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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for LHX3

Z-value: 0.37

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Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
ENSG00000107187.11 LIM homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3hg19_v2_chr9_-_139096955_139096979,
hg19_v2_chr9_-_139094988_139095012
-0.154.2e-01Click!

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_13835147 0.53 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr12_-_10282836 0.52 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
C-type lectin domain family 7, member A
chr9_-_75567962 0.46 ENST00000297785.3
ENST00000376939.1
aldehyde dehydrogenase 1 family, member A1
chr19_+_11457232 0.44 ENST00000587531.1
coiled-coil domain containing 159
chr12_-_10282681 0.40 ENST00000533022.1
C-type lectin domain family 7, member A
chr12_-_10282742 0.40 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
C-type lectin domain family 7, member A
chr19_+_49199209 0.32 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
fucosyltransferase 2 (secretor status included)
chr17_-_39093672 0.30 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
keratin 23 (histone deacetylase inducible)
chr18_+_72201664 0.28 ENST00000358821.3
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr9_+_125132803 0.27 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_+_27015628 0.27 ENST00000318627.2
fin bud initiation factor homolog (zebrafish)
chr3_-_141747950 0.26 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_-_23891693 0.26 ENST00000264867.2
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chrX_+_9431324 0.24 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr18_+_72201829 0.24 ENST00000582365.1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr17_+_68071458 0.24 ENST00000589377.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 0.23 ENST00000283936.1
ENST00000392671.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_+_50016411 0.23 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
Fc fragment of IgG, receptor, transporter, alpha
chr18_-_53303123 0.22 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
transcription factor 4
chr11_-_63376013 0.22 ENST00000540943.1
phospholipase A2, group XVI
chr10_+_696000 0.22 ENST00000381489.5
proline rich 26
chr1_+_81771806 0.22 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
latrophilin 2
chr2_+_26624775 0.21 ENST00000288710.2
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr12_-_52761262 0.21 ENST00000257901.3
keratin 85
chr19_+_50016610 0.20 ENST00000596975.1
Fc fragment of IgG, receptor, transporter, alpha
chr1_-_48866517 0.20 ENST00000371841.1
spermatogenesis associated 6
chr14_-_101295407 0.20 ENST00000596284.1
AL117190.2
chr12_+_59989918 0.19 ENST00000547379.1
ENST00000549465.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr10_-_27529486 0.19 ENST00000375888.1
acyl-CoA binding domain containing 5
chr15_+_64680003 0.19 ENST00000261884.3
thyroid hormone receptor interactor 4
chr1_+_244214577 0.19 ENST00000358704.4
zinc finger and BTB domain containing 18
chrX_+_108779004 0.18 ENST00000218004.1
nuclear transport factor 2-like export factor 2
chr16_-_28634874 0.18 ENST00000395609.1
ENST00000350842.4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr19_-_6279932 0.18 ENST00000252674.7
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr17_+_1674982 0.18 ENST00000572048.1
ENST00000573763.1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chrX_+_105412290 0.17 ENST00000357175.2
ENST00000337685.2
melanoma associated antigen (mutated) 1-like 1
chr1_-_182641037 0.17 ENST00000483095.2
regulator of G-protein signaling 8
chr8_+_105352050 0.17 ENST00000297581.2
dendrocyte expressed seven transmembrane protein
chr1_-_182640988 0.17 ENST00000367556.1
regulator of G-protein signaling 8
chr4_-_41884582 0.17 ENST00000499082.2
long intergenic non-protein coding RNA 682
chr19_-_49149553 0.17 ENST00000084798.4
carbonic anhydrase XI
chr16_-_28937027 0.15 ENST00000358201.4
rabaptin, RAB GTPase binding effector protein 2
chr22_+_23487513 0.15 ENST00000263116.2
ENST00000341989.4
RAB36, member RAS oncogene family
chr4_+_186990298 0.15 ENST00000296795.3
ENST00000513189.1
toll-like receptor 3
chr5_+_67586465 0.15 ENST00000336483.5
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr14_-_21566731 0.14 ENST00000360947.3
zinc finger protein 219
chr1_+_115572415 0.14 ENST00000256592.1
thyroid stimulating hormone, beta
chr1_-_57285038 0.14 ENST00000343433.6
chromosome 1 open reading frame 168
chrM_-_14670 0.13 ENST00000361681.2
mitochondrially encoded NADH dehydrogenase 6
chr10_+_695888 0.13 ENST00000441152.2
proline rich 26
chr20_+_5987890 0.13 ENST00000378868.4
cardiolipin synthase 1
chr17_-_10372875 0.13 ENST00000255381.2
myosin, heavy chain 4, skeletal muscle
chr19_-_11457162 0.12 ENST00000590482.1
transmembrane protein 205
chr2_-_99279928 0.12 ENST00000414521.2
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr8_-_110986918 0.12 ENST00000297404.1
potassium channel, subfamily V, member 1
chr6_-_2634820 0.12 ENST00000296847.3
chromosome 6 open reading frame 195
chr10_-_90611566 0.11 ENST00000371930.4
ankyrin repeat domain 22
chr3_+_157827841 0.11 ENST00000295930.3
ENST00000471994.1
ENST00000464171.1
ENST00000312179.6
ENST00000475278.2
arginine/serine-rich coiled-coil 1
chr2_+_234826016 0.11 ENST00000324695.4
ENST00000433712.2
transient receptor potential cation channel, subfamily M, member 8
chr12_-_118628350 0.10 ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chr7_+_107224364 0.10 ENST00000491150.1
B-cell receptor-associated protein 29
chr19_+_11457175 0.10 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
coiled-coil domain containing 159
chr3_-_191000172 0.09 ENST00000427544.2
urotensin 2B
chr5_+_140529630 0.09 ENST00000543635.1
protocadherin beta 6
chr11_-_67980744 0.08 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr19_-_43969796 0.08 ENST00000244333.3
LY6/PLAUR domain containing 3
chr5_+_147691979 0.08 ENST00000274565.4
serine peptidase inhibitor, Kazal type 7 (putative)
chr6_+_130339710 0.08 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr4_+_113568207 0.08 ENST00000511529.1
La ribonucleoprotein domain family, member 7
chr14_-_21567009 0.08 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
zinc finger protein 219
chr3_+_46919235 0.07 ENST00000449590.1
parathyroid hormone 1 receptor
chr9_-_116065551 0.07 ENST00000297894.5
ring finger protein 183
chr2_-_99871570 0.06 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
lysozyme G-like 2
chr7_-_36764142 0.06 ENST00000258749.5
ENST00000535891.1
acyloxyacyl hydrolase (neutrophil)
chr3_-_141719195 0.06 ENST00000397991.4
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_-_25268104 0.06 ENST00000222674.2
neuropeptide VF precursor
chr6_-_49712123 0.06 ENST00000263045.4
cysteine-rich secretory protein 3
chr12_+_49740700 0.06 ENST00000549441.2
ENST00000395069.3
DnaJ (Hsp40) homolog, subfamily C, member 22
chr10_-_115904361 0.05 ENST00000428953.1
ENST00000543782.1
chromosome 10 open reading frame 118
chr15_-_75748115 0.05 ENST00000360439.4
SIN3 transcription regulator family member A
chr4_+_41937131 0.05 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
transmembrane protein 33
chr6_+_26104104 0.05 ENST00000377803.2
histone cluster 1, H4c
chr17_-_64225508 0.05 ENST00000205948.6
apolipoprotein H (beta-2-glycoprotein I)
chr6_-_49712147 0.05 ENST00000433368.2
ENST00000354620.4
cysteine-rich secretory protein 3
chr11_-_128894053 0.05 ENST00000392657.3
Rho GTPase activating protein 32
chr3_-_47517302 0.05 ENST00000441517.2
ENST00000545718.1
SREBF chaperone
chr18_+_28956740 0.05 ENST00000308128.4
ENST00000359747.4
desmoglein 4
chr2_-_166930131 0.05 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
sodium channel, voltage-gated, type I, alpha subunit
chr5_+_140557371 0.04 ENST00000239444.2
protocadherin beta 8
chr12_-_86650077 0.04 ENST00000552808.2
ENST00000547225.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr17_-_60142609 0.04 ENST00000397786.2
mediator complex subunit 13
chr7_+_30185406 0.04 ENST00000324489.5
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chrX_+_24167746 0.04 ENST00000428571.1
ENST00000539115.1
zinc finger protein, X-linked
chr6_+_114178512 0.04 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr12_-_53994805 0.04 ENST00000328463.7
activating transcription factor 7
chr11_-_327537 0.04 ENST00000602735.1
interferon induced transmembrane protein 3
chr3_+_101443476 0.03 ENST00000327230.4
ENST00000494050.1
centrosomal protein 97kDa
chr3_+_69812877 0.03 ENST00000457080.1
ENST00000328528.6
microphthalmia-associated transcription factor
chr4_-_41884620 0.03 ENST00000504870.1
long intergenic non-protein coding RNA 682
chr9_-_215744 0.03 ENST00000382387.2
chromosome 9 open reading frame 66
chr14_+_55493920 0.03 ENST00000395472.2
ENST00000555846.1
suppressor of cytokine signaling 4
chr6_+_72926145 0.03 ENST00000425662.2
ENST00000453976.2
regulating synaptic membrane exocytosis 1
chr4_-_185275104 0.03 ENST00000317596.3
RP11-290F5.2
chr4_+_3344141 0.03 ENST00000306648.7
regulator of G-protein signaling 12
chr5_-_78809950 0.03 ENST00000334082.6
homer homolog 1 (Drosophila)
chrX_+_24167828 0.03 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
zinc finger protein, X-linked
chr14_-_45252031 0.03 ENST00000556405.1
RP11-398E10.1
chr6_-_66417107 0.02 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
eyes shut homolog (Drosophila)
chr6_+_83072923 0.02 ENST00000535040.1
trophoblast glycoprotein
chr7_-_122840015 0.02 ENST00000194130.2
solute carrier family 13 (sodium/sulfate symporter), member 1
chr19_+_48949030 0.02 ENST00000253237.5
glutamate-rich WD repeat containing 1
chr1_-_24126051 0.02 ENST00000445705.1
UDP-galactose-4-epimerase
chr14_+_55494323 0.02 ENST00000339298.2
suppressor of cytokine signaling 4
chr9_-_128246769 0.02 ENST00000444226.1
mitogen-activated protein kinase associated protein 1
chr13_-_81801115 0.02 ENST00000567258.1
long intergenic non-protein coding RNA 564
chr11_-_67981046 0.02 ENST00000402789.1
ENST00000402185.2
ENST00000458496.1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr20_+_11008408 0.02 ENST00000378252.1
chromosome 20 open reading frame 187
chr15_+_65843130 0.02 ENST00000569894.1
protein tyrosine phosphatase-like A domain containing 1
chr5_-_43557791 0.02 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
poly(A) binding protein interacting protein 1
chr12_+_64798095 0.01 ENST00000332707.5
exportin, tRNA
chr8_-_49834299 0.01 ENST00000396822.1
snail family zinc finger 2
chrM_+_10053 0.01 ENST00000361227.2
mitochondrially encoded NADH dehydrogenase 3
chrX_+_84258832 0.01 ENST00000373173.2
apolipoprotein O-like
chr1_-_231005310 0.01 ENST00000470540.1
chromosome 1 open reading frame 198
chr3_+_138340049 0.01 ENST00000464668.1
Fas apoptotic inhibitory molecule
chr8_-_25281747 0.01 ENST00000421054.2
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr2_+_185463093 0.01 ENST00000302277.6
zinc finger protein 804A
chr8_+_119294456 0.01 ENST00000366457.2
Uncharacterized protein
chr5_-_16916624 0.01 ENST00000513882.1
myosin X
chr19_+_9296279 0.01 ENST00000344248.2
olfactory receptor, family 7, subfamily D, member 2
chr2_-_145278475 0.00 ENST00000558170.2
zinc finger E-box binding homeobox 2
chr1_-_24126023 0.00 ENST00000429356.1
UDP-galactose-4-epimerase
chr8_+_92261516 0.00 ENST00000276609.3
ENST00000309536.2
solute carrier family 26 (anion exchanger), member 7
chr3_-_20053741 0.00 ENST00000389050.4
protein phosphatase 2C-like domain containing 1
chr3_+_141106643 0.00 ENST00000514251.1
zinc finger and BTB domain containing 38
chr1_-_92952433 0.00 ENST00000294702.5
growth factor independent 1 transcription repressor

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 0.2 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.1 1.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.2 GO:0034241 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.1 0.5 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.4 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 0.1 GO:0034343 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.3 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.1 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:0043203 axon hillock(GO:0043203)
0.0 0.0 GO:0001674 female germ cell nucleus(GO:0001674)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 1.3 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0030572 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1