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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for KLF3
Z-value: 0.93
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Transcription factors associated with KLF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF3 | hg19_v2_chr4_+_38665810_38665827 | 0.22 | 2.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_7013897 Show fit | 2.85 |
ENST00000007969.8
ENST00000323702.5 |
leucine rich repeat containing 23 |
|
| chr2_+_172378757 Show fit | 2.35 |
ENST00000409484.1
ENST00000321348.4 ENST00000375252.3 |
cytochrome b reductase 1 |
|
| chr1_+_38022572 Show fit | 2.20 |
ENST00000541606.1
|
dynein, axonemal, light intermediate chain 1 |
|
| chr16_+_618837 Show fit | 1.88 |
ENST00000409439.2
|
phosphatidylinositol glycan anchor biosynthesis, class Q |
|
| chr1_-_42921915 Show fit | 1.88 |
ENST00000372565.3
ENST00000433602.2 |
zinc finger, MYND-type containing 12 |
|
| chrX_+_152338301 Show fit | 1.86 |
ENST00000453825.2
|
paraneoplastic Ma antigen family member 6A |
|
| chr16_+_84209539 Show fit | 1.80 |
ENST00000569735.1
|
dynein, axonemal, assembly factor 1 |
|
| chr22_-_50970506 Show fit | 1.78 |
ENST00000428989.2
ENST00000403326.1 |
outer dense fiber of sperm tails 3B |
|
| chr11_-_5248294 Show fit | 1.72 |
ENST00000335295.4
|
hemoglobin, beta |
|
| chr1_-_60539405 Show fit | 1.70 |
ENST00000450089.2
|
chromosome 1 open reading frame 87 |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.2 | 2.9 | GO:0090315 | negative regulation of protein targeting to membrane(GO:0090315) |
| 0.1 | 2.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.4 | 2.2 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.0 | 2.0 | GO:0010039 | response to iron ion(GO:0010039) |
| 0.3 | 1.8 | GO:1901569 | leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569) |
| 0.1 | 1.8 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.4 | 1.7 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 0.2 | 1.6 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.1 | 1.4 | GO:0045475 | locomotor rhythm(GO:0045475) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.3 | 3.4 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 2.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 2.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.4 | 1.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.1 | 1.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 1.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 1.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 1.2 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 1.1 | GO:0031526 | brush border membrane(GO:0031526) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.4 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.5 | 2.8 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.2 | 2.7 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.1 | 2.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 2.1 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 1.9 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.6 | 1.8 | GO:0052870 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.3 | 1.7 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 1.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 1.5 | GO:0008013 | beta-catenin binding(GO:0008013) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.0 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.4 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.3 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.2 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 2.7 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 2.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 1.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.2 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 1.1 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.0 | 1.1 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.0 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |