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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for KLF12

Z-value: 1.16

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Transcription factors associated with KLF12

Gene Symbol Gene ID Gene Info
KLF12
ENSG00000118922.12 Kruppel like factor 12

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF12hg19_v2_chr13_-_74708372_747084090.144.5e-01Click!

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_234104079 3.85 ENST00000417661.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr15_-_90039805 3.66 ENST00000544600.1
ENST00000268122.4
RHCG
Rh family, C glycoprotein
chr15_+_89402148 3.03 ENST00000560601.1
ACAN
aggrecan
chr8_+_22022800 2.84 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chrX_-_48325857 2.70 ENST00000376875.1
SLC38A5
solute carrier family 38, member 5
chr17_-_76899275 2.50 ENST00000322630.2
ENST00000586713.1
DDC8
Protein DDC8 homolog
chr1_-_47655686 2.23 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr2_+_24272576 2.08 ENST00000380986.4
ENST00000452109.1
FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr2_+_24272543 2.08 ENST00000380991.4
FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr17_+_7211280 1.90 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
EIF5A
eukaryotic translation initiation factor 5A
chr14_+_65171315 1.80 ENST00000394691.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr12_-_54778471 1.65 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
ZNF385A
zinc finger protein 385A
chr18_-_31628558 1.63 ENST00000535384.1
NOL4
nucleolar protein 4
chr1_+_155178481 1.61 ENST00000368376.3
MTX1
metaxin 1
chr1_+_155178518 1.59 ENST00000316721.4
MTX1
metaxin 1
chr8_+_124194875 1.59 ENST00000522648.1
ENST00000276699.6
FAM83A
family with sequence similarity 83, member A
chr20_+_44637526 1.53 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr8_+_124194752 1.53 ENST00000318462.6
FAM83A
family with sequence similarity 83, member A
chr9_+_131084846 1.50 ENST00000608951.1
COQ4
coenzyme Q4
chr7_+_143013198 1.50 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr22_+_31489344 1.45 ENST00000404574.1
SMTN
smoothelin
chr17_+_1665253 1.35 ENST00000254722.4
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr7_+_2687173 1.35 ENST00000403167.1
TTYH3
tweety family member 3
chr17_+_7210921 1.32 ENST00000573542.1
EIF5A
eukaryotic translation initiation factor 5A
chr3_-_52567792 1.31 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2
5'-nucleotidase domain containing 2
chr17_+_1665345 1.29 ENST00000576406.1
ENST00000571149.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_+_74417192 1.25 ENST00000554320.1
COQ6
coenzyme Q6 monooxygenase
chr9_-_131085021 1.24 ENST00000372890.4
TRUB2
TruB pseudouridine (psi) synthase family member 2
chr17_+_7210852 1.21 ENST00000576930.1
EIF5A
eukaryotic translation initiation factor 5A
chr11_-_57089671 1.18 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr8_+_22022653 1.18 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr11_-_568369 1.17 ENST00000534540.1
ENST00000528245.1
ENST00000500447.1
ENST00000533920.1
MIR210HG
MIR210 host gene (non-protein coding)
chr17_-_39637392 1.17 ENST00000246639.2
ENST00000393989.1
KRT35
keratin 35
chr3_+_52350335 1.16 ENST00000420323.2
DNAH1
dynein, axonemal, heavy chain 1
chr17_-_36831156 1.13 ENST00000325814.5
C17orf96
chromosome 17 open reading frame 96
chr4_-_74904398 1.08 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr2_-_192711968 1.07 ENST00000304141.4
SDPR
serum deprivation response
chr22_-_38699003 1.06 ENST00000451964.1
CSNK1E
casein kinase 1, epsilon
chr12_-_67072714 1.05 ENST00000545666.1
ENST00000398016.3
ENST00000359742.4
ENST00000286445.7
ENST00000538211.1
GRIP1
glutamate receptor interacting protein 1
chr9_-_99064386 1.04 ENST00000375262.2
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr2_+_90458201 1.03 ENST00000603238.1
CH17-132F21.1
Uncharacterized protein
chr4_+_128702969 1.03 ENST00000508776.1
ENST00000439123.2
HSPA4L
heat shock 70kDa protein 4-like
chr17_+_7210898 1.02 ENST00000572815.1
EIF5A
eukaryotic translation initiation factor 5A
chr15_+_74218787 1.01 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr22_-_37640456 1.01 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_+_50574585 1.00 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr1_-_155177677 1.00 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
THBS3
thrombospondin 3
chr14_+_85996471 0.98 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_-_1643368 0.97 ENST00000399682.1
KRTAP5-4
keratin associated protein 5-4
chr5_+_34656331 0.97 ENST00000265109.3
RAI14
retinoic acid induced 14
chr12_-_57328187 0.96 ENST00000293502.1
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr22_-_50524298 0.95 ENST00000311597.5
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr11_-_66103867 0.94 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chrX_+_49028265 0.92 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr17_-_41174424 0.92 ENST00000355653.3
VAT1
vesicle amine transport 1
chr6_-_66417107 0.90 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr4_+_4387983 0.90 ENST00000397958.1
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr6_+_101847105 0.89 ENST00000369137.3
ENST00000318991.6
GRIK2
glutamate receptor, ionotropic, kainate 2
chrX_+_152953505 0.89 ENST00000253122.5
SLC6A8
solute carrier family 6 (neurotransmitter transporter), member 8
chr16_+_28889801 0.89 ENST00000395503.4
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr1_+_32687971 0.88 ENST00000373586.1
EIF3I
eukaryotic translation initiation factor 3, subunit I
chr5_-_139930713 0.88 ENST00000602657.1
SRA1
steroid receptor RNA activator 1
chr10_+_99473455 0.88 ENST00000285605.6
MARVELD1
MARVEL domain containing 1
chr11_+_66360665 0.88 ENST00000310190.4
CCS
copper chaperone for superoxide dismutase
chr20_+_58152524 0.87 ENST00000359926.3
PHACTR3
phosphatase and actin regulator 3
chr9_-_99064429 0.87 ENST00000375263.3
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr12_+_50366620 0.85 ENST00000315520.5
AQP6
aquaporin 6, kidney specific
chr16_+_28889703 0.85 ENST00000357084.3
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr19_+_45174994 0.82 ENST00000403660.3
CEACAM19
carcinoembryonic antigen-related cell adhesion molecule 19
chr19_+_45174724 0.82 ENST00000358777.4
CEACAM19
carcinoembryonic antigen-related cell adhesion molecule 19
chr19_-_45909585 0.81 ENST00000593226.1
ENST00000418234.2
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr7_+_142458507 0.80 ENST00000492062.1
PRSS1
protease, serine, 1 (trypsin 1)
chr9_+_116207007 0.80 ENST00000374140.2
RGS3
regulator of G-protein signaling 3
chr14_+_65171099 0.79 ENST00000247226.7
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_-_2160180 0.79 ENST00000381406.4
IGF2
insulin-like growth factor 2 (somatomedin A)
chr14_+_96343100 0.78 ENST00000503525.2
LINC00617
long intergenic non-protein coding RNA 617
chr3_+_50316458 0.78 ENST00000316436.3
LSMEM2
leucine-rich single-pass membrane protein 2
chr10_+_81272287 0.77 ENST00000520547.2
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr5_+_34656569 0.77 ENST00000428746.2
RAI14
retinoic acid induced 14
chr4_+_128703295 0.77 ENST00000296464.4
ENST00000508549.1
HSPA4L
heat shock 70kDa protein 4-like
chr3_-_182703688 0.75 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1
chr1_+_16083154 0.74 ENST00000375771.1
FBLIM1
filamin binding LIM protein 1
chrX_+_68048803 0.73 ENST00000204961.4
EFNB1
ephrin-B1
chr12_-_96184533 0.72 ENST00000343702.4
ENST00000344911.4
NTN4
netrin 4
chr1_-_31661000 0.72 ENST00000263693.1
ENST00000398657.2
ENST00000526106.1
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr16_-_67360662 0.70 ENST00000304372.5
KCTD19
potassium channel tetramerization domain containing 19
chr1_-_19229014 0.70 ENST00000538839.1
ENST00000290597.5
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr14_+_74416989 0.70 ENST00000334571.2
ENST00000554920.1
COQ6
coenzyme Q6 monooxygenase
chr11_-_66360548 0.69 ENST00000333861.3
CCDC87
coiled-coil domain containing 87
chrX_-_134156502 0.69 ENST00000391440.1
FAM127C
family with sequence similarity 127, member C
chr16_-_67978016 0.68 ENST00000264005.5
LCAT
lecithin-cholesterol acyltransferase
chr5_+_167181917 0.68 ENST00000519204.1
TENM2
teneurin transmembrane protein 2
chrX_-_134186144 0.68 ENST00000370775.2
FAM127B
family with sequence similarity 127, member B
chr14_+_75469606 0.68 ENST00000266126.5
EIF2B2
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
chr11_+_71164149 0.67 ENST00000319023.2
NADSYN1
NAD synthetase 1
chr17_-_7155274 0.67 ENST00000318988.6
ENST00000575783.1
ENST00000573600.1
CTDNEP1
CTD nuclear envelope phosphatase 1
chr3_+_130569592 0.66 ENST00000533801.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chrX_+_47082408 0.66 ENST00000518022.1
ENST00000276052.6
CDK16
cyclin-dependent kinase 16
chr6_-_27775694 0.66 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chr9_+_126131131 0.66 ENST00000373629.2
CRB2
crumbs homolog 2 (Drosophila)
chr1_-_32687923 0.65 ENST00000309777.6
ENST00000344461.3
ENST00000373593.1
ENST00000545122.1
TMEM234
transmembrane protein 234
chr17_+_79989937 0.64 ENST00000580965.1
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr1_-_216596738 0.64 ENST00000307340.3
ENST00000366943.2
ENST00000366942.3
USH2A
Usher syndrome 2A (autosomal recessive, mild)
chr6_+_35995552 0.63 ENST00000468133.1
MAPK14
mitogen-activated protein kinase 14
chr17_-_73840415 0.62 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D
unc-13 homolog D (C. elegans)
chr5_+_52776228 0.62 ENST00000256759.3
FST
follistatin
chr17_-_7154984 0.61 ENST00000574322.1
CTDNEP1
CTD nuclear envelope phosphatase 1
chr17_-_36906058 0.61 ENST00000580830.1
PCGF2
polycomb group ring finger 2
chr16_+_30671223 0.60 ENST00000568722.1
FBRS
fibrosin
chr20_-_30433396 0.60 ENST00000375978.3
FOXS1
forkhead box S1
chr1_+_109792641 0.60 ENST00000271332.3
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2
chr8_-_143857402 0.59 ENST00000523332.1
LYNX1
Ly6/neurotoxin 1
chr1_-_205904950 0.59 ENST00000340781.4
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr2_+_219745020 0.58 ENST00000258411.3
WNT10A
wingless-type MMTV integration site family, member 10A
chrX_+_152086373 0.56 ENST00000318529.8
ZNF185
zinc finger protein 185 (LIM domain)
chr12_+_121416340 0.56 ENST00000257555.6
ENST00000400024.2
HNF1A
HNF1 homeobox A
chr9_-_34637806 0.55 ENST00000477726.1
SIGMAR1
sigma non-opioid intracellular receptor 1
chr17_-_39150385 0.55 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr19_-_49926698 0.55 ENST00000270631.1
PTH2
parathyroid hormone 2
chr20_+_34713312 0.55 ENST00000373946.3
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr11_-_65374430 0.55 ENST00000532507.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr7_+_107220660 0.54 ENST00000465919.1
ENST00000445771.2
ENST00000479917.1
ENST00000421217.1
ENST00000457837.1
BCAP29
B-cell receptor-associated protein 29
chr17_-_40829026 0.54 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr1_-_203274418 0.54 ENST00000457348.1
RP11-134P9.1
long intergenic non-protein coding RNA 1136
chr12_+_27677085 0.53 ENST00000545334.1
ENST00000540114.1
ENST00000537927.1
ENST00000318304.8
ENST00000535047.1
ENST00000542629.1
ENST00000228425.6
PPFIBP1
PTPRF interacting protein, binding protein 1 (liprin beta 1)
chr16_+_30194916 0.53 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
CORO1A
coronin, actin binding protein, 1A
chr1_+_55013889 0.53 ENST00000343744.2
ENST00000371316.3
ACOT11
acyl-CoA thioesterase 11
chr14_+_22748980 0.53 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr8_-_37797621 0.53 ENST00000524298.1
ENST00000307599.4
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr12_+_121416489 0.52 ENST00000541395.1
ENST00000544413.1
HNF1A
HNF1 homeobox A
chr11_+_117070037 0.51 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN
transgelin
chr16_-_29875057 0.51 ENST00000219789.6
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr14_-_74416829 0.51 ENST00000534936.1
FAM161B
family with sequence similarity 161, member B
chr13_-_67804445 0.51 ENST00000456367.1
ENST00000377861.3
ENST00000544246.1
PCDH9
protocadherin 9
chr17_-_40828969 0.50 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr6_+_35995531 0.49 ENST00000229794.4
MAPK14
mitogen-activated protein kinase 14
chr14_+_61788429 0.49 ENST00000332981.5
PRKCH
protein kinase C, eta
chr3_-_48057890 0.49 ENST00000434267.1
MAP4
microtubule-associated protein 4
chr5_+_74633036 0.49 ENST00000343975.5
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
chr5_-_180632147 0.48 ENST00000274773.7
TRIM7
tripartite motif containing 7
chr10_-_77161004 0.48 ENST00000418818.2
RP11-399K21.11
RP11-399K21.11
chr10_+_104155450 0.48 ENST00000471698.1
ENST00000189444.6
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr11_+_62475130 0.48 ENST00000294117.5
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr6_+_35773070 0.48 ENST00000373853.1
ENST00000360215.1
LHFPL5
lipoma HMGIC fusion partner-like 5
chrX_-_70288234 0.48 ENST00000276105.3
ENST00000374274.3
SNX12
sorting nexin 12
chr12_+_107168418 0.48 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
RIC8B
RIC8 guanine nucleotide exchange factor B
chr13_-_67802549 0.47 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr17_+_17942594 0.47 ENST00000268719.4
GID4
GID complex subunit 4
chr3_-_99833333 0.47 ENST00000354552.3
ENST00000331335.5
ENST00000398326.2
FILIP1L
filamin A interacting protein 1-like
chr2_+_89999259 0.47 ENST00000558026.1
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr11_+_71249071 0.46 ENST00000398534.3
KRTAP5-8
keratin associated protein 5-8
chr16_+_69140122 0.46 ENST00000219322.3
HAS3
hyaluronan synthase 3
chr10_-_77161650 0.46 ENST00000372524.4
ZNF503
zinc finger protein 503
chr8_+_145086574 0.46 ENST00000377470.3
ENST00000447830.2
SPATC1
spermatogenesis and centriole associated 1
chr19_-_41220957 0.46 ENST00000596357.1
ENST00000243583.6
ENST00000600080.1
ENST00000595254.1
ENST00000601967.1
ADCK4
aarF domain containing kinase 4
chr6_-_43021612 0.45 ENST00000535468.1
CUL7
cullin 7
chr14_+_23563952 0.45 ENST00000319074.4
C14orf119
chromosome 14 open reading frame 119
chr10_-_77161533 0.45 ENST00000535216.1
ZNF503
zinc finger protein 503
chr7_-_140178775 0.44 ENST00000474576.1
ENST00000473444.1
ENST00000471104.1
MKRN1
makorin ring finger protein 1
chr7_+_123295861 0.44 ENST00000458573.2
ENST00000456238.2
LMOD2
leiomodin 2 (cardiac)
chr1_+_145209092 0.44 ENST00000362074.6
ENST00000344859.3
NOTCH2NL
notch 2 N-terminal like
chr2_-_89247338 0.44 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr6_-_30640811 0.43 ENST00000376442.3
DHX16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr3_-_51994694 0.43 ENST00000395014.2
PCBP4
poly(rC) binding protein 4
chr17_+_900342 0.42 ENST00000327158.4
TIMM22
translocase of inner mitochondrial membrane 22 homolog (yeast)
chr17_-_57784755 0.41 ENST00000537860.1
ENST00000393038.2
ENST00000409433.2
PTRH2
peptidyl-tRNA hydrolase 2
chr9_+_35673853 0.41 ENST00000378357.4
CA9
carbonic anhydrase IX
chr20_-_656437 0.41 ENST00000488788.2
RP5-850E9.3
Uncharacterized protein
chr9_-_117853297 0.41 ENST00000542877.1
ENST00000537320.1
ENST00000341037.4
TNC
tenascin C
chr1_+_178694300 0.41 ENST00000367635.3
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr16_-_1843720 0.41 ENST00000415638.3
ENST00000215539.3
IGFALS
insulin-like growth factor binding protein, acid labile subunit
chr8_-_101962777 0.40 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr15_-_34394119 0.40 ENST00000256545.4
EMC7
ER membrane protein complex subunit 7
chr16_+_1291240 0.40 ENST00000561736.1
TPSAB1
tryptase alpha/beta 1
chr7_+_107220899 0.40 ENST00000379117.2
ENST00000473124.1
BCAP29
B-cell receptor-associated protein 29
chr14_-_53417732 0.40 ENST00000399304.3
ENST00000395631.2
ENST00000341590.3
ENST00000343279.4
FERMT2
fermitin family member 2
chr14_+_23564700 0.39 ENST00000554203.1
C14orf119
chromosome 14 open reading frame 119
chr5_+_169780485 0.39 ENST00000377360.4
KCNIP1
Kv channel interacting protein 1
chr12_+_107168342 0.38 ENST00000392837.4
RIC8B
RIC8 guanine nucleotide exchange factor B
chr2_-_208634287 0.38 ENST00000295417.3
FZD5
frizzled family receptor 5
chr2_+_185463093 0.38 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr7_+_100273736 0.38 ENST00000412215.1
ENST00000393924.1
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr8_-_98290087 0.38 ENST00000322128.3
TSPYL5
TSPY-like 5
chr11_-_117186946 0.37 ENST00000313005.6
ENST00000528053.1
BACE1
beta-site APP-cleaving enzyme 1
chr11_+_65154070 0.37 ENST00000317568.5
ENST00000531296.1
ENST00000533782.1
ENST00000355991.5
ENST00000416776.2
ENST00000526201.1
FRMD8
FERM domain containing 8
chr17_+_57784826 0.37 ENST00000262291.4
VMP1
vacuole membrane protein 1
chr6_+_31895467 0.37 ENST00000556679.1
ENST00000456570.1
CFB
CFB
complement factor B
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr15_-_34394008 0.37 ENST00000527822.1
ENST00000528949.1
EMC7
ER membrane protein complex subunit 7
chr1_-_43205811 0.37 ENST00000372539.3
ENST00000296387.1
ENST00000539749.1
CLDN19
claudin 19
chr3_+_193853927 0.36 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr1_+_214161854 0.36 ENST00000435016.1
PROX1
prospero homeobox 1
chr12_-_109125285 0.36 ENST00000552871.1
ENST00000261401.3
CORO1C
coronin, actin binding protein, 1C
chr16_+_30937213 0.36 ENST00000427128.1
FBXL19
F-box and leucine-rich repeat protein 19
chrX_-_30877837 0.35 ENST00000378930.3
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr4_-_73935409 0.35 ENST00000507544.2
ENST00000295890.4
COX18
COX18 cytochrome C oxidase assembly factor
chr16_+_770975 0.35 ENST00000569529.1
ENST00000564000.1
ENST00000219535.3
FAM173A
family with sequence similarity 173, member A
chr1_+_153600869 0.35 ENST00000292169.1
ENST00000368696.3
ENST00000436839.1
S100A1
S100 calcium binding protein A1
chr14_+_85996507 0.35 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr3_+_130569429 0.35 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr1_-_31538517 0.35 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
PUM1
pumilio RNA-binding family member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
1.2 3.7 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.8 6.2 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.6 1.7 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076)
0.5 6.0 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.5 2.6 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.4 1.3 GO:0035623 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.3 1.6 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.3 0.9 GO:0015680 intracellular copper ion transport(GO:0015680)
0.3 1.9 GO:0061370 testosterone biosynthetic process(GO:0061370)
0.2 0.5 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 1.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.2 1.3 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 0.9 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.2 0.5 GO:0006532 aspartate biosynthetic process(GO:0006532)
0.2 4.0 GO:0001502 cartilage condensation(GO:0001502)
0.2 0.7 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.2 1.5 GO:2001268 positive regulation of keratinocyte migration(GO:0051549) negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.2 0.7 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.2 1.0 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.2 3.0 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 3.8 GO:0006743 ubiquinone metabolic process(GO:0006743)
0.1 0.7 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 1.9 GO:0015816 glycine transport(GO:0015816)
0.1 0.6 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.4 GO:0060061 Spemann organizer formation(GO:0060061)
0.1 0.4 GO:0035910 trochlear nerve development(GO:0021558) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.5 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.1 0.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.7 GO:0014028 notochord formation(GO:0014028)
0.1 0.4 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.1 0.9 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 0.8 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.5 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.1 0.9 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 1.0 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.1 0.3 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.1 0.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 1.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 0.5 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.9 GO:0006600 creatine metabolic process(GO:0006600)
0.1 1.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.9 GO:0099639 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.1 1.1 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 1.0 GO:0060346 bone trabecula formation(GO:0060346)
0.1 0.2 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854)
0.1 0.2 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911) cardiac vascular smooth muscle cell differentiation(GO:0060947)
0.1 0.9 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.1 0.9 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 1.8 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 1.3 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.1 GO:0046449 creatinine metabolic process(GO:0046449)
0.1 0.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.6 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.1 1.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 0.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.6 GO:0022417 protein maturation by protein folding(GO:0022417)
0.1 0.7 GO:0097264 self proteolysis(GO:0097264)
0.1 0.6 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.5 GO:0034351 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1 0.8 GO:0043320 natural killer cell degranulation(GO:0043320)
0.1 0.3 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 1.1 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.1 1.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.5 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.1 GO:0035937 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.0 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.3 GO:0032328 alanine transport(GO:0032328)
0.0 0.6 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:1990637 response to prolactin(GO:1990637)
0.0 0.1 GO:0060454 detection of temperature stimulus involved in thermoception(GO:0050960) positive regulation of gastric acid secretion(GO:0060454) response to capsazepine(GO:1901594)
0.0 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.6 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.6 GO:0014041 regulation of neuron maturation(GO:0014041)
0.0 0.2 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.2 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 0.2 GO:0030047 actin modification(GO:0030047)
0.0 1.0 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.9 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.2 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.1 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.0 0.4 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0 0.1 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.8 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 1.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.2 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.0 0.4 GO:0030091 protein repair(GO:0030091)
0.0 0.4 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.0 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.3 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 0.4 GO:0033622 integrin activation(GO:0033622)
0.0 0.3 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.3 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.9 GO:0006833 water transport(GO:0006833)
0.0 1.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:2000979 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) regulation of forebrain neuron differentiation(GO:2000977) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.1 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834) apoptotic process involved in luteolysis(GO:0061364)
0.0 0.2 GO:0001302 replicative cell aging(GO:0001302)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.0 0.2 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.5 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.4 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.5 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 1.1 GO:0035904 aorta development(GO:0035904)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.2 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.1 GO:1901805 beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457)
0.0 0.7 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.3 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.1 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.2 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 0.6 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.0 0.7 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.3 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.1 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.7 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 3.2 GO:0031424 keratinization(GO:0031424)
0.0 0.9 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 3.0 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 0.2 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672) response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.9 GO:2000273 positive regulation of receptor activity(GO:2000273)
0.0 0.3 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 0.7 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.3 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.2 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 2.6 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.2 GO:0015747 urate transport(GO:0015747)
0.0 0.5 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0060297 regulation of sarcomere organization(GO:0060297)
0.0 1.5 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 0.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 2.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.3 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.7 GO:0007566 embryo implantation(GO:0007566)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.3 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.1 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.2 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.2 GO:0060732 regulation of inositol phosphate biosynthetic process(GO:0010919) positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.3 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 1.4 GO:1902476 chloride transmembrane transport(GO:1902476)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.4 GO:0005642 annulate lamellae(GO:0005642)
0.3 1.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.3 1.2 GO:0036156 inner dynein arm(GO:0036156)
0.2 0.6 GO:0002139 stereocilia coupling link(GO:0002139)
0.2 2.6 GO:0043203 axon hillock(GO:0043203)
0.1 1.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 0.5 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 0.4 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.9 GO:0098845 postsynaptic endosome(GO:0098845)
0.1 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.1 0.7 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 5.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.8 GO:0001739 sex chromatin(GO:0001739)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.3 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 0.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1 0.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.6 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 1.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.5 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.1 GO:1903349 extrinsic component of omegasome membrane(GO:0097629) omegasome membrane(GO:1903349)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0016600 flotillin complex(GO:0016600)
0.0 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.3 GO:0000322 storage vacuole(GO:0000322)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 1.9 GO:0045095 keratin filament(GO:0045095)
0.0 1.4 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.9 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 3.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.0 GO:0031941 filamentous actin(GO:0031941)
0.0 0.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 8.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.4 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.6 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 2.9 GO:0001650 fibrillar center(GO:0001650)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0097361 CIA complex(GO:0097361)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 3.4 GO:0031968 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 0.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.8 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 4.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.3 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.6 3.8 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.3 1.9 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.3 5.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 0.9 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.2 2.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 3.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.2 0.5 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2 0.7 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.2 0.5 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.1 0.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 1.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.4 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 1.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.7 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 3.7 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.9 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 0.5 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 1.5 GO:0045499 chemorepellent activity(GO:0045499)
0.1 3.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.1 GO:0004985 opioid receptor activity(GO:0004985)
0.1 1.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 1.3 GO:0048185 activin binding(GO:0048185)
0.1 0.4 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.3 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 2.0 GO:0071949 FAD binding(GO:0071949)
0.1 1.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.4 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.7 GO:0015266 protein channel activity(GO:0015266)
0.1 0.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 1.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0001003 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.0 0.9 GO:0015250 water channel activity(GO:0015250)
0.0 0.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.7 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.2 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.2 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 1.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.6 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.4 GO:0045545 syndecan binding(GO:0045545)
0.0 0.3 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 0.7 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.9 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.4 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.0 0.8 GO:0070402 NADPH binding(GO:0070402)
0.0 5.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0031005 filamin binding(GO:0031005)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.0 0.2 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.9 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 3.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.7 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.9 GO:0019956 chemokine binding(GO:0019956)
0.0 0.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.5 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.2 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 1.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.3 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.4 GO:0001848 complement binding(GO:0001848)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.2 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 2.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 7.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.9 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.1 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.0 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.9 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 5.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 1.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.0 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.9 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.4 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.4 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.5 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.1 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins