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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for LHX2

Z-value: 0.38

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Transcription factors associated with LHX2

Gene Symbol Gene ID Gene Info
LHX2
ENSG00000106689.6 LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX2hg19_v2_chr9_+_126773880_126773895,
hg19_v2_chr9_+_126777676_126777700		-0.115.5e-01Click!

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_38859996 2.35 ENST00000264651.2
KRT24
keratin 24
chr18_+_29027696 1.85 ENST00000257189.4
DSG3
desmoglein 3
chr4_+_69313145 1.69 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr6_-_131291572 1.09 ENST00000529208.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr6_+_53883790 0.92 ENST00000509997.1
MLIP
muscular LMNA-interacting protein
chr3_+_57882024 0.85 ENST00000494088.1
SLMAP
sarcolemma associated protein
chr1_+_152975488 0.83 ENST00000542696.1
SPRR3
small proline-rich protein 3
chr19_+_42212501 0.74 ENST00000398599.4
CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr19_+_15838834 0.72 ENST00000305899.3
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr9_+_105757590 0.71 ENST00000374798.3
ENST00000487798.1
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr6_+_53883708 0.71 ENST00000514921.1
ENST00000274897.5
ENST00000370877.2
MLIP
muscular LMNA-interacting protein
chr19_+_42212526 0.66 ENST00000598976.1
ENST00000435837.2
ENST00000221992.6
ENST00000405816.1
CEA
CEACAM5
Uncharacterized protein
carcinoembryonic antigen-related cell adhesion molecule 5
chr11_-_62323702 0.64 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr14_+_56584414 0.63 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr6_+_26199737 0.62 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr18_+_34124507 0.61 ENST00000591635.1
FHOD3
formin homology 2 domain containing 3
chr1_+_62439037 0.59 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr1_+_192127578 0.55 ENST00000367460.3
RGS18
regulator of G-protein signaling 18
chr2_+_102953608 0.55 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr14_-_34420259 0.54 ENST00000250457.3
ENST00000547327.2
EGLN3
egl-9 family hypoxia-inducible factor 3
chr4_-_159956333 0.52 ENST00000434826.2
C4orf45
chromosome 4 open reading frame 45
chr4_-_109541539 0.51 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr8_+_22424551 0.47 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr10_+_95326416 0.45 ENST00000371481.4
ENST00000371483.4
ENST00000604414.1
FFAR4
free fatty acid receptor 4
chr12_+_122688090 0.45 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr4_+_88532028 0.44 ENST00000282478.7
DSPP
dentin sialophosphoprotein
chr17_+_17082842 0.42 ENST00000579361.1
MPRIP
myosin phosphatase Rho interacting protein
chr10_-_90712520 0.42 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr17_-_57229155 0.41 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr21_-_31859755 0.39 ENST00000334055.3
KRTAP19-2
keratin associated protein 19-2
chr6_-_66417107 0.38 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr12_-_118797475 0.38 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr10_-_24770632 0.38 ENST00000596413.1
AL353583.1
AL353583.1
chr17_-_39140549 0.37 ENST00000377755.4
KRT40
keratin 40
chr3_+_62936098 0.36 ENST00000475886.1
ENST00000465684.1
ENST00000465262.1
ENST00000468072.1
LINC00698
long intergenic non-protein coding RNA 698
chr3_-_149095652 0.36 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr1_-_198509804 0.36 ENST00000489986.1
ENST00000367382.1
ATP6V1G3
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
chr17_+_61086917 0.35 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr2_+_210517895 0.35 ENST00000447185.1
MAP2
microtubule-associated protein 2
chr4_-_89951028 0.34 ENST00000506913.1
FAM13A
family with sequence similarity 13, member A
chr17_-_39222131 0.34 ENST00000394015.2
KRTAP2-4
keratin associated protein 2-4
chr11_+_31391381 0.34 ENST00000465995.1
ENST00000536040.1
DNAJC24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr12_-_10978957 0.33 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr9_+_116207007 0.33 ENST00000374140.2
RGS3
regulator of G-protein signaling 3
chr4_-_90756769 0.33 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr2_-_112237835 0.32 ENST00000442293.1
ENST00000439494.1
MIR4435-1HG
MIR4435-1 host gene (non-protein coding)
chr12_+_128399965 0.32 ENST00000540882.1
ENST00000542089.1
LINC00507
long intergenic non-protein coding RNA 507
chr10_-_29923893 0.31 ENST00000355867.4
SVIL
supervillin
chr11_+_63606373 0.30 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
MARK2
MAP/microtubule affinity-regulating kinase 2
chr14_-_51027838 0.30 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr6_+_123038689 0.30 ENST00000354275.2
ENST00000368446.1
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr10_-_14372870 0.28 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr9_-_21202204 0.28 ENST00000239347.3
IFNA7
interferon, alpha 7
chr9_-_77643307 0.27 ENST00000376834.3
ENST00000376830.3
C9orf41
chromosome 9 open reading frame 41
chr11_+_64001962 0.27 ENST00000309422.2
VEGFB
vascular endothelial growth factor B
chr11_-_55703876 0.27 ENST00000301532.3
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr16_+_23652773 0.27 ENST00000563998.1
ENST00000568589.1
ENST00000568272.1
DCTN5
dynactin 5 (p25)
chr10_+_4828815 0.26 ENST00000533295.1
AKR1E2
aldo-keto reductase family 1, member E2
chr8_-_93029865 0.26 ENST00000422361.2
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_+_126661253 0.25 ENST00000368326.1
ENST00000368325.1
ENST00000368328.4
CENPW
centromere protein W
chr3_+_57881966 0.24 ENST00000495364.1
SLMAP
sarcolemma associated protein
chr6_-_26027480 0.23 ENST00000377364.3
HIST1H4B
histone cluster 1, H4b
chr2_+_87769459 0.23 ENST00000414030.1
ENST00000437561.1
LINC00152
long intergenic non-protein coding RNA 152
chr16_-_18887627 0.23 ENST00000563235.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr6_+_125524785 0.22 ENST00000392482.2
TPD52L1
tumor protein D52-like 1
chr5_-_175388327 0.22 ENST00000432305.2
ENST00000505969.1
THOC3
THO complex 3
chr2_-_55237484 0.21 ENST00000394609.2
RTN4
reticulon 4
chr12_+_12510352 0.21 ENST00000298571.6
LOH12CR1
loss of heterozygosity, 12, chromosomal region 1
chr7_-_54826869 0.21 ENST00000450622.1
SEC61G
Sec61 gamma subunit
chr2_+_68961934 0.20 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chrX_+_18725758 0.20 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
PPEF1
protein phosphatase, EF-hand calcium binding domain 1
chr4_+_70796784 0.20 ENST00000246891.4
ENST00000444405.3
CSN1S1
casein alpha s1
chr14_+_22554680 0.19 ENST00000390451.2
TRAV23DV6
T cell receptor alpha variable 23/delta variable 6
chr2_+_68961905 0.19 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr21_-_27423339 0.18 ENST00000415997.1
APP
amyloid beta (A4) precursor protein
chr11_-_2323089 0.18 ENST00000456145.2
C11orf21
chromosome 11 open reading frame 21
chr14_+_22573582 0.18 ENST00000390453.1
TRAV24
T cell receptor alpha variable 24
chr7_-_54826920 0.18 ENST00000395535.3
ENST00000352861.4
SEC61G
Sec61 gamma subunit
chr17_-_39216344 0.18 ENST00000391418.2
KRTAP2-3
keratin associated protein 2-3
chr13_-_19755975 0.18 ENST00000400113.3
TUBA3C
tubulin, alpha 3c
chr6_+_105404899 0.18 ENST00000345080.4
LIN28B
lin-28 homolog B (C. elegans)
chr15_+_58430567 0.17 ENST00000536493.1
AQP9
aquaporin 9
chr4_-_100575781 0.17 ENST00000511828.1
RP11-766F14.2
Protein LOC285556
chr13_-_45768841 0.17 ENST00000379108.1
KCTD4
potassium channel tetramerization domain containing 4
chr11_+_120973375 0.16 ENST00000264037.2
TECTA
tectorin alpha
chr13_+_19756173 0.16 ENST00000382988.2
RP11-408E5.4
RP11-408E5.4
chr20_+_30697298 0.16 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr15_+_58430368 0.16 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr16_+_24741013 0.16 ENST00000315183.7
ENST00000395799.3
TNRC6A
trinucleotide repeat containing 6A
chr10_-_4285923 0.15 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr2_-_55276320 0.15 ENST00000357376.3
RTN4
reticulon 4
chr4_+_128554081 0.15 ENST00000335251.6
ENST00000296461.5
INTU
inturned planar cell polarity protein
chr18_-_19994830 0.15 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr6_-_26043885 0.15 ENST00000357905.2
HIST1H2BB
histone cluster 1, H2bb
chr6_+_130339710 0.14 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chrX_-_19988382 0.14 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr5_+_180682720 0.13 ENST00000599439.1
AC008443.1
CDNA: FLJ23158 fis, clone LNG09623; Uncharacterized protein
chr8_+_52730143 0.13 ENST00000415643.1
AC090186.1
Uncharacterized protein
chr9_-_116061476 0.13 ENST00000441031.3
RNF183
ring finger protein 183
chr12_-_113574028 0.13 ENST00000546530.1
ENST00000261729.5
RASAL1
RAS protein activator like 1 (GAP1 like)
chr2_+_173686303 0.13 ENST00000397087.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_+_52682052 0.13 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr16_+_23652700 0.13 ENST00000300087.2
DCTN5
dynactin 5 (p25)
chr2_+_234627424 0.12 ENST00000373409.3
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr18_+_3466248 0.12 ENST00000581029.1
ENST00000581442.1
ENST00000579007.1
RP11-838N2.4
RP11-838N2.4
chr2_-_55496174 0.12 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
MTIF2
mitochondrial translational initiation factor 2
chr3_+_35722424 0.12 ENST00000396481.2
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_+_35722844 0.12 ENST00000436702.1
ENST00000438071.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr12_-_10955226 0.11 ENST00000240687.2
TAS2R7
taste receptor, type 2, member 7
chr16_-_23652570 0.11 ENST00000261584.4
PALB2
partner and localizer of BRCA2
chr7_-_122840015 0.11 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr4_+_147096837 0.11 ENST00000296581.5
ENST00000502781.1
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chrX_+_105937068 0.11 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr4_-_153332886 0.11 ENST00000603841.1
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chrX_-_11284095 0.11 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr17_-_33864772 0.11 ENST00000361112.4
SLFN12L
schlafen family member 12-like
chr12_+_128399917 0.10 ENST00000544645.1
LINC00507
long intergenic non-protein coding RNA 507
chr2_-_166930131 0.10 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr1_+_95616933 0.09 ENST00000604203.1
RP11-57H12.6
TMEM56-RWDD3 readthrough
chr3_-_160823040 0.09 ENST00000484127.1
ENST00000492353.1
ENST00000473142.1
ENST00000468268.1
ENST00000460353.1
ENST00000320474.4
ENST00000392781.2
B3GALNT1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr2_+_87135076 0.09 ENST00000409776.2
RGPD1
RANBP2-like and GRIP domain containing 1
chr19_-_44384291 0.09 ENST00000324394.6
ZNF404
zinc finger protein 404
chr19_+_20188830 0.09 ENST00000418063.2
ZNF90
zinc finger protein 90
chr3_+_38017264 0.09 ENST00000436654.1
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr7_-_103848405 0.09 ENST00000447452.2
ENST00000545943.1
ENST00000297431.4
ORC5
origin recognition complex, subunit 5
chr14_+_101297740 0.09 ENST00000555928.1
MEG3
maternally expressed 3 (non-protein coding)
chr6_+_30848557 0.09 ENST00000460944.2
ENST00000324771.8
DDR1
discoidin domain receptor tyrosine kinase 1
chr8_-_109260897 0.08 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr21_+_35014783 0.08 ENST00000381291.4
ENST00000381285.4
ENST00000399367.3
ENST00000399352.1
ENST00000399355.2
ENST00000399349.1
ITSN1
intersectin 1 (SH3 domain protein)
chr11_-_104827425 0.08 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr3_-_160823158 0.08 ENST00000392779.2
ENST00000392780.1
ENST00000494173.1
B3GALNT1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr1_-_153518270 0.08 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr4_-_120243545 0.08 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr12_+_9980069 0.08 ENST00000354855.3
ENST00000324214.4
ENST00000279544.3
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr15_+_69854027 0.08 ENST00000498938.2
RP11-279F6.1
RP11-279F6.1
chr8_-_19459993 0.08 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr14_-_107211459 0.07 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chr2_+_45168875 0.07 ENST00000260653.3
SIX3
SIX homeobox 3
chr4_+_70916119 0.07 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chrX_+_30233668 0.06 ENST00000378988.4
MAGEB2
melanoma antigen family B, 2
chr12_-_74686314 0.06 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr7_-_112758589 0.06 ENST00000413744.1
ENST00000439551.1
ENST00000441359.1
LINC00998
long intergenic non-protein coding RNA 998
chr4_+_71226468 0.06 ENST00000226460.4
SMR3A
submaxillary gland androgen regulated protein 3A
chr7_+_37960163 0.06 ENST00000199448.4
ENST00000559325.1
ENST00000423717.1
EPDR1
ependymin related 1
chr14_+_69865401 0.06 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
SLC39A9
solute carrier family 39, member 9
chr10_+_69865866 0.06 ENST00000354393.2
MYPN
myopalladin
chr12_+_16064106 0.06 ENST00000428559.2
DERA
deoxyribose-phosphate aldolase (putative)
chr17_-_34308524 0.05 ENST00000293275.3
CCL16
chemokine (C-C motif) ligand 16
chr6_+_132873832 0.05 ENST00000275200.1
TAAR8
trace amine associated receptor 8
chr17_+_45000483 0.05 ENST00000576910.2
ENST00000439730.2
ENST00000393456.2
ENST00000415811.2
ENST00000575949.1
ENST00000225567.4
ENST00000572403.1
ENST00000570879.1
GOSR2
golgi SNAP receptor complex member 2
chr12_+_6554021 0.05 ENST00000266557.3
CD27
CD27 molecule
chr21_-_35014027 0.04 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr2_-_231084659 0.04 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr5_-_159546396 0.04 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr12_-_11548496 0.04 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2
PRB1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr8_-_82395461 0.04 ENST00000256104.4
FABP4
fatty acid binding protein 4, adipocyte
chr2_+_90139056 0.03 ENST00000492446.1
IGKV1D-16
immunoglobulin kappa variable 1D-16
chrX_+_99839799 0.03 ENST00000373031.4
TNMD
tenomodulin
chr18_+_3247779 0.03 ENST00000578611.1
ENST00000583449.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_+_182419261 0.03 ENST00000294854.8
ENST00000542961.1
RGSL1
regulator of G-protein signaling like 1
chr5_-_78281603 0.03 ENST00000264914.4
ARSB
arylsulfatase B
chr6_+_3259148 0.03 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr7_-_151217166 0.03 ENST00000496004.1
RHEB
Ras homolog enriched in brain
chr1_-_147142557 0.02 ENST00000369238.6
ACP6
acid phosphatase 6, lysophosphatidic
chr20_-_31989307 0.02 ENST00000473997.1
ENST00000544843.1
ENST00000346416.2
ENST00000357886.4
ENST00000339269.5
CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr12_-_91573316 0.02 ENST00000393155.1
DCN
decorin
chrX_+_52513455 0.01 ENST00000446098.1
XAGE1C
X antigen family, member 1C
chrX_-_20074895 0.01 ENST00000543767.1
MAP7D2
MAP7 domain containing 2
chr5_+_179921344 0.01 ENST00000261951.4
CNOT6
CCR4-NOT transcription complex, subunit 6
chr1_-_168464875 0.01 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chrX_+_19373700 0.01 ENST00000379804.1
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr14_+_27342334 0.01 ENST00000548170.1
ENST00000552926.1
RP11-384J4.1
RP11-384J4.1
chr11_-_104972158 0.00 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr1_+_160709076 0.00 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr11_+_94706973 0.00 ENST00000536741.1
KDM4D
lysine (K)-specific demethylase 4D
chr17_-_39306054 0.00 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chr1_-_232651312 0.00 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr5_-_133702761 0.00 ENST00000521118.1
ENST00000265334.4
ENST00000435211.1
CDKL3
cyclin-dependent kinase-like 3

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.4 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 0.6 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.5 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 1.1 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.4 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.3 GO:1903284 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 1.4 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.0 0.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 5.4 GO:0070268 cornification(GO:0070268)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.4 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.3 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.3 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.0 0.1 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.1 GO:0009946 proximal/distal axis specification(GO:0009946) neuroblast differentiation(GO:0014016)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:0006789 bilirubin conjugation(GO:0006789)
0.0 0.9 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.4 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.3 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.9 GO:0031424 keratinization(GO:0031424)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.2 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.6 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.0 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0033150 cytoskeletal calyx(GO:0033150)
0.1 0.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.4 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.1 GO:0008091 spectrin(GO:0008091)
0.0 1.8 GO:0030057 desmosome(GO:0030057)
0.0 1.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.8 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 3.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.4 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.7 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 1.4 GO:0034235 GPI anchor binding(GO:0034235)
0.1 0.4 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 1.1 GO:0042731 PH domain binding(GO:0042731)
0.1 0.3 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.3 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.2 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.0 0.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.4 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.7 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.9 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.6 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.0 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.3 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling