding RNA 867
chr12_+_12938541 0.66 ENST00000356591.4
APOLD1
apolipoprotein L domain containing 1
chrX_+_99899180 0.62 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr9_-_39239171 0.61 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr19_+_13842559 0.57 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chr11_+_5617858 0.56 ENST00000380097.3
TRIM6
tripartite motif containing 6
chr12_-_8218997 0.55 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr6_+_44194762 0.54 ENST00000371708.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chrX_+_78200829 0.52 ENST00000544091.1
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr8_-_82359662 0.52 ENST00000519260.1
ENST00000256103.2
PMP2
peripheral myelin protein 2
chr7_+_130126165 0.52 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST
mesoderm specific transcript
chr5_-_141061777 0.52 ENST00000239440.4
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr5_-_141061759 0.51 ENST00000508305.1
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr21_+_42733870 0.51 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr19_+_11546093 0.51 ENST00000591462.1
PRKCSH
protein kinase C substrate 80K-H
chr2_+_169926047 0.51 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_-_66103867 0.50 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr11_-_2162468 0.47 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_-_28257080 0.46 ENST00000579954.1
ENST00000540801.1
ENST00000269033.3
ENST00000590153.1
ENST00000582084.1
SSH2
slingshot protein phosphatase 2
chr17_-_33390667 0.45 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr19_-_54872556 0.44 ENST00000444687.1
LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr3_+_46412345 0.43 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr10_+_5005598 0.43 ENST00000442997.1
AKR1C1
aldo-keto reductase family 1, member C1
chr1_+_196912902 0.42 ENST00000476712.2
ENST00000367415.5
CFHR2
complement factor H-related 2
chr2_-_187713891 0.42 ENST00000295131.2
ZSWIM2
zinc finger, SWIM-type containing 2
chr12_-_71182695 0.42 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr3_+_158991025 0.41 ENST00000337808.6
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr11_-_2162162 0.40 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_-_105588231 0.40 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr3_-_98241760 0.38 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
CLDND1
claudin domain containing 1
chr3_+_11178779 0.37 ENST00000438284.2
HRH1
histamine receptor H1
chr16_+_31366455 0.36 ENST00000268296.4
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr12_+_62654155 0.36 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15
ubiquitin specific peptidase 15
chr11_-_14913190 0.34 ENST00000532378.1
CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
chrX_+_99839799 0.33 ENST00000373031.4
TNMD
tenomodulin
chr15_+_59903975 0.32 ENST00000560585.1
ENST00000396065.1
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr2_-_152830441 0.32 ENST00000534999.1
ENST00000397327.2
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr11_-_4719072 0.31 ENST00000396950.3
ENST00000532598.1
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr15_-_51535208 0.31 ENST00000405913.3
ENST00000559878.1
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr16_+_23847339 0.30 ENST00000303531.7
PRKCB
protein kinase C, beta
chr14_+_94492674 0.30 ENST00000203664.5
ENST00000553723.1
OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr11_+_67250490 0.28 ENST00000528641.2
ENST00000279146.3
AIP
aryl hydrocarbon receptor interacting protein
chr1_+_213224572 0.28 ENST00000543470.1
ENST00000366960.3
ENST00000366959.3
ENST00000543354.1
RPS6KC1
ribosomal protein S6 kinase, 52kDa, polypeptide 1
chr4_-_122085469 0.27 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr4_-_123542224 0.27 ENST00000264497.3
IL21
interleukin 21
chr20_+_48429356 0.27 ENST00000361573.2
ENST00000541138.1
ENST00000539601.1
SLC9A8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr21_-_43786634 0.27 ENST00000291527.2
TFF1
trefoil factor 1
chr6_+_32146131 0.27 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr20_+_48429233 0.27 ENST00000417961.1
SLC9A8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr5_-_138533973 0.27 ENST00000507002.1
ENST00000505830.1
ENST00000508639.1
ENST00000265195.5
SIL1
SIL1 nucleotide exchange factor
chr18_+_9885934 0.26 ENST00000357775.5
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr1_-_67266939 0.26 ENST00000304526.2
INSL5
insulin-like 5
chr16_-_80603558 0.26 ENST00000567317.1
RP11-18F14.1
RP11-18F14.1
chr12_-_68553512 0.25 ENST00000229135.3
IFNG
interferon, gamma
chr10_-_14996321 0.25 ENST00000378289.4
DCLRE1C
DNA cross-link repair 1C
chr3_-_87325728 0.25 ENST00000350375.2
POU1F1
POU class 1 homeobox 1
chr10_-_128210005 0.24 ENST00000284694.7
ENST00000454341.1
ENST00000432642.1
ENST00000392694.1
C10orf90
chromosome 10 open reading frame 90
chr1_+_159796534 0.23 ENST00000289707.5
SLAMF8
SLAM family member 8
chr5_-_138534071 0.22 ENST00000394817.2
SIL1
SIL1 nucleotide exchange factor
chr18_+_55888767 0.22 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr12_+_54891495 0.21 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr1_+_117297007 0.21 ENST00000369478.3
ENST00000369477.1
CD2
CD2 molecule
chr4_-_123377880 0.20 ENST00000226730.4
IL2
interleukin 2
chr16_+_31366536 0.20 ENST00000562522.1
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_-_153521597 0.20 ENST00000368712.1
S100A3
S100 calcium binding protein A3
chr5_+_147582387 0.20 ENST00000325630.2
SPINK6
serine peptidase inhibitor, Kazal type 6
chr4_+_95128996 0.19 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr1_-_6662919 0.19 ENST00000377658.4
ENST00000377663.3
KLHL21
kelch-like family member 21
chr13_+_109248500 0.19 ENST00000356711.2
MYO16
myosin XVI
chr9_-_73029540 0.18 ENST00000377126.2
KLF9
Kruppel-like factor 9
chr5_+_145317356 0.18 ENST00000511217.1
SH3RF2
SH3 domain containing ring finger 2
chr6_+_159291090 0.17 ENST00000367073.4
ENST00000608817.1
C6orf99
chromosome 6 open reading frame 99
chr22_+_22749343 0.17 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43
chr12_+_62654119 0.17 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr18_-_74207146 0.17 ENST00000443185.2
ZNF516
zinc finger protein 516
chr6_+_159290917 0.16 ENST00000367072.1
C6orf99
chromosome 6 open reading frame 99
chr17_-_59668550 0.16 ENST00000521764.1
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr18_+_32290218 0.16 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr17_+_41052808 0.16 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr16_+_15596123 0.16 ENST00000452191.2
C16orf45
chromosome 16 open reading frame 45
chr6_+_150070857 0.15 ENST00000544496.1
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr11_-_66103932 0.15 ENST00000311320.4
RIN1
Ras and Rab interactor 1
chr10_-_31288398 0.15 ENST00000538351.2
ZNF438
zinc finger protein 438
chr3_-_18466026 0.14 ENST00000417717.2
SATB1
SATB homeobox 1
chr12_-_95510743 0.14 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr12_-_8765446 0.14 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chr3_+_191046810 0.14 ENST00000392455.3
ENST00000392456.3
CCDC50
coiled-coil domain containing 50
chr10_-_50396425 0.14 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr13_+_98605902 0.14 ENST00000460070.1
ENST00000481455.1
ENST00000261574.5
ENST00000493281.1
ENST00000463157.1
ENST00000471898.1
ENST00000489058.1
ENST00000481689.1
IPO5
importin 5
chr11_-_66104237 0.14 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr2_+_161993465 0.14 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr19_+_35820064 0.13 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22
CD22 molecule
chr17_-_73150629 0.13 ENST00000356033.4
ENST00000405458.3
ENST00000409753.3
HN1
hematological and neurological expressed 1
chr14_+_58765103 0.13 ENST00000355431.3
ENST00000348476.3
ENST00000395168.3
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr17_-_54893250 0.13 ENST00000397862.2
C17orf67
chromosome 17 open reading frame 67
chr10_-_74114714 0.13 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr3_+_156807663 0.13 ENST00000467995.1
ENST00000474477.1
ENST00000471719.1
LINC00881
long intergenic non-protein coding RNA 881
chr3_-_157251383 0.12 ENST00000487753.1
ENST00000489602.1
ENST00000461299.1
ENST00000479987.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr15_+_42566384 0.11 ENST00000440615.2
ENST00000318010.8
GANC
glucosidase, alpha; neutral C
chr2_-_231789941 0.11 ENST00000392040.1
ENST00000438398.1
GPR55
G protein-coupled receptor 55
chr18_-_74839891 0.11 ENST00000581878.1
MBP
myelin basic protein
chr16_+_28996364 0.11 ENST00000564277.1
LAT
linker for activation of T cells
chr11_-_5207612 0.11 ENST00000380367.1
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr15_+_75335604 0.10 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase
chr22_+_23101182 0.10 ENST00000390312.2
IGLV2-14
immunoglobulin lambda variable 2-14
chr10_-_75008620 0.10 ENST00000372950.4
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr13_+_76378407 0.09 ENST00000447038.1
LMO7
LIM domain 7
chr3_-_155011483 0.09 ENST00000489090.1
RP11-451G4.2
RP11-451G4.2
chr10_+_69865866 0.08 ENST00000354393.2
MYPN
myopalladin
chr19_-_44008863 0.07 ENST00000601646.1
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr16_-_67281413 0.07 ENST00000258201.4
FHOD1
formin homology 2 domain containing 1
chr20_+_30946106 0.07 ENST00000375687.4
ENST00000542461.1
ASXL1
additional sex combs like 1 (Drosophila)
chr3_+_130150307 0.07 ENST00000512836.1
COL6A5
collagen, type VI, alpha 5
chr13_-_31038370 0.07 ENST00000399489.1
ENST00000339872.4
HMGB1
high mobility group box 1
chr2_+_161993412 0.07 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr15_+_38226827 0.06 ENST00000559502.1
ENST00000558148.1
ENST00000558158.1
TMCO5A
transmembrane and coiled-coil domains 5A
chr11_-_51412448 0.06 ENST00000319760.6
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr7_+_132937820 0.06 ENST00000393161.2
ENST00000253861.4
EXOC4
exocyst complex component 4
chr10_+_17686124 0.05 ENST00000377524.3
STAM
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr8_-_141774467 0.05 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2
protein tyrosine kinase 2
chr8_-_19102999 0.05 ENST00000517949.1
RP11-1080G15.1
RP11-1080G15.1
chr3_-_37216055 0.05 ENST00000336686.4
LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr3_+_98699880 0.05 ENST00000473756.1
LINC00973
long intergenic non-protein coding RNA 973
chr17_-_7590745 0.05 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
TP53
tumor protein p53
chr6_+_149539767 0.04 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TAB2
RP1-111D6.3
TGF-beta activated kinase 1/MAP3K7 binding protein 2
RP1-111D6.3
chr3_-_49395705 0.04 ENST00000419349.1
GPX1
glutathione peroxidase 1
chr16_+_29127282 0.04 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chrX_+_154254960 0.04 ENST00000369498.3
FUNDC2
FUN14 domain containing 2
chr8_+_120220561 0.04 ENST00000276681.6
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr12_+_9142131 0.04 ENST00000356986.3
ENST00000266551.4
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr8_-_17752912 0.04 ENST00000398054.1
ENST00000381840.2
FGL1
fibrinogen-like 1
chr12_-_53343602 0.03 ENST00000546897.1
ENST00000552551.1
KRT8
keratin 8
chr6_-_43027105 0.03 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr2_+_36923830 0.03 ENST00000379242.3
ENST00000389975.3
VIT
vitrin
chr3_+_127771212 0.02 ENST00000243253.3
ENST00000481210.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr1_-_205744574 0.02 ENST00000367139.3
ENST00000235932.4
ENST00000437324.2
ENST00000414729.1
RAB7L1
RAB7, member RAS oncogene family-like 1
chr14_-_24711470 0.02 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr2_-_145275211 0.02 ENST00000462355.1
ZEB2
zinc finger E-box binding homeobox 2
chr8_-_17752996 0.00 ENST00000381841.2
ENST00000427924.1
FGL1
fibrinogen-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of JUND

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.8 GO:0061143 alveolar primary septum development(GO:0061143)
0.6 3.0 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.6 2.3 GO:0071727 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.2 2.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 0.7 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 1.5 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.2 1.2 GO:0071724 toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.2 0.7 GO:0007538 primary sex determination(GO:0007538)
0.1 0.5 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 1.0 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.8 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 0.8 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.5 GO:0015862 uridine transport(GO:0015862)
0.1 0.3 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.1 0.3 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.1 1.2 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 0.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 2.5 GO:0003417 growth plate cartilage development(GO:0003417)
0.1 0.9 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.5 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.3 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.1 0.3 GO:2000309 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.1 0.3 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.3 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.1 0.4 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1 0.4 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 0.4 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 0.3 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.1 0.6 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.6 GO:0002741 positive regulation of cytokine secretion involved in immune response(GO:0002741) regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.3 GO:0051344 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.5 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.5 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.4 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.7 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.6 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.7 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.9 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.2 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.0 2.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.2 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.5 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.4 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 1.3 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0051414 response to cortisol(GO:0051414)
0.0 0.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.0 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0035633 maintenance of blood-brain barrier(GO:0035633) chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 1.1 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.1 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.6 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 1.0 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 2.0 GO:0007030 Golgi organization(GO:0007030)
0.0 0.3 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.5 GO:0061024 membrane organization(GO:0061024)
0.0 0.5 GO:0010591 regulation of lamellipodium assembly(GO:0010591)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.3 1.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.8 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) mitotic spindle midzone(GO:1990023)
0.0 1.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 2.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.5 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.2 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0033565 ESCRT-0 complex(GO:0033565)
0.0 0.3 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 2.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.6 GO:0008305 integrin complex(GO:0008305)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0008859 exoribonuclease II activity(GO:0008859)
0.5 2.3 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.4 1.5 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.2 2.2 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 0.7 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 1.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 1.2 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.8 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 0.4 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.1 3.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.3 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 1.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.3 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1 0.5 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 0.5 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.5 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.6 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.8 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.4 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.1 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 2.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.9 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.0 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 0.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.1 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 1.2 PID AURORA B PATHWAY Aurora B signaling
0.0 1.0 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.4 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.8 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 0.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 2.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 3.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 2.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.1 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers