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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for KLF16_SP2
Z-value: 2.04
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF16 | hg19_v2_chr19_-_1863567_1863586 | -0.54 | 2.1e-03 | Click! |
| SP2 | hg19_v2_chr17_+_45973516_45973618 | -0.03 | 8.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_158380371 Show fit | 15.89 |
ENST00000389418.4
ENST00000389416.4 |
protein tyrosine phosphatase, receptor type, N polypeptide 2 |
|
| chr21_-_43916433 Show fit | 13.85 |
ENST00000291536.3
|
radial spoke head 1 homolog (Chlamydomonas) |
|
| chr7_-_158380465 Show fit | 13.38 |
ENST00000389413.3
ENST00000409483.1 |
protein tyrosine phosphatase, receptor type, N polypeptide 2 |
|
| chr16_-_67427389 Show fit | 12.35 |
ENST00000562206.1
ENST00000290942.5 ENST00000393957.2 |
tubulin polymerization-promoting protein family member 3 |
|
| chr11_+_2466218 Show fit | 12.03 |
ENST00000155840.5
|
potassium voltage-gated channel, KQT-like subfamily, member 1 |
|
| chr16_+_67465016 Show fit | 11.07 |
ENST00000326152.5
|
hydroxysteroid (11-beta) dehydrogenase 2 |
|
| chr19_-_55672037 Show fit | 10.90 |
ENST00000588076.1
|
dynein, axonemal, assembly factor 3 |
|
| chr7_-_123174610 Show fit | 10.51 |
ENST00000324698.6
ENST00000434450.1 |
IQ motif and ubiquitin domain containing |
|
| chr19_-_55677999 Show fit | 10.33 |
ENST00000532817.1
ENST00000527223.2 ENST00000391720.4 |
dynein, axonemal, assembly factor 3 |
|
| chr6_+_43612750 Show fit | 10.31 |
ENST00000372165.4
ENST00000372163.4 |
radial spoke head 9 homolog (Chlamydomonas) |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 81.2 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 1.2 | 61.0 | GO:0035082 | axoneme assembly(GO:0035082) |
| 4.5 | 22.5 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.2 | 21.2 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 1.9 | 21.0 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.5 | 20.5 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.3 | 18.7 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.3 | 18.0 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.9 | 17.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.3 | 14.7 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 50.5 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 1.3 | 36.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 35.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 2.1 | 29.8 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.8 | 25.9 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.2 | 25.3 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 20.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 18.9 | GO:0036064 | ciliary basal body(GO:0036064) |
| 1.0 | 18.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 17.0 | GO:0016604 | nuclear body(GO:0016604) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 73.6 | GO:0003677 | DNA binding(GO:0003677) |
| 1.2 | 34.3 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 33.7 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 0.1 | 27.0 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 26.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 1.1 | 24.9 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.3 | 19.6 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 1.1 | 17.3 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.2 | 17.2 | GO:0033558 | protein deacetylase activity(GO:0033558) |
| 0.7 | 16.9 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 19.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.3 | 17.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 16.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 13.3 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.2 | 13.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 12.2 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.2 | 11.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 11.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 10.7 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 38.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 27.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.3 | 25.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 17.6 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.6 | 15.0 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.3 | 14.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 13.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.5 | 13.2 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.2 | 12.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 11.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |