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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for LHX6

Z-value: 0.72

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Transcription factors associated with LHX6

Gene Symbol Gene ID Gene Info
LHX6
ENSG00000106852.11 LIM homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX6hg19_v2_chr9_-_124976154_124976177,
hg19_v2_chr9_-_124976185_124976212		-0.202.9e-01Click!

Activity profile of LHX6 motif

Sorted Z-values of LHX6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_35938674 3.96 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL
calcyphosine-like
chr12_+_7013897 3.65 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr12_+_7014064 3.63 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr21_-_43916433 3.41 ENST00000291536.3
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr4_+_165675197 3.01 ENST00000515485.1
RP11-294O2.2
RP11-294O2.2
chr10_-_123274693 2.96 ENST00000429361.1
FGFR2
fibroblast growth factor receptor 2
chr17_-_1532106 2.81 ENST00000301335.5
ENST00000382147.4
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr21_-_43916296 2.56 ENST00000398352.3
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr12_+_7014126 2.50 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr4_+_165675269 2.21 ENST00000507311.1
RP11-294O2.2
RP11-294O2.2
chr1_-_36906474 2.10 ENST00000433045.2
OSCP1
organic solute carrier partner 1
chr16_-_55866997 1.91 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr11_-_33913708 1.62 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr13_+_37006421 1.52 ENST00000255465.4
CCNA1
cyclin A1
chr13_+_37006398 1.51 ENST00000418263.1
CCNA1
cyclin A1
chr13_+_37005967 1.30 ENST00000440264.1
ENST00000449823.1
CCNA1
cyclin A1
chr18_+_44526786 1.26 ENST00000245121.5
ENST00000356157.7
KATNAL2
katanin p60 subunit A-like 2
chr17_-_1531635 1.19 ENST00000571650.1
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr9_+_1050331 1.17 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
DMRT2
doublesex and mab-3 related transcription factor 2
chr3_-_129147432 1.17 ENST00000503957.1
ENST00000505956.1
ENST00000326085.3
EFCAB12
EF-hand calcium binding domain 12
chr4_-_138453559 1.11 ENST00000511115.1
PCDH18
protocadherin 18
chr14_+_74034310 1.05 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr6_-_167040731 1.04 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr12_-_102133191 1.02 ENST00000392924.1
ENST00000266743.2
ENST00000392927.3
SYCP3
synaptonemal complex protein 3
chr22_-_39190116 0.98 ENST00000406622.1
ENST00000216068.4
ENST00000406199.3
SUN2
DNAL4
Sad1 and UNC84 domain containing 2
dynein, axonemal, light chain 4
chr18_+_5238055 0.96 ENST00000582363.1
ENST00000582008.1
ENST00000580082.1
LINC00667
long intergenic non-protein coding RNA 667
chr15_+_40697988 0.96 ENST00000487418.2
ENST00000479013.2
IVD
isovaleryl-CoA dehydrogenase
chr1_+_28261492 0.95 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr5_+_142149955 0.94 ENST00000378004.3
ARHGAP26
Rho GTPase activating protein 26
chr13_-_86373536 0.92 ENST00000400286.2
SLITRK6
SLIT and NTRK-like family, member 6
chr6_+_29691198 0.91 ENST00000440587.2
ENST00000434407.2
HLA-F
major histocompatibility complex, class I, F
chr6_+_29691056 0.89 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr16_-_55867146 0.89 ENST00000422046.2
CES1
carboxylesterase 1
chr5_-_54830871 0.89 ENST00000307259.8
PPAP2A
phosphatidic acid phosphatase type 2A
chr10_-_28571015 0.87 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr1_+_28261621 0.85 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr3_-_112693865 0.84 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
CD200R1
CD200 receptor 1
chr3_-_121553830 0.82 ENST00000498104.1
ENST00000460108.1
ENST00000349820.6
ENST00000462442.1
ENST00000310864.6
IQCB1
IQ motif containing B1
chr5_-_54830784 0.81 ENST00000264775.5
PPAP2A
phosphatidic acid phosphatase type 2A
chr5_-_20575959 0.76 ENST00000507958.1
CDH18
cadherin 18, type 2
chrX_+_77154935 0.74 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr1_-_48866517 0.73 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr17_+_57408994 0.72 ENST00000312655.4
YPEL2
yippee-like 2 (Drosophila)
chr3_-_112693759 0.72 ENST00000440122.2
ENST00000490004.1
CD200R1
CD200 receptor 1
chr6_+_39760129 0.71 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr11_-_76155700 0.69 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr3_+_108541545 0.68 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr17_-_73937116 0.67 ENST00000586717.1
ENST00000389570.4
ENST00000319129.5
FBF1
Fas (TNFRSF6) binding factor 1
chr7_+_70597109 0.65 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr11_+_100862811 0.65 ENST00000303130.2
TMEM133
transmembrane protein 133
chr6_+_26402465 0.64 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr6_+_148663729 0.62 ENST00000367467.3
SASH1
SAM and SH3 domain containing 1
chr19_-_40931891 0.62 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chr1_+_145438469 0.62 ENST00000369317.4
TXNIP
thioredoxin interacting protein
chr20_+_19867150 0.61 ENST00000255006.6
RIN2
Ras and Rab interactor 2
chr3_+_108541608 0.61 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr11_+_17298255 0.61 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
NUCB2
nucleobindin 2
chr4_-_1723040 0.60 ENST00000382936.3
ENST00000536901.1
ENST00000303277.2
TMEM129
transmembrane protein 129
chr11_+_17298297 0.60 ENST00000529010.1
NUCB2
nucleobindin 2
chr9_+_71944241 0.59 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr6_-_49681235 0.58 ENST00000339139.4
CRISP2
cysteine-rich secretory protein 2
chr17_+_73452695 0.58 ENST00000582186.1
ENST00000582455.1
ENST00000581252.1
ENST00000579208.1
KIAA0195
KIAA0195
chr16_+_31885079 0.58 ENST00000300870.10
ENST00000394846.3
ZNF267
zinc finger protein 267
chr11_-_102651343 0.57 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr7_+_149571045 0.56 ENST00000479613.1
ENST00000606024.1
ENST00000464662.1
ENST00000425642.2
ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr7_+_120590803 0.55 ENST00000315870.5
ENST00000339121.5
ENST00000445699.1
ING3
inhibitor of growth family, member 3
chr18_+_60190682 0.55 ENST00000588676.1
ZCCHC2
zinc finger, CCHC domain containing 2
chr6_-_32095968 0.53 ENST00000375203.3
ENST00000375201.4
ATF6B
activating transcription factor 6 beta
chr19_+_56459198 0.53 ENST00000291971.3
ENST00000590542.1
NLRP8
NLR family, pyrin domain containing 8
chr3_+_179280668 0.52 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A
actin-like 6A
chr3_-_105587879 0.51 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr1_+_44115814 0.51 ENST00000372396.3
KDM4A
lysine (K)-specific demethylase 4A
chr2_-_242089677 0.51 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr4_+_155702496 0.51 ENST00000510397.1
RBM46
RNA binding motif protein 46
chr10_-_46168156 0.50 ENST00000374371.2
ENST00000335258.7
ZFAND4
zinc finger, AN1-type domain 4
chr6_+_30457244 0.50 ENST00000376630.4
HLA-E
major histocompatibility complex, class I, E
chr2_+_220143989 0.50 ENST00000336576.5
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr6_+_36164487 0.49 ENST00000357641.6
BRPF3
bromodomain and PHD finger containing, 3
chr18_+_5238549 0.49 ENST00000580684.1
LINC00667
long intergenic non-protein coding RNA 667
chr1_-_190446759 0.49 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr14_+_100842735 0.48 ENST00000554998.1
ENST00000402312.3
ENST00000335290.6
ENST00000554175.1
WDR25
WD repeat domain 25
chr11_-_76155618 0.47 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr3_-_42003479 0.47 ENST00000420927.1
ULK4
unc-51 like kinase 4
chr11_-_133826852 0.46 ENST00000533871.2
ENST00000321016.8
IGSF9B
immunoglobulin superfamily, member 9B
chr6_+_52051171 0.45 ENST00000340057.1
IL17A
interleukin 17A
chr18_+_60190226 0.45 ENST00000269499.5
ZCCHC2
zinc finger, CCHC domain containing 2
chr17_-_62208169 0.45 ENST00000606895.1
ERN1
endoplasmic reticulum to nucleus signaling 1
chr17_+_42148097 0.45 ENST00000269097.4
G6PC3
glucose 6 phosphatase, catalytic, 3
chr1_-_13390765 0.44 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr2_+_201936458 0.42 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr6_-_139613269 0.42 ENST00000358430.3
TXLNB
taxilin beta
chr16_-_66584059 0.41 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr11_+_77532233 0.41 ENST00000525409.1
AAMDC
adipogenesis associated, Mth938 domain containing
chr5_+_142149932 0.41 ENST00000274498.4
ARHGAP26
Rho GTPase activating protein 26
chr18_-_21017817 0.41 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
TMEM241
transmembrane protein 241
chr1_-_236228403 0.40 ENST00000366595.3
NID1
nidogen 1
chr11_+_77532155 0.39 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
AAMDC
adipogenesis associated, Mth938 domain containing
chr11_-_236326 0.39 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
SIRT3
sirtuin 3
chr1_-_236228417 0.38 ENST00000264187.6
NID1
nidogen 1
chr11_-_128894053 0.38 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr6_+_26402517 0.38 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr18_-_5238525 0.38 ENST00000581170.1
ENST00000579933.1
ENST00000581067.1
RP11-835E18.5
LINC00526
RP11-835E18.5
long intergenic non-protein coding RNA 526
chr14_+_21249200 0.37 ENST00000304677.2
RNASE6
ribonuclease, RNase A family, k6
chr17_+_73452545 0.37 ENST00000314256.7
KIAA0195
KIAA0195
chr12_-_45270151 0.37 ENST00000429094.2
NELL2
NEL-like 2 (chicken)
chr11_-_124981475 0.36 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr4_-_66536196 0.36 ENST00000511294.1
EPHA5
EPH receptor A5
chr16_+_31724552 0.35 ENST00000539915.1
ENST00000316491.9
ENST00000399681.3
ENST00000398696.3
ENST00000534369.1
ZNF720
zinc finger protein 720
chr4_+_113558272 0.35 ENST00000509061.1
ENST00000508577.1
ENST00000513553.1
LARP7
La ribonucleoprotein domain family, member 7
chr6_-_24358264 0.34 ENST00000378454.3
DCDC2
doublecortin domain containing 2
chr13_+_73632897 0.34 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr12_-_45270077 0.33 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NELL2
NEL-like 2 (chicken)
chr19_-_54663473 0.33 ENST00000222224.3
LENG1
leukocyte receptor cluster (LRC) member 1
chr17_-_44439084 0.33 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ARL17B
ADP-ribosylation factor-like 17B
chr12_+_118573663 0.33 ENST00000261313.2
PEBP1
phosphatidylethanolamine binding protein 1
chr1_-_1709845 0.33 ENST00000341426.5
ENST00000344463.4
NADK
NAD kinase
chr12_-_82152420 0.32 ENST00000552948.1
ENST00000548586.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr12_-_45269430 0.32 ENST00000395487.2
NELL2
NEL-like 2 (chicken)
chr10_-_48416849 0.32 ENST00000249598.1
GDF2
growth differentiation factor 2
chr17_-_41466555 0.31 ENST00000586231.1
LINC00910
long intergenic non-protein coding RNA 910
chr3_-_105588231 0.31 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr11_-_102714534 0.31 ENST00000299855.5
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr17_+_41323204 0.30 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
NBR1
neighbor of BRCA1 gene 1
chr14_+_76127529 0.30 ENST00000556977.1
ENST00000557636.1
ENST00000286650.5
ENST00000298832.9
TTLL5
tubulin tyrosine ligase-like family, member 5
chr7_-_86849883 0.30 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr9_+_104161123 0.29 ENST00000374861.3
ENST00000339664.2
ENST00000259395.4
ZNF189
zinc finger protein 189
chr17_-_47841485 0.29 ENST00000506156.1
ENST00000240364.2
FAM117A
family with sequence similarity 117, member A
chr1_-_228613026 0.29 ENST00000366696.1
HIST3H3
histone cluster 3, H3
chr11_+_59856130 0.28 ENST00000278888.3
MS4A2
membrane-spanning 4-domains, subfamily A, member 2
chrY_+_14813160 0.28 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr19_-_41870026 0.28 ENST00000243578.3
B9D2
B9 protein domain 2
chr12_-_56753858 0.28 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa
chr1_+_152943122 0.28 ENST00000328051.2
SPRR4
small proline-rich protein 4
chrX_+_19362011 0.28 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr22_+_41777927 0.28 ENST00000266304.4
TEF
thyrotrophic embryonic factor
chr13_-_41593425 0.27 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_-_33285505 0.27 ENST00000431845.2
ZBTB22
zinc finger and BTB domain containing 22
chr6_+_30585486 0.26 ENST00000259873.4
ENST00000506373.2
MRPS18B
mitochondrial ribosomal protein S18B
chr9_+_104296122 0.26 ENST00000389120.3
RNF20
ring finger protein 20, E3 ubiquitin protein ligase
chr14_-_104181771 0.26 ENST00000554913.1
ENST00000554974.1
ENST00000553361.1
ENST00000555055.1
ENST00000555964.1
ENST00000556682.1
ENST00000445556.1
ENST00000553332.1
ENST00000352127.7
XRCC3
X-ray repair complementing defective repair in Chinese hamster cells 3
chr19_-_51071302 0.26 ENST00000389201.3
ENST00000600381.1
LRRC4B
leucine rich repeat containing 4B
chr19_-_10491130 0.26 ENST00000530829.1
ENST00000529370.1
TYK2
tyrosine kinase 2
chr4_-_103748880 0.26 ENST00000453744.2
ENST00000349311.8
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr19_-_12833361 0.26 ENST00000592287.1
TNPO2
transportin 2
chr19_-_10491234 0.25 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2
tyrosine kinase 2
chr19_-_47137942 0.25 ENST00000300873.4
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr1_-_1710229 0.24 ENST00000341991.3
NADK
NAD kinase
chr2_-_152118352 0.24 ENST00000331426.5
RBM43
RNA binding motif protein 43
chr19_-_12833164 0.24 ENST00000356861.5
TNPO2
transportin 2
chr14_+_22293618 0.23 ENST00000390432.2
TRAV10
T cell receptor alpha variable 10
chr6_-_85474219 0.23 ENST00000369663.5
TBX18
T-box 18
chr17_-_74733404 0.23 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2
serine/arginine-rich splicing factor 2
chr3_-_160823158 0.23 ENST00000392779.2
ENST00000392780.1
ENST00000494173.1
B3GALNT1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr3_-_157221380 0.22 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr10_-_72142345 0.22 ENST00000373224.1
ENST00000446961.1
ENST00000358141.2
ENST00000357631.2
LRRC20
leucine rich repeat containing 20
chrX_-_6453159 0.22 ENST00000381089.3
ENST00000398729.1
VCX3A
variable charge, X-linked 3A
chr3_-_160823040 0.22 ENST00000484127.1
ENST00000492353.1
ENST00000473142.1
ENST00000468268.1
ENST00000460353.1
ENST00000320474.4
ENST00000392781.2
B3GALNT1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr2_-_227050079 0.22 ENST00000423838.1
AC068138.1
AC068138.1
chr19_+_7694623 0.21 ENST00000594797.1
ENST00000456958.3
ENST00000601406.1
PET100
PET100 homolog (S. cerevisiae)
chr9_+_12775011 0.21 ENST00000319264.3
LURAP1L
leucine rich adaptor protein 1-like
chr11_+_67798090 0.21 ENST00000313468.5
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr5_+_174151536 0.21 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr4_-_74486109 0.21 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr4_-_66536057 0.20 ENST00000273854.3
EPHA5
EPH receptor A5
chr11_-_18548426 0.20 ENST00000357193.3
ENST00000536719.1
TSG101
tumor susceptibility 101
chrX_+_77166172 0.20 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr6_-_31125850 0.20 ENST00000507751.1
ENST00000448162.2
ENST00000502557.1
ENST00000503420.1
ENST00000507892.1
ENST00000507226.1
ENST00000513222.1
ENST00000503934.1
ENST00000396263.2
ENST00000508683.1
ENST00000428174.1
ENST00000448141.2
ENST00000507829.1
ENST00000455279.2
ENST00000376266.5
CCHCR1
coiled-coil alpha-helical rod protein 1
chr15_-_77712477 0.19 ENST00000560626.2
PEAK1
pseudopodium-enriched atypical kinase 1
chr6_-_33385854 0.19 ENST00000488478.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr10_-_104001231 0.19 ENST00000370002.3
PITX3
paired-like homeodomain 3
chr6_-_33385655 0.18 ENST00000440279.3
ENST00000607266.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr8_+_9413410 0.18 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chrX_-_47509887 0.18 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1
ELK1, member of ETS oncogene family
chr3_-_157221357 0.17 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr2_+_201936707 0.17 ENST00000433898.1
ENST00000454214.1
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr6_-_33385870 0.17 ENST00000488034.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr3_+_115342349 0.17 ENST00000393780.3
GAP43
growth associated protein 43
chr9_-_127905736 0.17 ENST00000336505.6
ENST00000373549.4
SCAI
suppressor of cancer cell invasion
chr17_+_18086392 0.17 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr6_-_33385823 0.16 ENST00000494751.1
ENST00000374496.3
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr17_+_80416482 0.16 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF
nuclear prelamin A recognition factor
chr6_-_33385902 0.16 ENST00000374500.5
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr18_-_65184217 0.16 ENST00000310045.7
DSEL
dermatan sulfate epimerase-like
chr2_-_3521518 0.16 ENST00000382093.5
ADI1
acireductone dioxygenase 1
chr7_+_100210133 0.16 ENST00000393950.2
ENST00000424091.2
MOSPD3
motile sperm domain containing 3
chr5_-_159846399 0.15 ENST00000297151.4
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr7_-_77427676 0.15 ENST00000257663.3
TMEM60
transmembrane protein 60
chr12_-_2113583 0.15 ENST00000397173.4
ENST00000280665.6
DCP1B
decapping mRNA 1B
chr17_+_66511540 0.15 ENST00000588188.2
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr14_-_99947168 0.15 ENST00000331768.5
SETD3
SET domain containing 3
chr20_+_35807512 0.14 ENST00000373622.5
RPN2
ribophorin II
chr14_-_52535712 0.14 ENST00000216286.5
ENST00000541773.1
NID2
nidogen 2 (osteonidogen)
chr11_+_67798114 0.14 ENST00000453471.2
ENST00000528492.1
ENST00000526339.1
ENST00000525419.1
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr7_+_100209725 0.14 ENST00000223054.4
MOSPD3
motile sperm domain containing 3
chrM_+_10758 0.14 ENST00000361381.2
MT-ND4
mitochondrially encoded NADH dehydrogenase 4
chr12_-_102455902 0.13 ENST00000240079.6
CCDC53
coiled-coil domain containing 53
chr2_-_74405929 0.13 ENST00000396049.4
MOB1A
MOB kinase activator 1A
chr17_-_44657017 0.13 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ARL17A
ADP-ribosylation factor-like 17A
chrX_+_49020882 0.13 ENST00000454342.1
MAGIX
MAGI family member, X-linked
chr20_+_5731083 0.13 ENST00000445603.1
ENST00000442185.1
C20orf196
chromosome 20 open reading frame 196

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604)
0.7 2.8 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.2 2.3 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.2 1.2 GO:0061055 myotome development(GO:0061055)
0.2 5.4 GO:0007141 male meiosis I(GO:0007141)
0.2 0.8 GO:0048496 maintenance of organ identity(GO:0048496)
0.2 1.0 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.2 0.9 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.6 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 1.8 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 1.2 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.5 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 0.6 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 1.0 GO:0006552 leucine catabolic process(GO:0006552)
0.1 0.4 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 6.3 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.9 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 0.5 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.5 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 0.3 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.1 0.2 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.1 4.0 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 1.0 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 0.6 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.2 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.1 0.2 GO:2000397 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.1 0.2 GO:0071284 cellular response to lead ion(GO:0071284)
0.1 0.5 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.1 1.6 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.2 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.1 0.4 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.1 0.3 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.1 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
0.0 0.3 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.2 GO:0070213 negative regulation of sister chromatid cohesion(GO:0045875) protein auto-ADP-ribosylation(GO:0070213)
0.0 0.5 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.8 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.8 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.4 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.2 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.4 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 1.0 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.7 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.2 GO:0019236 response to pheromone(GO:0019236)
0.0 1.1 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 0.9 GO:0010038 response to metal ion(GO:0010038)
0.0 0.6 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.6 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.5 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.4 GO:0007507 heart development(GO:0007507)
0.0 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.4 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.4 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.6 GO:0007035 vacuolar acidification(GO:0007035)
0.0 1.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.6 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.2 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.2 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.3 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 1.0 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.1 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.0 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 1.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 1.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.3 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
0.4 6.0 GO:0001520 outer dense fiber(GO:0001520)
0.2 2.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 0.7 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.9 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.0 GO:0000800 lateral element(GO:0000800)
0.1 1.0 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.7 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.2 GO:0035061 interchromatin granule(GO:0035061)
0.0 2.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.6 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.8 GO:0005605 basal lamina(GO:0005605)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 1.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.3 1.8 GO:0046979 TAP2 binding(GO:0046979)
0.2 3.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 0.5 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.2 1.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.4 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.1 1.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.4 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.4 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 0.8 GO:0043237 laminin-1 binding(GO:0043237)
0.1 4.0 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 1.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.3 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.2 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 1.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.7 GO:0032027 myosin light chain binding(GO:0032027)
0.1 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.2 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.1 1.0 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.5 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.3 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.3 GO:0019863 IgE binding(GO:0019863)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.6 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 1.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.6 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.4 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.3 GO:0070410 co-SMAD binding(GO:0070410)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 0.8 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.7 PID FGF PATHWAY FGF signaling pathway
0.0 1.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID MYC PATHWAY C-MYC pathway
0.0 0.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 3.0 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.2 4.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 4.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 1.0 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.3 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 1.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis