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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for LHX3

Z-value: 0.37

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Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
LHX3
ENSG00000107187.11 LIM homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3hg19_v2_chr9_-_139096955_139096979,
hg19_v2_chr9_-_139094988_139095012		-0.154.2e-01Click!

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_13835147 0.53 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr12_-_10282836 0.52 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr9_-_75567962 0.46 ENST00000297785.3
ENST00000376939.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr19_+_11457232 0.44 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr12_-_10282681 0.40 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr12_-_10282742 0.40 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr19_+_49199209 0.32 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr17_-_39093672 0.30 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr18_+_72201664 0.28 ENST00000358821.3
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr9_+_125132803 0.27 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_+_27015628 0.27 ENST00000318627.2
FIBIN
fin bud initiation factor homolog (zebrafish)
chr3_-_141747950 0.26 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_-_23891693 0.26 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chrX_+_9431324 0.24 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr18_+_72201829 0.24 ENST00000582365.1
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr17_+_68071458 0.24 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 0.23 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_+_50016411 0.23 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr18_-_53303123 0.22 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4
transcription factor 4
chr11_-_63376013 0.22 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr10_+_696000 0.22 ENST00000381489.5
PRR26
proline rich 26
chr1_+_81771806 0.22 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2
latrophilin 2
chr2_+_26624775 0.21 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr12_-_52761262 0.21 ENST00000257901.3
KRT85
keratin 85
chr19_+_50016610 0.20 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_-_48866517 0.20 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr14_-_101295407 0.20 ENST00000596284.1
AL117190.2
AL117190.2
chr12_+_59989918 0.19 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr10_-_27529486 0.19 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr15_+_64680003 0.19 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr1_+_244214577 0.19 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chrX_+_108779004 0.18 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr16_-_28634874 0.18 ENST00000395609.1
ENST00000350842.4
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr19_-_6279932 0.18 ENST00000252674.7
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr17_+_1674982 0.18 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chrX_+_105412290 0.17 ENST00000357175.2
ENST00000337685.2
MUM1L1
melanoma associated antigen (mutated) 1-like 1
chr1_-_182641037 0.17 ENST00000483095.2
RGS8
regulator of G-protein signaling 8
chr8_+_105352050 0.17 ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr1_-_182640988 0.17 ENST00000367556.1
RGS8
regulator of G-protein signaling 8
chr4_-_41884582 0.17 ENST00000499082.2
LINC00682
long intergenic non-protein coding RNA 682
chr19_-_49149553 0.17 ENST00000084798.4
CA11
carbonic anhydrase XI
chr16_-_28937027 0.15 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr22_+_23487513 0.15 ENST00000263116.2
ENST00000341989.4
RAB36
RAB36, member RAS oncogene family
chr4_+_186990298 0.15 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr5_+_67586465 0.15 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr14_-_21566731 0.14 ENST00000360947.3
ZNF219
zinc finger protein 219
chr1_+_115572415 0.14 ENST00000256592.1
TSHB
thyroid stimulating hormone, beta
chr1_-_57285038 0.14 ENST00000343433.6
C1orf168
chromosome 1 open reading frame 168
chrM_-_14670 0.13 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr10_+_695888 0.13 ENST00000441152.2
PRR26
proline rich 26
chr20_+_5987890 0.13 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr17_-_10372875 0.13 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr19_-_11457162 0.12 ENST00000590482.1
TMEM205
transmembrane protein 205
chr2_-_99279928 0.12 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr8_-_110986918 0.12 ENST00000297404.1
KCNV1
potassium channel, subfamily V, member 1
chr6_-_2634820 0.12 ENST00000296847.3
C6orf195
chromosome 6 open reading frame 195
chr10_-_90611566 0.11 ENST00000371930.4
ANKRD22
ankyrin repeat domain 22
chr3_+_157827841 0.11 ENST00000295930.3
ENST00000471994.1
ENST00000464171.1
ENST00000312179.6
ENST00000475278.2
RSRC1
arginine/serine-rich coiled-coil 1
chr2_+_234826016 0.11 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr12_-_118628350 0.10 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr7_+_107224364 0.10 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr19_+_11457175 0.10 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr3_-_191000172 0.09 ENST00000427544.2
UTS2B
urotensin 2B
chr5_+_140529630 0.09 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr11_-_67980744 0.08 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr19_-_43969796 0.08 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chr5_+_147691979 0.08 ENST00000274565.4
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr6_+_130339710 0.08 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr4_+_113568207 0.08 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr14_-_21567009 0.08 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
ZNF219
zinc finger protein 219
chr3_+_46919235 0.07 ENST00000449590.1
PTH1R
parathyroid hormone 1 receptor
chr9_-_116065551 0.07 ENST00000297894.5
RNF183
ring finger protein 183
chr2_-_99871570 0.06 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr7_-_36764142 0.06 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr3_-_141719195 0.06 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_-_25268104 0.06 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr6_-_49712123 0.06 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr12_+_49740700 0.06 ENST00000549441.2
ENST00000395069.3
DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr10_-_115904361 0.05 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr15_-_75748115 0.05 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr4_+_41937131 0.05 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr6_+_26104104 0.05 ENST00000377803.2
HIST1H4C
histone cluster 1, H4c
chr17_-_64225508 0.05 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr6_-_49712147 0.05 ENST00000433368.2
ENST00000354620.4
CRISP3
cysteine-rich secretory protein 3
chr11_-_128894053 0.05 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr3_-_47517302 0.05 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr18_+_28956740 0.05 ENST00000308128.4
ENST00000359747.4
DSG4
desmoglein 4
chr2_-_166930131 0.05 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr5_+_140557371 0.04 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr12_-_86650077 0.04 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr17_-_60142609 0.04 ENST00000397786.2
MED13
mediator complex subunit 13
chr7_+_30185406 0.04 ENST00000324489.5
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chrX_+_24167746 0.04 ENST00000428571.1
ENST00000539115.1
ZFX
zinc finger protein, X-linked
chr6_+_114178512 0.04 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr12_-_53994805 0.04 ENST00000328463.7
ATF7
activating transcription factor 7
chr11_-_327537 0.04 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr3_+_101443476 0.03 ENST00000327230.4
ENST00000494050.1
CEP97
centrosomal protein 97kDa
chr3_+_69812877 0.03 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr4_-_41884620 0.03 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr9_-_215744 0.03 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr14_+_55493920 0.03 ENST00000395472.2
ENST00000555846.1
SOCS4
suppressor of cytokine signaling 4
chr6_+_72926145 0.03 ENST00000425662.2
ENST00000453976.2
RIMS1
regulating synaptic membrane exocytosis 1
chr4_-_185275104 0.03 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr4_+_3344141 0.03 ENST00000306648.7
RGS12
regulator of G-protein signaling 12
chr5_-_78809950 0.03 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chrX_+_24167828 0.03 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX
zinc finger protein, X-linked
chr14_-_45252031 0.03 ENST00000556405.1
RP11-398E10.1
RP11-398E10.1
chr6_-_66417107 0.02 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr6_+_83072923 0.02 ENST00000535040.1
TPBG
trophoblast glycoprotein
chr7_-_122840015 0.02 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr19_+_48949030 0.02 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr1_-_24126051 0.02 ENST00000445705.1
GALE
UDP-galactose-4-epimerase
chr14_+_55494323 0.02 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr9_-_128246769 0.02 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr13_-_81801115 0.02 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr11_-_67981046 0.02 ENST00000402789.1
ENST00000402185.2
ENST00000458496.1
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr20_+_11008408 0.02 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr15_+_65843130 0.02 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr5_-_43557791 0.02 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
PAIP1
poly(A) binding protein interacting protein 1
chr12_+_64798095 0.01 ENST00000332707.5
XPOT
exportin, tRNA
chr8_-_49834299 0.01 ENST00000396822.1
SNAI2
snail family zinc finger 2
chrM_+_10053 0.01 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chrX_+_84258832 0.01 ENST00000373173.2
APOOL
apolipoprotein O-like
chr1_-_231005310 0.01 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr3_+_138340049 0.01 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr8_-_25281747 0.01 ENST00000421054.2
GNRH1
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr2_+_185463093 0.01 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr8_+_119294456 0.01 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr5_-_16916624 0.01 ENST00000513882.1
MYO10
myosin X
chr19_+_9296279 0.01 ENST00000344248.2
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr2_-_145278475 0.00 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr1_-_24126023 0.00 ENST00000429356.1
GALE
UDP-galactose-4-epimerase
chr8_+_92261516 0.00 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr3_-_20053741 0.00 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr3_+_141106643 0.00 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr1_-_92952433 0.00 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 0.2 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.1 1.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.2 GO:0034241 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.1 0.5 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.4 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 0.1 GO:0034343 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.3 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.1 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:0043203 axon hillock(GO:0043203)
0.0 0.0 GO:0001674 female germ cell nucleus(GO:0001674)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 1.3 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0030572 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1