ISMARA results: KLF12

Project

Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

Navigation

Downloads

Results for KLF12

Z-value: 1.16

Motif logo

Transcription factors associated with KLF12

Gene Symbol	Gene ID	Gene Info
KLF12 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000118922.12	Kruppel like factor 12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF12	hg19_v2_chr13_-_74708372_74708409	0.14	4.5e-01	Click!

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_234104079 Show fit	3.85	ENST00000417661.1	INPP5D Ensembl NCBI GeneCards UniProt NextProt Show fit	inositol polyphosphate-5-phosphatase, 145kDa
chr15_-_90039805 Show fit	3.66	ENST00000544600.1 ENST00000268122.4	RHCG Ensembl NCBI GeneCards UniProt NextProt Show fit	Rh family, C glycoprotein
chr15_+_89402148 Show fit	3.03	ENST00000560601.1	ACAN Ensembl NCBI GeneCards UniProt NextProt Show fit	aggrecan
chr8_+_22022800 Show fit	2.84	ENST00000397814.3	BMP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	bone morphogenetic protein 1
chrX_-_48325857 Show fit	2.70	ENST00000376875.1	SLC38A5 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 38, member 5
chr17_-_76899275 Show fit	2.50	ENST00000322630.2 ENST00000586713.1	DDC8 Ensembl NCBI GeneCards UniProt NextProt Show fit	Protein DDC8 homolog
chr1_-_47655686 Show fit	2.23	ENST00000294338.2	PDZK1IP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	PDZK1 interacting protein 1
chr2_+_24272576 Show fit	2.08	ENST00000380986.4 ENST00000452109.1	FKBP1B Ensembl NCBI GeneCards UniProt NextProt Show fit	FK506 binding protein 1B, 12.6 kDa
chr2_+_24272543 Show fit	2.08	ENST00000380991.4	FKBP1B Ensembl NCBI GeneCards UniProt NextProt Show fit	FK506 binding protein 1B, 12.6 kDa
chr17_+_7211280 Show fit	1.90	ENST00000419711.2 ENST00000571955.1 ENST00000573714.1	EIF5A Ensembl NCBI GeneCards UniProt NextProt Show fit	eukaryotic translation initiation factor 5A

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	6.2	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.5	6.0	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2	4.0	GO:0001502	cartilage condensation(GO:0001502)
1.3	3.8	GO:0045659	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1	3.8	GO:0006743	ubiquinone metabolic process(GO:0006743)
1.2	3.7	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	3.2	GO:0031424	keratinization(GO:0031424)
0.2	3.0	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.0	3.0	GO:0007173	epidermal growth factor receptor signaling pathway(GO:0007173)
0.5	2.6	GO:0071279	cellular response to cobalt ion(GO:0071279)

Showing 1 to 10 of 163 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.2	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1	5.5	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.5	5.4	GO:0005642	annulate lamellae(GO:0005642)
0.0	4.7	GO:0016324	apical plasma membrane(GO:0016324)
0.0	3.4	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0	3.4	GO:0031968	mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0	3.2	GO:0043202	lysosomal lumen(GO:0043202)
0.0	2.9	GO:0001650	fibrillar center(GO:0001650)
0.0	2.8	GO:0034707	chloride channel complex(GO:0034707)
0.2	2.6	GO:0043203	axon hillock(GO:0043203)

Showing 1 to 10 of 77 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.4	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	5.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.8	4.2	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.6	3.8	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	3.7	GO:0030506	ankyrin binding(GO:0030506)
0.0	3.6	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.2	3.1	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1	3.0	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	2.7	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	2.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)

Showing 1 to 10 of 118 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.8	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	2.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	1.8	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	1.4	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	1.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	1.3	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	1.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	1.1	PID P53 REGULATION PATHWAY	p53 pathway
0.0	1.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 19 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.2	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2	4.7	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	3.8	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.2	3.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	2.9	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.1	2.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	1.9	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.1	1.9	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	1.7	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	1.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix

Showing 1 to 10 of 45 entries

Results for KLF12

Z-value: 1.16

Motif logo

Transcription factors associated with KLF12

Activity-expression correlation:

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: