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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for LEF1

Z-value: 1.02

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Transcription factors associated with LEF1

Gene Symbol Gene ID Gene Info
LEF1
ENSG00000138795.5 lymphoid enhancer binding factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109087872_109087881,
hg19_v2_chr4_-_109088940_109089037		-0.193.2e-01Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_141747950 1.89 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_+_137514687 1.61 ENST00000394894.3
KIF20A
kinesin family member 20A
chr2_-_1748214 1.51 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
PXDN
peroxidasin homolog (Drosophila)
chrX_+_38420783 1.46 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr5_+_137514834 1.40 ENST00000508792.1
ENST00000504621.1
KIF20A
kinesin family member 20A
chr1_+_82266053 1.34 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr11_-_75017734 1.20 ENST00000532525.1
ARRB1
arrestin, beta 1
chr5_-_146833485 1.14 ENST00000398514.3
DPYSL3
dihydropyrimidinase-like 3
chr1_-_205419053 1.14 ENST00000367154.1
LEMD1
LEM domain containing 1
chr3_-_112320749 1.10 ENST00000610103.1
RP11-572C15.6
RP11-572C15.6
chr3_-_112360116 1.07 ENST00000206423.3
ENST00000439685.2
CCDC80
coiled-coil domain containing 80
chr9_+_101705893 1.02 ENST00000375001.3
COL15A1
collagen, type XV, alpha 1
chr14_+_54863739 1.01 ENST00000541304.1
CDKN3
cyclin-dependent kinase inhibitor 3
chr14_+_54863667 0.99 ENST00000335183.6
CDKN3
cyclin-dependent kinase inhibitor 3
chr20_+_37554955 0.99 ENST00000217429.4
FAM83D
family with sequence similarity 83, member D
chr14_+_54863682 0.97 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
CDKN3
cyclin-dependent kinase inhibitor 3
chr14_-_61124977 0.97 ENST00000554986.1
SIX1
SIX homeobox 1
chr3_-_71179699 0.93 ENST00000497355.1
FOXP1
forkhead box P1
chr7_-_148581360 0.91 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_148581251 0.90 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_25268104 0.89 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr3_-_71179988 0.88 ENST00000491238.1
FOXP1
forkhead box P1
chr17_-_46623441 0.87 ENST00000330070.4
HOXB2
homeobox B2
chr1_+_196743943 0.87 ENST00000471440.2
ENST00000391985.3
CFHR3
complement factor H-related 3
chr7_-_19813192 0.87 ENST00000422233.1
ENST00000433641.1
TMEM196
transmembrane protein 196
chr9_-_23826298 0.85 ENST00000380117.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr3_+_19189946 0.85 ENST00000328405.2
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr4_+_95972822 0.84 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr5_+_54455946 0.83 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr1_+_196743912 0.82 ENST00000367425.4
CFHR3
complement factor H-related 3
chrX_-_48328631 0.80 ENST00000429543.1
ENST00000317669.5
SLC38A5
solute carrier family 38, member 5
chrX_-_48328551 0.80 ENST00000376876.3
SLC38A5
solute carrier family 38, member 5
chr2_+_233734994 0.79 ENST00000331342.2
C2orf82
chromosome 2 open reading frame 82
chr7_+_120628731 0.79 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr5_+_161494521 0.78 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr15_-_74495188 0.77 ENST00000563965.1
ENST00000395105.4
STRA6
stimulated by retinoic acid 6
chr8_-_124553437 0.76 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr11_-_41481135 0.75 ENST00000528697.1
ENST00000530763.1
LRRC4C
leucine rich repeat containing 4C
chr10_+_114710425 0.75 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr8_-_133772794 0.73 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
TMEM71
transmembrane protein 71
chr6_-_64029879 0.72 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr1_+_47799542 0.71 ENST00000471289.2
ENST00000450808.2
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr3_+_111260856 0.71 ENST00000352690.4
CD96
CD96 molecule
chr7_+_28452130 0.70 ENST00000357727.2
CREB5
cAMP responsive element binding protein 5
chr7_-_27219849 0.68 ENST00000396344.4
HOXA10
homeobox A10
chr5_+_161494770 0.68 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr2_-_47572105 0.67 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
AC073283.4
chr9_-_27005686 0.66 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr14_+_85996471 0.66 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr4_+_71494461 0.66 ENST00000396073.3
ENAM
enamelin
chr19_-_49864746 0.65 ENST00000598810.1
TEAD2
TEA domain family member 2
chr3_-_71353892 0.64 ENST00000484350.1
FOXP1
forkhead box P1
chr10_-_69597915 0.60 ENST00000225171.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr3_+_39509163 0.60 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
MOBP
myelin-associated oligodendrocyte basic protein
chr8_-_16859690 0.60 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr5_+_161274940 0.60 ENST00000393943.4
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_+_58655461 0.60 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr9_+_116638562 0.59 ENST00000374126.5
ENST00000288466.7
ZNF618
zinc finger protein 618
chr7_+_73245193 0.59 ENST00000340958.2
CLDN4
claudin 4
chr2_+_162272605 0.59 ENST00000389554.3
TBR1
T-box, brain, 1
chr9_-_94186131 0.59 ENST00000297689.3
NFIL3
nuclear factor, interleukin 3 regulated
chr7_+_129847688 0.58 ENST00000297819.3
SSMEM1
serine-rich single-pass membrane protein 1
chr1_-_226496772 0.58 ENST00000359525.2
ENST00000460719.1
LIN9
lin-9 homolog (C. elegans)
chr6_-_153304148 0.58 ENST00000229758.3
FBXO5
F-box protein 5
chr10_-_17171817 0.57 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr5_+_126112794 0.57 ENST00000261366.5
ENST00000395354.1
LMNB1
lamin B1
chr7_-_41742697 0.57 ENST00000242208.4
INHBA
inhibin, beta A
chr2_-_86564776 0.57 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1
receptor accessory protein 1
chr3_+_141105235 0.57 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr3_-_141747439 0.57 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_-_16759711 0.56 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_+_5410607 0.55 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chrX_-_100183894 0.55 ENST00000328526.5
ENST00000372956.2
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr2_+_11679963 0.55 ENST00000263834.5
GREB1
growth regulation by estrogen in breast cancer 1
chr13_+_30002741 0.54 ENST00000380808.2
MTUS2
microtubule associated tumor suppressor candidate 2
chr6_-_153304697 0.54 ENST00000367241.3
FBXO5
F-box protein 5
chr10_-_101380121 0.54 ENST00000370495.4
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr5_+_172068232 0.53 ENST00000520919.1
ENST00000522853.1
ENST00000369800.5
NEURL1B
neuralized E3 ubiquitin protein ligase 1B
chr17_+_80416050 0.53 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF
nuclear prelamin A recognition factor
chr8_-_93107696 0.52 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr21_-_32185570 0.51 ENST00000329621.4
KRTAP8-1
keratin associated protein 8-1
chrX_+_46937745 0.51 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
RGN
regucalcin
chr7_+_80275621 0.51 ENST00000426978.1
ENST00000432207.1
CD36
CD36 molecule (thrombospondin receptor)
chr19_+_751122 0.50 ENST00000215582.6
MISP
mitotic spindle positioning
chr15_-_37392086 0.50 ENST00000561208.1
MEIS2
Meis homeobox 2
chr7_+_7811992 0.50 ENST00000406829.1
RPA3-AS1
RPA3 antisense RNA 1
chr5_-_137674000 0.50 ENST00000510119.1
ENST00000513970.1
CDC25C
cell division cycle 25C
chr4_-_23891658 0.50 ENST00000507380.1
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr2_+_27665232 0.49 ENST00000543753.1
ENST00000288873.3
KRTCAP3
keratinocyte associated protein 3
chrX_+_95939711 0.49 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr9_+_133971909 0.49 ENST00000247291.3
ENST00000372302.1
ENST00000372300.1
ENST00000372298.1
AIF1L
allograft inflammatory factor 1-like
chr11_+_65408273 0.48 ENST00000394227.3
SIPA1
signal-induced proliferation-associated 1
chr5_+_31193847 0.48 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr5_-_65017921 0.48 ENST00000381007.4
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr11_-_85430163 0.47 ENST00000529581.1
ENST00000533577.1
SYTL2
synaptotagmin-like 2
chr9_+_133971863 0.47 ENST00000372309.3
AIF1L
allograft inflammatory factor 1-like
chr6_-_112575838 0.47 ENST00000455073.1
LAMA4
laminin, alpha 4
chr2_-_72375167 0.47 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr11_-_85430204 0.47 ENST00000389958.3
ENST00000527794.1
SYTL2
synaptotagmin-like 2
chr3_+_39509070 0.46 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
MOBP
myelin-associated oligodendrocyte basic protein
chr20_+_3776371 0.46 ENST00000245960.5
CDC25B
cell division cycle 25B
chr3_+_182983090 0.46 ENST00000465010.1
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr2_+_27665289 0.46 ENST00000407293.1
KRTCAP3
keratinocyte associated protein 3
chr7_+_80275953 0.45 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chr11_-_66445219 0.45 ENST00000525754.1
ENST00000531969.1
ENST00000524637.1
ENST00000531036.2
ENST00000310046.4
RBM4B
RNA binding motif protein 4B
chr13_-_24895566 0.44 ENST00000422229.2
AL359736.1
protein PCOTH isoform 1
chr9_+_77230499 0.44 ENST00000396204.2
RORB
RAR-related orphan receptor B
chr9_+_84304628 0.44 ENST00000437181.1
RP11-154D17.1
RP11-154D17.1
chrY_-_15591485 0.44 ENST00000382896.4
ENST00000537580.1
ENST00000540140.1
ENST00000545955.1
ENST00000538878.1
UTY
ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
chr21_+_39628852 0.44 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chrX_+_54835493 0.44 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr2_-_157189180 0.44 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr5_+_170846640 0.43 ENST00000274625.5
FGF18
fibroblast growth factor 18
chrX_-_43832711 0.43 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr7_-_99698338 0.43 ENST00000354230.3
ENST00000425308.1
MCM7
minichromosome maintenance complex component 7
chr7_+_80275752 0.43 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chrX_-_80457385 0.42 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr18_-_74728998 0.41 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP
myelin basic protein
chr3_-_33686925 0.41 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr12_+_54378923 0.41 ENST00000303460.4
HOXC10
homeobox C10
chr1_+_84630367 0.41 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr18_+_72922710 0.40 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr7_-_29234802 0.40 ENST00000449801.1
ENST00000409850.1
CPVL
carboxypeptidase, vitellogenic-like
chr18_-_24445729 0.40 ENST00000383168.4
AQP4
aquaporin 4
chr3_-_148804275 0.40 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
HLTF
helicase-like transcription factor
chr11_-_57298187 0.40 ENST00000525158.1
ENST00000257245.4
ENST00000525587.1
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr7_+_39017504 0.39 ENST00000403058.1
POU6F2
POU class 6 homeobox 2
chrX_+_95939638 0.39 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr4_+_96012614 0.39 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr2_-_26205340 0.39 ENST00000264712.3
KIF3C
kinesin family member 3C
chr11_+_112832202 0.39 ENST00000534015.1
NCAM1
neural cell adhesion molecule 1
chr12_-_16761007 0.39 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr17_-_79849438 0.39 ENST00000331204.4
ENST00000505490.2
ALYREF
Aly/REF export factor
chr12_+_1738363 0.39 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr3_-_147124547 0.38 ENST00000491672.1
ENST00000383075.3
ZIC4
Zic family member 4
chr4_+_95128748 0.38 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr10_+_114710516 0.38 ENST00000542695.1
ENST00000346198.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr17_-_43025005 0.37 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
KIF18B
kinesin family member 18B
chr15_-_37391614 0.37 ENST00000219869.9
MEIS2
Meis homeobox 2
chr17_+_79679299 0.37 ENST00000331531.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr14_+_61201445 0.37 ENST00000261245.4
ENST00000539616.2
MNAT1
MNAT CDK-activating kinase assembly factor 1
chr7_+_139528952 0.37 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr4_-_140477353 0.37 ENST00000406354.1
ENST00000506866.2
SETD7
SET domain containing (lysine methyltransferase) 7
chr2_+_177028805 0.36 ENST00000249440.3
HOXD3
homeobox D3
chr12_+_54955235 0.36 ENST00000550620.1
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr6_-_15586238 0.36 ENST00000462989.2
DTNBP1
dystrobrevin binding protein 1
chr1_+_100111580 0.36 ENST00000605497.1
PALMD
palmdelphin
chr7_-_25702669 0.36 ENST00000446840.1
AC003090.1
AC003090.1
chr8_-_93107827 0.36 ENST00000520724.1
ENST00000518844.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_70056762 0.36 ENST00000282570.3
GMCL1
germ cell-less, spermatogenesis associated 1
chr2_-_161056762 0.35 ENST00000428609.2
ENST00000409967.2
ITGB6
integrin, beta 6
chrX_+_37545012 0.35 ENST00000378616.3
XK
X-linked Kx blood group (McLeod syndrome)
chrX_+_69488155 0.35 ENST00000374495.3
ARR3
arrestin 3, retinal (X-arrestin)
chr16_-_22385901 0.35 ENST00000268383.2
CDR2
cerebellar degeneration-related protein 2, 62kDa
chr13_+_30002846 0.35 ENST00000542829.1
MTUS2
microtubule associated tumor suppressor candidate 2
chr15_-_37393406 0.35 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr14_-_23479331 0.34 ENST00000397377.1
ENST00000397379.3
ENST00000406429.2
ENST00000341470.4
ENST00000555998.1
ENST00000397376.2
ENST00000553675.1
ENST00000553931.1
ENST00000555575.1
ENST00000553958.1
ENST00000555098.1
ENST00000556419.1
ENST00000553606.1
ENST00000299088.6
ENST00000554179.1
ENST00000397382.4
C14orf93
chromosome 14 open reading frame 93
chr2_+_204732666 0.34 ENST00000295854.6
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr4_-_139163491 0.34 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr6_-_25874440 0.34 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr11_+_112832133 0.34 ENST00000524665.1
NCAM1
neural cell adhesion molecule 1
chr17_-_39637392 0.33 ENST00000246639.2
ENST00000393989.1
KRT35
keratin 35
chr8_+_63161491 0.33 ENST00000523211.1
ENST00000524201.1
NKAIN3
Na+/K+ transporting ATPase interacting 3
chr15_-_101792137 0.33 ENST00000254190.3
CHSY1
chondroitin sulfate synthase 1
chr2_+_96991033 0.33 ENST00000420176.1
ENST00000536814.1
ENST00000439118.2
ITPRIPL1
inositol 1,4,5-trisphosphate receptor interacting protein-like 1
chr6_+_90604188 0.33 ENST00000369352.1
GJA10
gap junction protein, alpha 10, 62kDa
chr10_+_114710211 0.33 ENST00000349937.2
ENST00000369397.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr14_-_81425828 0.33 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr11_-_84634217 0.32 ENST00000524982.1
DLG2
discs, large homolog 2 (Drosophila)
chr1_-_156542328 0.32 ENST00000361170.2
IQGAP3
IQ motif containing GTPase activating protein 3
chr1_-_54303949 0.32 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin
chr2_+_172864490 0.32 ENST00000315796.4
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr7_-_47621736 0.32 ENST00000311160.9
TNS3
tensin 3
chr2_-_161056802 0.31 ENST00000283249.2
ENST00000409872.1
ITGB6
integrin, beta 6
chr18_-_74207146 0.31 ENST00000443185.2
ZNF516
zinc finger protein 516
chr17_+_79679369 0.31 ENST00000350690.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr20_+_36149602 0.31 ENST00000062104.2
ENST00000346199.2
NNAT
neuronatin
chr5_+_161495038 0.31 ENST00000393933.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chrX_+_15518923 0.31 ENST00000348343.6
BMX
BMX non-receptor tyrosine kinase
chr12_-_118406777 0.31 ENST00000339824.5
KSR2
kinase suppressor of ras 2
chr11_-_84634447 0.31 ENST00000532653.1
DLG2
discs, large homolog 2 (Drosophila)
chr11_-_87908600 0.30 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38
RAB38, member RAS oncogene family
chr6_-_30654977 0.30 ENST00000399199.3
PPP1R18
protein phosphatase 1, regulatory subunit 18
chr10_-_99393208 0.30 ENST00000307450.6
MORN4
MORN repeat containing 4
chr1_+_93544791 0.30 ENST00000545708.1
ENST00000540243.1
ENST00000370298.4
MTF2
metal response element binding transcription factor 2
chr12_-_122240792 0.30 ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
ENST00000541657.1
AC084018.1
RHOF
AC084018.1
ras homolog family member F (in filopodia)
chr4_+_95129061 0.30 ENST00000354268.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr11_+_112130988 0.30 ENST00000595053.1
AP002884.2
LOC100132686 protein; Uncharacterized protein
chr3_+_107244229 0.29 ENST00000456419.1
ENST00000402163.2
BBX
bobby sox homolog (Drosophila)
chr11_-_75917569 0.29 ENST00000322563.3
WNT11
wingless-type MMTV integration site family, member 11
chr2_+_198669365 0.29 ENST00000428675.1
PLCL1
phospholipase C-like 1
chr4_+_95128996 0.29 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr15_-_41120896 0.29 ENST00000299174.5
ENST00000427255.2
PPP1R14D
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chrX_+_36254051 0.29 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr1_+_100111479 0.29 ENST00000263174.4
PALMD
palmdelphin
chr11_+_126081662 0.29 ENST00000528985.1
ENST00000529731.1
ENST00000360194.4
ENST00000530043.1
FAM118B
family with sequence similarity 118, member B
chr11_-_57194948 0.29 ENST00000533235.1
ENST00000526621.1
ENST00000352187.1
SLC43A3
solute carrier family 43, member 3
chr2_-_2334888 0.28 ENST00000428368.2
ENST00000399161.2
MYT1L
myelin transcription factor 1-like
chr21_+_30671690 0.28 ENST00000399921.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr9_-_113341985 0.28 ENST00000374469.1
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.5 2.5 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.4 1.1 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.3 1.0 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.3 1.0 GO:0021569 rhombomere 3 development(GO:0021569)
0.3 1.7 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.3 0.8 GO:0070631 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.2 1.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 1.0 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2 1.7 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2 0.7 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.2 0.7 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.2 0.6 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.2 0.6 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 0.7 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.2 0.7 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.2 0.5 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.2 0.5 GO:1904530 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.2 0.5 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.2 1.0 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.2 0.6 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.2 0.8 GO:0061143 alveolar primary septum development(GO:0061143)
0.2 0.9 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.4 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 2.4 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.9 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 3.0 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.2 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 0.4 GO:0031133 regulation of axon diameter(GO:0031133)
0.1 1.6 GO:0015816 glycine transport(GO:0015816)
0.1 0.3 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 1.2 GO:0090240 positive regulation of histone H4 acetylation(GO:0090240)
0.1 0.4 GO:0060023 soft palate development(GO:0060023)
0.1 0.8 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.4 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.1 0.4 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1 0.3 GO:0060031 mediolateral intercalation(GO:0060031) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775)
0.1 0.5 GO:0042631 cellular response to water deprivation(GO:0042631)
0.1 0.1 GO:1904616 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 1.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 0.7 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 0.3 GO:0060931 sinoatrial node cell development(GO:0060931)
0.1 0.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.3 GO:2000705 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.9 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.6 GO:0097338 response to clozapine(GO:0097338)
0.1 1.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 0.4 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.4 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.8 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.0 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.4 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.4 GO:0071895 odontoblast differentiation(GO:0071895)
0.1 0.3 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.1 0.2 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.1 0.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.2 GO:0071288 cellular response to mercury ion(GO:0071288)
0.1 0.3 GO:0048286 lung alveolus development(GO:0048286)
0.1 0.2 GO:0051572 negative regulation of histone H3-K36 methylation(GO:0000415) negative regulation of histone H3-K4 methylation(GO:0051572)
0.1 0.4 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 0.4 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 2.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.2 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.6 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.5 GO:0007144 female meiosis I(GO:0007144)
0.1 0.2 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1 0.2 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.1 1.3 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.3 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.6 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.2 GO:0003358 noradrenergic neuron development(GO:0003358)
0.0 0.5 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.2 GO:0071484 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.0 0.3 GO:1901631 positive regulation of presynaptic membrane organization(GO:1901631) positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.6 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.4 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.5 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.0 0.7 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 1.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.2 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.3 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.3 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.4 GO:0097106 postsynaptic density organization(GO:0097106)
0.0 0.2 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0 0.1 GO:0042441 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.2 GO:2001270 regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.3 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.4 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.4 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 0.0 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.0 0.2 GO:0003263 cardioblast proliferation(GO:0003263) regulation of cardioblast proliferation(GO:0003264)
0.0 0.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.4 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.7 GO:0060065 uterus development(GO:0060065)
0.0 0.6 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.4 GO:0007512 adult heart development(GO:0007512)
0.0 0.2 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 3.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.1 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.0 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.0 0.1 GO:1904396 regulation of neuromuscular junction development(GO:1904396)
0.0 0.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.2 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.4 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.2 GO:1904783 positive regulation of NMDA glutamate receptor activity(GO:1904783)
0.0 0.3 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.0 0.0 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0 0.2 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.1 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.0 GO:0048864 stem cell development(GO:0048864)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.3 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.5 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.2 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.3 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.2 GO:0050893 sensory processing(GO:0050893)
0.0 0.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.3 GO:0060539 diaphragm development(GO:0060539)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0043271 negative regulation of ion transport(GO:0043271)
0.0 0.2 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.9 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.1 GO:0071042 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.0 0.2 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 1.0 GO:0051310 metaphase plate congression(GO:0051310)
0.0 0.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.2 GO:0007351 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.2 GO:0060346 bone trabecula formation(GO:0060346)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.6 GO:0046710 GDP metabolic process(GO:0046710) receptor localization to synapse(GO:0097120)
0.0 0.5 GO:0051923 sulfation(GO:0051923)
0.0 0.2 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) negative regulation of chromatin silencing(GO:0031936) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.4 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.0 1.0 GO:0008542 visual learning(GO:0008542)
0.0 0.2 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.3 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.0 GO:0090260 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of retinal ganglion cell axon guidance(GO:0090260) negative regulation of neutrophil migration(GO:1902623)
0.0 0.1 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)
0.0 0.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.0 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763) regulation of glutamate metabolic process(GO:2000211)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.0 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:2000973 midbrain morphogenesis(GO:1904693) regulation of pro-B cell differentiation(GO:2000973)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 0.8 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.2 0.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.2 0.6 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.2 1.4 GO:0005638 lamin filament(GO:0005638)
0.1 1.3 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.1 0.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 1.8 GO:0045120 pronucleus(GO:0045120)
0.1 0.3 GO:0031012 extracellular matrix(GO:0031012)
0.1 1.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.3 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.3 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.1 2.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.4 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 0.4 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 0.9 GO:0045180 basal cortex(GO:0045180)
0.0 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 1.0 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.4 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 1.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.4 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 1.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.0 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 0.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.0 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 1.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.5 GO:0005605 basal lamina(GO:0005605)
0.0 0.4 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.3 0.3 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.3 1.5 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.3 1.7 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 0.7 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.2 0.7 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.2 1.8 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.7 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.2 0.7 GO:0009041 uridylate kinase activity(GO:0009041)
0.2 0.5 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 1.6 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.6 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 1.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.8 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 0.4 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 0.5 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 1.1 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1 1.3 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 2.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.8 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851) neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.9 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 1.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 0.4 GO:0002046 opsin binding(GO:0002046)
0.1 0.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.3 GO:0038025 reelin receptor activity(GO:0038025)
0.1 0.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.5 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.9 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.2 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 0.6 GO:0031419 cobalamin binding(GO:0031419)
0.1 3.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 1.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.2 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0 0.3 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.6 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.6 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.5 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 1.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 2.7 GO:0043621 protein self-association(GO:0043621)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.6 GO:0031005 filamin binding(GO:0031005)
0.0 0.5 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 3.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.4 GO:0032027 myosin light chain binding(GO:0032027)
0.0 1.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.8 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.6 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 1.1 GO:0019894 kinesin binding(GO:0019894)
0.0 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.1 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.4 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.1 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 1.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.0 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.1 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.0 GO:0098960 postsynaptic neurotransmitter receptor activity(GO:0098960) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.0 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 1.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.7 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.7 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 2.6 PID E2F PATHWAY E2F transcription factor network
0.0 0.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.9 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.9 PID FGF PATHWAY FGF signaling pathway
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.5 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 REACTOME KINESINS Genes involved in Kinesins
0.1 2.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 1.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.7 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.6 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 1.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling